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2019

CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential: Journal of Immunology

De Simone, G., Mazza, EMC., Cassotta, A., Davydov, AN., Kuka, M., Zanon, V., De Paoli, F., Scamardella, E., Metsger, M., Roberto, A., Pilipow, K., Colombo, FS., Tenedini, E., Tagliafico, E., Gattinoni, L., Mavilio, D., Peano, C., Price, DA., Singh, SP., Farber, JM. & 9 others, Serra, V., Cucca, F., Ferrari, F., Orrù, V., Fiorillo, E., Iannacone, M., Chudakov, DM., Sallusto, F. & Lugli, E., 2019, In : Journal of Immunology. 203, 12, p. 3179-3189 11 p.

Research output: Contribution to journalArticle

CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential

De Simone, G., Mazza, E. M. C., Cassotta, A., Davydov, A. N., Kuka, M., Zanon, V., De Paoli, F., Scamardella, E., Metsger, M., Roberto, A., Pilipow, K., Colombo, F. S., Tenedini, E., Tagliafico, E., Gattinoni, L., Mavilio, D., Peano, C., Price, D. A., Singh, S. P., Farber, J. M. & 9 others, Serra, V., Cucca, F., Ferrari, F., Orrù, V., Fiorillo, E., Iannacone, M., Chudakov, D. M., Sallusto, F. & Lugli, E., Dec 15 2019, In : Journal of immunology (Baltimore, Md. : 1950). 203, 12, p. 3179-3189 11 p.

Research output: Contribution to journalArticle

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

Bénéchet, A. P., De Simone, G., Di Lucia, P., Cilenti, F., Barbiera, G., Le Bert, N., Fumagalli, V., Lusito, E., Moalli, F., Bianchessi, V., Andreata, F., Zordan, P., Bono, E., Giustini, L., Bonilla, W. V., Bleriot, C., Kunasegaran, K., Gonzalez-Aseguinolaza, G., Pinschewer, D. D., Kennedy, P. T. F. & 8 others, Naldini, L., Kuka, M., Ginhoux, F., Cantore, A., Bertoletti, A., Ostuni, R., Guidotti, L. G. & Iannacone, M., Oct 10 2019, In : Nature. 574, 7777, p. 200-205 6 p.

Research output: Contribution to journalArticle

Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates

Milani, M., Annoni, A., Moalli, F., Liu, T., Cesana, D., Calabria, A., Bartolaccini, S., Biffi, M., Russo, F., Visigalli, I., Raimondi, A., Patarroyo-White, S., Drager, D., Cristofori, P., Ayuso, E., Montini, E., Peters, R., Iannacone, M., Cantore, A. & Naldini, L., Jan 1 2019, In : Science Translational Medicine. 11, 493

Research output: Contribution to journalArticle

2018

Alum/toll-like receptor 7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node

Vo, HTM., Baudner, BC., Sammicheli, S., Iannacone, M., D'Oro, U. & Piccioli, D., 2018, In : Frontiers in Immunology. 9, 5, 641.

Research output: Contribution to journalArticle

In vivo imaging of adaptive immune responses to viruses

De Giovanni, M. & Iannacone, M., 2018, In : Current Opinion in Virology. 28, p. 102-107 6 p.

Research output: Contribution to journalArticle

The conduit system exports locally secreted IgM from lymph nodes

Thierry, GR., Kuka, M., De Giovanni, M., Mondor, I., Brouilly, N., Iannacone, M. & Bajénoff, M., 2018, In : Journal of Experimental Medicine. 215, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticle

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+T cells

Moalli, F., Ficht, X., Germann, P., Vladymyrov, M., Stolp, B., De Vries, I., Lyck, R., Balmer, J., Fiocchi, A., Kreutzfeldt, M., Merkler, D., Iannacone, M., Ariga, A., Stoffel, MH., Sharpe, J., Bähler, M., Sixt, M., Diz‑Muñoz, A. & Stein, JV., 2018, In : Journal of Experimental Medicine. 215, 7, p. 1869-1890 22 p.

Research output: Contribution to journalArticle

Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction in mice and is safe and effective during acute viral infection

Jofra, T., Di Fonte, R., Galvani, G., Kuka, M., Iannacone, M., Battaglia, M. & Fousteri, G., 2018, In : European Journal of Immunology. 48, 8, p. 1389-1399 11 p.

Research output: Contribution to journalArticle

Viral subversion of B cell responses within secondary lymphoid organs

Kuka, M. & Iannacone, M., 2018, In : Nature Reviews Immunology. 18, p. 255-265 11 p.

Research output: Contribution to journalArticle

2017

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

Brewitz, A., Eickhoff, S., Dähling, S., Quast, T., Bedoui, S., Kroczek, RA., Kurts, C., Garbi, N., Barchet, W., Iannacone, M., Klauschen, F., Kolanus, W., Kaisho, T., Colonna, M., Germain, RN. & Kastenmüller, W., 2017, In : Immunity. 46, 2, p. 205-219 15 p.

Research output: Contribution to journalArticle

Determinants of hepatic effector CD8+ T cell dynamics

Benechet, AP. & Iannacone, M., 2017, In : Journal of Hepatology. 66, 1, p. 228-233 6 p.

Research output: Contribution to journalArticle

Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology

Fioravanti, J., Di Lucia, P., Magini, D., Moalli, F., Boni, C., Benechet, AP., Fumagalli, V., Inverso, D., Vecchi, A., Fiocchi, A., Wieland, S., Purcell, R., Ferrari, C., Chisari, FV., Guidotti, LG. & Iannacone, M., 2017, In : Journal of Hepatology. 67, 3, p. 543-548 6 p.

Research output: Contribution to journalArticle

Extrinsic protein tyrosine phosphatase non-receptor 22 signals contribute to CD8 T cell exhaustion and promote persistence of chronic lymphocytic choriomeningitis virus infection

Jofra, T., Galvani, G., Kuka, M., Di Fonte, R., Mfarrej, BG., Iannacone, M., Salek-Ardakani, S., Battaglia, M. & Fousteri, G., 2017, In : Frontiers in Immunology. 8, 6, 811.

Research output: Contribution to journalArticle

In vivo chronic stimulation unveils autoreactive potential of Wiskott-Aldrich syndrome protein-deficient b cells

Castiello, MC., Pala, F., Sereni, L., Draghici, E., Inverso, D., Sauer, AV., Schena, F., Fontana, E., Radaelli, E., Uva, P., Cervantes-Luevano, KE., Benvenuti, F., Poliani, PL., Iannacone, M., Traggiai, E., Villa, A. & Bosticardo, M., 2017, In : Frontiers in Immunology. 8, 4, 490.

Research output: Contribution to journalArticle

Microcirculation in the murine liver: A computational fluid dynamic model based on 3D reconstruction from in vivo microscopy

Piergiovanni, M., Bianchi, E., Capitani, G., Li Piani, I., Ganzer, L., Guidotti, LG., Iannacone, M. & Dubini, G., 2017, In : Journal of Biomechanics. 63, 12, p. 125-134 10 p.

Research output: Contribution to journalArticle

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria

Gaertner, F., Ahmad, Z., Rosenberger, G., Fan, S., Nicolai, L., Busch, B., Yavuz, G., Luckner, M., Ishikawa-Ankerhold, H., Hennel, R., Benechet, A., Lorenz, M., Chandraratne, S., Schubert, I., Helmer, S., Striednig, B., Stark, K., Janko, M., Böttcher, RT., Verschoor, A. & 11 others, Leon, C., Gachet, C., Gudermann, T., Mederos y Schnitzler, M., Pincus, Z., Iannacone, M., Haas, R., Wanner, G., Lauber, K., Sixt, M. & Massberg, S., 2017, In : Cell. 171, 6, p. 1368-1382.e23

Research output: Contribution to journalArticle

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

Jiménez de Oya, N., De Giovanni, M., Fioravanti, J., Übelhart, R., Di Lucia, P., Fiocchi, A., Iacovelli, S., Efremov, DG., Caligaris-Cappio, F., Jumaa, H., Ghia, P., Guidotti, LG. & Iannacone, M., 2017, In : EMBO Molecular Medicine. 9, 11, p. 1482-1490 9 p.

Research output: Contribution to journalArticle

Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

Medaglia, C., Giladi, A., Stoler-Barak, L., De Giovanni, M., Salame, TM., Biram, A., David, E., Li, H., Iannacone, M., Shulman, Z. & Amit, I., 2017, In : Science. 358, 6370, p. 1622-1626 5 p.

Research output: Contribution to journalArticle

Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine

Pirzgalska, RM., Seixas, E., Seidman, JS., Link, VM., Sánchez, NM., Mahú, I., Mendes, R., Gres, V., Kubasova, N., Morris, I., Arús, BA., Larabee, CM., Vasques, M., Tortosa, F., Sousa, AL., Anandan, S., Tranfield, E., Hahn, MK., Iannacone, M., Spann, NJ. & 2 others, Glass, CK. & Domingos, AI., 2017, In : Nature Medicine. 23, 11, p. 1309-1318 10 p.

Research output: Contribution to journalArticle

2016

IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

Catarinella, M., Monestiroli, A., Escobar, G., Fiocchi, A., Tran, N. L., Aiolfi, R., Marra, P., Esposito, A., Cipriani, F., Aldrighetti, L., Iannacone, M., Naldini, L., Guidotti, L. G. & Sitia, G., Feb 1 2016, In : EMBO Molecular Medicine. 8, 2, p. 155-170 16 p.

Research output: Contribution to journalArticle

Spatiotemporal dynamics of effector CD8+ T cell responses within the liver

Inverso, D. & Iannacone, M., Jan 1 2016, In : Journal of Leukocyte Biology. 99, 1, p. 51-55 5 p.

Research output: Contribution to journalArticle

2015

A luminescent poly(amidoamine)-iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy

Maggioni, D., Galli, M., D'Alfonso, L., Inverso, D., Dozzi, M. V., Sironi, L., Iannacone, M., Collini, M., Ferruti, P., Ranucci, E. & D'Alfonso, G., Jan 20 2015, In : Inorganic Chemistry. 54, 2, p. 544-553 10 p.

Research output: Contribution to journalArticle

Editorial overview: Viral pathogenesis

Guidotti, L. G. & Iannacone, M., May 31 2015, In : Current Opinion in Virology. 11, p. v-vii 461.

Research output: Contribution to journalArticle

Hepatic effector CD8+ T-cell dynamics

Iannacone, M., May 7 2015, In : Cellular and Molecular Immunology. 12, 3, p. 269-272 4 p.

Research output: Contribution to journalArticle

Immunosurveillance of the liver by intravascular effector CD8+ T cells

Guidotti, L. G., Inverso, D., Sironi, L., Di Lucia, P., Fioravanti, J., Ganzer, L., Fiocchi, A., Vacca, M., Aiolfi, R., Sammicheli, S., Mainetti, M., Cataudella, T., Raimondi, A., Gonzalez-Aseguinolaza, G., Protzer, U., Ruggeri, Z. M., Chisari, F. V., Isogawa, M., Sitia, G. & Iannacone, M., Apr 23 2015, In : Cell. 161, 3, p. 486-500 15 p.

Research output: Contribution to journalArticle

Mouse models of hepatitis B virus pathogenesis

Iannacone, M. & Guidotti, L. G., Nov 1 2015, In : Cold Spring Harbor perspectives in medicine. 5, 11, a021477.

Research output: Contribution to journalArticle

PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner

Fousteri, G., Jofra, T., Di Fonte, R., Kuka, M., Iannacone, M. & Battaglia, M., Feb 1 2015, In : Clinical Immunology. 156, 2, p. 98-108 11 p.

Research output: Contribution to journalArticle

2014

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Ilyinskii, P. O., Roy, C. J., O'Neil, C. P., Browning, E. A., Pittet, L. A., Altreuter, D. H., Alexis, F., Tonti, E., Shi, J., Basto, P. A., Iannacone, M., Radovic-Moreno, A. F., Langer, R. S., Farokhzad, O. C., von Andrian, U. H., Johnston, L. P. M. & Kishimoto, T. K., May 19 2014, In : Vaccine. 32, 24, p. 2882-2895 14 p.

Research output: Contribution to journalArticle

In vivo flow mapping in complex vessel networks by single image correlation

Sironi, L., Bouzin, M., Inverso, D., D'Alfonso, L., Pozzi, P., Cotelli, F., Guidotti, L. G., Iannacone, M., Collini, M. & Chirico, G., 2014, In : Scientific Reports. 4, 7341.

Research output: Contribution to journalArticle

The role of lymph node sinus macrophages in host defense

Kuka, M. & Iannacone, M., 2014, In : Annals of the New York Academy of Sciences. 1319, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

2013

Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and memory fate decisions

Henrickson, S. E., Perro, M., Loughhead, S. M., Senman, B., Stutte, S., Quigley, M., Alexe, G., Iannacone, M., Flynn, M. P., Omid, S., Jesneck, J. L., Imam, S., Mempel, T. R., Mazo, I. B., Haining, W. N. & Von Andrian, U. H., Sep 19 2013, In : Immunity. 39, 3, p. 496-507 12 p.

Research output: Contribution to journalArticle

Bisphosphonates Target B Cells to Enhance Humoral Immune Responses

Tonti, E., JiménezdeOya, N., Galliverti, G., Moseman, E. A., DiLucia, P., Amabile, A., Sammicheli, S., DeGiovanni, M., Sironi, L., Chevrier, N., Sitia, G., Gennari, L., Guidotti, L., VonAndrian, U. & Iannacone, M., 2013, In : Cell Reports. 5, 2, p. 323-330 8 p.

Research output: Contribution to journalArticle

Effector CD8 T cell trafficking within the liver

Guidotti, L. G. & Iannacone, M., Aug 2013, In : Molecular Immunology. 55, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

2012

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B

Sitia, G., Aiolfi, R., Di Lucia, P., Mainetti, M., Fiocchi, A., Mingozzi, F., Esposito, A., Ruggeri, Z. M., Chisari, F. V., Iannacone, M. & Guidotti, L. G., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32

Research output: Contribution to journalArticle

B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive Immunity

Moseman, E. A., Iannacone, M., Bosurgi, L., Tonti, E., Chevrier, N., Tumanov, A., Fu, Y. X., Hacohen, N. & von Andrian, U. H., Mar 23 2012, In : Immunity. 36, 3, p. 415-426 12 p.

Research output: Contribution to journalArticle

Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes

Sung, J. H., Zhang, H., Ashley Moseman, E., Alvarez, D., Iannacone, M., Henrickson, S. E., De La Torre, J. C., Groom, J. R., Luster, A. D. & Von Andrian, U. H., Sep 14 2012, In : Cell. 150, 6, p. 1249-1263 15 p.

Research output: Contribution to journalArticle

Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4 + T cell help

Tonti, E., Fedeli, M., Napolitano, A., Iannacone, M., Von Andrian, U. H., Guidotti, L. G., Abrignani, S., Casorati, G. & Dellabona, P., Apr 1 2012, In : Journal of Immunology. 188, 7, p. 3217-3222 6 p.

Research output: Contribution to journalArticle

2011

Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis

Sitia, G., Iannacone, M., Aiolfi, R., Isogawa, M., van Rooijen, N., Scozzesi, C., Bianchi, M. E., von Andrian, U. H., Chisari, F. V. & Guidotti, L. G., Jun 2011, In : PLoS Pathogens. 7, 6, e1002061.

Research output: Contribution to journalArticle

Systematic discovery of TLR signaling components delineates viral-sensing circuits

Chevrier, N., Mertins, P., Artyomov, M. N., Shalek, A. K., Iannacone, M., Ciaccio, M. F., Gat-Viks, I., Tonti, E., Degrace, M. M., Clauser, K. R., Garber, M., Eisenhaure, T. M., Yosef, N., Robinson, J., Sutton, A., Andersen, M. S., Root, D. E., Von Andrian, U., Jones, R. B., Park, H. & 4 others, Carr, S. A., Regev, A., Amit, I. & Hacohen, N., Nov 11 2011, In : Cell. 147, 4, p. 853-867 15 p.

Research output: Contribution to journalArticle

2010

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

Iannacone, M., Moseman, E. A., Tonti, E., Bosurgi, L., Junt, T., Henrickson, S. E., Whelan, S. P., Guidotti, L. G. & Von Andrian, U. H., Jun 24 2010, In : Nature. 465, 7301, p. 1079-1083 5 p.

Research output: Contribution to journalArticle

2009

On the role of platelets in the pathogenesis of viral hepatitis

Iannacone, M., Sitia, G. & Guidotti, L. G., Sep 2009, In : Journal of Hepatology. 51, 3, p. 599-600 2 p.

Research output: Contribution to journalArticle

2008

Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus

Iannacone, M., Sitia, G., Isogawa, M., Whitmire, J. K., Marchese, P., Chisari, F. V., Ruggeri, Z. M. & Guidotti, L. G., Jan 15 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

2007

Acute thrombocytopenia after liver transplant: Role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment

Nascimbene, A., Iannacone, M., Brando, B. & De Gasperi, A., Nov 2007, In : Journal of Hepatology. 47, 5, p. 651-657 7 p.

Research output: Contribution to journalArticle

HBV pathogenesis in animal models: Recent advances on the role of platelets

Iannacone, M., Sitia, G., Ruggeri, Z. M. & Guidotti, L. G., Apr 2007, In : Journal of Hepatology. 46, 4, p. 719-726 8 p.

Research output: Contribution to journalArticle

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., Van Rooijen, N., Mempel, T. R., Whelan, S. P. & Von Andrian, U. H., Nov 1 2007, In : Nature. 450, 7166, p. 110-114 5 p.

Research output: Contribution to journalArticle