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Research Output 1999 2018

2018

Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B

Bai, Y., Wu, X., Brennan, KM., Wang, DS., D'Antonio, M., Moran, J., Svaren, J. & Shy, ME., 2018, In : Annals of Clinical and Translational Neurology. 5, 4, p. 445-455 11 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Charcot-Marie-Tooth Disease
Unfolded Protein Response
Mutation
Mutant Proteins

Neuroactive steroids and diabetic complications in the nervous system

Giatti, S., Mastrangelo, R., D'Antonio, M., Pesaresi, M., Romano, S., Diviccaro, S., Caruso, D., Mitro, N. & Melcangi, RC., 2018, In : Frontiers in Neuroendocrinology. 48, 4, p. 58-69 12 p.

Research output: Contribution to journalArticle

Diabetes Complications
Nervous System
Steroids
Diabetic Neuropathies
Brain Diseases
Spinal Ganglia
Virus Replication
Myelin Sheath
Knockout Mice
Interferons
2017

Endoplasmic reticulum protein quality control failure in myelin disorders

Volpi, VG., Touvier, T. & D'Antonio, M., 2017, In : Frontiers in Molecular Neuroscience. 9, 2, 162.

Research output: Contribution to journalArticle

Myelin Sheath
Endoplasmic Reticulum
Quality Control
Proteins
Unfolded Protein Response

Sox2 expression in schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve

Roberts, SL., Dun, XP., Doddrell, RDS., Mindos, T., Drake, LK., Onaitis, MW., Florio, F., Quattrini, A., Lloyd, AC., D’Antonio, M. & Parkinson, DB., 2017, In : Development (Cambridge). 144, 17, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

Schwann Cells
Macrophages
Peripheral Nervous System
Axons
Stem Cells
2016

Ablation of Perk in schwann cells improves myelination in the S63del charcot-marie-tooth 1B mouse

Sidoli, M., Musner, N., Silvestri, N., Ungaro, D., D’Antonio, M., Cavener, D. R., Laura Feltri, M. & Wrabetz, L., Nov 2 2016, In : Journal of Neuroscience. 36, 44, p. 11350-11361 12 p.

Research output: Contribution to journalArticle

Schwann Cells
Tooth
Unfolded Protein Response
Endoplasmic Reticulum Stress
Endoplasmic Reticulum

Perk ablation ameliorates myelination in S63del-Charcot-Marie-Tooth IB neuropathy

Musner, N., Sidoli, M., Zambroni, D., del Carro, U., Ungaro, D., D’Antonio, M., Feltri, M. L. & Wrabetz, L., Mar 1 2016, In : ASN Neuro. 8, 2

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Endoplasmic Reticulum
Tooth
Charcot-Marie-Tooth Disease
Myelin P0 Protein

Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: Insights into pathogenesis

Riva, N., Clarelli, F., Domi, T., Cerri, F., Gallia, F., Trimarco, A., Brambilla, P., Lunetta, C., Lazzerini, A., Lauria, G., Taveggia, C., Iannaccone, S., Nobile-Orazio, E., Comi, G., D'Antonio, M., Martinelli-Boneschi, F. & Quattrini, A., Dec 16 2016, In : Scientific Reports. 6, 39297.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Peripheral Nerves
Transcriptome
Gene Expression
Small Nucleolar RNA

Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: Insights into pathogenesis

Riva, N., Clarelli, F., Domi, T., Cerri, F., Gallia, F., Trimarco, A., Brambilla, P., Lunetta, C., Lazzerini, A., Lauria, G., Taveggia, C., Iannaccone, S., Nobile-Orazio, E., Comi, G., D'Antonio, M., Martinelli Boneschi, F. & Quattrini, A., Dec 16 2016, In : Scientific Reports. 6, 39297.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Peripheral Nerves
Transcriptome
Gene Expression
Small Nucleolar RNA
2015

HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins

Brügger, V., Engler, S., Pereira, J. A., Ruff, S., Horn, M., Welzl, H., Münger, E., Vaquié, A., Sidiropoulos, P. N. M., Egger, B., Yotovski, P., Filgueira, L., Somandin, C., Lühmann, T. C., D’Antonio, M., Yamaguchi, T., Matthias, P., Suter, U. & Jacob, C., Sep 25 2015, In : PLoS Biology. 13, 9, e1002258.

Research output: Contribution to journalArticle

Histone Deacetylases
myelin sheath
Myelin Sheath
histones
Maintenance

Lack of sterol regulatory element binding factor-1c imposes glial fatty acid utilization leading to peripheral neuropathy

Cermenati, G., Audano, M., Giatti, S., Carozzi, V., Porretta-Serapiglia, C., Pettinato, E., Ferri, C., D'Antonio, M., De Fabiani, E., Crestani, M., Scurati, S., Saez, E., Azcoitia, I., Cavaletti, G., Garcia-Segura, L. M., Melcangi, R. C., Caruso, D. & Mitro, N., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 571-583 13 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Sterols
Neuroglia
Fatty Acids
Myelin Sheath

Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy

Vaccari, I., Carbone, A., Previtali, S. C., Mironova, Y. A., Alberizzi, V., Noseda, R., Rivellini, C., Bianchi, F., Del Carro, U., D'Antonio, M., Lenk, G. M., Wrabetz, L., Giger, R. J., Meisler, M. H. & Bolino, A., Jan 15 2015, In : Human Molecular Genetics. 24, 2, p. 383-396 14 p., ddu451.

Research output: Contribution to journalArticle

Schwann Cells
Motor Neurons
Tooth
Demyelinating Diseases
Autophagy

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

Touvier, T., De Palma, C., Rigamonti, E., Scagliola, A., Incerti, E., Mazelin, L., Thomas, J. L., D'Antonio, M., Politi, L., Schaeffer, L., Clementi, E. & Brunelli, S., Jan 1 2015, In : Cell Death and Disease. 6, 2, e1663.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Skeletal Muscle
Muscles
Muscle Development
Growth

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

Das, I., Krzyzosiak, A., Schneider, K., Wrabetz, L., D'Antonio, M., Barry, N., Sigurdardottir, A. & Bertolotti, A., Apr 10 2015, In : Science. 348, 6231, p. 239-242 4 p.

Research output: Contribution to journalArticle

Proteostasis Deficiencies
Phosphoric Monoester Hydrolases
Biological Phenomena
Protein Phosphatase 1
Phosphoprotein Phosphatases

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function

Mitro, N., Cermenati, G., Audano, M., Giatti, S., D’Antonio, M., De Fabiani, E., Crestani, M., Saez, E., Azcoitia, I., Cavaletti, G., Garcia-Segura, L. M., Melcangi, R. C. & Caruso, D., Dec 1 2015, In : SpringerPlus. 4, p. 1-32 32 p., L45.

Research output: Contribution to journalArticle

2013

Resetting translational homeostasis restores myelination in charcot-marie-tooth disease type 1B mice

D'Antonio, M., Musner, N., Scapin, C., Ungaro, D., Del Carro, U., Ron, D., Laura Feltri, M. & Wrabetz, L., 2013, In : Journal of Experimental Medicine. 210, 4, p. 821-838 18 p.

Research output: Contribution to journalArticle

Charcot-Marie-Tooth Disease
Schwann Cells
Unfolded Protein Response
Homeostasis
Myelin P0 Protein
2011

P0S63del impedes the arrival of wild-type P0 glycoprotein to myelin in CMT1B mice

Fratta, P., Saveri, P., Zambroni, D., Ferri, C., Tinelli, E., Messing, A., D'Antonio, M., Feltri, M. L. & Wrabetz, L., Jun 2011, In : Human Molecular Genetics. 20, 11, p. 2081-2090 10 p., ddr081.

Research output: Contribution to journalArticle

Myelin P0 Protein
Myelin Sheath
Unfolded Protein Response
Demyelinating Diseases
Endoplasmic Reticulum
2010

P0 (protein zero) mutation S34C underlies instability of internodal myelin in S63C mice

Avila, R. L., D'Antonio, M., Bachi, A., Inouye, H., Feltri, M. L., Wrabetz, L. & Kirschner, D. A., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 42001-42012 12 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Myelin Sheath
Defects
Mutation
Dissection
2009

Myelin under stress

D'Antonio, M., Feltri, M. L. & Wrabetz, L., Nov 15 2009, In : Journal of Neuroscience Research. 87, 15, p. 3241-3249 9 p.

Research output: Contribution to journalArticle

Myelin Sheath
Proteins
Endoplasmic Reticulum
Unfolded Protein Response
Endoplasmic Reticulum Stress

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

Woodhoo, A., Alonso, M. B. D., Droggiti, A., Turmaine, M., D'Antonio, M., Parkinson, D. B., Wilton, D. K., Al-Shawi, R., Simons, P., Shen, J., Guillemot, F., Radtke, F., Meijer, D., Feltri, M. L., Wrabetz, L., Mirsky, R. & Jessen, K. R., Jul 2009, In : Nature Neuroscience. 12, 7, p. 839-847 9 p.

Research output: Contribution to journalArticle

Schwann Cells
Cell Differentiation
Pathology
Demyelinating Diseases
Myelin Sheath
2008

Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice

Pennuto, M., Tinelli, E., Malaguti, M., Del Carro, U., D'Antonio, M., Ron, D., Quattrini, A., Feltri, M. L. & Wrabetz, L., Feb 7 2008, In : Neuron. 57, 3, p. 393-405 13 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Demyelinating Diseases
Tooth
Schwann Cells
Transcription Factor CHOP
2006

Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice

Wrabetz, L., D'Antonio, M., Pennuto, M., Dati, G., Tinelli, E., Fratta, P., Previtali, S., Imperiale, D., Zielasek, J., Toyka, K., Avila, R. L., Kirschner, D. A., Messing, A., Feltri, M. L. & Quattrini, A., Feb 22 2006, In : Journal of Neuroscience. 26, 8, p. 2358-2368 11 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Myelin Sheath
Transgenic Mice
Unfolded Protein Response
Alleles

Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelination

D'Antonio, M., Michalovich, D., Paterson, M., Droggiti, A., Woodhoo, A., Mirsky, R. & Jessen, K. R., Apr 1 2006, In : GLIA. 53, 5, p. 501-515 15 p.

Research output: Contribution to journalArticle

Schwann Cells
Computational Biology
Embryonic Development
Genes
Synucleins

TGFβ type II receptor signaling controls schwann cell death and proliferation in developing nerves

D'Antonio, M., Droggiti, A., Feltri, M. L., Roes, J., Wrabetz, L., Mirsky, R. & Jessen, K. R., Aug 16 2006, In : Journal of Neuroscience. 26, 33, p. 8417-8427 11 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Schwann Cells
Transforming Growth Factors
Cell Death
Cell Proliferation
2004

Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death

Parkinson, D. B., Bhaskaran, A., Droggiti, A., Dickinson, S., D'Antonio, M., Mirsky, R. & Jessen, K. R., Feb 2 2004, In : Journal of Cell Biology. 164, 3, p. 385-394 10 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Schwann Cells
Cell Death
Cell Proliferation
Protein Kinases
2000

P0 glycoprotein overexpression causes congenital hypomyelination of peripheral nerves

Wrabetz, L., Feltri, M. L., Quattrini, A., Imperiale, D., Previtali, S., D'Antonio, M., Martini, R., Yin, X., Trapp, B. D., Zhou, L., Chiu, S. Y. & Messing, A., Mar 6 2000, In : Journal of Cell Biology. 148, 5, p. 1021-1033 13 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Peripheral Nerves
Schwann Cells
Breeding
Gene Dosage
1999

A novel P0 glycoprotein transgene activates expression of lacZ in myelin-forming Schwann cells

Feltri, M. L., D'Antonio, M., Quattrini, A., Numerato, R., Arona, M., Previtali, S., Chiu, S. Y., Messing, A. & Wrabetz, L., 1999, In : European Journal of Neuroscience. 11, 5, p. 1577-1586 10 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Schwann Cells
Myelin Sheath
Transgenes
5' Flanking Region

P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells

Feltri, M. L., D'Antonio, M., Previtali, S., Fasolini, M., Messing, A. & Wrabetz, L., 1999, In : Annals of the New York Academy of Sciences. 883, p. 116-123 8 p.

Research output: Contribution to journalArticle

Schwann Cells
Laminin
Myelin Sheath
Transgenic Mice
Adhesion