• 378 Citations
  • 13 h-Index
20042019
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Research Output 2004 2019

  • 378 Citations
  • 13 h-Index
  • 24 Article
  • 1 Conference contribution
  • 1 Review article
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Article
2019
2 Citations (Scopus)

D-Aspartate treatment attenuates myelin damage and stimulates myelin repair

de Rosa, V., Secondo, A., Pannaccione, A., Ciccone, R., Formisano, L., Guida, N., Crispino, R., Fico, A., Polishchuk, R., D'Aniello, A., Annunziato, L. & Boscia, F., Jan 1 2019, In : EMBO Molecular Medicine. 11, 1, e9278.

Research output: Contribution to journalArticle

D-Aspartic Acid
Myelin Sheath
Oligodendroglia
Amino Acid Transport System X-AG
Glutamate Receptors
2 Citations (Scopus)

Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway

Laudati, G., Mascolo, L., Guida, N., Sirabella, R., Pizzorusso, V., Bruzzaniti, S., Serani, A., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., Mar 1 2019, In : NeuroToxicology. 71, p. 6-15 10 p.

Research output: Contribution to journalArticle

Kv Channel-Interacting Proteins
Sirtuin 1
Thimerosal
Neurons
Toxicity
2018

Models and methods for conditioning the ischemic brain

Vinciguerra, A., Cuomo, O., Cepparulo, P., Anzilotti, S., Brancaccio, P., Sirabella, R., Guida, N., Annunziato, L. & Pignataro, G., Dec 1 2018, In : Journal of Neuroscience Methods. 310, p. 63-74 12 p.

Research output: Contribution to journalArticle

Brain
Biological Phenomena
Ischemic Preconditioning
Ischemia
Research Personnel

Na+/Ca2+ exchanger 1 on nuclear envelope controls PTEN/Akt pathway via nucleoplasmic Ca2+ regulation during neuronal differentiation

Secondo, A., Esposito, A., Petrozziello, T., Boscia, F., Molinaro, P., Tedeschi, V., Pannaccione, A., Ciccone, R., Guida, N., Di Renzo, G. & Annunziato, L., Dec 2018, In : Cell Death Discovery. 4, p. 12

Research output: Contribution to journalArticle

Nuclear Envelope
Phosphatidylinositol 3-Kinases
GAP-43 Protein
Neurons
Nuclear Localization Signals
6 Citations (Scopus)

Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation

Anzilotti, S., Brancaccio, P., Simeone, G., Valsecchi, V., Vinciguerra, A., Secondo, A., Petrozziello, T., Guida, N., Sirabella, R., Cuomo, O., Cepparulo, P., Herchuelz, A., Amoroso, S., DI Renzo, G., Annunziato, L. & Pignataro, G., Feb 1 2018, In : Cell Death and Disease. 9, 2, 206.

Research output: Contribution to journalArticle

Poisons
Neurotoxins
Amyotrophic Lateral Sclerosis
Down-Regulation
Motor Neurons
2 Citations (Scopus)

The miR206-JunD circuit mediates the neurotoxic effect of methylmercury in cortical neurons

Guida, N., Valsecchi, V., Laudati, G., Serani, A., Mascolo, L., Molinaro, P., Montuori, P., Renzo, G. D., Canzoniero, L. M. & Formisano, L., Jun 1 2018, In : Toxicological Sciences. 163, 2, p. 569-578 10 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
Sp4 Transcription Factor
Brain-Derived Neurotrophic Factor
Neurons
Networks (circuits)
2017
11 Citations (Scopus)

p38/Sp1/Sp4/HDAC4/BDNF axis is a novel molecular pathway of the neurotoxic effect of the methylmercury

Guida, N., Laudati, G., Mascolo, L., Valsecchi, V., Sirabella, R., Selleri, C., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., 2017, In : Frontiers in Neuroscience. 11, JAN

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Proteins
Histone Deacetylases
Transfection
Protein Isoforms
9 Citations (Scopus)

The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death

Guida, N., Laudati, G., Serani, A., Mascolo, L., Molinaro, P., Montuori, P., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., Oct 15 2017, In : Biochemical Pharmacology. 142, p. 229-241 13 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Caspase 8
Polychlorinated Biphenyls
Protein Kinases
Phosphotransferases
2016

MC1568 inhibits thimerosal-induced apoptotic cell death by preventing HDAC4 up-regulation in neuronal cells and in rat prefrontal cortex

Guida, N., Laudati, G., Mascolo, L., Cuomo, O., Anzilotti, S., Sirabella, R., Santopaolo, M., Galgani, M., Montuori, P., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., 2016, In : Journal of Toxicological Sciences. 154, 2, p. 1-14 14 p.

Research output: Contribution to journalArticle

Thimerosal
Cell death
Prefrontal Cortex
Rats
Cell Death
13 Citations (Scopus)

Methylmercury upregulates RE-1 silencing transcription factor (REST) in SH-SY5Y cells and mouse cerebellum

Guida, N., Laudati, G., Anzilotti, S., Sirabella, R., Cuomo, O., Brancaccio, P., Santopaolo, M., Galgani, M., Montuori, P., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., Jan 1 2016, In : NeuroToxicology. 52, p. 89-97 9 p.

Research output: Contribution to journalArticle

Cerebellum
Transcription Factors
Up-Regulation
Cell death
Histones
2015
13 Citations (Scopus)

Extracellular signal-related kinase 2/specificity protein 1/specificity protein 3/repressor element-1 silencing transcription factor pathway is involved in Aroclor 1254-induced toxicity in SH-SY5Y neuronal cells

Formisano, L., Guida, N., Laudati, G., Boscia, F., Esposito, A., Secondo, A., Di Renzo, G. & Canzoniero, L. M. T., Jan 1 2015, In : Journal of Neuroscience Research. 93, 1, p. 167-177 11 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
Chlorodiphenyl (54% Chlorine)
Repressor Proteins
Transcription Factors
Phosphotransferases
19 Citations (Scopus)

MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoter

Formisano, L., Guida, N., Laudati, G., Mascolo, L., Di Renzo, G. & Canzoniero, L. M. T., Jan 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 2, p. 236-243 8 p., A6.

Research output: Contribution to journalArticle

Chlorodiphenyl (54% Chlorine)
Synapsins
Transcription Factors
Histone Deacetylases
Cell Death
4 Citations (Scopus)

Pharmacological Characterization of the Newly Synthesized 5-Amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide Hydrochloride (BED) as a Potent NCX3 Inhibitor That Worsens Anoxic Injury in Cortical Neurons, Organotypic Hippocampal Cultures, and Ischemic Brain

Secondo, A., Pignataro, G., Ambrosino, P., Pannaccione, A., Molinaro, P., Boscia, F., Cantile, M., Cuomo, O., Esposito, A., Sisalli, M. J., Scorziello, A., Guida, N., Anzilotti, S., Fiorino, F., Severino, B., Santagada, V., Caliendo, G., Di Renzo, G. & Annunziato, L., Aug 19 2015, In : ACS Chemical Neuroscience. 6, 8, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Neurons
Brain
Protein Isoforms
Pharmacology
Wounds and Injuries
18 Citations (Scopus)

Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death

Guida, N., Laudati, G., Anzilotti, S., Secondo, A., Montuori, P., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., Nov 1 2015, In : Toxicology and Applied Pharmacology. 288, 3, p. 387-398 12 p.

Research output: Contribution to journalArticle

Sirtuin 1
Polychlorinated Biphenyls
Cell death
Cell Death
Down-Regulation
39 Citations (Scopus)

Sp3/REST/HDAC1/HDAC2 complex represses and Sp1/HIF-1/p300 complex activates ncx1 gene transcription, in brain ischemia and in ischemic brain preconditioning, by Epigenetic mechanism

Formisano, L., Guida, N., Valsecchi, V., Cantile, M., Cuomo, O., Vinciguerra, A., Laudati, G., Pignataro, G., Sirabella, R., Di Renzo, G. & Annunziato, L., May 13 2015, In : Journal of Neuroscience. 35, 19, p. 7332-7348 17 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Ischemic Preconditioning
Brain Ischemia
Epigenomics
Middle Cerebral Artery Infarction
2014
22 Citations (Scopus)

Histone deacetylase 4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di(2-ethylhexyl)phthalate (DEHP), determining neuronal death

Guida, N., Laudati, G., Galgani, M., Santopaolo, M., Montuori, P., Triassi, M., Di Renzo, G., Canzoniero, L. M. T. & Formisano, L., Oct 1 2014, In : Toxicology and Applied Pharmacology. 280, 1, p. 190-198 9 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Ubiquitin
Proteolysis
Degradation
Proteins
32 Citations (Scopus)

MicroRNA-103-1 selectively downregulates brain NCX1 and its inhibition by anti-miRNA ameliorates stroke damage and neurological deficits

Vinciguerra, A., Formisano, L., Cerullo, P., Guida, N., Cuomo, O., Esposito, A., Di Renzo, G., Annunziato, L. & Pignataro, G., Jan 1 2014, In : Molecular Therapy. 22, 10, p. 1829-1838 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Down-Regulation
Stroke
Brain
Membrane Transport Proteins
2013
1 Citation (Scopus)

Erratum: Silencing or knocking out the Na+/Ca2+ exchanger-3 (NCX3) impairs oligodendrocyte differentiation (Cell Death and Differentiation (2013) 20 (184) DOI: 10.1038/cdd.2012.139)

Boscia, F., D'Avanzo, C., Pannaccione, A., Secondo, A., Casamassa, A., Formisano, L., Guida, N., Sokolow, S., Herchuelz, A. & Annunziato, L., Jan 2013, In : Cell Death and Differentiation. 20, 1, p. 184 1 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

NCX1 is a new rest target gene: Role in cerebral ischemia

Formisano, L., Guida, N., Valsecchi, V., Pignataro, G., Vinciguerra, A., Pannaccione, A., Secondo, A., Boscia, F., Molinaro, P., Sisalli, M. J., Sirabella, R., Casamassa, A., Canzoniero, L. M. T., Di Renzo, G. & Annunziato, L., Feb 2013, In : Neurobiology of Disease. 50, 1, p. 76-85 10 p.

Research output: Contribution to journalArticle

Brain Ischemia
Genes
Middle Cerebral Artery Infarction
RE1-silencing transcription factor
Ions
2012
21 Citations (Scopus)

ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na +/Ca 2+exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells

Sirabella, R., Secondo, A., Pannaccione, A., Molinaro, P., Formisano, L., Guida, N., Di Renzo, G., Annunziato, L. & Cataldi, M., Sep 2012, In : Journal of Neurochemistry. 122, 5, p. 911-922 12 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
PC12 Cells
Response Elements
52 Citations (Scopus)

Silencing or knocking out the Na +/Ca 2+ exchanger-3 (NCX3) impairs oligodendrocyte differentiation

Boscia, F., D'Avanzo, C., Pannaccione, A., Secondo, A., Casamassa, A., Formisano, L., Guida, N. & Annunziato, L., Apr 2012, In : Cell Death and Differentiation. 19, 4, p. 562-572 11 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
Oligodendroglia
Myelin Basic Protein
Calcium Signaling
Cyclic Nucleotides
2011
39 Citations (Scopus)

The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning

Pignataro, G., Esposito, E., Cuomo, O., Sirabella, R., Boscia, F., Guida, N., Di Renzo, G. & Annunziato, L., Jan 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 1, p. 362-370 9 p.

Research output: Contribution to journalArticle

Ischemic Postconditioning
Sodium-Calcium Exchanger
Protein Isoforms
Stroke
Intraventricular Infusions
17 Citations (Scopus)

The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells

Formisano, L., Guida, N., Cocco, S., Secondo, A., Sirabella, R., Ulianich, L., Paturzo, F., Di Renzo, G. & Canzoniero, L. M. T., Sep 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 3, p. 997-1003 7 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
Chlorodiphenyl (54% Chlorine)
Polychlorinated Biphenyls
Neuroblastoma
Transcription Factors
2004
9 Citations (Scopus)

Sea urchin neural α2 tubulin gene: Isolation and promoter analysis

Costa, S., Ragusa, M. A., Drago, G., Casano, C., Alaimo, G., Guida, N. & Gianguzza, F., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 446-453 8 p.

Research output: Contribution to journalArticle

Sea Urchins
Tubulin
Genes
Reporter Genes
Paracentrotus