• 2885 Citations
  • 29 h-Index
1983 …2018
If you made any changes in Pure these will be visible here soon.

Research Output 1983 2018

  • 2885 Citations
  • 29 h-Index
  • 49 Article
  • 1 Chapter
  • 1 Letter
Filter
Article
2018

miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling

Migliore, C., Morando, E., Ghiso, E., Anastasi, S., Leoni, V. P., Apicella, M., Cora', D., Sapino, A., Pietrantonio, F., Braud, F. D., Columbano, A., Segatto, O. & Giordano, S., Sep 1 2018, In : EMBO Molecular Medicine. 10, 9, p. 10.15252/emmm.201708746

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Therapeutics
Neoplasms
Down-Regulation
RNA

miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling

Migliore, C., Morando, E., Ghiso, E., Anastasi, S., Leoni, V. P., Apicella, M., Cora', D., Sapino, A., Pietrantonio, F., De Braud, F., Columbano, A., Segatto, O. & Giordano, S., Sep 2018, In : EMBO Molecular Medicine. 10, 9

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Therapeutics
Neoplasms
Down-Regulation
RNA
2016
9 Citations (Scopus)

Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics

Anastasi, S., Lamberti, D., Alemà, S. & Segatto, O., Feb 1 2016, In : Seminars in Cell and Developmental Biology. 50, p. 115-124 10 p.

Research output: Contribution to journalArticle

Oncogenes
Neoplasms
Therapeutics
Cell Movement
Cell Survival
2015
36 Citations (Scopus)

Epigenetic silencing of miR-145-5p contributes to brain metastasis

Donzelli, S., Mori, F., Bellissimo, T., Sacconi, A., Casini, B., Frixa, T., Roscilli, G., Aurisicchio, L., Facciolo, F., Pompili, A., Carosi, M. A., Pescarmona, E., Segatto, O., Pond, G., Muti, P., Telera, S., Strano, S., Yarden, Y. & Blandino, G., 2015, In : Oncotarget. 6, 34, p. 35183-35201 19 p.

Research output: Contribution to journalArticle

Epigenomics
Neoplasm Metastasis
Brain
MicroRNAs
Neoplasms
3 Citations (Scopus)

Mitogen-inducible gene-6 mediates feedback inhibition from mutated BRAF towards the epidermal growth factor receptor and thereby limits malignant transformation

Milewska, M., Romano, D., Herrero, A., Guerriero, M. L., Birtwistle, M., Quehenberger, F., Hatzl, S., Kholodenko, B. N., Segatto, O., Kolch, W. & Zebisch, A., Jun 12 2015, In : PLoS One. 10, 6, e0129859.

Research output: Contribution to journalArticle

Mitogens
Epidermal Growth Factor Receptor
Genes
Feedback
genes
2014
4 Citations (Scopus)

A pervasive role for MIG6 in restraining cell proliferation

Anastasi, S., Castellani, L., Alemà, S. & Segatto, O., Mar 2014, In : Cell Death and Differentiation. 21, 3, p. 345-347 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
Breast Neoplasms
Therapeutics
Antibodies, Monoclonal, Humanized
Translational Medical Research
Gene Amplification
2011
64 Citations (Scopus)

Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors

Segatto, O., Anastasi, S. & Alemà, S., Jun 1 2011, In : Journal of Cell Science. 124, 11, p. 1785-1793 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mammals
Morphogenesis
Carcinogenesis
Homeostasis
2010
74 Citations (Scopus)

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

Frosi, Y., Anastasi, S., Ballarò, C., Varsano, G., Castellani, L., Maspero, E., Polo, S., Alemà, S. & Segatto, O., May 3 2010, In : Journal of Cell Biology. 189, 3, p. 557-571 15 p.

Research output: Contribution to journalArticle

Transducers
Epidermal Growth Factor Receptor
Phosphotransferases
Endocytosis
Lysosomes
75 Citations (Scopus)

Mig-6 controls EGFR trafficking and suppresses gliomagenesis

Ying, H., Zheng, H., Scott, K., Wiedemeyer, R., Yan, H., Lim, C., Huang, J., Dhakal, S., Ivanova, E., Xiao, Y., Zhang, H., Hu, J., Stommel, J. M., Lee, M. A., Chen, A. J., Paik, J. H., Segatto, O., Brennan, C., Elferink, L. A., Wang, Y. A. & 2 others, Chin, L. & DePinho, R. A., Apr 13 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 6912-6917 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Glioblastoma
Endosomes
Lysosomes
Ligands
2007
50 Citations (Scopus)

The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity

Anastasi, S., Baietti, M. F., Frosi, Y., Alemà, S. & Segatto, O., Dec 13 2007, In : Oncogene. 26, 57, p. 7833-7846 14 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Morphogenesis
Vertebrates
Homeostasis
Skin
2005
60 Citations (Scopus)

Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways

Talora, C., Cialfi, S., Segatto, O., Morrone, S., Kim Choi, J., Frati, L., Dotto, G. P., Gulino, A. & Screpanti, I., May 1 2005, In : Experimental Cell Research. 305, 2, p. 343-354 12 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Growth
Transcription Factor AP-1
Cell Line
Keratinocytes
84 Citations (Scopus)

Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin

Anastasi, S., Sala, G., Huiping, C., Caprini, E., Russo, G., Iacovelli, S., Lucini, F., Ingvarsson, S. & Segatto, O., Jun 30 2005, In : Oncogene. 24, 28, p. 4540-4548 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Breast
ErbB-2 Receptor
Gene Amplification
Receptor Protein-Tyrosine Kinases
38 Citations (Scopus)

Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype

Ballarò, C., Ceccarelli, S., Tiveron, C., Tatangelo, L., Salvatore, A. M., Segatto, O. & Alemà, S., Aug 2005, In : EMBO Reports. 6, 8, p. 755-761 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Skin
Phenotype
Feedback
Vibrissae
2003
82 Citations (Scopus)

Feedback inhibition by RALT controls signal output by the ErbB network

Anastasi, S., Fiorentino, L., Fiorini, M., Fraioli, R., Sala, G., Castellani, L., Alemà, S., Alimandi, M. & Segatto, O., Jul 3 2003, In : Oncogene. 22, 27, p. 4221-4234 14 p.

Research output: Contribution to journalArticle

Transducers
Ligands
Epidermal Growth Factor Receptor
Receptor-Interacting Protein Serine-Threonine Kinases
Receptor Protein-Tyrosine Kinases
2002
62 Citations (Scopus)

Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control

Fiorini, M., Ballarò, C., Sala, G., Falcone, G., Alemà, S. & Segatto, O., Sep 19 2002, In : Oncogene. 21, 42, p. 6530-6539 10 p.

Research output: Contribution to journalArticle

Transducers
Extracellular Signal-Regulated MAP Kinases
Pharmacology
Proteasome Endopeptidase Complex
ErbB Receptors
2001
33 Citations (Scopus)

Negative regulation of receptor tyrosine kinase signals

Fiorini, M., Alimandi, M., Fiorentino, L., Sala, G. & Segatto, O., Feb 16 2001, In : FEBS Letters. 490, 3, p. 132-141 10 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Invertebrates
Tuning
2000
107 Citations (Scopus)

Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain

Fiorentino, L., Pertica, C., Fiorini, M., Talora, C., Crescenzi, M., Castellani, L., Alema, S., Benedetti, P. & Segatto, O., 2000, In : Molecular and Cellular Biology. 20, 20, p. 7735-7750 16 p.

Research output: Contribution to journalArticle

Transducers
Mitogens
Phosphotransferases
Proteins
Fibroblasts
1995
60 Citations (Scopus)

Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase

Ricci, A., Lanfrancone, L., Chiari, R., Belardo, G., Pertica, C., Natali, P. G., Pelicci, P. G. & Segatto, O., Oct 19 1995, In : Oncogene. 11, 8, p. 1518-1529 12 p.

Research output: Contribution to journalArticle

src Homology Domains
TYK2 Kinase
Phosphotransferases
Binding Sites
Cytosol
117 Citations (Scopus)

Constitutive phosphorylation of Shc proteins in human tumors

Pelicci, G., Lanfrancone, L., Salcini, A. E., Romano, A., Mele, S., Borrello, M. G., Segatto, O., Di Fiore, P. P. & Pelicci, P. G., 1995, In : Oncogene. 11, 5, p. 899-907 9 p.

Research output: Contribution to journalArticle

Phosphorylation
src Homology Domains
Protein-Tyrosine Kinases
Phosphoproteins
Neoplasms
1994
25 Citations (Scopus)

Expression of gp185(HER-2) in human cutaneous melanoma: Implications for experimental immunotherapeutics

Natali, P. G., Nicotra, M. R., Digiesi, G., Cavaliere, R., Bigotti, A., Trizio, D. & Segatto, O., 1994, In : International Journal of Cancer. 56, 3, p. 341-346 6 p.

Research output: Contribution to journalArticle

Experimental Melanomas
Melanoma
Skin
Intradermal Nevus
Breast Neoplasms
1993
96 Citations (Scopus)

Shc products are substrates of erbB-2 kinase

Segatto, O., Pelicci, G., Giuli, S., Digiesi, G., Di Fiore, P. P., McGlade, J., Pawson, T. & Pelicci, P. G., Aug 1993, In : Oncogene. 8, 8, p. 2105-2112 8 p.

Research output: Contribution to journalArticle

src Homology Domains
Epidermal Growth Factor Receptor
Signal Transduction
Phosphotransferases
Phosphorylation
1992
23 Citations (Scopus)

A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2

Di Fiore, P. P., Helin, K., Kraus, M. H., Pierce, J. H., Artrip, J., Segatto, O. & Bottaro, D. P., Nov 1992, In : EMBO Journal. 11, 11, p. 3927-3933 7 p.

Research output: Contribution to journalArticle

Amino Acid Substitution
Epidermal Growth Factor Receptor
Substitution reactions
Amino Acids
Threonine
91 Citations (Scopus)

Changes in expression of α6/β4 integrin heterodimer in primary and metastatic breast cancer

Natali, P. G., Nicotra, M. R., Botti, C., Mottolese, M., Bigotti, A. & Segatto, O., 1992, In : British Journal of Cancer. 66, 2, p. 318-322 5 p.

Research output: Contribution to journalArticle

Integrins
Breast
Epithelium
Basement Membrane
Breast Neoplasms
15 Citations (Scopus)

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling

Segatto, O., Lonardo, F., Helin, K., Wexler, D., Fazioli, F., Rhee, S. G. & Di Fiore, P. P., Jul 1992, In : Oncogene. 7, 7, p. 1339-1346 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Phosphotransferases
Type C Phospholipases
Phosphotyrosine
23 Citations (Scopus)

Identification and biochemical characterization of novel putative substrates for the epidermal growth factor receptor kinase

Fazioli, F., Bottaro, D. P., Minichiello, L., Auricchio, A., Wong, W. T., Segatto, O. & Di Fiore, P. P., 1992, In : Journal of Biological Chemistry. 267, 8, p. 5155-5161 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Substrates
Epidermal Growth Factor
Tyrosine
Proteins
34 Citations (Scopus)

Production and characterization of murine mAbs to the extracellular domain of human neu oncogene product gp185(HER2)

Digiesi, G., Giacomini, P., Fraioli, R., Mariani, M., Nicotra, M. R., Segatto, O. & Natali, P. G., 1992, In : Hybridoma. 11, 4, p. 519-527 9 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Epitopes
TYK2 Kinase
erbB-2 Genes
Neoplasm Antibodies
1991
5 Citations (Scopus)

Cloning, expression, and biological effects of erbB-2/neu gene in mammalian cells

Fiore, P. P. D., Segatto, O. & Aaronson, S. A., 1991, In : Methods in Enzymology. 198, p. 272-277 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

The erbB-2 Mitogenic Signaling Pathway: Tyrosine Phosphorylation of Phospholipase C-γ and GTPase-Activating Protein Does Not Correlate with erbB-2 Mitogenic Potency

Fazioli, F., Kim, U. H., Rhee, S. G., Molloy, C. J., Segatto, O. & Di Fiore, P. P., Apr 1991, In : Molecular and Cellular Biology. 11, 4, p. 2040-2048 9 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Type C Phospholipases
Epidermal Growth Factor Receptor
Tyrosine
Phosphorylation
36 Citations (Scopus)

The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gp185erbB-2 Determine the Specificity of Signal Transduction

Segatto, O., Lonardo, F., Wexler, D., Fazioli, F., Pierce, J. H., Bottaro, D. P., White, M. F. & Di Fiore, P. P., Jun 1991, In : Molecular and Cellular Biology. 11, 6, p. 3191-3202 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Signal Transduction
Protein-Tyrosine Kinases
Sequence Homology
Substrate Specificity
1990
106 Citations (Scopus)

EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling

Di Fiore, P. P., Segatto, O., Taylor, W. G., Aaronson, S. A. & Pierce, J. H., 1990, In : Science. 248, 4951, p. 79-83 5 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Epidermal Growth Factor Receptor
Growth Factor Receptors
Protein-Tyrosine Kinases
Signal Transduction
49 Citations (Scopus)
Receptor Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Phosphotransferases
erbB-2 Genes
NIH 3T3 Cells
117 Citations (Scopus)

The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand

Lonardo, F., Di Marco, E., King, C. R., Pierce, J. H., Segatto, O., Aaronson, S. A. & Di Fiore, P. P., 1990, In : New Biologist. 2, 11, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
NIH 3T3 Cells
Protein-Tyrosine Kinases
Ligands
Epidermal Growth Factor Receptor
53 Citations (Scopus)

The role of autophosphorylation in modulation of erbB-2 transforming function

Segatto, O., Lonardo, F., Pierce, J. H., Bottaro, D. P. & Di Fiore, P. P., 1990, In : New Biologist. 2, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Tyrosine
Phosphorylation
Proto-Oncogene Proteins pp60(c-src)
TYK2 Kinase
Modulation
1989
32 Citations (Scopus)

Analysis of the antigenic profile of uveal melanoma lesions with anti-cutaneous melanoma-associated antigen and anti-HLA monoclonal antibodies

Natali, P. G., Bigotti, A., Nicotra, M. R., Nardi, R. M., Delovu, A., Segatto, O. & Ferrone, S., 1989, In : Cancer Research. 49, 5, p. 1269-1274 6 p.

Research output: Contribution to journalArticle

Melanoma-Specific Antigens
Monoclonal Antibodies
Skin
Melanoma
HLA Antigens
1988
154 Citations (Scopus)

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene

Segatto, O., King, C. R., Pierce, J. H., Di Fiore, P. P. & Aaronson, S. A., 1988, In : Molecular and Cellular Biology. 8, 12, p. 5570-5574 5 p.

Research output: Contribution to journalArticle

1987
34 Citations (Scopus)

Analysis with monoclonal antibodies of the molecular and cellular heterogeneity of human high molecular weight melanoma associated antigen

Ziai, M. R., Imberti, L., Nicotra, M. R., Badaracco, G., Segatto, O., Natali, P. G. & Ferrone, S., 1987, In : Cancer Research. 47, 9, p. 2474-2480 7 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
Melanoma
Epitopes
Staining and Labeling
HMW-MAA
818 Citations (Scopus)

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

Di Fiore, P. P., Pierce, J. H., Kraus, M. H., Segatto, O., King, C. R. & Aaronson, S. A., 1987, In : Science. 237, 4811, p. 178-182 5 p.

Research output: Contribution to journalArticle

NIH 3T3 Cells
Oncogenes
Growth Factor Receptors
erbB-2 Genes
Moloney murine leukemia virus
23 Citations (Scopus)

Multiple epitope recognition: An approach to improved radioimmunodetection of tumor-associated antigens

Giacomini, P., Segatto, O. & Natali, P. G., 1987, In : International Journal of Cancer. 39, 6, p. 729-736 8 p.

Research output: Contribution to journalArticle

Radioimmunodetection
Neoplasm Antigens
Radioimmunoassay
Epitopes
Neoplasms
43 Citations (Scopus)

The human transforming growth factor type α coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells

Finzi, E., Fleming, T., Segatto, O., Pennington, C. Y., Bringman, T. S., Derynck, R. & Aaronson, S. A., 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 11, p. 3733-3737 5 p.

Research output: Contribution to journalArticle

NIH 3T3 Cells
Transforming Growth Factors
Oncogenes
Growth
Terminal Repeat Sequences
1986
4 Citations (Scopus)

Clinical improvement and partial correction of the T cell defects of acquired immunodeficiency syndrome (AIDS) and lymphoadenopathy syndrome (LAS) by a calf thymus acid lysate

Valesini, G., Barnaba, V., Levrero, M., Balsano, F., Segatto, O. & Natali, P. G., 1986, In : European Journal of Cancer and Clinical Oncology. 22, 4, p. 531-532 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

In vitro modulation of T-cell differentiation antigens on human thymocytes and splenocytes by a calf thymus acid lysate

Segatto, O., Viora, M. & Carsetti, R., 1986, In : International Journal of Immunotherapy. 2, 4, p. 301-308 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Role of genes for normal growth factors in human malignancy.

Aaronson, S. A., Igarashi, H., Rao, C. D., Finzi, E., Fleming, T. P., Segatto, O. & Robbins, K. C., 1986, In : Princess Takamatsu symposia. 17, p. 95-108 14 p.

Research output: Contribution to journalArticle

Transforming Growth Factor alpha
Intercellular Signaling Peptides and Proteins
NIH 3T3 Cells
Genes
Neoplasms
1 Citation (Scopus)

Thy 1.2 antigen inducing capacity of a calf thymus acid hydrolysate and its fractions

Segatto, O., Secchi, C., Berrini, A. & Natali, P. G., 1986, In : International Journal of Tissue Reactions. 8, 3, p. 225-229 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Thy 1.2 inducing activity of a partially purified calf thymus acid lysate

Segatto, O., Berrini, A. & Cuomo, M., 1986, In : International Journal of Immunotherapy. 2, 4, p. 309-315 7 p.

Research output: Contribution to journalArticle

1985

Lymphoid stroma of Warthin's tumor: Phenotypic analogies with gut-associated lymphoid tissue

Segatto, O., Giacomini, P., Santoro, L., Perrino, A. & Natali, P. G., 1985, In : Clinical Immunology and Immunopathology. 34, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Adenolymphoma
Lymphoid Tissue
Lymphocytes
Immunoglobulin A
Secretory Component
7 Citations (Scopus)

Lymphoid stroma of Warthin's tumor: Phenotypic analogies with gut-associated lymphoid tissue

Segatto, O., Giacomini, P., Santoro, L., Perrino, A. & Natali, P. G., 1985, In : Clinical Immunology and Immunopathology. 34, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Adenolymphoma
Lymphoid Tissue
Lymphocytes
Immunoglobulin A
Secretory Component
1984
53 Citations (Scopus)

Differential tissue distribution and ontogeny of DC-1 and HLA-DR antigens

Natali, P. G., Segatto, O., Ferrone, S., Tosi, R. & Corte, G., Feb 1984, In : Immunogenetics. 19, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Tissue Distribution
Antigens
Epithelium
Histocompatibility Antigens Class II
1983
3 Citations (Scopus)

Isolation of viable melanoma cells from surgically removed lesions using dishes coated with monoclonal antibody to a high molecular weight melanoma associated antigen

Natali, P. G., Segatto, O., Zupi, G., Cavaliere, R., Giacomini, P. & Ferrone, S., Sep 16 1983, In : Journal of Immunological Methods. 62, 3, p. 337-346 10 p.

Research output: Contribution to journalArticle

Melanoma
Monoclonal Antibodies
Plastics
HMW-MAA
Growth