20022017

Research output per year

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Fingerprint Dive into the research topics where Oronza Antonietta Botrugno is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model

Trifirò, P., Cappa, A., Brambillasca, S., Botrugno, O. A., Cera, M. R., Zuffo, R. D., Dessanti, P., Meroni, G., Thaler, F., Villa, M., Minucci, S., Mercurio, C., Varasi, M. & Vianello, P., Jul 1 2017, In : Future Medicinal Chemistry. 9, 11, p. 1161-1174 14 p.

Research output: Contribution to journalArticle

  • Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration

    Sartori, L., Mercurio, C., Amigoni, F., Cappa, A., Fagá, G., Fattori, R., Legnaghi, E., Ciossani, G., Mattevi, A., Meroni, G., Moretti, L., Cecatiello, V., Pasqualato, S., Romussi, A., Thaler, F., Trifiró, P., Villa, M., Vultaggio, S., Botrugno, O. A., Dessanti, P. & 6 others, Minucci, S., Zagarrí, E., Carettoni, D., Iuzzolino, L., Varasi, M. & Vianello, P., Mar 9 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 1673-1692 20 p.

    Research output: Contribution to journalArticle

  • Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship

    Vianello, P., Sartori, L., Amigoni, F., Cappa, A., Fagá, G., Fattori, R., Legnaghi, E., Ciossani, G., Mattevi, A., Meroni, G., Moretti, L., Cecatiello, V., Pasqualato, S., Romussi, A., Thaler, F., Trifiró, P., Villa, M., Botrugno, O. A., Dessanti, P., Minucci, S. & 4 others, Vultaggio, S., Zagarrí, E., Varasi, M. & Mercurio, C., Mar 9 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 1693-1715 23 p.

    Research output: Contribution to journalArticle

  • Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

    Vianello, P., Botrugno, O. A., Cappa, A., Dal Zuffo, R., Dessanti, P., Mai, A., Marrocco, B., Mattevi, A., Meroni, G., Minucci, S., Stazi, G., Thaler, F., Trifiró, P., Valente, S., Villa, M., Varasi, M. & Mercurio, C., Feb 25 2016, In : Journal of Medicinal Chemistry. 59, 4, p. 1501-1517 17 p.

    Research output: Contribution to journalArticle

  • Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: Enzyme selectivity and in-cell studies

    Valente, S., Rodriguez, V., Mercurio, C., Vianello, P., Saponara, B., Cirilli, R., Ciossani, G., Labella, D., Marrocco, B., Ruoppolo, G., Botrugno, O. A., Dessanti, P., Minucci, S., Mattevi, A., Varasi, M. & Mai, A., Feb 12 2015, In : ACS Medicinal Chemistry Letters. 6, 2, p. 173-177 5 p.

    Research output: Contribution to journalArticle