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Research Output

2019

LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β

Rossi, M., Bucci, G., Rizzotto, D., Bordo, D., Marzi, M. J., Puppo, M., Flinois, A., Spadaro, D., Citi, S., Emionite, L., Cilli, M., Nicassio, F., Inga, A., Briata, P. & Gherzi, R., Dec 1 2019, In : Nature Communications. 10, 1, 1969.

Research output: Contribution to journalArticle

Open Access
2017

Corrigendum: Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP

Russo, A., Catillo, M., Esposito, D., Briata, P., Pietropaolo, C. & Russo, G., Dec 1 2017, In : Nucleic Acids Research. 45, 21, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2016

Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease

Briata, P., Bordo, D., Puppo, M., Gorlero, F., Rossi, M., Perrone-Bizzozero, N. & Gherzi, R., Mar 1 2016, In : Wiley Interdisciplinary Reviews: RNA. 7, 2, p. 227-240 14 p.

Research output: Contribution to journalArticle

miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition

Puppo, M., Bucci, G., Rossi, M., Giovarelli, M., Bordo, D., Moshiri, A., Gorlero, F., Gherzi, R. & Briata, P., Jul 26 2016, In : Cell Reports. 16, 4, p. 967-978 12 p.

Research output: Contribution to journalArticle

miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition

Puppo, M., Bucci, G., Rossi, M., Giovarelli, M., Bordo, D., Moshiri, A., Gorlero, F., Gherzi, R. & Briata, P., Jul 26 2016, In : Cell Reports. 16, 4, p. 967 - 978 12 p.

Research output: Contribution to journalArticle

2015

Retraction to The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling [PLoS Biol, (2015), 13, 11]

Gherzi, R., Trabucchi, M., Ponassi, M., Ruggiero, T., Corte, G., Moroni, C., Chen, C. Y., Khabar, K. S., Andersen, J. S. & Briata, P., Nov 16 2015, In : PLoS Biology. 13, 11, e1002314.

Research output: Contribution to journalArticle

2014

H19 long noncoding RNA controls the mRNA decay promoting function of KSRP

Giovarelli, M., Bucci, G., Ramos, A., Bordo, D., Wilusz, C. J., Chen, C. Y., Puppo, M., Briata, P. & Gherzi, R., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. E5023-E5028

Research output: Contribution to journalArticle

KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression

Chou, C. F., Lin, Y. Y., Wang, H. K., Zhu, X., Giovarelli, M., Briata, P., Gherzi, R., Garvey, W. T. & Chen, C. Y., 2014, In : Diabetes. 63, 9, p. 2949-2961 13 p.

Research output: Contribution to journalArticle

KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue

Lin, Y. Y., Chou, C. F., Giovarelli, M., Briata, P., Gherzi, R. & Chen, C. Y., 2014, In : Molecular and Cellular Biology. 34, 12, p. 2339-2349 11 p.

Research output: Contribution to journalArticle

KSRP Controls Pleiotropic Cellular Functions

Gherzi, R., Chen, C. Y., Ramos, A. & Briata, P., Oct 1 2014, In : Seminars in Cell and Developmental Biology. 34, p. 2-8 7 p.

Research output: Contribution to journalArticle

2013

Functional and molecular insights into KSRP function in mRNA decay

Briata, P., Chen, C. Y., Ramos, A. & Gherzi, R., Jun 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 6-7, p. 689-694 6 p.

Research output: Contribution to journalArticle

KSRP silencing favors neural differentiation of P19 teratocarcinoma cells

Giovarelli, M., Bucci, G., Pasero, M., Gherzi, R. & Briata, P., May 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 5, p. 469-479 11 p.

Research output: Contribution to journalArticle

2012

Bone Morphogenetic Protein/SMAD Signaling Orients Cell Fate Decision by Impairing KSRP-Dependent MicroRNA Maturation

Pasero, M., Giovarelli, M., Bucci, G., Gherzi, R. & Briata, P., Nov 29 2012, In : Cell Reports. 2, 5, p. 1159-1168 10 p.

Research output: Contribution to journalArticle

KH domains with impaired nucleic acid binding as a tool for functional analysis

Hollingworth, D., Candel, A. M., Nicastro, G., Martin, S. R., Briata, P., Gherzi, R. & Ramos, A., Aug 2012, In : Nucleic Acids Research. 40, 14, p. 6873-6886 14 p.

Research output: Contribution to journalArticle

Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP

Repetto, E., Briata, P., Kuziner, N., Harfe, B. D., McManus, M. T., Gherzi, R., Rosenfeld, M. G. & Trabucchi, M., Jul 2012, In : PLoS Genetics. 8, 7, e1002823.

Research output: Contribution to journalArticle

Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis

Nicastro, G., García-Mayoral, M. F., Hollingworth, D., Kelly, G., Martin, S. R., Briata, P., Gherzi, R. & Ramos, A., Dec 2012, In : Nature Structural and Molecular Biology. 19, 12, p. 1282-1286 5 p.

Research output: Contribution to journalArticle

PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis

Briata, P., Lin, W. J., Giovarelli, M., Pasero, M., Chou, C. F., Trabucchi, M., Rosenfeld, M. G., Chen, C. Y. & Gherzi, R., Mar 2012, In : Cell Death and Differentiation. 19, 3, p. 478-487 10 p.

Research output: Contribution to journalArticle

2011

Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP

Russo, A., Catillo, M., Esposito, D., Briata, P., Pietropaolo, C. & Russo, G., Sep 2011, In : Nucleic Acids Research. 39, 17, p. 7576-7585 10 p.

Research output: Contribution to journalArticle

KSRP, many functions for a single protein

Briata, P., Chen, C. Y., Giovarelli, M., Pasero, M., Trabucchi, M., Ramos, A. & Gherzi, R., Jan 1 2011, In : Frontiers in Bioscience. 16, 5, p. 1787-1796 10 p.

Research output: Contribution to journalArticle

2010

Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation

Gherzi, R., Trabucchi, M., Ponassi, M., Gallouzi, I. E., Rosenfeld, M. G. & Briata, P., Jun 2010, In : Cell Death and Differentiation. 17, 6, p. 975-983 9 p.

Research output: Contribution to journalArticle

KSRP promotes the maturation of a group of miRNA precuresors

Trabucchi, M., Briata, P., Filipowicz, W., Ramos, A., Gherzi, R. & Rosenfeld, M. G., 2010, Advances in Experimental Medicine and Biology. Vol. 700. p. 36-42 7 p. (Advances in Experimental Medicine and Biology; vol. 700).

Research output: Chapter in Book/Report/Conference proceedingChapter

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

Díaz-Moreno, I., Hollingworth, D., Kelly, G., Martin, S., García-Mayoral, M., Briata, P., Gherzi, R. & Ramos, A., Apr 10 2010, In : Nucleic Acids Research. 38, 15, p. 5193-5205 13 p., gkq216.

Research output: Contribution to journalArticle

The role of KSRP in mRNA decay and microRNA precursor maturation

Gherzi, R., Chen, C. Y., Trabucchi, M., Ramos, A. & Briata, P., Sep 2010, In : Wiley Interdisciplinary Reviews: RNA. 1, 2, p. 230-239 10 p.

Research output: Contribution to journalArticle

2009

How to control miRNA maturation?

Trabucchi, M., Briata, P., Filipowicz, W., Rosenfeld, M. G., Ramos, A. & Gherzi, R., Nov 2009, In : RNA Biology. 6, 5, p. 536-540 5 p.

Research output: Contribution to journalArticle

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells

Nechama, M., Peng, Y., Bell, O., Briata, P., Gherzi, R., Schoenberg, D. R. & Naveh-Many, T., Sep 23 2009, In : BMC Cell Biology. 10, p. 70 1 p., 1471.

Research output: Contribution to journalArticle

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages

Ruggiero, T., Trabucchi, M., De Santa, F., Zupo, S., Harfe, B. D., McManus, M. T., Rosenfeld, M. G., Briata, P. & Gherzi, R., Sep 2009, In : FASEB Journal. 23, 9, p. 2898-2908 11 p.

Research output: Contribution to journalArticle

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Díaz-Moreno, I., Hollingworth, D., Frenkiel, T. A., Kelly, G., Martin, S., Howell, S., García-Mayoral, M., Gherzi, R., Briata, P. & Ramos, A., Mar 2009, In : Nature Structural and Molecular Biology. 16, 3, p. 238-246 9 p.

Research output: Contribution to journalArticle

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

Trabucchi, M., Briata, P., Garcia-Mayoral, M., Haase, A. D., Filipowicz, W., Ramos, A., Gherzi, R. & Rosenfeld, M. G., Jun 18 2009, In : Nature. 459, 7249, p. 1010-1014 5 p.

Research output: Contribution to journalArticle

2008

The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels

Nechama, M., Ben-Dov, I. Z., Briata, P., Gherzi, R. & Naveh-Many, T., Oct 2008, In : FASEB Journal. 22, 10, p. 3458-3468 11 p.

Research output: Contribution to journalArticle

2007

Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling

Ruggiero, T., Trabucchi, M., Ponassi, M., Corte, G., Chen, C. Y., al-Haj, L., Khabar, K. S. A., Briata, P. & Gherzi, R., Apr 16 2007, In : BMC Molecular Biology. 8, 28.

Research output: Contribution to journalArticle

2006

The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling.

Gherzi, R., Trabucchi, M., Ponassi, M., Ruggiero, T., Corte, G., Moroni, C., Chen, C. Y., Khabar, K. S., Andersen, J. S. & Briata, P., Dec 2006, In : PLoS Biology. 5, 1

Research output: Contribution to journalArticle

2005

p38-Dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

Briata, P., Forcales, S. V., Ponassi, M., Corte, G., Chen, C. Y., Karin, M., Puri, P. L. & Gherzi, R., Dec 22 2005, In : Molecular Cell. 20, 6, p. 891-903 13 p.

Research output: Contribution to journalArticle

2004

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

Gherzi, R., Lee, K. Y., Briata, P., Wegmüller, D., Moroni, C., Karin, M. & Chen, C. Y., Jun 4 2004, In : Molecular Cell. 14, 5, p. 571-583 13 p.

Research output: Contribution to journalArticle

2003

Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11β-hydroxylase

Hiroi, N., Kino, T., Bassett, M., Rainey, W. E., Phung, M., Abu-Asab, M., Fojo, T., Briata, P., Chrousos, G. P. & Bornstein, S. R., May 1 2003, In : Hormone and Metabolic Research. 35, 5, p. 273-278 6 p.

Research output: Contribution to journalArticle

Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway

Baek, S. H., Kioussi, C., Briata, P., Wang, D., Nguyen, H. D., Ohgi, K. A., Glass, C. K., Wynshaw-Boris, A., Rose, D. W. & Rosenfeld, M. G., Mar 18 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 6, p. 3245-3250 6 p.

Research output: Contribution to journalArticle

The Wnt/β-catenin→Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs

Briata, P., Ilengo, C., Corte, G., Moroni, C., Rosenfeld, M. G., Chen, C. Y. & Gherzi, R., Nov 2003, In : Molecular Cell. 12, 5, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

2002

Identification of a Wnt/Dvl/β-catenin → Pitx2 pathway mediating cell-type-specific proliferation during development

Kioussi, C., Briata, P., Baek, S. H., Rose, D. W., Hamblet, N. S., Herman, T., Ohgi, K. A., Lin, C., Gleiberman, A., Wang, J., Brault, V., Ruiz-Lozano, P., Nguyen, H. D., Kemler, R., Glass, C. K., Wynshaw-Boris, A. & Rosenfeld, M. G., Nov 27 2002, In : Cell. 111, 5, p. 673-685 13 p.

Research output: Contribution to journalArticle

Pitx genes during cardiovascular development

Kioussi, C., Briata, P., Baek, S. H., Wynshaw-Boris, A., Rose, D. W. & Rosenfeld, M. G., 2002, In : Cold Spring Harbor Symposia on Quantitative Biology. 67, p. 81-87 7 p.

Research output: Contribution to journalArticle

2000

Multistep signaling and transcriptional requirements for pituitary organogenesis in vivo

Rosenfeld, M. G., Briata, P., Dasen, J., Gleiberman, A. S., Kioussi, C., Lin, C., O'Connell, S. M., Ryan, A., Szeto, D. P., Treier, M., Katzenellenbogen, B., Nilson, J., Lawrence, A., Arnhold, I., Frohman, L. & Kochupillai, N., 2000, In : Recent Progress in Hormone Research. 55, p. 1-14 14 p.

Research output: Contribution to journalArticle

1999

Binding properties of the human homeodomain protein OTX2 to a DNA target sequence

Briata, P., Ilengo, C., Bobola, N. & Corte, G., Feb 19 1999, In : FEBS Letters. 445, 1, p. 160-164 5 p.

Research output: Contribution to journalArticle

OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression

Bobola, N., Briata, P., Ilengo, C., Rosatto, N., Craft, C., Corte, G. & Ravazzolo, R., Apr 1 1999, In : Mechanisms of Development. 82, 1-2, p. 165-169 5 p.

Research output: Contribution to journalArticle

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

Lin, C. R., Kloussi, C., O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisúa-Belmonte, J. C. & Rosenfeld, M. G., Sep 16 1999, In : Nature. 401, 6750, p. 279-282 4 p.

Research output: Contribution to journalArticle

1998

EMX2 protein in the developing mouse brain and olfactory area

Mallamaci, A., Iannone, R., Briata, P., Pintonello, L., Mercurio, S., Boncinelli, E. & Corte, G., Sep 1998, In : Mechanisms of Development. 77, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation

Acampora, D., Avantaggiato, V., Tuorto, F., Briata, P., Corte, G. & Simeone, A., 1998, In : Development. 125, 24, p. 5091-5104 14 p.

Research output: Contribution to journalArticle

1997

Implication of OTX2 in pigment epithelium determination and neural retina differentiation

Bovolenta, P., Mallamaci, A., Briata, P., Corte, G. & Boncinelli, E., 1997, In : Journal of Neuroscience. 17, 11, p. 4243-4252 10 p.

Research output: Contribution to journalArticle

Mapping of a potent transcriptional repression region of the human homeodomain protein EVX1

Briata, P., Ilengo, C., Van Dewerken, R. & Corte, G., Jan 27 1997, In : FEBS Letters. 402, 2-3, p. 131-135 5 p.

Research output: Contribution to journalArticle

1996

EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons

Briata, P., Di Blas, E., Gulisano, M., Mallamaci, A., Iannone, R., Boncinelli, E. & Corte, G., Jul 1996, In : Mechanisms of Development. 57, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

Erratum: Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells (Journal of Biological Chemistry (1995) 270 (27695-27701))

Briata, P., Van De Werken, R., Airoldi, I., Ilengo, C., Di Blas, E., Boncinelli, E. & Corte, G., 1996, In : Journal of Biological Chemistry. 271, 31, p. 19008 1 p.

Research output: Contribution to journalArticle

OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area

Mallamaci, A., Di Blas, E., Briata, P., Boncinelli, E. & Corte, G., Aug 1996, In : Mechanisms of Development. 58, 1-2, p. 165-178 14 p.

Research output: Contribution to journalArticle