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Research Output

2019

Alterations of RNA metabolism by proteomic analysis of breast cancer cells exposed to marycin: A new optically active porphyrin

Taverna, E., De Bortoli, M., Maffioli, E., Corno, C., Ciusani, E., Trivulzio, S., Pinelli, A., Tedeschi, G., Perego, P. & Bongarzone, I., Jan 1 2019, In : Current Molecular Pharmacology. 12, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15

Mofers, A., Perego, P., Selvaraju, K., Gatti, L., Gullbo, J., Linder, S. & D’Arcy, P., Jan 1 2019, In : PLoS One. 14, 10, e0223807.

Research output: Contribution to journalArticle

Open Access

Effcacy of a selective binder of αvβ3 integrin linked to the tyrosine kinase inhibitor sunitinib in ovarian carcinoma preclinical models

Sartori, A., Corno, C., De Cesare, M., Scanziani, E., Minoli, L., Battistini, L., Zanardi, F. & Perego, P., Apr 2019, In : Cancers. 11, 4, 531.

Research output: Contribution to journalArticle

Open Access

KiSS1 in regulation of metastasis and response to antitumor drugs

Corno, C. & Perego, P., Jan 2019, In : Drug Resistance Updates. 42, p. 12-21 10 p.

Research output: Contribution to journalReview article

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

Leonetti, A., Sharma, S., Minari, R., Perego, P., Giovannetti, E. & Tiseo, M., Oct 29 2019, In : British Journal of Cancer. 121, 9, p. 725-737 13 p.

Research output: Contribution to journalReview article

Role of FoxO proteins in cellular response to antitumor agents

Beretta, G. L., Corno, C., Zaffaroni, N. & Perego, P., Jan 1 2019, In : Cancers. 11, 1, 90.

Research output: Contribution to journalReview article

Open Access
2018

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

EORTC PAMM Group, Mar 2018, In : Cancer Chemotherapy and Pharmacology. 81, 3, p. 427-441 15 p.

Research output: Contribution to journalReview article

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models

Corno, C., Stucchi, S., De Cesare, M., Carenini, N., Stamatakos, S., Ciusani, E., Minoli, L., Scanziani, E., Argueta, C., Landesman, Y., Zaffaroni, N., Gatti, L. & Perego, P., 2018, In : Biochemical Pharmacology. 147, p. 93-103 11 p.

Research output: Contribution to journalArticle

Tau mutations as a novel risk factor for cancer—response

Rossi, G., Redaelli, V., Perego, P., Ferrari, R., Giaccone, G. & Tagliavini, F., Nov 15 2018, In : Cancer Research. 78, 22, 1 p.

Research output: Contribution to journalLetter

Tau Mutations Serve as a Novel Risk Factor for Cancer

Rossi, G., Redaelli, V., Contiero, P., Fabiano, S., Tagliabue, G., Perego, P., Benussi, L., Bruni, A. C., Filippini, G., Farinotti, M., Giaccone, G., Buiatiotis, S., Manzoni, C., Ferrari, R. & Tagliavini, F., Jul 1 2018, In : Cancer Research. 78, 13, p. 3731-3739 9 p.

Research output: Contribution to journalArticle

2017

Integrin-targeted peptide- and peptidomimetic-drug conjugates for the treatment of tumors

Arosio, D., Manzoni, L., Corno, C. & Perego, P., May 1 2017, In : Recent Patents on Anti-Cancer Drug Discovery. 12, 2, p. 148-168 21 p.

Research output: Contribution to journalReview article

Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7

Misiak, M., Heldt, M., Szeligowska, M., Mazzini, S., Scaglioni, L., Grabe, G. J., Serocki, M., Lica, J., Switalska, M., Wietrzyk, J., Beretta, G. L., Perego, P., Zietkowski, D., Baginski, M., Borowski, E. & Skladanowski, A., Jan 1 2017, In : Oncotarget. 8, 62, p. 105137-105154 18 p.

Research output: Contribution to journalArticle

2016

Antisecretive and antitumor activity of abiraterone acetate in human adrenocortical cancer: A preclinical study

Fiorentini, C., Fragni, M., Perego, P., Vezzoli, S., Bonini, S. A., Tortoreto, M., Galli, D., Claps, M., Tiberio, G. A., Terzolo, M., Missale, C., Memo, M., Procopio, G., Zaffaroni, N., Berruti, A. & Sigala, S., Dec 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4594-4602 9 p.

Research output: Contribution to journalArticle

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

Arrighetti, N., Cossa, G., De Cecco, L., Stucchi, S., Carenini, N., Corna, E., Gandellini, P., Zaffaroni, N., Perego, P. & Gatti, L., Nov 1 2016, In : Toxicology and Applied Pharmacology. 310, p. 9-19 11 p.

Research output: Contribution to journalArticle

RECQL4 modulates MDR1 expression and chemoresistance - Letter

Perego, P., Dec 15 2016, In : Cancer Research. 76, 24, p. 7290 1 p.

Research output: Contribution to journalLetter

Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells

Corno, C., Gatti, L., Lanzi, C., Zaffaroni, N., Colombo, D. & Perego, P., May 1 2016, In : Current Medicinal Chemistry. 23, 15, p. 1496-1512 17 p.

Research output: Contribution to journalReview article

Synthetic sulfoglycolipids targeting the serine–threonine protein kinase Akt

Costa, B., Dangate, M., Vetro, M., Donvito, G., Gabrielli, L., Amigoni, L., Cassinelli, G., Lanzi, C., Ceriani, M., De Gioia, L., Filippi, G., Cipolla, L., Zaffaroni, N., Perego, P. & Colombo, D., Aug 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3396-3405 10 p.

Research output: Contribution to journalArticle

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness

Beretta, G. L., De Cesare, M., Albano, L., Magnifico, A., Carenini, N., Corna, E., Perego, P. & Gatti, L., Mar 1 2016, In : Tumori. 102, 2, p. 144-149 6 p.

Research output: Contribution to journalArticle

2015

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

Vetro, M., Costa, B., Donvito, G., Arrighetti, N., Cipolla, L., Perego, P., Compostella, F., Ronchetti, F. & Colombo, D., Jan 28 2015, In : Organic and Biomolecular Chemistry. 13, 4, p. 1091-1099 9 p.

Research output: Contribution to journalArticle

Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery

Bianchi, A., Arosio, D., Perego, P., De Cesare, M., Carenini, N., Zaffaroni, N., De Matteo, M. & Manzoni, L., Jul 21 2015, In : Organic and Biomolecular Chemistry. 13, 27, p. 7530-7541 12 p.

Research output: Contribution to journalArticle

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Granata, A., Nicoletti, R., Perego, P., Iorio, E., Krishnamachary, B., Benigni, F., Ricci, A., Podo, F., Bhujwalla, Z. M., Canevari, S., Bagnoli, M. & Mezzanzanica, D., 2015, In : Oncotarget. 6, 13, p. 11216-11230 15 p.

Research output: Contribution to journalArticle

Microenvironment-modulated metastatic CD133+/CXCR4+/EpCAM-lung cancer-initiating cells sustain tumor dissemination and correlate with poor prognosis

Bertolini, G., D'Amico, L., Moro, M., Landoni, E., Perego, P., Miceli, R., Gatti, L., Andriani, F., Wong, D., Caserini, R., Tortoreto, M., Milione, M., Ferracini, R., Mariani, L., Pastorino, U., Roato, I., Sozzi, G. & Roz, L., Sep 1 2015, In : Cancer Research. 75, 17, p. 3636-3649 14 p.

Research output: Contribution to journalArticle

Nucleolar targeting by platinum: P53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction

Peterson, E. J., Menon, V. R., Gatti, L., Kipping, R., Dewasinghe, D., Perego, P., Povirk, L. F. & Farrell, N. P., Jan 5 2015, In : Molecular Pharmaceutics. 12, 1, p. 287-297 11 p.

Research output: Contribution to journalArticle

Orchestration of DSB repair: a novel BRCA2 connection

Gatti, L. & Perego, P., Jan 1 2015, In : Cell Cycle. 14, 14, p. 2195-2196 2 p.

Research output: Contribution to journalArticle

Preface: Histone deacetylases as therapeutic targets

Perego, P., 2015, In : Critical Reviews in Oncogenesis. 20, 1-2

Research output: Contribution to journalArticle

Targeting the invasive phenotype of cisplatin-resistant Non-Small Cell Lung Cancer cells by a novel histone deacetylase inhibitor

Zuco, V., Cassinelli, G., Cossa, G., Gatti, L., Favini, E., Tortoreto, M., Cominetti, D., Scanziani, E., Castiglioni, V., Cincinelli, R., Giannini, G., Zunino, F., Zaffaroni, N., Lanzi, C. & Perego, P., Mar 15 2015, In : Biochemical Pharmacology. 94, 2, p. 79-90 12 p.

Research output: Contribution to journalArticle

2014

7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors

Cincinelli, R., Musso, L., Merlini, L., Giannini, G., Vesci, L., Milazzo, F. M., Carenini, N., Perego, P., Penco, S., Artali, R., Zunino, F., Pisano, C. & Dallavalle, S., Feb 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 3, p. 1089-1103 15 p.

Research output: Contribution to journalArticle

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma

Gatti, L., De Cesare, M., Ciusani, E., Corna, E., Arrighetti, N., Cominetti, D., Belvisi, L., Potenza, D., Moroni, E., Vasile, F., Lecis, D., Delia, D., Castiglioni, V., Scanziani, E., Seneci, P., Zaffaroni, N. & Perego, P., Jan 6 2014, In : Molecular Pharmaceutics. 11, 1, p. 283-293 11 p.

Research output: Contribution to journalArticle

Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts

Gomez-Lira, M., Ferronato, S., Malerba, G., Santinami, M., Maurichi, A., Sangalli, A., Turco, A., Perego, P. & Rodolfo, M., Oct 1 2014, In : Experimental Dermatology. 23, 10, p. 766-768 3 p.

Research output: Contribution to journalArticle

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells

Cossa, G., Lanzi, C., Cassinelli, G., Carenini, N., Arrighetti, N., Gatti, L., Corna, E., Zunino, F., Zaffaroni, N. & Perego, P., Jun 1 2014, In : Cancer Letters. 347, 2, p. 212-224 13 p.

Research output: Contribution to journalArticle

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals

Gatti, L., Sevko, A., de Cesare, M., Arrighetti, N., Manenti, G., Ciusani, E., Verderio, P., Ciniselli, C. M., Cominetti, D., Carenini, N., Corna, E., Zaffaroni, N., Rodolfo, M., Rivoltini, L., Umansky, V. & Perego, P., 2014, In : Oncotarget. 5, 12, p. 4516-4528 13 p.

Research output: Contribution to journalArticle

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatments

Gatti, L., Cossa, G., Tinelli, S., Carenini, N., Arrighetti, N., Pennati, M., Cominetti, D., De Cesare, M., Zunino, F., Zaffaroni, N. & Perego, P., Mar 2014, In : Journal of Pharmacology and Experimental Therapeutics. 348, 3, p. 360-371 12 p.

Research output: Contribution to journalArticle

P53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression

Novello, C., Pazzaglia, L., Conti, A., Quattrini, I., Pollino, S., Perego, P., Picci, P. & Benassi, M. S., Dec 9 2014, In : PLoS One. 9, 12, e114757.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-phosphate mimics based on a sulfoquinovose scaffold: Synthesis and evaluation as protein kinase B inhibitors

Gabrielli, L., Calloni, I., Donvito, G., Costa, B., Arrighetti, N., Perego, P., Colombo, D., Ronchetti, F., Nicotra, F. & Cipolla, L., 2014, In : European Journal of Organic Chemistry. 2014, 27, p. 5962-5967 6 p.

Research output: Contribution to journalArticle

Synergistic cooperation between sunitinib and cisplatin promotes apoptotic cell death in human medullary thyroid cancer

Lopergolo, A., Nicolini, V., Favini, E., Bo, L. D., Tortoreto, M., Cominetti, D., Folini, M., Perego, P., Castiglioni, V., Scanziani, E., Borrello, M. G., Zaffaroni, N., Cassinelli, G. & Lanzi, C., Feb 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 2, p. 498-509 12 p.

Research output: Contribution to journalArticle

2013

Camptothecin resistance in cancer: Insights into the molecular mechanisms of a DNA-damaging drug

Beretta, G. L., Gatti, L., Perego, P. & Zaffaroni, N., Apr 2013, In : Current Medicinal Chemistry. 20, 12, p. 1541-1565 25 p.

Research output: Contribution to journalArticle

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

Bagnoli, M., Beretta, G. L., Gatti, L., Pilotti, S., Alberti, P., Tarantino, E., Barbareschi, M., Canevari, S., Mezzanzanica, D. & Perego, P., 2013, In : BioMed Research International. 2013, 143202.

Research output: Contribution to journalArticle

Drug combinations with proteasome inhibitors in antitumor therapy

Gatti, L., Zuco, V., Zaffaroni, N. & Perego, P., 2013, In : Current Pharmaceutical Design. 19, 22, p. 4094-4114 21 p.

Research output: Contribution to journalArticle

Modulation of sensitivity to antitumor agents by targeting the MAPK survival pathway

Cossa, G., Gatti, L., Cassinelli, G., Lanzi, C., Zaffaroni, N. & Perego, P., 2013, In : Current Pharmaceutical Design. 19, 5, p. 883-894 12 p.

Research output: Contribution to journalArticle

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

Lecis, D., De Cesare, M., Perego, P., Conti, A., Corna, E., Drago, C., Seneci, P., Walczak, H., Colombo, M. P., Delia, D. & Sangaletti, S., Nov 2013, In : Cell Death and Disease. 4, 11, e920.

Research output: Contribution to journalArticle

Targeting the akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

Cassinelli, G., Zuco, V., Gatti, L., Lanzi, C., Zaffaroni, N., Colombo, D. & Perego, P., May 2013, In : Current Medicinal Chemistry. 20, 15, p. 1923-1945 23 p.

Research output: Contribution to journalArticle

The ubiquitin proteasome system as a source of drug targets for cancer therapy.

Perego, P., 2013, In : Current Pharmaceutical Design. 19, 22, p. 4024 1 p.

Research output: Contribution to journalArticle

2012

Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery

Pilkington-Miksa, M., Arosio, D., Battistini, L., Belvisi, L., De Matteo, M., Vasile, F., Burreddu, P., Carta, P., Rassu, G., Perego, P., Carenini, N., Zunino, F., De Cesare, M., Castiglioni, V., Scanziani, E., Scolastico, C., Casiraghi, G., Zanardi, F. & Manzoni, L., Aug 15 2012, In : Bioconjugate Chemistry. 23, 8, p. 1610-1622 13 p.

Research output: Contribution to journalArticle

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Lecis, D., Mastrangelo, E., Belvisi, L., Bolognesi, M., Civera, M., Cossu, F., De Cesare, M., Delia, D., Drago, C., Manenti, G., Manzoni, L., Milani, M., Moroni, E., Perego, P., Potenza, D., Rizzo, V., Scavullo, C., Scolastico, C., Servida, F., Vasile, F. & 1 others, Seneci, P., Nov 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 22, p. 6709-6723 15 p.

Research output: Contribution to journalArticle

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Manzoni, L., Belvisi, L., Bianchi, A., Conti, A., Drago, C., De Matteo, M., Ferrante, L., Mastrangelo, E., Perego, P., Potenza, D., Scolastico, C., Servida, F., Timpano, G., Vasile, F., Rizzo, V. & Seneci, P., Nov 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 22, p. 6687-6708 22 p.

Research output: Contribution to journalArticle

Namitecan: A hydrophilic camptothecin with a promising preclinical profile

Beretta, G. L., Zuco, V., De Cesare, M., Perego, P. & Zaffaroni, N., Jul 2012, In : Current Medicinal Chemistry. 19, 21, p. 3488-3501 14 p.

Research output: Contribution to journalArticle

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase i inhibition

Perego, P., Cossa, G., Tinelli, S., Corna, E., Carenini, N., Gatti, L., De Cesare, M., Ciusani, E., Zunino, F., Luison, E., Canevari, S., Zaffaroni, N. & Beretta, G. L., Jan 1 2012, In : Biochemical Pharmacology. 83, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle