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Research Output 2005 2019

2019

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Swuec, P., Lavatelli, F., Tasaki, M., Paissoni, C., Rognoni, P., Maritan, M., Brambilla, F., Milani, P., Mauri, P., Camilloni, C., Palladini, G., Merlini, G., Ricagno, S. & Bolognesi, M., Dec 1 2019, In : Nature Communications. 10, 1, 1269.

Research output: Contribution to journalArticle

Open Access
Immunoglobulin Light Chains
Amyloidosis
Amyloid
Light
sheds

Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains

Maritan, M., Romeo, M., Oberti, L., Sormanni, P., Tasaki, M., Russo, R., Ambrosetti, A., Motta, P., Rognoni, P., Mazzini, G., Barbiroli, A., Palladini, G., Vendruscolo, M., Diomede, L., Bolognesi, M., Merlini, G., Lavatelli, F. & Ricagno, S., Jan 1 2019, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

Light
Immunoglobulin Light Chains
Amyloidogenic Proteins
Poisons
Amyloidosis

The concurrency of several biophysical traits links immunoglobulin light chains with toxicity in AL amyloidosis

Oberti, L., Maritan, M., Rognoni, P., Barbiroli, A., Lavatelli, F., Russo, R., Palladini, G., Bolognesi, M., Merlini, G. & Ricagno, S., Mar 29 2019, In : Amyloid. 26, sup1, p. 107-108 2 p.

Research output: Contribution to journalLetter

2017

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage

Diomede, L., Romeo, M., Rognoni, P., Beeg, M., Foray, C., Ghibaudi, E., Palladini, G., Cherny, R. A., Verga, L., Capello, G. L., Perfetti, V., Fiordaliso, F., Merlini, G. & Salmona, M., Sep 20 2017, In : Antioxidants and Redox Signaling. 27, 9, p. 567-582 16 p.

Research output: Contribution to journalArticle

Oxidative stress
Amyloidosis
Metal ions
Reactive Oxygen Species
Oxidative Stress

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage

Diomede, L., Romeo, M., Rognoni, P., Beeg, M., Foray, C., Ghibaudi, E., Palladini, G., Cherny, R. A., Verga, L., Capello, G. L., Perfetti, V., Fiordaliso, F., Merlini, G. & Salmona, M., Sep 20 2017, In : Antioxidants and Redox Signaling. 27, 9, p. 567-582 16 p.

Research output: Contribution to journalArticle

Oxidative stress
Amyloidosis
Metal ions
Reactive Oxygen Species
Oxidative Stress

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity

Oberti, L., Rognoni, P., Barbiroli, A., Lavatelli, F., Russo, R., Maritan, M., Palladini, G., Bolognesi, M., Merlini, G. & Ricagno, S., Dec 1 2017, In : Scientific Reports. 7, 1, 16809.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloid
Light
Amyloidosis
Protein Stability

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

Imperlini, E., Gnecchi, M., Rognoni, P., Sabidò, E., Ciuffreda, M. C., Palladini, G., Espadas, G., Mancuso, F. M., Bozzola, M., Malpasso, G., Valentini, V., Palladini, G., Orrù, S., Ferraro, G., Milani, P., Perlini, S., Salvatore, F., Merlini, G. & Lavatelli, F., Nov 15 2017, In : Scientific Reports. 7, 1, p. 15661

Research output: Contribution to journalArticle

Amyloidosis
Light
Proteome
Proteins
Cardiomyopathies

Proteotoxicity in cardiac amyloidosis: Amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

Imperlini, E., Gnecchi, M., Rognoni, P., Sabidò, E., Ciuffreda, M. C., Palladini, G., Espadas, G., Mancuso, F. M., Bozzola, M., Malpasso, G., Valentini, V., Palladini, G., Orrù, S., Ferraro, G., Milani, P., Perlini, S., Salvatore, F., Merlini, G. & Lavatelli, F., Dec 1 2017, In : Scientific Reports. 7, 1, 15661.

Research output: Contribution to journalArticle

Amyloidosis
Light
Proteome
Proteins
Cardiomyopathies

Regulated expression of amyloidogenic immunoglobulin light chains in mice

Nuvolone, M., Sorce, S., Pelczar, P., Rushing, E., Lavatelli, F., Rognoni, P., Valentini, V., Palladini, G., Merlini, G. & Aguzzi, A., Mar 16 2017, In : Amyloid. 24, p. 52-53 2 p.

Research output: Contribution to journalLetter

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Oliva, L., Orfanelli, U., Resnati, M., Raimondi, A., Orsi, A., Milan, E., Palladini, G., Milani, P., Cerruti, F., Cascio, P., Casarini, S., Rognoni, P., Touvier, T., Marcatti, M., Ciceri, F., Mangiacavalli, S., Corso, A., Merlini, G. & Cenci, S., 2017, In : Blood. 129, 15, p. 2132-2142 11 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Plasma Cells
Toxicity
Plasmas
Light

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Oliva, L., Orfanelli, U., Resnati, M., Raimondi, A., Orsi, A., Milan, E., Palladini, G., Milani, P., Cerruti, F., Cascio, P., Casarini, S., Rognoni, P., Touvier, T., Marcatti, M., Ciceri, F., Mangiacavalli, S., Corso, A., Merlini, G. & Cenci, S., Apr 13 2017, In : Blood. 129, 15, p. 2132-2142 11 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Plasma Cells
Toxicity
Plasmas
Light
2016

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study

Ami, D., Lavatelli, F., Rognoni, P., Palladini, G., Raimondi, S., Giorgetti, S., Monti, L., Doglia, S. M., Natalello, A. & Merlini, G., Jul 4 2016, In : Scientific Reports. 6, 29096.

Research output: Contribution to journalArticle

Amyloidosis
Fourier Analysis
Amyloid
Light
Abdominal Subcutaneous Fat
2015

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis

Lavatelli, F., Imperlini, E., Orrù, S., Rognoni, P., Sarnataro, D., Palladini, G., Malpasso, G., Soriano, M. E., Di Fonzo, A., Valentini, V., Gnecchi, M., Perlini, S., Salvatore, F. & Merlini, G., Nov 1 2015, In : FASEB Journal. 29, 11, p. 4614-4628 15 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Mitochondrial Proteins
Amyloidosis
Fibroblasts
Cardiomyopathies
2014

A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis

Diomede, L., Rognoni, P., Lavatelli, F., Romeo, M., Del Favero, E., Cantù, L., Ghibaudi, E., Di Fonzo, A., Corbelli, A., Fiordaliso, F., Palladini, G., Valentini, V., Perfetti, V., Salmona, M. & Merlini, G., Jun 5 2014, In : Blood. 123, 23, p. 3543-3552 10 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Caenorhabditis elegans
Amyloidosis
Assays
Light

Investigating heart-specific toxicity of amyloidogenic immunoglobulin light chains: A lesson from C. elegans

Diomede, L., Rognoni, P., Lavatelli, F., Romeo, M., di Fonzo, A., Foray, C., Fiordaliso, F., Palladini, G., Valentini, V., Perfetti, V., Salmona, M. & Merlini, G., Jul 1 2014, In : Worm. 3, 3, p. e965590

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Light
Amyloidosis
Amyloid
Poisons
2013

A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli

Rognoni, P., Lavatelli, F., Casarini, S., Palladini, G., Verga, L., Pedrazzoli, P., Valentini, G., Merlini, G. & Perfetti, V., Sep 27 2013, In : PLoS One. 8, 9, e76022.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Bence Jones Protein
immunoglobulins
Escherichia coli
Immunoglobulins

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

Guan, J., Mishra, S., Shi, J., Plovie, E., Qiu, Y., Cao, X., Gianni, D., Jiang, B., Del Monte, F., Connors, L. H., Seldin, D. C., Lavatelli, F., Rognoni, P., Palladini, G., Merlini, G., Falk, R. H., Semigran, M. J., Dec, G. W., MacRae, C. A. & Liao, R., 2013, In : Basic Research in Cardiology. 108, 5, 378.

Research output: Contribution to journalArticle

Amyloidosis
Light
Cardiomyopathies
Cell Death
Mortality
2012

In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells

Arosio, P., Owczarz, M., Müller-Späth, T., Rognoni, P., Beeg, M., Wu, H., Salmona, M. & Morbidelli, M., Mar 14 2012, In : PLoS One. 7, 3, e33372.

Research output: Contribution to journalArticle

aggregation behavior
myeloma
Multiple Myeloma
Dimers
Agglomeration

The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44

Perfetti, V., Palladini, G., Casarini, S., Navazza, V., Rognoni, P., Obici, L., Invernizzi, R., Perlini, S., Klersy, C. & Merlini, G., Jan 5 2012, In : Blood. 119, 1, p. 144-150 7 p.

Research output: Contribution to journalArticle

Amyloid
Genes
Light
Amyloidosis
Logistics
2011

A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum

Lavatelli, F., Brambilla, F., Valentini, V., Rognoni, P., Casarini, S., Di Silvestre, D., Perfetti, V., Palladini, G., Sarais, G., Mauri, P. & Merlini, G., Mar 2011, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 3, p. 409-419 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Proteomics
Purification
Immunoglobulins
Serum
2010

Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy

Comincini, S., Rognoni, P., Chiarelli, L. R., Azzalin, A., Miracco, C. & Valentini, G., 2010, In : Journal of Biomedicine and Biotechnology. 2010, 301067.

Research output: Contribution to journalArticle

Astrocytoma
Neoplasms
Proteins
Neuroglia
Polysaccharides
2006

Nuclear mRNA retention and aberrant doppel protein expression in human astrocytic tumor cells

Comincini, S., Chiarelli, L. R., Zelini, P., Del Vecchio, I., Azzalin, A., Arias, A., Ferrara, V., Rognoni, P., Dipoto, A., Nano, R., Valentini, G. & Ferretti, L., Dec 2006, In : Oncology Reports. 16, 6, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

Astrocytoma
Messenger RNA
RNA Isoforms
Nuclear RNA
Neoplasms
2005

SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase

Gorrini, M., Lupi, A., Iadarola, P., Dos Santos, C., Rognoni, P., Dalzoppo, D., Carrabino, N., Pozzi, E., Baritussio, A. & Luisetti, M., Dec 13 2005, In : Respiratory Research. 6, 146.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Leukocyte Elastase
Carbohydrates
Carrier Proteins
Pulmonary Emphysema