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Paolo Michieli

1991 …2017
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Hepatocyte Growth Factor Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Growth Medicine & Life Sciences
Oncogenes Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
p53 Genes Medicine & Life Sciences
Mutation Medicine & Life Sciences
Antibodies Medicine & Life Sciences

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Research Output 1991 2017

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors

Mira, A., Morello, V., Céspedes, M. V., Perera, T., Comoglio, P. M., Mangues, R. & Michieli, P., Jan 1 2017, In : Oncotarget. 8, 24, p. 38193-38213 21 p.

Research output: Contribution to journal › Article

Angiogenesis Inhibitors
Hepatocyte Growth Factor
Colorectal Neoplasms
Glucose
SCID Mice

Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy

Godar, M., Morello, V., Sadi, A., Hultberg, A., De Jonge, N., Basilico, C., Hanssens, V., Saunders, M., Lambrecht, B. N., El Khattabi, M., De Haard, H., Michieli, P. & Blanchetot, C., Aug 22 2016, In : Scientific Reports. 6, 31621.

Research output: Contribution to journal › Article

Anti-Idiotypic Antibodies
Antibodies
Bispecific Antibodies
Epitopes
Single-Domain Antibodies

Dual Constant Domain-Fab: A novel strategy to improve half-life and potency of a Met therapeutic antibody

Cignetto, S., Modica, C., Chiriaco, C., Fontani, L., Milla, P., Michieli, P., Comoglio, P. M. & Vigna, E., Jun 1 2016, In : Molecular Oncology. 10, 6, p. 938-948 11 p.

Research output: Contribution to journal › Article

Half-Life
Antibodies
Neoplasms
Molecular Weight
Immunoglobulin Fab Fragments

Depleting MET-expressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling

Hultberg, A., Morello, V., Huyghe, L., De Jonge, N., Blanchetot, C., Hanssens, V., De Boeck, G., Silence, K., Festjens, E., Heukers, R., Roux, B., Lamballe, F., Ginestier, C., Charafe-Jauffret, E., Maina, F., Brouckaert, P., Saunders, M., Thibault, A., Dreier, T., De Haard, H. & 1 others, Michieli, P., Aug 15 2015, In : Cancer Research. 75, 16, p. 3373-3383 11 p.

Research output: Contribution to journal › Article

Neoplasm Antibodies
Hepatocyte Growth Factor
Antibodies
Neoplasms
Therapeutics

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

VanSchaeybroeck, S., Kalimutho, M., Dunne, P. D., Carson, R., Allen, W., Jithesh, P. V., Redmond, K. L., Sasazuki, T., Shirasawa, S., Blayney, J., Michieli, P., Fenning, C., Lenz, H. J., Lawler, M., Longley, D. B. & Johnston, P. G., Jun 26 2014, In : Cell Reports. 7, 6, p. 1940-1955 16 p.

Research output: Contribution to journal › Article

Mitogen-Activated Protein Kinase Kinases
Colorectal Neoplasms
Chemical activation
Metalloproteases
Systems Biology