Paolo Michieli

Istituto Oncologico Candiolo

Emailpaolo.michieli@ircc.it

4426 Citations
26 h-Index

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23 Similar Profiles

Hepatocyte Growth Factor Medicine & Life Sciences

Neoplasms Medicine & Life Sciences

Growth Medicine & Life Sciences

Oncogenes Medicine & Life Sciences

Phosphotransferases Medicine & Life Sciences

p53 Genes Medicine & Life Sciences

Mutation Medicine & Life Sciences

Antibodies Medicine & Life Sciences

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Research Output 1991 2017

4426 Citations
26 h-Index
40 Article

8 Citations (Scopus)

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors

Mira, A., Morello, V., Céspedes, M. V., Perera, T., Comoglio, P. M., Mangues, R. & Michieli, P., Jan 1 2017, In : Oncotarget. 8, 24, p. 38193-38213 21 p.

Research output: Contribution to journal › Article

Angiogenesis Inhibitors

Hepatocyte Growth Factor

Colorectal Neoplasms

Glucose

SCID Mice

4 Citations (Scopus)

Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy

Godar, M., Morello, V., Sadi, A., Hultberg, A., De Jonge, N., Basilico, C., Hanssens, V., Saunders, M., Lambrecht, B. N., El Khattabi, M., De Haard, H., Michieli, P. & Blanchetot, C., Aug 22 2016, In : Scientific Reports. 6, 31621.

Research output: Contribution to journal › Article

Anti-Idiotypic Antibodies

Antibodies

Bispecific Antibodies

Epitopes

Single-Domain Antibodies

7 Citations (Scopus)

Dual Constant Domain-Fab: A novel strategy to improve half-life and potency of a Met therapeutic antibody

Cignetto, S., Modica, C., Chiriaco, C., Fontani, L., Milla, P., Michieli, P., Comoglio, P. M. & Vigna, E., Jun 1 2016, In : Molecular Oncology. 10, 6, p. 938-948 11 p.

Research output: Contribution to journal › Article

Half-Life

Antibodies

Neoplasms

Molecular Weight

Immunoglobulin Fab Fragments

13 Citations (Scopus)

Depleting MET-expressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling

Hultberg, A., Morello, V., Huyghe, L., De Jonge, N., Blanchetot, C., Hanssens, V., De Boeck, G., Silence, K., Festjens, E., Heukers, R., Roux, B., Lamballe, F., Ginestier, C., Charafe-Jauffret, E., Maina, F., Brouckaert, P., Saunders, M., Thibault, A., Dreier, T., De Haard, H. & 1 others, Michieli, P., Aug 15 2015, In : Cancer Research. 75, 16, p. 3373-3383 11 p.

Research output: Contribution to journal › Article

Neoplasm Antibodies

Hepatocyte Growth Factor

Antibodies

Neoplasms

Therapeutics

45 Citations (Scopus)

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

VanSchaeybroeck, S., Kalimutho, M., Dunne, P. D., Carson, R., Allen, W., Jithesh, P. V., Redmond, K. L., Sasazuki, T., Shirasawa, S., Blayney, J., Michieli, P., Fenning, C., Lenz, H. J., Lawler, M., Longley, D. B. & Johnston, P. G., Jun 26 2014, In : Cell Reports. 7, 6, p. 1940-1955 16 p.

Research output: Contribution to journal › Article

Mitogen-Activated Protein Kinase Kinases

Colorectal Neoplasms

Chemical activation

Metalloproteases

Systems Biology