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Research Output

2019

Combination of PPARg agonist pioglitazone and trabectedin induce adipocyte differentiation to overcome trabectedin resistance in myxoid liposarcomas

Frapolli, R., Bello, E., Ponzo, M., Craparotta, I., Mannarino, L., Ballabio, S., Marchini, S., Carrassa, L., Ubezio, P., Porcu, L., Brich, S., Sanfilippo, R., Casali, P. G., Gronchi, A., Pilotti, S. & D'Incalci, M., Dec 15 2019, In : Clinical Cancer Research. 25, 24, p. 7565-7575 11 p.

Research output: Contribution to journalArticle

Combination of PPARg agonist pioglitazone and trabectedin induce adipocyte differentiation to overcome trabectedin resistance in myxoid liposarcomas

Frapolli, R., Bello, E., Ponzo, M., Craparotta, I., Mannarino, L., Ballabio, S., Marchini, S., Carrassa, L., Ubezio, P., Porcu, L., Brich, S., Sanfilippo, R., Casali, P. G., Gronchi, A., Pilotti, S. & D'Incalci, M., Dec 15 2019, In : Clin. Cancer Res.. 25, 24, p. 7565-7575 11 p.

Research output: Contribution to journalArticle

2018

ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells

Portale, F., Cricrì, G., Bresolin, S., Lupi, M., Gaspari, S., Silvestri, D., Russo, B., Marino, N., Ubezio, P., Pagni, F., Vergani, P., Te Kronnie, G., Valsecchi, M. G., Locatelli, F., Rizzari, C., Biondi, A., Dander, E. & D'Amico, G., Sep 27 2018, In : Haematologica.

Research output: Contribution to journalArticle

Tumor progression and metastatic dissemination in ovarian cancer after dose-dense or conventional paclitaxel and cisplatin plus bevacizumab

Bizzaro, F., Falcetta, F., D’Agostini, E., Decio, A., Minoli, L., Erba, E., Alessandro Peccatori, F., Scanziani, E., Colombo, N., Zucchetti, M., Bani, M. R., Ubezio, P. & Giavazzi, R., 2018, In : International Journal of Cancer. 143, 9, p. 2187-2199 13 p.

Research output: Contribution to journalArticle

Tumor progression and metastatic dissemination in ovarian cancer after dose-dense or conventional paclitaxel and cisplatin plus bevacizumab

Bizzaro, F., Falcetta, F., D'Agostini, E., Decio, A., Minoli, L., Erba, E., Peccatori, F. A., Scanziani, E., Colombo, N., Zucchetti, M., Bani, M., Ubezio, P. & Giavazzi, R., 2018, In : International Journal of Cancer. p. 2187-2199

Research output: Contribution to journalArticle

2017

Application of 3D Mass Spectrometry Imaging to TKIs

Morosi, L., Giordano, S., Falcetta, F., Frapolli, R., Licandro, S. A., Matteo, C., Zucchetti, M., Ubezio, P., Erba, E., Visentin, S., D'Incalci, M. & Davoli, E., Nov 1 2017, In : Clinical Pharmacology and Therapeutics. 102, 5, p. 748-751 4 p.

Research output: Contribution to journalArticle

Modeling cytostatic and cytotoxic responses to new treatment regimens for ovarian cancer

Falcetta, F., Bizzaro, F., D'Agostini, E., Bani, M. R., Giavazzi, R. & Ubezio, P., Dec 1 2017, In : Cancer Research. 77, 23, p. 6759-6769 11 p.

Research output: Contribution to journalArticle

Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts

Vázquez, R., Licandro, S. A., Astorgues-Xerri, L., Lettera, E., Panini, N., Romano, M., Erba, E., Ubezio, P., Bello, E., Libener, R., Orecchia, S., Grosso, F., Riveiro, M. E., Cvitkovic, E., Bekradda, M., D'Incalci, M. & Frapolli, R., Jan 1 2017, In : International Journal of Cancer. 140, 1, p. 197-207 11 p.

Research output: Contribution to journalArticle

2016

Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer

Sitia, L., Ferrari, R., Violatto, M. B., Talamini, L., Dragoni, L., Colombo, C., Colombo, L., Lupi, M., Ubezio, P., D'Incalci, M., Morbidelli, M., Salmona, M., Moscatelli, D. & Bigini, P., Mar 14 2016, In : Biomacromolecules. 17, 3, p. 744-755 12 p.

Research output: Contribution to journalArticle

Integrated experimental and simulation study of the response to sequential treatment with erlotinib and gemcitabine in pancreatic cancer

Ubezio, P., Falcetta, F., Carrassa, L. & Lupi, M., Mar 29 2016, In : Oncotarget. 7, 13, p. 15492-15506 15 p.

Research output: Contribution to journalArticle

PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

Colombo, C., Morosi, L., Bello, E., Ferrari, R., Licandro, S. A., Lupi, M., Ubezio, P., Morbidelli, M., Zucchetti, M., DIncalci, M., Moscatelli, D. & Frapolli, R., Jan 4 2016, In : Molecular Pharmaceutics. 13, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

Small interfering RNA delivery through positively charged polymer nanoparticles

Dragoni, L., Ferrari, R., Lupi, M., Cesana, A., Falcetta, F., Ubezio, P., D'Incalci, M., Morbidelli, M. & Moscatelli, D., Feb 18 2016, In : Nanotechnology. 27, 12, 125102.

Research output: Contribution to journalArticle

2015

Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression

Centritto, F., Paroni, G., Bolis, M., Garattini, S. K., Kurosaki, M., Barzago, M. M., Zanetti, A., Fisher, J. N., Scott, M. F., Pattini, L., Lupi, M., Ubezio, P., Piccotti, F., Zambelli, A., Rizzo, P., Gianni', M., Fratelli, M., Terao, M. & Garattini, E., Jul 1 2015, In : EMBO Molecular Medicine. 7, 7, p. 950-972 23 p.

Research output: Contribution to journalArticle

2014

A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma

Lupi, M., Colombo, C., Frapolli, R., Ferrari, R., Sitia, L., Dragoni, L., Bello, E., Licandro, S. A., Falcetta, F., Ubezio, P., Bigini, P., Salmona, M., D'Incalci, M., Morbidelli, M. & Moscatelli, D., Aug 22 2014, In : Nanotechnology. 25, 33, 335706.

Research output: Contribution to journalArticle

Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles

Ferrari, R., Lupi, M., Falcetta, F., Bigini, P., Paolella, K., Fiordaliso, F., Bisighini, C., Salmona, M., D'Incalci, M., Morbidelli, M., Moscatelli, D. & Ubezio, P., Jan 31 2014, In : Nanotechnology. 25, 4, 045102.

Research output: Contribution to journalArticle

2013

A methyl methacrylate-HEMA-CLn copolymerization investigation: From kinetics to bioapplications

Ferrari, R., Rooney, T. R., Lupi, M., Ubezio, P., Hutchinson, R. A. & Moscatelli, D., Oct 2013, In : Macromolecular Bioscience. 13, 10, p. 1347-1357 11 p.

Research output: Contribution to journalArticle

Biocompatible fluorescent nanoparticles for in vivo stem cell tracking

Cova, L., Bigini, P., Diana, V., Sitia, L., Ferrari, R., Pesce, R. M., Khalaf, R., Bossolasco, P., Ubezio, P., Lupi, M., Tortarolo, M., Colombo, L., Giardino, D., Silani, V., Morbidelli, M., Salmona, M. & Moscatelli, D., Jun 21 2013, In : Nanotechnology. 24, 24, 245603.

Research output: Contribution to journalArticle

Cytotoxicity of PMMA-based nanoparticles synthesized adopting SDS and Tween 80

Colombo, C., Lupi, M., Ubezio, P. & Moscatelli, D., Feb 2013, In : Macromolecular Symposia. 324, 1, p. 134-139 6 p.

Research output: Contribution to journalArticle

Dynamic Rendering of the Heterogeneous Cell Response to Anticancer Treatments

Falcetta, F., Lupi, M., Colombo, V. & Ubezio, P., Oct 2013, In : PLoS Computational Biology. 9, 10, e1003293.

Research output: Contribution to journalArticle

Modeling of non-small cell lung cancer volume changes during CT-based image guided radiotherapy: Patterns observed and clinical implications

Gay, H. A., Taylor, Q. Q., Kiriyama, F., Dieck, G. T., Jenkins, T., Walker, P., Allison, R. R. & Ubezio, P., 2013, In : Computational and Mathematical Methods in Medicine. 2013, 637181.

Research output: Contribution to journalArticle

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

Zucchetti, M., Bonezzi, K., Frapolli, R., Sala, F., Borsotti, P., Zangarini, M., Cvitkovic, E., Noel, K., Ubezio, P., Giavazzi, R., D'Incalci, M. & Taraboletti, G., Oct 2013, In : Cancer Chemotherapy and Pharmacology. 72, 4, p. 879-887 9 p.

Research output: Contribution to journalArticle

Synthesis of surfactant free PCL-PEG brushed nanoparticles with tunable degradation kinetics

Ferrari, R., Colombo, C., Casali, C., Lupi, M., Ubezio, P., Falcetta, F., D'Incalci, M., Morbidelli, M. & Moscatelli, D., 2013, In : International Journal of Pharmaceutics. 453, 2, p. 551-559 9 p.

Research output: Contribution to journalArticle

2012

A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Della Vittoria Scarpati, G., Falcetta, F., Carlomagno, C., Ubezio, P., Marchini, S., De Stefano, A., Singh, V. K., D'Incalci, M., De Placido, S. & Pepe, S., Jul 15 2012, In : International Journal of Radiation Oncology Biology Physics. 83, 4, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models

Di Francesco, A. M., Ubezio, P., Torella, A. R., Meco, D., Pierri, F., Barone, G., Cusano, G., Pisano, C., D'Incalci, M. & Riccardi, R., Aug 2012, In : Investigational New Drugs. 30, 4, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: Implications for antineoplastic combination therapies

Bonezzi, K., Belotti, D., North, B. J., Ghilardi, C., Borsotti, P., Resovi, A., Ubezio, P., Riva, A., Giavazzi, R., Verdin, E. & Taraboletti, G., Sep 2012, In : Neoplasia (United States). 14, 9, p. 846-854 9 p.

Research output: Contribution to journalArticle

Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA

Paroni, G., Fratelli, M., Gardini, G., Bassano, C., Flora, M., Zanetti, A., Guarnaccia, V., Ubezio, P., Centritto, F., Terao, M. & Garattini, E., Jul 19 2012, In : Oncogene. 31, 29, p. 3431-3443 13 p.

Research output: Contribution to journalArticle

2011

Chemotherapeutic activity of silymarin combined with doxorubicin or paclitaxel in sensitive and multidrug-resistant colon cancer cells

Colombo, V., Lupi, M., Falcetta, F., Forestieri, D., D'Incalci, M. & Ubezio, P., Feb 2011, In : Cancer Chemotherapy and Pharmacology. 67, 2, p. 369-379 11 p.

Research output: Contribution to journalArticle

Combination of PI3K/mTOR inhibitors: Antitumor activity and molecular correlates

Mazzoletti, M., Bortolin, F., Brunelli, L., Pastorelli, R., Di Giandomenico, S., Erba, E., Ubezio, P. & Broggini, M., Jul 1 2011, In : Cancer Research. 71, 13, p. 4573-4584 12 p.

Research output: Contribution to journalArticle

Interoperability of time series cytometric data: A cross platform approach for modeling tumor heterogeneity

Khan, I. A., Lupi, M., Campbell, L., Chappell, S. C., Brown, M. R., Wiltshire, M., Smith, P. J., Ubezio, P. & Errington, R. J., Mar 2011, In : Cytometry Part A. 79 A, 3, p. 214-226 13 p.

Research output: Contribution to journalArticle

2010

Miniaturizing bromodeoxyuridine incorporation enables the usage of flow cytometry for cell cycle analysis of adherent tissue culture cells for high throughput screening

Cappella, P., Giorgini, M. L., Ernestina Re, C., Ubezio, P., Ciomei, M. & Moll, J., Oct 2010, In : Cytometry Part A. 77, 10, p. 953-961 9 p.

Research output: Contribution to journalArticle

2009

Quantitative assessment of the complex dynamics of G1, S, and G2-M checkpoint activities

Ubezio, P., Lupi, M., Branduardi, D., Cappella, P., Cavallini, E., Colombo, V., Matera, G., Natoli, C., Tomasoni, D. & D'Incalci, M., Jun 15 2009, In : Cancer Research. 69, 12, p. 5234-5240 7 p.

Research output: Contribution to journalArticle

2008

Cell killing and resistance in pre-operative breast cancer chemotherapy

Ubezio, P. & Cameron, D., Jul 21 2008, In : BMC Cancer. 8, 201.

Research output: Contribution to journalArticle

In vivo measurement of vascular modulation in experimental tumors using a fluorescent contrast agent

Valentini, G., D'Andrea, C., Ferrari, R., Pifferi, A., Cubeddu, R., Martinelli, M., Natoli, C., Ubezio, P. & Giavazzi, R., Sep 2008, In : Photochemistry and Photobiology. 84, 5, p. 1249-1256 8 p.

Research output: Contribution to journalArticle

2007

Antiproliferative activity of cisplatin detected by CFSE in p53-proficient and p53-deficient cells

Ubezio, P., Lupi, M. & Matera, G., Sep 2007, In : Immunological Investigations. 36, 5-6, p. 847-859 13 p.

Research output: Contribution to journalArticle

The contribution of p53 in the dynamics of cell cycle response to DNA damage interpreted by a mathematical model

Lupi, M., Matera, G., Natoli, C., Colombo, V. & Ubezio, P., Apr 15 2007, In : Cell Cycle. 6, 8, p. 943-950 8 p.

Research output: Contribution to journalArticle

2006

Fluorescent imaging of vascular shutdown in-vivo

Valentini, G., D'Andrea, C., Ferrari, R., Pifferi, A., Cubeddu, R., Martinelli, M., Natoli, C., Ubezio, P. & Giavazzi, R., 2006, Optics InfoBase Conference Papers. Optical Society of America

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model

Gobbi, M., Colombo, L., Morbin, M., Mazzoleni, G., Accardo, E., Vanoni, M., Del Favero, E., Cantú, L., Kirschner, D. A., Manzoni, C., Beeg, M., Ceci, P., Ubezio, P., Forloni, G., Tagliavini, F. & Salmona, M., Jan 13 2006, In : Journal of Biological Chemistry. 281, 2, p. 843-849 7 p.

Research output: Contribution to journalArticle

Interpreting cell cycle effects of drugs: The case of melphalan

Lupi, M., Cappella, P., Matera, G., Natoli, C. & Ubezio, P., Apr 2006, In : Cancer Chemotherapy and Pharmacology. 57, 4, p. 443-457 15 p.

Research output: Contribution to journalArticle

Modelling the balance between quiescence and cell death in normal and tumour cell populations

Spinelli, L., Torricelli, A., Ubezio, P. & Basse, B., Aug 2006, In : Mathematical Biosciences. 202, 2, p. 349-370 22 p.

Research output: Contribution to journalArticle

Neurodegeneration induced by complex I inhibition in a cellular model of familial amyotrophic lateral sclerosis

Rizzardini, M., Lupi, M., Mangolini, A., Babetto, E., Ubezio, P. & Cantoni, L., Apr 28 2006, In : Brain Research Bulletin. 69, 4, p. 465-474 10 p.

Research output: Contribution to journalArticle

The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis

Naumova, E., Ubezio, P., Garofalo, A., Borsotti, P., Cassis, L., Riccardi, E., Scanziani, E., Eccles, S. A., Bani, M. R. & Giavazzi, R., Mar 15 2006, In : Clinical Cancer Research. 12, 6, p. 1839-1849 11 p.

Research output: Contribution to journalArticle

2005

Combination of trabectedin and irinotecan is highly effective in a human rhabdomyosarcoma xenograft

Riccardi, A., Meco, D., Ubezio, P., Mazzarella, G., Marabese, M., Faircloth, G. T., Jimeno, J., D'Incalci, M. & Riccardi, R., Sep 2005, In : Anti-Cancer Drugs. 16, 8, p. 811-815 5 p.

Research output: Contribution to journalArticle

2004

Calpain as a multi-site regulator of cell cycle

Jánossy, J., Ubezio, P., Apáti, Á., Magócsi, M., Tompa, P. & Friedrich, P., Apr 15 2004, In : Biochemical Pharmacology. 67, 8, p. 1513-1521 9 p.

Research output: Contribution to journalArticle

Cytostatic and Cytotoxic Effects of Topotecan Decoded by a Novel Mathematical Simulation Approach

Lupi, M., Matera, G., Branduardi, D., D'Incalci, M. & Ubezio, P., Apr 15 2004, In : Cancer Research. 64, 8, p. 2825-2832 8 p.

Research output: Contribution to journalArticle

Heterogeneous cell response to topotecan in a CFSE-based proliferation test

Matera, G., Lupi, M. & Ubezio, P., Dec 2004, In : Cytometry Part A. 62, 2, p. 118-128 11 p.

Research output: Contribution to journalArticle