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Research Output 1967 2020

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Article
2020
Open Access
Romano-Ward Syndrome
Induced Pluripotent Stem Cells
Cell Line
Germ Layers
Pluripotent Stem Cells
2019

Calmodulin mutations and life-threatening cardiac arrhythmias: Insights from the International Calmodulinopathy Registry

Crotti, L., Spazzolini, C., Tester, D. J., Ghidoni, A., Baruteau, A. E., Beckmann, B. M., Behr, E. R., Bennett, J. S., Bezzina, C. R., Bhuiyan, Z. A., Celiker, A., Cerrone, M., Dagradi, F., De Ferrari, G. M., Etheridge, S. P., Fatah, M., Garcia-Pavia, P., Al-Ghamdi, S., Hamilton, R. M., Al-Hassnan, Z. N. & 21 others, Horie, M., Jimenez-Jaimez, J., Kanter, R. J., Kaski, J. P., Kotta, M. C., Lahrouchi, N., Makita, N., Norrish, G., Odland, H. H., Ohno, S., Papagiannis, J., Parati, G., Sekarski, N., Tveten, K., Vatta, M., Webster, G., Wilde, A. A. M., Wojciak, J., George, A. L., Ackerman, M. J. & Schwartz, P. J., Sep 14 2019, In : European Heart Journal. 40, 35, p. 2964-2975A

Research output: Contribution to journalArticle

Calmodulin
Registries
Cardiac Arrhythmias
Mutation
Phenotype

Cardiac sympathetic denervation via a transtracheal approach: It's a long way to Tipperary

Schwartz, P. J. & Pugliese, L., Jan 2019, In : Heart Rhythm. 16, 1, p. 125-127 3 p.

Research output: Contribution to journalArticle

Cardiac sympathetic denervation via a transtracheal approach: It's a long way to Tipperary

Schwartz, P. J. & Pugliese, L., 2019, In : Heart Rhythm. 16, 1, p. 125-127 3 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Induced Pluripotent Stem Cells
Cardiac Myocytes
Drug Repositioning

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Mura, M., Lee, Y-K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Tse, H-F. & Gnecchi, M., May 2019, In : Stem Cell Research. 37, p. 101431

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cell Line
Mutation
Pluripotent Stem Cells
Retroviridae

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation

Mura, M., Lee, Y. K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Tse, H. F. & Gnecchi, M., May 1 2019, In : Stem Cell Research. 37, 101431.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Cell Line
Mutation
Pluripotent Stem Cells
Retroviridae

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Mura, M., Lee, Y. K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Tse, H. F. & Gnecchi, M., May 1 2019, In : Stem Cell Research. 37, 101437.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Cell Line
Mutation
Pluripotent Stem Cells
Retroviridae

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation

Mura, M., Lee, Y-K., Pisano, F., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Tse, H-F. & Gnecchi, M., May 2019, In : Stem Cell Research. 37, p. 101437

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cell Line
Mutation
Pluripotent Stem Cells
Retroviridae
Romano-Ward Syndrome
Induced Pluripotent Stem Cells
Cell Line
Germ Layers
Pluripotent Stem Cells
Open Access
Romano-Ward Syndrome
Induced Pluripotent Stem Cells
Cell Line
Genes
Long QT Syndrome
Romano-Ward Syndrome
Induced Pluripotent Stem Cells
Cell Line
Genes
Long QT Syndrome

Generation of two human induced pluripotent stem cell (hiPSC) lines from a long QT syndrome South African founder population

Mura, M., Pisano, F., Stefanello, M., Ginevrino, M., Boni, M., Calabrò, F., Crotti, L., Valente, E. M., Schwartz, P. J., Brink, P. A. & Gnecchi, M., Aug 1 2019, In : Stem Cell Research. 39, 1 p.

Research output: Contribution to journalArticle

Open Access
Long QT Syndrome
Induced Pluripotent Stem Cells
Cell Line
Population
Pluripotent Stem Cells

Genetic Mosaicism in Calmodulinopathy

Wren, L. M., Jiménez-Jáimez, J., Al-Ghamdi, S., Al-Aama, J. Y., Bdeir, A., Al-Hassnan, Z. N., Kuan, J. L., Foo, R. Y., Potet, F., Johnson, C. N., Aziz, M. C., Carvill, G. L., Kaski, J-P., Crotti, L., Perin, F., Monserrat, L., Burridge, P. W., Schwartz, P. J., Chazin, W. J., Bhuiyan, Z. A. & 1 others, George, A. L., Sep 2019, In : Circulation. Genomic and precision medicine. 12, 9, p. 375-385 11 p.

Research output: Contribution to journalArticle

Mosaicism
Calmodulin
Mutation
Fetal Death
Cardiac Arrhythmias

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest

Van Der Werf, C., Lieve, K. V., Bos, J. M., Lane, C. M., Denjoy, I., Roses-Noguer, F., Aiba, T., Wada, Y., Ingles, J., Leren, I. S., Rudic, B., Schwartz, P. J., Maltret, A., Sacher, F., Skinner, J. R., Krahn, A. D., Roston, T. M., Tfelt-Hansen, J., Swan, H., Robyns, T. & 17 others, Ohno, S., Roberts, J. D., Van Den Berg, M. P., Kammeraad, J. A., Probst, V., Kannankeril, P. J., Blom, N. A., Behr, E. R., Borggrefe, M., Haugaa, K. H., Semsarian, C., Horie, M., Shimizu, W., Till, J. A., Leenhardt, A., Ackerman, M. J. & Wilde, A. A., Sep 14 2019, In : European Heart Journal. 40, 35, p. 2953-2961 9 p.

Research output: Contribution to journalArticle

Implantable Defibrillators
Sudden Cardiac Death
Shock
Polymorphic catecholergic ventricular tachycardia
Flecainide

International Triadin Knockout Syndrome Registry: The Clinical Phenotype and Treatment Outcomes of Patients with Triadin Knockout Syndrome

Clemens, D. J., Tester, D. J., Giudicessi, J. R., Bos, J. M., Rohatgi, R. K., Abrams, D. J., Balaji, S., Crotti, L., Faure, J., Napolitano, C., Priori, S. G., Probst, V., Rooryck-Thambo, C., Roux-Buisson, N., Sacher, F., Schwartz, P. J., Silka, M. J., Walsh, M. A. & Ackerman, M. J., Feb 1 2019, In : Circulation: Genomic and Precision Medicine. 12, 2, p. 65-75 11 p., e002419.

Research output: Contribution to journalArticle

Open Access
Registries
Phenotype
Heart Arrest
Genetic Therapy
Cardiac Arrhythmias
Open Access
Long QT Syndrome
Induced Pluripotent Stem Cells
Cardiac Myocytes
Cardiac Electrophysiology
Technology

Mexiletine Shortens the QT Interval in Patients with Potassium Channel-Mediated Type 2 Long QT Syndrome

Bos, J. M., Crotti, L., Rohatgi, R. K., Castelletti, S., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., May 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 5, e007280.

Research output: Contribution to journalArticle

Open Access
Mexiletine
Long QT Syndrome
Potassium Channels
Sodium Channel Blockers
Therapeutics

Physical Inactivity Is a Risk Factor for Primary Ventricular Fibrillation

De Ferrari, G. M., Dusi, V., Ruffinazzi, M., Gionti, V., Cacciavillani, L., Noussan, P., Zacà, V., Sanna, T., Crotti, L. & Schwartz, P. J., Apr 30 2019, In : Journal of the American College of Cardiology. 73, 16, p. 2117-2118 2 p.

Research output: Contribution to journalArticle

Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1

ter Bekke, R. M. A., Moers, A. M. E., de Jong, M. M. J., Johnson, D. M., Schwartz, P. J., Vanoli, E. & Volders, P. G. A., Jul 1 2019, In : International Journal of Cardiology. 286, p. 66-72 7 p.

Research output: Contribution to journalArticle

Open Access
Romano-Ward Syndrome
Stellate Ganglion
Canidae
Torsades de Pointes
Ventricular Fibrillation
Ventricular Fibrillation
Sudden Death
Myocardial Infarction
Blood Pressure
Hypokalemia

Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies

Wu, J. C., Garg, P., Yoshida, Y., Yamanaka, S., Gepstein, L., Hulot, J-S., Knollmann, B. C. & Schwartz, P. J., Aug 30 2019, In : Circulation Research. 125, 6, p. 653-658 6 p.

Research output: Contribution to journalArticle

Channelopathies
Long QT Syndrome
Induced Pluripotent Stem Cells
Precision Medicine
Genetic Testing
2018

Alberto Zanchetti (27 July 1926)

all Alberto Zanchetti’s pupils, Jul 1 2018, In : European Heart Journal. 39, 25, p. 2344-2345 2 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Pharmaceutical Preparations
Therapeutics

Bongani Mayosi, 1967-2018

Schwartz, P. J. & Ntsekhe, M., Dec 7 2018, In : European Heart Journal. 39, 46, p. 4051-4061 11 p.

Research output: Contribution to journalArticle

Cardiac arrest and Brugada syndrome: Is drug-induced type 1 ECG pattern always a marker of low risk?

Delise, P., Allocca, G., Sitta, N., Migliore, F., Dagradi, F., Spazzolini, C., Sciarra, L., Carinci, V., Corrado, D., Calò, L. & Schwartz, P. J., Mar 1 2018, In : International Journal of Cardiology. 254, p. 142-145 4 p.

Research output: Contribution to journalArticle

Brugada Syndrome
Heart Arrest
Electrocardiography
Pharmaceutical Preparations
Syncope

Determinants of occurrence and survival after sudden cardiac arrest–A European perspective

Empana, J. P., Blom, M. T., Bӧttiger, B. W., Dagres, N., Dekker, J. M., Gislason, G., Jouven, X., Meitinger, T., Ristagno, G., Schwartz, P. J., Jonsson, M., Tfelt-Hansen, J., Truhlar, A., Tan, H. L., Investigators, O. B. O. T. ESCAPE-NET., Fumagalli, F. & Latini, R., Mar 1 2018, In : Resuscitation. 124, p. 7-13 7 p.

Research output: Contribution to journalArticle

Determinants of occurrence and survival after sudden cardiac arrest–A European perspective: The ESCAPE-NET project

Empana, J. P., Blom, M. T., Bӧttiger, B. W., Dagres, N., Dekker, J. M., Gislason, G., Jouven, X., Meitinger, T., Ristagno, G., Schwartz, P. J., Jonsson, M., Tfelt-Hansen, J., Truhlar, A., Tan, H. L. & on behalf of the ESCAPE-NET Investigators, Mar 1 2018, In : Resuscitation. 124, p. 7-13 7 p.

Research output: Contribution to journalArticle

Sudden Cardiac Death
Cohort Studies
Population
Genome-Wide Association Study
European Union

European Sudden Cardiac Arrest network: Towards Prevention, Education and New Effective Treatments (ESCAPE-NET)

Tan, H. L., Dagres, N., Böttiger, B. W. & Schwartz, P. J., Jan 7 2018, In : European Heart Journal. 39, 2, p. 86-88 3 p.

Research output: Contribution to journalArticle

For neonatal ECG screening there is no reason to relinquish old Bazett's correction

Stramba-Badiale, M., Karnad, D. R., Goulene, K. M., Panicker, G. K., Dagradi, F., Spazzolini, C., Kothari, S., Lokhandwala, Y. Y. & Schwartz, P. J., Aug 1 2018, In : European Heart Journal. 39, 31, p. 2888-2895 8 p.

Research output: Contribution to journalArticle

Neonatal Screening
Long QT Syndrome
Electrocardiography
Heart Rate
ROC Curve
Jervell-Lange Nielsen Syndrome
Induced Pluripotent Stem Cells
Cell Line
Mutation
Genes
Jervell-Lange Nielsen Syndrome
Induced Pluripotent Stem Cells
Cell Line
Mutation
Genes
Romano-Ward Syndrome
Induced Pluripotent Stem Cells
Cell Line
Deafness
Retroviridae
Romano-Ward Syndrome
Induced Pluripotent Stem Cells
Cell Line
Deafness
Retroviridae

Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model

Mehta, A., Ramachandra, C. J. A., Singh, P., Chitre, A., Lua, C. H., Mura, M., Crotti, L., Wong, P., Schwartz, P. J., Gnecchi, M. & Shim, W., Apr 21 2018, In : European Heart Journal. 39, 16, p. 1446-1455 10 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Induced Pluripotent Stem Cells
Cardiac Myocytes
Calcium
Mutation

Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model

Mehta, A., Ramachandra, C. J. A., Singh, P., Chitre, A., Lua, C. H., Mura, M., Crotti, L., Wong, P., Schwartz, P. J., Gnecchi, M. & Shim, W., Apr 21 2018, In : European Heart Journal. 39, 16, p. 1446-1455 10 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Induced Pluripotent Stem Cells
Cardiac Myocytes
Calcium
Mutation

Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review

Roston, T. M., Jones, K., Hawkins, N. M., Bos, J. M., Schwartz, P. J., Perry, F., Ackerman, M. J., Laksman, Z. W. M., Kaul, P., Lieve, K. V. V., Atallah, J., Krahn, A. D. & Sanatani, S., Dec 1 2018, In : Heart Rhythm. 15, 12, p. 1791-1799 9 p.

Research output: Contribution to journalArticle

Implantable Defibrillators
Shock
Primary Prevention
Flecainide
Guideline Adherence

In Memoriam: Alberto Zanchetti (Parma July 27, 1926 - Milan March 24, 2018)

all of Alberto Zanchetti’s students, May 2018, In : Journal of clinical hypertension (Greenwich, Conn.). 20, 5, p. 826-828 3 p.

Research output: Contribution to journalArticle

Innovation in cardiovascular disease in Europe with focus on arrhythmias: Current status, opportunities, roadblocks, and the role of multiple stakeholders

Prinzen, F. W., Dagres, N., Bollmann, A., Arnar, D. O., Bove, S., Camm, J., Casadei, B., Kirchhof, P., Kuck, K. H., Lumens, J., Michel, M. C., Schwartz, P. J., Van Vleymen, B., Vardas, P. & Hindricks, G., May 1 2018, In : Europace. 20, 5, p. 733-738 6 p.

Research output: Contribution to journalArticle

Medical Societies
Cardiology
Cardiac Arrhythmias
Industry
Cardiovascular Diseases

SCN5A mutations in 442 neonates and children: Genotype-phenotype correlation and identification of higher-risk subgroups

Baruteau, A. E., Kyndt, F., Behr, E. R., Vink, A. S., Lachaud, M., Joong, A., Schott, J. J., Horie, M., Denjoy, I., Crotti, L., Shimizu, W., Bos, J. M., Stephenson, E. A., Wong, L., Abrams, D. J., Davis, A. M., Winbo, A., Dubin, A. M., Sanatani, S., Liberman, L. & 30 others, Kaski, J. P., Rudic, B., Kwok, S. Y., Rieubland, C., Tfelt-Hansen, J., Van Hare, G. F., Guyomarc'h-Delasalle, B., Blom, N. A., Wijeyeratne, Y. D., Gourraud, J. B., Marec, H. L., Ozawa, J., Fressart, V., Lupoglazoff, J. M., Dagradi, F., Spazzolini, C., Aiba, T., Tester, D. J., Zahavich, L. A., Beauséjour-Ladouceur, V., Jadhav, M., Skinner, J. R., Franciosi, S., Krahn, A. D., Abdelsayed, M., Ruben, P. C., Yung, T. C., Ackerman, M. J., Wilde, A. A. & Schwartz, P. J., Aug 1 2018, In : European Heart Journal. 39, 31, p. 2879-2887 9 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Newborn Infant
Mutation
Phenotype
Genotype