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Research Output 2004 2019

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2019

Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants

Lucafò, M., Stocco, G., Martelossi, S., Favretto, D., Franca, R., Malusà, N., Lora, A., Bramuzzo, M., Naviglio, S., Cecchin, E., Toffoli, G., Ventura, A. & Decorti, G., Apr 2019, In : Genes. 10, 4, 12 p., 277.

Research output: Contribution to journalArticle

Open Access
Azathioprine
Biotransformation
Thioguanine
Inflammatory Bowel Diseases
Nucleotides
Open Access
Azathioprine
Biotransformation
Thioguanine
Inflammatory Bowel Diseases
Nucleotides

MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome

Cuzzoni, E., Franca, R., De Iudicibus, S., Marcuzzi, A., Lucafò, M., Pelin, M., Favretto, D., Monti, E., Morello, W., Ghio, L., La Scola, C., Mencarelli, F., Pasini, A., Montini, G., Decorti, G. & Stocco, G., Dec 2019, In : European Journal of Clinical Pharmacology. 75, 12, p. 1675-1683 9 p.

Research output: Contribution to journalArticle

MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome

Cuzzoni, E., Franca, R., De Iudicibus, S., Marcuzzi, A., Lucafò, M., Pelin, M., Favretto, D., Monti, E., Morello, W., Ghio, L., La Scola, C., Mencarelli, F., Pasini, A., Montini, G., Decorti, G. & Stocco, G., 2019, In : European Journal of Clinical Pharmacology. 75, 12, p. 1675-1683

Research output: Contribution to journalArticle

Steroids
Cytokines
Macrophage Migration-Inhibitory Factors
Nephrotic Syndrome
Congenital Nephrosis

PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients

Franca, R., Stocco, G., Favretto, D., Giurici, N., del Rizzo, I., Locatelli, F., Vinti, L., Biondi, A., Colombini, A., Fagioli, F., Barisone, E., Pelin, M., Martellossi, S., Ventura, A., Decorti, G. & Rabusin, M., Jan 1 2019, (Accepted/In press) In : Pharmacogenomics Journal.

Research output: Contribution to journalArticle

Validation Studies
Pharmacokinetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Inflammatory Bowel Diseases
Pediatrics
Pediatrics
Drug Monitoring
Inflammatory Bowel Diseases
Monitoring
Expert Testimony
Pediatrics
Drug Monitoring
Inflammatory Bowel Diseases
Monitoring
Expert Testimony
2017

Multicentric Case-Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease

Stocco, G., Martelossi, S., Arrigo, S., Barabino, A., Aloi, M., Martinelli, M., Miele, E., Knafelz, D., Romano, C., Naviglio, S., Favretto, D., Cuzzoni, E., Franca, R., Decorti, G. & Ventura, A., Apr 1 2017, In : Inflammatory Bowel Diseases. 23, 4, p. 628-634 7 p.

Research output: Contribution to journalArticle

Azathioprine
Inflammatory Bowel Diseases
Case-Control Studies
Pharmacokinetics
Pediatrics

Multicentric Case-Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease

Stocco, G., Martelossi, S., Arrigo, S., Barabino, A., Aloi, M., Martinelli, M., Miele, E., Knafelz, D., Romano, C., Naviglio, S., Favretto, D., Cuzzoni, E., Franca, R., Decorti, G. & Ventura, A., 2017, In : Inflammatory Bowel Diseases. 23, 4, p. 628-634 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphoblastic leukemia patients treated with AIEOP-BFM ALL 2000 protocol

Franca, R., Rebora, P., Bertorello, N., Fagioli, F., Conter, V., Biondi, A., Colombini, A., Micalizzi, C., Zecca, M., Parasole, R., Petruzziello, F., Basso, G., Putti, M. C., Locatelli, N., d'Adamo, P., Valsecchi, M. G., Decorti, G. & Rabusin, M., Jan 2017, In : Pharmacogenomics Journal. 17, 1, p. 4-10 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Liver
Logistic Models
Therapeutics

Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphoblastic leukemia patients treated with AIEOP-BFM ALL 2000 protocol

Franca, R., Rebora, P., Bertorello, N., Fagioli, F., Conter, V., Biondi, A., Colombini, A., Micalizzi, C., Zecca, M., Parasole, R., Petruzziello, F., Basso, G., Putti, M. C., Locatelli, F., d'Adamo, P., Valsecchi, M. G., Decorti, G. & Rabusin, M., Jan 1 2017, In : Pharmacogenomics Journal. 17, 1, p. 4-10 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Liver
Logistic Models
Therapeutics

Targeting kinase-activating genetic lesions to improve therapy of pediatric acute lymphoblastic leukemia

Kuzelicki, N. K., Sorio, C., Toffoletti, E., Montecchini, O., Poropat, A., Rabusin, M., Curci, D., Paladin, D., Stocco, G., Decorti, G. & Franca, R., Jul 27 2017, In : Current Medicinal Chemistry.

Research output: Contribution to journalArticle

Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Phosphotransferases
Fusion reactions
2015

Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome

Cuzzoni, E., De Iudicibus, S., Franca, R., Stocco, G., Lucafò, M., Pelin, M., Favretto, D., Pasini, A., Montini, G. & Decorti, G., Sep 1 2015, In : Pharmacogenomics. 16, 14, p. 1631-1648 18 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Glucocorticoids
Pediatrics
Anti-Inflammatory Agents
Glucocorticoid Receptors

Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphoblastic leukemia patients treated with AIEOP-BFM ALL 2000 protocol

Franca, R., Rebora, P., Bertorello, N., Fagioli, F., Conter, V., Biondi, A., Colombini, A., Micalizzi, C., Zecca, M., Parasole, R., Petruzziello, F., Basso, G., Putti, M. C., Locatelli, F., d'Adamo, P., Valsecchi, M. G., Decorti, G. & Rabusin, M., Dec 8 2015, (Accepted/In press) In : Pharmacogenomics Journal.

Research output: Contribution to journalArticle

Pharmacogenetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Liver
Logistic Models
Therapeutics

Role of pharmacogenetics in hematopoietic stem cell transplantation outcome in children

Franca, R., Stocco, G., Favretto, D., Giurici, N., Decorti, G. & Rabusin, M., Aug 14 2015, In : International Journal of Molecular Sciences. 16, 8, p. 18601-18627 27 p.

Research output: Contribution to journalArticle

transplantation
stem cells
Pharmacogenetics
Hematopoietic Stem Cell Transplantation
Stem cells
2014

Deletion of glutathione-S-transferase M1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease

Stocco, G., Cuzzoni, E., De Iudicibus, S., Franca, R., Favretto, D., Malusà, N., Londero, M., Cont, G., Bartoli, F., Martelossi, S., Ventura, A. & Decorti, G., Jan 2014, In : Journal of Clinical Gastroenterology. 48, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Azathioprine
Inflammatory Bowel Diseases
Thioguanine
Nucleotides
Pyrophosphatases

Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?

Stocco, G., Pelin, M., Franca, R., De Iudicibus, S., Cuzzoni, E., Favretto, D., Martelossi, S., Ventura, A. & Decorti, G., Apr 7 2014, In : World Journal of Gastroenterology. 20, 13, p. 3534-3541 8 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Azathioprine
Glutathione Transferase
Inflammatory Bowel Diseases
6-Mercaptopurine

TNF-α SNP rs1800629 and risk of relapse in childhood acute lymphoblastic leukemia: Relation to immunophenotype

Franca, R., Rebora, P., Athanasakis, E., Favretto, D., Verzegnassi, F., Basso, G., Tommasini, A., Valsecchi, M. G., Decorti, G. & Rabusin, M., 2014, In : Pharmacogenomics. 15, 5, p. 619-627 9 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Single Nucleotide Polymorphism
Recurrence
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Alleles
2013
Enzyme Therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
6-Mercaptopurine
Pharmacogenetics
Genotype

Pharmacogenomic approaches for tailored anti-leukemic therapy in children

Stocco, G., Franca, R., Verzegnassi, F., Londero, M., Rabusin, M. & Decorti, G., Jun 2013, In : Current Medicinal Chemistry. 20, 17, p. 2237-2253 17 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Pharmacogenetics
Cytotoxins
Polymorphism

Research highlights: Highlights from the latest articles in acute lymphoblastic leukemia pharmacogenomics

Stocco, G., Franca, R., Londero, M. & Decorti, G., Feb 2013, In : Pharmacogenomics. 14, 3, p. 235-236 2 p.

Research output: Contribution to journalArticle

2012

Glutathione S-transferase homozygous deletions and relapse in childhood acute lymphoblastic leukemia: A novel study design in a large Italian AIEOP cohort

Franca, R., Rebora, P., Basso, G., Biondi, A., Cazzaniga, G., Crovella, S., Decorti, G., Fagioli, F., Giarin, E., Locatelli, F., Poggi, V., Valsecchi, M. G. & Rabusin, M., Dec 2012, In : Pharmacogenomics. 13, 16, p. 1905-1916 12 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prednisone
Recurrence
Gene Deletion

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

Stocco, G., Yang, W., Crews, K. R., Thierfelder, W. E., Decorti, G., Londero, M., Franca, R., Rabusin, M., Valsecchi, M. G., Pei, D., Cheng, C., Paugh, S. W., Ramsey, L. B., Diouf, B., Mccorkle, J. R., Jones, T. S., Pui, C. H., Relling, M. V. & Evans, W. E., Nov 2012, In : Human Molecular Genetics. 21, 21, p. 4793-4804 12 p., dds302.

Research output: Contribution to journalArticle

thiopurine methyltransferase
Casein Kinases
6-Mercaptopurine
Neurons
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Personalized therapies in pediatric inflammatory and autoimmune diseases

Stocco, G., de Iudicibus, S., Franca, R., Addobbati, R. & Decorti, G., 2012, In : Current Pharmaceutical Design. 18, 35, p. 5766-5775 10 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Pediatrics
Juvenile Arthritis
Inflammatory Bowel Diseases
Therapeutics
2011

Identification and Functional Characterization of Bilitranslocase in Sea-Bass (Dicentrarchus labrax) Hepatopancreas

Delneri, A., Franca, R., Terdoslavich, M., Montanič, S., Čurin Šerbec, V., Tramer, F., Francese, M. & Passamonti, S., Dec 2011, In : Analytical Letters. 44, 18, p. 2887-2900 14 p.

Research output: Contribution to journalArticle

Hepatopancreas
Bass
Fish
Fishes
Rats

Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease

de Iudicibus, S., Franca, R., Martelossi, S., Ventura, A. & Decorti, G., Mar 7 2011, In : World Journal of Gastroenterology. 17, 9, p. 1095-1108 14 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Glucocorticoids
Glucocorticoid Receptors
Genes
Cytoplasmic and Nuclear Receptors
2010

Expression of kidney and liver bilitranslocase in response to acute biliary obstruction

Brandoni, A., Di Giusto, G., Franca, R., Passamonti, S. & Torres, A. M., Apr 2010, In : Nephron - Physiology. 114, 4

Research output: Contribution to journalArticle

Kidney
Sulfobromophthalein
Liver
Cell Membrane
Bile Ducts

The ectopic FOF1 ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1

Giorgio, V., Bisetto, E., Franca, R., Harris, D. A., Passamonti, S. & Lippe, G., Apr 2010, In : Journal of Bioenergetics and Biomembranes. 42, 2, p. 117-123 7 p.

Research output: Contribution to journalArticle

Cholestasis
Adenosine Triphosphate
Mitochondrial Proton-Translocating ATPases
Liver
HDL Cholesterol
2009

Bioavailability of flavonoids: A review of their membrane transport and the function of bilitranslocase in animal and plant organisms

Passamonti, S., Terdoslavich, M., Franca, R., Vanzo, A., Tramer, F., Braidot, E., Petrussa, E. & Vianello, A., 2009, In : Current Drug Metabolism. 10, 4, p. 369-394 26 p.

Research output: Contribution to journalArticle

Flavonoids
Biological Availability
Animals
Membranes
Fruit
2007

Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity

Franca, R., Belfiore, A., Spadari, S. & Maga, G., Jun 2007, In : Proteins: Structure, Function and Genetics. 67, 4, p. 1128-1137 10 p.

Research output: Contribution to journalArticle

Substrate Specificity
Nucleosides
Adenosine Triphosphatases
Substrates
Viruses
2006

APOBEC deaminases as cellular antiviral factors: A novel natural host defense mechanism

Franca, R., Spadari, S. & Maga, G., May 1 2006, In : Medical Science Monitor. 12, 5

Research output: Contribution to journalArticle

Apolipoproteins B
Defense Mechanisms
Antiviral Agents
Peptides
Cytidine Deaminase
2005

Heterodimeric amino acid transporter glycoprotein domains determining functional subunit association

Franca, R., Veljkovic, E., Walter, S., Wagner, C. A. & Verrey, F., Jun 1 2005, In : Biochemical Journal. 388, 2, p. 435-443 9 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Glycoproteins
Tail
Light
Cystine
2004

SPECT and PET amino acid tracer influx via system L (h4F2hc-hLAT1) and its transstimulation

Lahoutte, T., Caveliers, V., Camargo, S. M. R., Franca, R., Ramadan, T., Veljkovic, E., Mertens, J., Bossuyt, A. & Verrey, F., Sep 1 2004, In : Journal of Nuclear Medicine. 45, 9, p. 1591-1596 6 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Phenylalanine
Amino Acids
Methyltyrosines
Oocytes