If you made any changes in Pure these will be visible here soon.

Research Output

2019

Combination of PPARg agonist pioglitazone and trabectedin induce adipocyte differentiation to overcome trabectedin resistance in myxoid liposarcomas

Frapolli, R., Bello, E., Ponzo, M., Craparotta, I., Mannarino, L., Ballabio, S., Marchini, S., Carrassa, L., Ubezio, P., Porcu, L., Brich, S., Sanfilippo, R., Casali, P. G., Gronchi, A., Pilotti, S. & D'Incalci, M., Dec 15 2019, In : Clin. Cancer Res.. 25, 24, p. 7565-7575 11 p.

Research output: Contribution to journalArticle

Combination of PPARg agonist pioglitazone and trabectedin induce adipocyte differentiation to overcome trabectedin resistance in myxoid liposarcomas

Frapolli, R., Bello, E., Ponzo, M., Craparotta, I., Mannarino, L., Ballabio, S., Marchini, S., Carrassa, L., Ubezio, P., Porcu, L., Brich, S., Sanfilippo, R., Casali, P. G., Gronchi, A., Pilotti, S. & D'Incalci, M., Dec 15 2019, In : Clinical Cancer Research. 25, 24, p. 7565-7575 11 p.

Research output: Contribution to journalArticle

Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin

Bello, E., Brich, S., Craparotta, I., Mannarino, L., Ballabio, S., Gatta, R., Marchini, S., Carrassa, L., Matteo, C., Sanfilippo, R., Gronchi, A., Casali, P. G., Pilotti, S., D’Incalci, M. & Frapolli, R., Sep 10 2019, In : British Journal of Cancer. 121, 6, p. 464-473 10 p.

Research output: Contribution to journalArticle

Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin

Bello, E., Brich, S., Craparotta, I., Mannarino, L., Ballabio, S., Gatta, R., Marchini, S., Carrassa, L., Matteo, C., Sanfilippo, R., Gronchi, A., Casali, P. G., Pilotti, S., D’Incalci, M. & Frapolli, R., Sep 10 2019, In : British Journal of Cancer. 121, 6, p. 464-473 10 p.

Research output: Contribution to journalArticle

2018

Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin

Capasso Palmiero, U., Morosi, L., Bello, E., Ponzo, M., Frapolli, R., Matteo, C., Ferrari, M., Zucchetti, M., Minoli, L., De Maglie, M., Romanelli, P., Morbidelli, M., D'Incalci, M. & Moscatelli, D., Apr 28 2018, In : Journal of Controlled Release. 276, p. 140-149 10 p.

Research output: Contribution to journalArticle

Wee1 inhibitor MK1775 sensitizes KRAS mutated NSCLC cells to sorafenib

Caiola, E., Frapolli, R., Tomanelli, M., Valerio, R., Iezzi, A., Garassino, M. C., Broggini, M. & Marabese, M., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalArticle

2017

A nanostructured matrices assessment to study drug distribution in solid tumor tissues by mass spectrometry imaging

Giordano, S., Pifferi, V., Morosi, L., Morelli, M., Falciola, L., Cappelletti, G., Visentin, S., Licandro, S. A., Frapolli, R., Zucchetti, M., Pastorelli, R., Brunelli, L., D’Incalci, M. & Davoli, E., Mar 21 2017, In : Nanomaterials. 7, 3, p. 7 71.

Research output: Contribution to journalArticle

Application of 3D Mass Spectrometry Imaging to TKIs

Morosi, L., Giordano, S., Falcetta, F., Frapolli, R., Licandro, S. A., Matteo, C., Zucchetti, M., Ubezio, P., Erba, E., Visentin, S., D'Incalci, M. & Davoli, E., Nov 1 2017, In : Clinical Pharmacology and Therapeutics. 102, 5, p. 748-751 4 p.

Research output: Contribution to journalArticle

Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release

Maiolo, D., Pigliacelli, C., Sánchez Moreno, P., Violatto, M. B., Talamini, L., Tirotta, I., Piccirillo, R., Zucchetti, M., Morosi, L., Frapolli, R., Candiani, G., Bigini, P., Metrangolo, P. & Baldelli Bombelli, F., Sep 26 2017, In : ACS Nano. 11, 9, p. 9413-9423 11 p.

Research output: Contribution to journalArticle

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magri, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., De Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Jan 1 2017, In : Nature. 552, p. 1-5 5 p.

Research output: Contribution to journalArticle

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magrì, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., de Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Dec 7 2017, In : Nature. 552, 7683, p. 116-120 5 p.

Research output: Contribution to journalArticle

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

Belgiovine, C., Bello, E., Liguori, M., Craparotta, I., Mannarino, L., Paracchini, L., Beltrame, L., Marchini, S., Galmarini, C. M., Mantovani, A., Frapolli, R., Allavena, P. & D'Incalci, M., Aug 22 2017, In : British Journal of Cancer. 117, 5, p. 628-638 11 p.

Research output: Contribution to journalArticle

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

Belgiovine, C., Bello, E., Liguori, M., Craparotta, I., Mannarino, L., Paracchini, L., Beltrame, L., Marchini, S., Galmarini, C. M., Mantovani, A., Frapolli, R., Allavena, P. & D'Incalci, M., Aug 22 2017, In : British Journal of Cancer. 117, 5, p. 628-638 11 p.

Research output: Contribution to journalArticle

Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts

Vázquez, R., Licandro, S. A., Astorgues-Xerri, L., Lettera, E., Panini, N., Romano, M., Erba, E., Ubezio, P., Bello, E., Libener, R., Orecchia, S., Grosso, F., Riveiro, M. E., Cvitkovic, E., Bekradda, M., D'Incalci, M. & Frapolli, R., Jan 1 2017, In : International Journal of Cancer. 140, 1, p. 197-207 11 p.

Research output: Contribution to journalArticle

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

Vázquez, R., Riveiro, M. E., Astorgues-Xerri, L., Odore, E., Rezai, K., Erba, E., Panini, N., Rinaldi, A., Kwee, I., Beltrame, L., Bekradda, M., Cvitkovic, E., Bertoni, F., Frapolli, R. & D'Incalci, M., Jan 31 2017, In : Oncotarget. 8, 5, p. 7598-7613 16 p.

Research output: Contribution to journalArticle

2016

3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors

Giordano, S., Morosi, L., Veglianese, P., Licandro, S. A., Frapolli, R., Zucchetti, M., Cappelletti, G., Falciola, L., Pifferi, V., Visentin, S., D'Incalci, M. & Davoli, E., Nov 14 2016, In : Scientific Reports. 6, 37027.

Research output: Contribution to journalArticle

Bevacizumab-induced inhibition of angiogenesis promotes a more homogeneous intratumoral distribution of paclitaxel, improving the antitumor response

Cesca, M., Morosi, L., Berndt, A., Nerini, I. F., Frapolli, R., Richter, P., Decio, A., Dirsch, O., Micotti, E., Giordano, S., D'Incalci, M., Davoli, E., Zucchetti, M. & Giavazzi, R., Jan 1 2016, In : Molecular Cancer Therapeutics. 15, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging

Giordano, S., Zucchetti, M., Decio, A. A., Cesca, M., Fuso Nerini, I., Maiezza, M., Ferrari, M., Licandro, S. A., Frapolli, R., Giavazzi, R., D'Incalci, M., Davoli, E. & Morosi, L., Dec 21 2016, In : Scientific Reports. 6, p. 39284

Research output: Contribution to journalArticle

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Mezzapelle, R., Rrapaj, E., Gatti, E., Ceriotti, C., De Marchis, F., Preti, A., Spinelli, A., Perani, L., Venturini, M., Valtorta, S., Moresco, R. M., Pecciarini, L., Doglioni, C., Frenquelli, M., Crippa, L., Recordati, C., Scanziani, E., De Vries, H., Berns, A., Frapolli, R. & 4 others, Boldorini, R., D'Incalci, M., Bianchi, M. E. & Crippa, M., Mar 10 2016, In : Scientific Reports. 6, p. 22850

Research output: Contribution to journalArticle

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Mezzapelle, R., Rrapaj, E., Gatti, E., Ceriotti, C., De Marchis, F., Preti, A., Spinelli, A. E., Perani, L., Venturini, M., Valtorta, S., Moresco, R. M., Pecciarini, L., Doglioni, C., Frenquelli, M., Crippa, L., Recordati, C., Scanziani, E., De Vries, H., Berns, A., Frapolli, R. & 4 others, Boldorini, R., D'Incalci, M., Bianchi, M. E. & Crippa, M. P., Mar 10 2016, In : Scientific Reports. 6, 22850.

Research output: Contribution to journalArticle

PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

Colombo, C., Morosi, L., Bello, E., Ferrari, R., Licandro, S. A., Lupi, M., Ubezio, P., Morbidelli, M., Zucchetti, M., DIncalci, M., Moscatelli, D. & Frapolli, R., Jan 4 2016, In : Molecular Pharmaceutics. 13, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

Snail levels control the migration mechanism of mesenchymal tumor cells

Belgiovine, C., Chiesa, G., Chiodi, I., Frapolli, R., Bonezzi, K., Taraboletti, G., D'incalci, M. & Mondello, C., Jul 1 2016, In : Oncology Letters. 12, 1, p. 767-771 5 p.

Research output: Contribution to journalArticle

Snail levels control the migration mechanism of mesenchymal tumor cells

Belgiovine, C., Chiesa, G., Chiodi, I., Frapolli, R., Bonezzi, K., Taraboletti, G., D'Incalci, M. & Mondello, C., Jul 1 2016, In : Oncology Letters. 12, 1, p. 767-771 5 p.

Research output: Contribution to journalArticle

Tumor-associated macrophages and anti-tumor therapies: complex links

Belgiovine, C., D’Incalci, M., Allavena, P. & Frapolli, R., Mar 8 2016, (Accepted/In press) In : Cellular and Molecular Life Sciences. p. 1-14 14 p.

Research output: Contribution to journalArticle

2015

Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1

Dossi, R., Frapolli, R., Di Giandomenico, S., Paracchini, L., Bozzi, F., Brich, S., Castiglioni, V., Borsotti, P., Belotti, D., Uboldi, S., Sanfilippo, R., Erba, E., Giavazzi, R., Marchini, S., Pilotti, S., D'Incalci, M. & Taraboletti, G., Feb 15 2015, In : International Journal of Cancer. 136, 3, p. 721-729 9 p.

Research output: Contribution to journalArticle

Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells

Caiola, E., Salles, D., Frapolli, R., Lupi, M., Rotella, G., Ronchi, A., Garassino, M. C., Mattschas, N., Colavecchio, S., Broggini, M., Wiesmüller, L. & Marabese, M., 2015, In : Oncotarget. 6, 30, p. 30072-30087 16 p.

Research output: Contribution to journalArticle

Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts

Pinessi, D., Ostano, P., Borsotti, P., Bello, E., Guffanti, F., Bizzaro, F., Frapolli, R., Bani, M. R., Chiorino, G., Taraboletti, G. & Resovi, A., Sep 3 2015, In : Connective Tissue Research. 56, 5, p. 355-363 9 p.

Research output: Contribution to journalArticle

Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors

Vázquez, R., Astorgues-Xerri, L., Bekradda, M., Gormley, J., Buick, R., Kerr, P., Cvitkovic, E., Raymond, E., D'Incalci, M., Frapolli, R. & Riveiro, M. E., 2015, In : Biochimie. 108, p. 101-107 7 p.

Research output: Contribution to journalArticle

HPLC-MS/MS method to measure trabectedin in tumors: Preliminary PK study in a mesothelioma xenograft model

Ceriani, L., Ferrari, M., Zangarini, M., Licandro, S. A., Bello, E., Frapolli, R., Falcetta, F., D'Incalci, M., Libener, R., Grosso, F., Aviles, P. & Zucchetti, M., Aug 1 2015, In : Bioanalysis. 7, 15, p. 1831-1842 12 p.

Research output: Contribution to journalArticle

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

Colmegna, B., Uboldi, S., Frapolli, R., Licandro, S. A., Panini, N., Galmarini, C. M., Badri, N., Spanswick, V. J., Bingham, J. P., Kiakos, K., Erba, E., Hartley, J. A. & D'Incalci, M., Dec 22 2015, In : British Journal of Cancer. 113, 12, p. 1687-1693 7 p.

Research output: Contribution to journalArticle

Longitudinal tracking of triple labeled umbilical cord derived mesenchymal stromal cells in a mouse model of Amyotrophic Lateral Sclerosis

Violatto, M. B., Santangelo, C., Capelli, C., Frapolli, R., Ferrari, R., Sitia, L., Tortarolo, M., Talamini, L., Previdi, S., Moscatelli, D., Salmona, M., Introna, M., Bendotti, C. & Bigini, P., Jul 1 2015, In : Stem Cell Research. 15, 1, p. 243-253 11 p.

Research output: Contribution to journalArticle

Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents

Amaral, A. T., Garofalo, C., Frapolli, R., Manara, M. C., Mancarella, C., Uboldi, S., Di Giandomenico, S., Ordóñez, J. L., Sevillano, V., Malaguarnera, R., Picci, P., Hassan, A. B., De Alava, E., D'Incalci, M. & Scotlandi, K., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

2014

A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma

Lupi, M., Colombo, C., Frapolli, R., Ferrari, R., Sitia, L., Dragoni, L., Bello, E., Licandro, S. A., Falcetta, F., Ubezio, P., Bigini, P., Salmona, M., D'Incalci, M., Morbidelli, M. & Moscatelli, D., Aug 22 2014, In : Nanotechnology. 25, 33, 335706.

Research output: Contribution to journalArticle

Mode of action of trabectedin in myxoid liposarcomas

Di Giandomenico, S., Frapolli, R., Bello, E., Uboldi, S., Licandro, S. A., Marchini, S., Beltrame, L., Brich, S., Mauro, V., Tamborini, E., Pilotti, S., Casali, P. G., Grosso, F., Sanfilippo, R., Gronchi, A., Mantovani, R., Gatta, R., Galmarini, C. M., Sousa-Faro, J. M. F. & D'Incalci, M., Oct 30 2014, In : Oncogene. 33, 44, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

2013

Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104)

Romano, M., Frapolli, R., Zangarini, M., Bello, E., Porcu, L., Galmarini, C. M., García-Fernández, L. F., Cuevas, C., Allavena, P., Erba, E. & D'Incalci, M., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2024-2033 10 p.

Research output: Contribution to journalArticle

New activities for the anti-tumor agent trabectedin: Taking two birds with one stone

D'Incalci, M., Frapolli, R., Germano, G. & Allavena, P., Apr 2013, In : Oncotarget. 4, 4, p. 496-497 2 p.

Research output: Contribution to journalArticle

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

Zucchetti, M., Bonezzi, K., Frapolli, R., Sala, F., Borsotti, P., Zangarini, M., Cvitkovic, E., Noel, K., Ubezio, P., Giavazzi, R., D'Incalci, M. & Taraboletti, G., Oct 2013, In : Cancer Chemotherapy and Pharmacology. 72, 4, p. 879-887 9 p.

Research output: Contribution to journalArticle

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

Germano, G., Frapolli, R., Belgiovine, C., Anselmo, A., Pesce, S., Liguori, M., Erba, E., Uboldi, S., Zucchetti, M., Pasqualini, F., Nebuloni, M., van Rooijen, N., Mortarini, R., Beltrame, L., Marchini, S., Fuso Nerini, I., Sanfilippo, R., Casali, P. G., Pilotti, S., Galmarini, C. M. & 4 others, Anichini, A., Mantovani, A., D'Incalci, M. & Allavena, P., Feb 11 2013, In : Cancer Cell. 23, 2, p. 249-262 14 p.

Research output: Contribution to journalArticle

The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin

D'Angelo, D., Borbone, E., Palmieri, D., Uboldi, S., Esposito, F., Frapolli, R., Pacelli, R., D'Incalci, M. & Fusco, A., Mar 2013, In : European Journal of Cancer. 49, 5, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

2012

Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo

Sulaiman, G. M., Ad'hiah, A. H., Al-Sammarrae, K. W., Bagnati, R., Frapolli, R., Bello, E., Uboldi, S., Romano, M., Panini, N., Scanziani, E., Pezzolato, M., Erba, E. & D'Incalci, M., May 2012, In : Food and Chemical Toxicology. 50, 5, p. 1632-1641 10 p.

Research output: Contribution to journalArticle

2011

Chemical characterization of iraqi propolis samples and assessing their antioxidant potentials

Sulaiman, G. M., Sammarrae, K. W. A., Ad'hiah, A. H., Zucchetti, M., Frapolli, R., Bello, E., Erba, E., D'Incalci, M. & Bagnati, R., Sep 2011, In : Food and Chemical Toxicology. 49, 9, p. 2415-2421 7 p.

Research output: Contribution to journalArticle

2010

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells

Germano, G., Frapolli, R., Simone, M., Tavecchio, M., Erba, E., Pesce, S., Pasqualini, F., Grosso, F., Sanfilippo, R., Casali, P. G., Gronchi, A., Virdis, E., Tarantino, E., Pilotti, S., Greco, A., Nebuloni, M., Galmarini, C. M., Tercero, J. C., Mantovani, A., D'Incalci, M. & 1 others, Allavena, P., Mar 15 2010, In : Cancer Research. 70, 6, p. 2235-2244 10 p.

Research output: Contribution to journalArticle

Clinical pharmacokinetics of the new oral camptothecin gimatecan: The inter-patient variability is related to α1-acid glycoprotein plasma levels

Frapolli, R., Zucchetti, M., Sessa, C., Marsoni, S., Viganò, L., Locatelli, A., Rulli, E., Compagnoni, A., Bello, E., Pisano, C., Carminati, P. & D'Incalci, M., Feb 2010, In : European Journal of Cancer. 46, 3, p. 505-516 12 p.

Research output: Contribution to journalArticle

Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors

Frapolli, R., Tamborini, E., Virdis, E., Bello, E., Tarantino, E., Marchini, S., Grosso, F., Sanfilippo, R., Gronchi, A., Tercero, J. C., Peloso, G., Casali, P., Pilotti, S. & D'Incalci, M., Oct 15 2010, In : Clinical Cancer Research. 16, 20, p. 4958-4967 10 p.

Research output: Contribution to journalArticle

Reduced expression of the rock inhibitor rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells

Belgiovine, C., Frapolli, R., Bonezzi, K., Chiodi, I., Favero, F., Mello-Grand, M., dei Tos, A. P., Giulotto, E., Taraboletti, G., D'Incalci, M. & Mondello, C., 2010, In : PLoS One. 5, 11, e14154.

Research output: Contribution to journalArticle

The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo

Brunelli, D., Tavecchio, M., Falcioni, C., Frapolli, R., Erba, E., Iori, R., Rollin, P., Barillari, J., Manzotti, C., Morazzoni, P. & D'Incalci, M., Apr 2010, In : Biochemical Pharmacology. 79, 8, p. 1141-1148 8 p.

Research output: Contribution to journalArticle

The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats

Cervellini, I., Bello, E., Frapolli, R., Porretta-Serapiglia, C., Oggioni, N., Canta, A., Lombardi, R., Camozzi, F., Roglio, I., Melcangi, R. C., D'incalci, M., Lauria, G., Ghezzi, P., Cavaletti, G. & Bianchi, R., 2010, In : Neurotoxicity Research. 18, 2, p. 151-160 10 p.

Research output: Contribution to journalArticle