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Research Output 2018 2020

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Article
2020

The "Metabolic biomarkers of frailty in older people with type 2 diabetes mellitus" (MetaboFrail) study: Rationale, design and methods

European MID-Frail Consortium, Jan 2020, In : Experimental Gerontology. 129, p. 110782

Research output: Contribution to journalArticle

Biomarkers
Medical problems
Type 2 Diabetes Mellitus
Geriatrics
Health
2019

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle

Picca, A., Mankowski, R. T., Kamenov, G., Anton, S. D., Manini, T. M., Buford, T. W., Saini, S. K., Calvani, R., Landi, F., Bernabei, R., Marzetti, E. & Leeuwenburgh, C., Nov 27 2019, In : Cells. 8, 12

Research output: Contribution to journalArticle

Mitochondrial DNA
DNA Damage
Muscle
Skeletal Muscle
Iron

Age- and Gender-Related Changes in Physical Function in Community-Dwelling Brazilian Adults Aged 50 to 102 Years

Coelho-Junior, H. J., Uchida, M. C., Gonçalves, I. O., Calvani, R., Rodrigues, B., Picca, A., Onder, G., Landi, F., Bernabei, R. & Marzetti, E., Nov 4 2019, In : Journal of Geriatric Physical Therapy.

Research output: Contribution to journalArticle

Independent Living
Sarcopenia
Leg
Muscle Strength
Ethnic Groups

All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy

Sultana, J., Giorgianni, F., Rea, F., Lucenteforte, E., Lombardi, N., Mugelli, A., Vannacci, A., Liperoti, R., Kirchmayer, U., Vitale, C., Chinellato, A., Roberto, G., Corrao, G., Trifirò, G., Agabiti, N., Bartolini, C., Bernabei, R., Bettiol, A., Bonassi, S., Caputi, A. P. & 11 others, Cascini, S., Cipriani, F., Davoli, M., Fini, M., Gini, R., Lapi, F., Onder, G., Sorge, C., Tari, M., Vetrano, D. L. & (I-GrADE), O. T. B. O. T. I. G. F. A. D. P. I. T. E., 2019, In : Expert Opinion on Drug Metabolism and Toxicology. 15, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

Italy
Antipsychotic Agents
Cohort Studies
Retrospective Studies
Mortality

Assessment of Muscle Function and Physical Performance in Daily Clinical Practice: A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Beaudart, C., Rolland, Y., Cruz-Jentoft, A. J., Bauer, J. M., Sieber, C., Cooper, C., Al-Daghri, N., Araujo de Carvalho, I., Bautmans, I., Bernabei, R., Bruyère, O., Cesari, M., Cherubini, A., Dawson-Hughes, B., Kanis, J. A., Kaufman, J-M., Landi, F., Maggi, S., McCloskey, E., Petermans, J. & 7 others, Rodriguez Mañas, L., Reginster, J-Y., Roller-Wirnsberger, R., Schaap, L. A., Uebelhart, D., Rizzoli, R. & Fielding, R. A., 2019, In : Calcified Tissue International. 105, 1

Research output: Contribution to journalArticle

Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis

On behalf of the European Geriatric Medicine Society Pharmacology special interest group, Feb 15 2019, In : European Geriatric Medicine. 10, 1, p. 9-36 28 p.

Research output: Contribution to journalArticle

Polypharmacy
Meta-Analysis
Publication Bias
PubMed
Pharmaceutical Preparations

Circulating amino acid signature in older people with Parkinson's disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study

Picca, A., Calvani, R., Landi, G., Marini, F., Biancolillo, A., Gervasoni, J., Persichilli, S., Primiano, A., Urbani, A., Bossola, M., Bentivoglio, A. R., Cesari, M., Landi, F., Bernabei, R., Marzetti, E. & Lo Monaco, M. R., Dec 2019, In : Experimental Gerontology. 128, p. 110766

Research output: Contribution to journalArticle

Exosomes
Parkinson Disease
Amino Acids
Discriminant Analysis
Least-Squares Analysis

Circulating amino acid signature in older people with Parkinson's disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study

Picca, A., Calvani, R., Landi, G., Marini, F., Biancolillo, A., Gervasoni, J., Persichilli, S., Primiano, A., Urbani, A., Bossola, M., Bentivoglio, A. R., Cesari, M., Landi, F., Bernabei, R., Marzetti, E. & Lo Monaco, M. R., Dec 1 2019, In : Experimental Gerontology. 128, 110766.

Research output: Contribution to journalArticle

Exosomes
Parkinson Disease
Amino Acids
Discriminant Analysis
Least-Squares Analysis

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Picca, A., Ponziani, F. R., Calvani, R., Marini, F., Biancolillo, A., Coelho-Junior, H. J., Gervasoni, J., Primiano, A., Putignani, L., Del Chierico, F., Reddel, S., Gasbarrini, A., Landi, F., Bernabei, R. & Marzetti, E., Dec 26 2019, In : Nutrients. 12, 1

Research output: Contribution to journalArticle

sarcopenia
Sarcopenia
intestinal microorganisms
Ruminococcus
inflammation

Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty “cytokinome” at its core

Marzetti, E., Picca, A., Marini, F., Biancolillo, A., Coelho-Junior, H. J., Gervasoni, J., Bossola, M., Cesari, M., Onder, G., Landi, F., Bernabei, R. & Calvani, R., Jul 15 2019, In : Experimental Gerontology. 122, p. 129-138 10 p.

Research output: Contribution to journalArticle

Sarcopenia
Discriminant Analysis
Discriminant analysis
Least-Squares Analysis
Chemokine CCL2
Parkinson disease
Exosomes
biomarkers
Biomarkers
Parkinson Disease
Nursing Homes
Activities of Daily Living
Urinary Incontinence
Dementia
Logistic Models

Sarcopenia-related parameters in adults with Down syndrome: A cross-sectional exploratory study

Coelho-Junior, H. J., Villani, E. R., Calvani, R., Carfì, A., Picca, A., Landi, F., Bernabei, R., Onder, G. & Marzetti, E., May 2019, In : Experimental Gerontology. 119, p. 93-99 7 p.

Research output: Contribution to journalArticle

Sarcopenia
Down Syndrome
Muscle
Cross-Sectional Studies
Muscles
2018

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Calvani, R., Picca, A., Marini, F., Biancolillo, A., Gervasoni, J., Persichilli, S., Primiano, A., Coelho-Junior, H. J., Bossola, M., Urbani, A., Landi, F., Bernabei, R. & Marzetti, E., Nov 6 2018, In : Nutrients. 10, 11

Research output: Contribution to journalArticle

sarcopenia
Sarcopenia
Amino Acids
amino acids
citrulline

Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart

Picca, A., Sirago, G., Pesce, V., Lezza, A. M. S., Calvani, R., Bossola, M., Villani, E. R., Landi, F., Leeuwenburgh, C., Bernabei, R., Carter, C. S. & Marzetti, E., Dec 17 2018, In : Biomolecules. 8, 4

Research output: Contribution to journalArticle

Enalapril
Oxidative stress
Quality Control
Hypertrophy
Quality control

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

Picca, A., Lezza, A. M. S., Leeuwenburgh, C., Pesce, V., Calvani, R., Bossola, M., Manes-Gravina, E., Landi, F., Bernabei, R. & Marzetti, E., Aug 1 2018, In : Rejuvenation Research. 21, 4, p. 350-359 10 p.

Research output: Contribution to journalArticle

Muscular Diseases
Mitochondrial DNA
Quality Control
Mitochondria
Inflammation

Impact of habitual physical activity and type of exercise on physical performance across ages in community-living people

Landi, F., Calvani, R., Picca, A., Tosato, M., Martone, A. M., D'Angelo, E., Serafini, E., Bernabei, R. & Marzetti, E., Jan 1 2018, In : PLoS One. 13, 1, e0191820.

Research output: Contribution to journalArticle

physical activity
exercise
Health
Exercise
Health Promotion

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart

Chimienti, G., Picca, A., Sirago, G., Fracasso, F., Calvani, R., Bernabei, R., Russo, F., Carter, C. S., Leeuwenburgh, C., Pesce, V., Marzetti, E. & Lezza, A. M. S., 2018, In : Free Radical Biology and Medicine. 124, p. 447-453 7 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Rats
Replication Origin
Purines
Mitochondrial Genome

Key Messages for a Frailty Prevention and Management Policy in Europe from the Advantage Joint Action Consortium

Rodríguez Mañas, L., García-Sánchez, I., Hendry, A., Bernabei, R., Roller-Wirnsberger, R., Gabrovec, B., Liew, A., Carriazo, A. M., Redon, J., Galluzzo, L., Viña, J., Antoniadou, E., Targowski, T., di Furia, L., Lattanzio, F., Bozdog, E. & Telo, M., Oct 1 2018, In : Journal of Nutrition, Health and Aging. 22, 8, p. 892-897 6 p.

Research output: Contribution to journalArticle

European Union
Administrative Personnel
Population
Pensions
Foster Home Care

Polypharmacy in Home Care in Europe: Cross-Sectional Data from the IBenC Study

Giovannini, S., van der Roest, H. G., Carfì, A., Finne-Soveri, H., Garms-Homolová, V., Declercq, A., Jónsson, P. V., van Hout, H., Vetrano, D. L., Gravina, E. M., Bernabei, R. & Onder, G., Feb 1 2018, In : Drugs and Aging. 35, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

Polypharmacy
Home Care Services
Odds Ratio
Confidence Intervals
Pharmaceutical Preparations

Precision Medicine: The Future Management of Geriatric Conditions

Fougère, B., Morley, J. E., Arai, H., Bauer, J. M., Bernabei, R., Cherubini, A., Dong, B., Martin, F. C., Flicker, L., Merchant, R. A., Rodriguez Mañas, L., Woo, J. & Vellas, B., May 18 2018, (Accepted/In press) In : Journal of Nutrition, Health and Aging. p. 1-4 4 p.

Research output: Contribution to journalArticle

Precision Medicine
Geriatrics
Population
Primary Health Care
Sarcopenia

Prevalence of Impulsive-Compulsive Symptoms in Elderly Parkinson's Disease Patients: A Case-Control Study

Lo Monaco, M. R., Petracca, M., Weintraub, D., Fusco, D., Liperoti, R., Zuccalà, G., La Carpia, D., Vetrano, D. L., Genovese, D., Pisciotta, M. S., Brandi, V., Padua, L., Imbimbo, I., Ricciardi, D., Bernabei, R., Silveri, M. C., Laudisio, A. & Bentivoglio, A. R., Apr 28 2018, In : Journal of Clinical Psychiatry. 79, 3

Research output: Contribution to journalArticle

Parkinson Disease
Case-Control Studies
Disruptive, Impulse Control, and Conduct Disorders
Control Groups
Population

Relationship between cardiovascular health metrics and physical performance in community-living people: Results from the Longevity check-up (Lookup) 7+ project

Landi, F., Calvani, R., Picca, A., Tosato, M., D’Angelo, E., Martone, A. M., Serafini, E., Ortolani, E., Savera, G., Salini, S., Acampora, N., Bernabei, R. & Marzetti, E., Dec 1 2018, In : Scientific Reports. 8, 1, 16353.

Research output: Contribution to journalArticle

Health
Body Mass Index
Ideal Body Weight
Physical Fitness
Primary Prevention
Independent Living
Selenium
Mortality
Serum
Thyroid Hormones

Selenium Concentrations and Mortality Among Community-Dwelling Older Adults: Results from ilSIRENTE Study

Giovannini, S., Onder, G., Lattanzio, F., Bustacchini, S., di Stefano, G., Moresi, R., Russo, A., Bernabei, R. & Landi, F., May 1 2018, In : Journal of Nutrition, Health and Aging. 22, 5, p. 608-612 5 p.

Research output: Contribution to journalArticle

Independent Living
Selenium
Mortality
Serum
Thyroid Hormones

The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods

Calvani, R., Picca, A., Marini, F., Biancolillo, A., Cesari, M., Pesce, V., Lezza, A. M. S., Bossola, M., Leeuwenburgh, C., Bernabei, R., Landi, F. & Marzetti, E., Oct 2018, In : European Journal of Internal Medicine. 56, p. 19-25 7 p.

Research output: Contribution to journalArticle

Sarcopenia
Biomarkers
Muscle Strength
Administrative Personnel
Health Personnel

The role of cognitive reserve in cognitive aging: what we can learn from Parkinson’s disease

Ciccarelli, N., Monaco, M. R. L., Fusco, D., Vetrano, D. L., Zuccalà, G., Bernabei, R., Brandi, V., Pisciotta, M. S. & Silveri, M. C., Jul 1 2018, In : Aging clinical and experimental research. 30, 7, p. 877-880 4 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Parkinson Disease
Linear Models
Regression Analysis
Intelligence Tests

The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

Marzetti, E., Cesari, M., Calvani, R., Msihid, J., Tosato, M., Rodriguez-Mañas, L., Lattanzio, F., Cherubini, A., Bejuit, R., Di Bari, M., Maggio, M., Vellas, B., Dantoine, T., Cruz-Jentoft, A. J., Sieber, C. C., Freiberger, E., Skalska, A., Grodzicki, T., Sinclair, A. J., Topinkova, E. & 12 others, Rýznarová, I., Strandberg, T., Schols, A. M. W. J., Schols, J. M. G. A., Roller-Wirnsberger, R., Jónsson, P. V., Ramel, A., Del Signore, S., Pahor, M., Roubenoff, R., Bernabei, R. & Landi, F., Nov 2018, In : Experimental Gerontology. 113, p. 48-57 10 p.

Research output: Contribution to journalArticle

Sarcopenia
Screening
Randomized Controlled Trials
Health
Comorbidity

The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

Marzetti, E., Cesari, M., Calvani, R., Msihid, J., Tosato, M., Rodriguez-Mañas, L., Lattanzio, F., Cherubini, A., Bejuit, R., Di Bari, M., Maggio, M., Vellas, B., Dantoine, T., Cruz-Jentoft, A. J., Sieber, C. C., Freiberger, E., Skalska, A., Grodzicki, T., Sinclair, A. J., Topinkova, E. & 13 others, Rýznarová, I., Strandberg, T., Schols, A. M. W. J., Schols, J. M. G. A., Roller-Wirnsberger, R., Jónsson, P. V., Ramel, A., Del Signore, S., Pahor, M., Roubenoff, R., Bernabei, R., Landi, F. & Consortium, F. T. SPRINTT., 2018, In : Experimental Gerontology. 113, p. 48-57 10 p.

Research output: Contribution to journalArticle