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Research Output 1992 2019

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Article
2019
Open Access
Chordata
Exons
Phosphotyrosine
Genes
Urochordata
2018

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

Zobel, M., Disanza, A., Senic-Matuglia, F., Franco, M., Colaluca, I. N., Confalonieri, S., Bisi, S., Barbieri, E., Caldieri, G., Sigismund, S., Pece, S., Chavrier, P., Di Fiore, P. P. & Scita, G., Sep 1 2018, In : Journal of Cell Biology. 217, 9, p. 3161-3182 22 p.

Research output: Contribution to journalArticle

Recycling
Actins
Guanine Nucleotide Exchange Factors
Cell Movement
Membranes

A Numb-Mdm2 fuzzy complex reveals an isoformspecific involvement of Numb in breast cancer

Colaluca, I. N., Basile, A., Freiburger, L., D'Uva, V., Disalvatore, D., Vecchi, M., Confalonieri, S., Tosoni, D., Cecatiello, V., Malabarba, M. G., Yang, C. J., Kainosho, M., Sattler, M., Mapelli, M., Pece, S. & di Fiore, P. P., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 745-762 18 p.

Research output: Contribution to journalArticle

Exons
Breast Neoplasms
Protein Isoforms
Ubiquitin-Protein Ligases
Homeostasis

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Salvatore, C., Malinverno, C., Neumann, B., Tischer, C., Palamidessi, A., Frittoli, E., Panagiotakopoulou, M., Disanza, A., Malet-Engra, G., Nastaly, P., Galli, C., Luise, C., Bertalot, G., Pece, S., Di Fiore, P. P., Gauthier, N., Ferrari, A., Maiuri, P. & Scita, G., Dec 1 2018, In : Nature Communications. 9, 1, 1475.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Intercellular Signaling Peptides and Proteins
cells
Cytology
gradients

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis

Avanzato, D., Pupo, E., Ducano, N., Isella, C., Bertalot, G., Luise, C., Pece, S., Bruna, A., Rueda, O. M., Caldas, C., Di Fiore, P. P., Sapino, A. & Lanzetti, L., Jul 1 2018, In : Cancer Research. 78, 13, p. 3432-3444 13 p.

Research output: Contribution to journalArticle

Glycolysis
Phosphorylation
Breast Neoplasms
Endocytosis
GTPase-Activating Proteins
2017

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Gulluni, F., Martini, M., De Santis, M. C., Campa, C. C., Ghigo, A., Margaria, J. P., Ciraolo, E., Franco, I., Ala, U., Annaratone, L., Disalvatore, D., Bertalot, G., Viale, G., Noatynska, A., Compagno, M., Sigismund, S., Montemurro, F., Thelen, M., Fan, F., Meraldi, P. & 6 others, Marchiò, C., Pece, S., Sapino, A., Chiarle, R., Di Fiore, P. P. & Hirsch, E., Oct 9 2017, In : Cancer Cell. 32, 4, p. 444-459.e7

Research output: Contribution to journalArticle

Spindle Apparatus
Genomic Instability
Phosphatidylinositol 3-Kinases
Breast Neoplasms
Kinetochores

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Gulluni, F., Martini, M., De Santis, M. C., Campa, C. C., Ghigo, A., Margaria, J. P., Ciraolo, E., Franco, I., Ala, U., Annaratone, L., Disalvatore, D., Bertalot, G., Viale, G., Noatynska, A., Compagno, M., Sigismund, S., Montemurro, F., Thelen, M., Fan, F., Meraldi, P. & 6 others, Marchiò, C., Pece, S., Sapino, A., Chiarle, R., Di Fiore, P. P. & Hirsch, E., 2017, In : Cancer Cell. 32, 4, p. 444

Research output: Contribution to journalArticle

Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers

Tosoni, D., Pambianco, S., Ekalle Soppo, B., Zecchini, S., Bertalot, G., Pruneri, G., Viale, G., Di Fiore, P. P. & Pece, S., May 1 2017, In : EMBO Molecular Medicine. 9, 5, p. 655-671 17 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cell- and Tissue-Based Therapy
Breast Neoplasms
Down-Regulation
Tissue Expansion

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

Grasso, S., Chapelle, J., Salemme, V., Aramu, S., Russo, I., Vitale, N., Verdun di Cantogno, L., Dallaglio, K., Castellano, I., Amici, A., Centonze, G., Sharma, N., Lunardi, S., Cabodi, S., Cavallo, F., Lamolinara, A., Stramucci, L., Moiso, E., Provero, P., Albini, A. & 11 others, Sapino, A., Staaf, J., Di Fiore, P. P., Bertalot, G., Pece, S., Tosoni, D., Confalonieri, S., Iezzi, M., Di Stefano, P., Turco, E. & Defilippi, P., Mar 16 2017, In : Nature Communications. 8, p. 14797

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Scaffolds
progressions
breast
Tumors

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

Grasso, S., Chapelle, J., Salemme, V., Aramu, S., Russo, I., Vitale, N., Di Cantogno, L. V., Dallaglio, K., Castellano, I., Amici, A., Centonze, G., Sharma, N., Lunardi, S., Cabodi, S., Cavallo, F., Lamolinara, A., Stramucci, L., Moiso, E., Provero, P., Albini, A. & 11 others, Sapino, A., Staaf, J., Di Fiore, P. P., Bertalot, G., Pece, S., Tosoni, D., Confalonieri, S., Iezzi, M., Di Stefano, P., Turco, E. & Defilippi, P., Mar 16 2017, In : Nature Communications. 8, 14797.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Scaffolds
progressions
breast
Tumors
2016

A Trust-Based Pact in Research Biobanks. From Theory to Practice

Sanchini, V., Bonizzi, G., Disalvatore, D., Monturano, M., Pece, S., Viale, G., Di Fiore, P. P. & Boniolo, G., May 2016, In : Bioethics. 30, 4, p. 260-71 12 p.

Research output: Contribution to journalArticle

Cancer Care Facilities
Informed Consent
Research
Italy
Guidelines

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

Calcagnì, A., Kors, L., Verschuren, E., De Cegli, R., Zampelli, N., Nusco, E., Confalonieri, S., Bertalot, G., Pece, S., Settembre, C., Malouf, G. G., Leemans, J. C., de Heer, E., Salvatore, M., Peters, D. J. M., Di Fiore, P. P. & Ballabio, A., Sep 26 2016, In : eLife. 5, September, e17047.

Research output: Contribution to journalArticle

Polytetrafluoroethylene
Renal Cell Carcinoma
Tumors
Fusion reactions
Cells

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

Calcagnì, A., Kors, L., Verschuren, E., De Cegli, R., Zampelli, N., Nusco, E., Confalonieri, S., Bertalot, G., Pece, S., Settembre, C., Malouf, G., Leemans, J. C., de Heer, E., Salvatore, M., Peters, D., Di Fiore, P. P. & Ballabio, A., Sep 26 2016, In : eLife. 5, September, e17047.

Research output: Contribution to journalArticle

Polytetrafluoroethylene
Renal Cell Carcinoma
Tumors
Fusion reactions
Cells
Non-Small Cell Lung Carcinoma
Lung Neoplasms
RNA
anaplastic lymphoma kinase
Calibration
2015

A Trust-Based Pact in Research Biobanks. From Theory to Practice

Sanchini, V., Bonizzi, G., Disalvatore, D., Monturano, M., Pece, S., Viale, G., Di Fiore, P. P. & Boniolo, G., 2015, (Accepted/In press) In : Bioethics.

Research output: Contribution to journalArticle

Cancer Care Facilities
Informed Consent
Research
Italy
Guidelines

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

Chiaradonna, F., Barozzi, I., Miccolo, C., Bucci, G., Palorini, R., Fornasari, L., Botrugno, O. A., Pruneri, G., Masullo, M., Passafaro, A., Galimberti, V. E., Fantin, V. R., Richon, V. M., Pece, S., Viale, G., Di Fiore, P. P., Draetta, G., Pelicci, P. G., Minucci, S. & Chiocca, S., Jul 1 2015, In : Antioxidants and Redox Signaling. 23, 1, p. 15-29 15 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Tumors
Cells
Breast Neoplasms
Genes

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

Tosoni, D., Zecchini, S., Coazzoli, M., Colaluca, I., Mazzarol, G., Rubio, A., Caccia, M., Villa, E., Zilian, O., Di Fiore, P. P. & Pece, S., Nov 23 2015, In : Journal of Cell Biology. 211, 4, p. 845-862 18 p.

Research output: Contribution to journalArticle

Breast
Stem Cells
Epithelial Cells
Human Mammary Glands
Neoplasms
Exome
Karyotype
Lung Neoplasms
Tomography
Mutation
2014

FlowFit: A bioconductor package to estimate proliferation in cell-tracking dye studies

Rambaldi, D., Pece, S. & Di Fiore, P. P., Jul 15 2014, In : Bioinformatics. 30, 14, p. 2060-2065 6 p.

Research output: Contribution to journalArticle

Cell Tracking
Dyes
Proliferation
Coloring Agents
Luminance

HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels

Puca, F., Colamaio, M., Federico, A., Gemei, M., Tosti, N., Bastos, A. U., Del Vecchio, L., Pece, S., Battista, S. & Fusco, A., 2014, In : Oncotarget. 5, 10, p. 3234-3245 12 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Colonic Neoplasms
Stem Cells
High Mobility Group Proteins
Neoplasms
2013

TPT1/ TCTP-regulated pathways in phenotypic reprogramming

Amson, R., Pece, S., Marine, J. C., Fiore, P. P. D. & Telerman, A., Jan 2013, In : Trends in Cell Biology. 23, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Messenger RNA
Ribonucleoproteins
Neoplastic Stem Cells
Virion
Protein Kinases
2012

Reciprocal repression between P53 and TCTP

Amson, R., Pece, S., Lespagnol, A., Vyas, R., Mazzarol, G., Tosoni, D., Colaluca, I., Viale, G., Rodrigues-Ferreira, S., Wynendaele, J., Chaloin, O., Hoebeke, J., Marine, J. C., Di Fiore, P. P. & Telerman, A., Jan 2012, In : Nature Medicine. 18, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

Tumors
Ubiquitination
Cells
Apoptosis
Breast Neoplasms

Trusted consent and research biobanks: Towards a 'new alliance' between researchers and donors

Boniolo, G., Di Fiore, P. P. & Pece, S., Feb 2012, In : Bioethics. 26, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Research Personnel
Access to Information
Informed Consent
Research
transaction
2011

Cobalamin deficiency-induced changes of epidermal growth factor (EGF)-receptor expression and EGF levels in rat spinal cord

Mutti, E., Magnaghi, V., Veber, D., Faroni, A., Pece, S., Di Fiore, P. P. & Scalabrino, G., Feb 28 2011, In : Brain Research. 1376, p. 23-30 8 p.

Research output: Contribution to journalArticle

Vitamin B 12
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Spinal Cord
Liver

Genomic characterization of asymptomatic CT-detected lung cancers

Belloni, E., Veronesi, G., Micucci, C., Javan, S., Minardi, S. P., Venturini, E., Maisonneuve, P., Volorio, S., Riboni, M., Bellomi, M., Scanagatta, P., Taliento, G., Pelosi, G., Pece, S., Spaggiari, L. & Pelicci, P. G., Mar 3 2011, In : Oncogene. 30, 9, p. 1117-1126 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Tomography
Neoplasms
Abnormal Karyotype
Aneuploidy

NUMB-ing down cancer by more than just a NOTCH

Pece, S., Confalonieri, S., R. Romano, P. & Di Fiore, P. P., Jan 2011, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1815, 1, p. 26-43 18 p.

Research output: Contribution to journalArticle

Neoplasms
Stem Cells
Maintenance
Notch Receptors
Adherens Junctions
2010
Neoplastic Stem Cells
Stem cells
Breast Neoplasms
Tumors
Cells
2009

Alterations of the Notch pathway in lung cancer

Westhoff, B., Colaluca, I. N., D'Ario, G., Donzelli, M., Tosoni, D., Volorio, S., Pelosi, G., Spaggiari, L., Mazzarol, G., Viale, G., Pece, S. & Di Fiore, P. P., Dec 19 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 52, p. 22293-22298 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Amyloid Precursor Protein Secretases
Mutation

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

Confalonieri, S., Quarto, M., Goisis, G., Nuciforo, P., Donzelli, M., Jodice, G., Pelosi, G., Viale, G., Pece, S. & Di Fiore, P. P., Aug 20 2009, In : Oncogene. 28, 33, p. 2959-2968 10 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Neoplasms
Ubiquitination
Ubiquitin-Protein Ligases

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Rustighi, A., Tiberi, L., Soldano, A., Napoli, M., Nuciforo, P., Rosato, A., Kaplan, F., Capobianco, A., Pece, S., Di Fiore, P. P. & Del Sal, G., 2009, In : Nature Cell Biology. 11, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
Notch Receptors
Breast Neoplasms
Amyloid Precursor Protein Secretases
Neoplasms
2008

Breast cancer metastases are molecularly distinct from their primary tumors

Vecchi, M., Confalonieri, S., Nuciforo, P., Viganò, M. A., Capra, M., Bianchi, M., Nicosia, D., Bianchi, F., Galimberti, V., Viale, G., Palermo, G., Riccardi, A., Campanini, R., Daidone, M. G., Pierotti, M. A., Pece, S. & Di Fiore, P. P., Apr 3 2008, In : Oncogene. 27, 15, p. 2148-2158 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Genes
Lymph Nodes

NUMB controls p53 tumour suppressor activity

Colaluca, I. N., Tosoni, D., Nuciforo, P., Senic-Matuglia, F., Galimberti, V., Viale, G., Pece, S. & Di Fiore, P. P., Jan 3 2008, In : Nature. 451, 7174, p. 76-80 5 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Phenotype
Proteins
Ubiquitin-Protein Ligases
2007

Prognostic implications of Numb immunoreactivity in salivary gland carcinomas

Maiorano, E., Favia, G., Pece, S., Resta, L., Maisonneuve, P., Di Fiore, P. P., Capodiferro, S., Urbani, U. & Viale, G., Oct 2007, In : International Journal of Immunopathology and Pharmacology. 20, 4, p. 779-789 11 p.

Research output: Contribution to journalArticle

Mucoepidermoid Carcinoma
Salivary Glands
Adenoids
Carcinoma
Adenoid Cystic Carcinoma
2006

In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients

Mey, V., Giovannetti, E., De Braud, F., Nannizzi, S., Curigliano, G., Verweij, F., De Cobelli, O., Pece, S., Del Tacca, M. & Danesi, R., Aug 7 2006, In : British Journal of Cancer. 95, 3, p. 289-297 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pemetrexed
Pharmacogenetics
Urinary Bladder Neoplasms
Deoxycytidine Kinase
2005

Cyclin D3 immunoreactivity is an independent predictor of survival in laryngeal squamous cell carcinoma

Pruneri, G., Pignataro, L., Valentini, S., Fabris, S., Maisonneuve, P., Carboni, N., Pece, S., Capra, M., Del Curto, B., Neri, A. & Viale, G., Jan 1 2005, In : Clinical Cancer Research. 11, 1, p. 242-248 7 p.

Research output: Contribution to journalArticle

Cyclin D3
Squamous Cell Carcinoma
Cyclin D1
Survival
Fluorescence In Situ Hybridization
2004

Endocytosis and cancer

Polo, S., Pece, S. & Di Fiore, P. P., Apr 2004, In : Current Opinion in Cell Biology. 16, 2, p. 156-161 6 p.

Research output: Contribution to journalArticle

Endocytosis
Neoplasms
Cell Surface Receptors
Eukaryotic Cells
Homeostasis

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Pece, S., Serresi, M., Santolini, E., Capra, M., Hulleman, E., Galimberti, V., Zurrida, S., Maisonneuve, P., Viale, G. & Di Fiore, P. P., Oct 25 2004, In : Journal of Cell Biology. 167, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Breast Neoplasms
Neoplasms
Homeostasis
2002

E-cadherin and Hakai: Signalling, remodeling or destruction?

Pece, S. & Gutkind, J. S., 2002, In : Nature Cell Biology. 4, 4

Research output: Contribution to journalArticle

Cadherins
Ubiquitin-Protein Ligases
Epithelial-Mesenchymal Transition
Recycling
Receptor Protein-Tyrosine Kinases
2001

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B

Montaner, S., Sodhi, A., Pece, S., Mesri, E. A. & Gutkind, J. S., Mar 15 2001, In : Cancer Research. 61, 6, p. 2641-2648 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Proto-Oncogene Proteins c-akt
G-Protein-Coupled Receptors
Cell Survival
Endothelial Cells
2000

Loss of PTEN expression leading to high Akt activation in human multiple myelomas

Hyun, T., Yam, A., Pece, S., Xie, X., Zhang, J., Miki, T., Gutkind, J. S. & Li, W., Nov 15 2000, In : Blood. 96, 10, p. 3560-3568 9 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Chemical activation
Phosphatidylinositol 3-Kinase
70-kDa Ribosomal Protein S6 Kinases
Cadherins
Chemical activation
Cell adhesion
Cell Adhesion
Signal Transduction
1999
Phosphatidylinositol 3-Kinase
Intercellular Junctions
Cadherins
Protein Kinases
Adhesion

Helicobacter pylori infection and host cell responses

Di Leo, A., Messa, C., Russo, F., Linsalata, M., Amati, L., Caradonna, L., Pece, S., Pellegrino, N. M., Caccavo, D., Antonaci, S. & Jirillo, E., 1999, In : Immunopharmacology and Immunotoxicology. 21, 4, p. 803-846 44 p.

Research output: Contribution to journalArticle

Polyamines
Helicobacter Infections
Helicobacter pylori
Carcinogens
Lipopolysaccharides

Lactoferrin-lipid A-lipopolysaccharide interaction: Inhibition by anti- human lactoferrin monoclonal antibody AGM 10.14

Caccavo, D., Afeltra, A., Pece, S., Giuliani, G., Freudenberg, M., Galanos, C. & Jirillo, E., 1999, In : Infection and Immunity. 67, 9, p. 4668-4672 5 p.

Research output: Contribution to journalArticle

Lipid A
Lactoferrin
Lipopolysaccharides
Monoclonal Antibodies
Epitopes

The role of Helicobacter pylori LPS in the pathogenesis of H. pylori-related gastropathy

Jirillo, E., Pece, S., Pellegrino, N. M., Di Leo, A., Russo, F., Linsalata, M., Messa, C., Amati, L., Caradonna, L., Moran, A. P. & Caccavo, D., 1999, In : Journal of Endotoxin Research. 5, 4, p. 222-226 5 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Lipopolysaccharides
Gastritis
Duodenal Ulcer
Signal transduction

The role of Helicobacter pylori LPS in the pathogenesis of H. pylori-related gastropathy

Jirillo, E., Pece, S., Pellegrino, N. M., Di Leo, A., Russo, F., Linsalata, M., Messa, C., Amati, L., Caradonna, L., Moran, A. P. & Caccavo, D., 1999, In : Innate Immunity. 5, 4, p. 222-226 5 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Gastritis
Duodenal Ulcer
Lipopolysaccharides
Gastrointestinal Contents
1998

Spontaneous and fas-induced apoptotic cell death in aged neutrophils

Tortorella, C., Piazzolla, G., Spaccavento, F., Pece, S., Jirillo, E. & Antonaci, S., 1998, In : Journal of Clinical Immunology. 18, 5, p. 321-329 9 p.

Research output: Contribution to journalArticle

Neutrophils
Cell Death
Fas Ligand Protein
Granulocyte Colony-Stimulating Factor
Apoptosis

The pathogenesis of fever and its therapeutic implications

Pece, S., Giuliani, G., Caccavo, D., Antonaci, S. & Jirillo, E., 1998, In : Medical Science Research. 26, 1, p. 3-7 5 p.

Research output: Contribution to journalArticle

Pyrogens
Fever
Cytokines
Hypothalamus
Interleukin-1