• 3830 Citations
  • 23 h-Index
20012018
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Research Output 2001 2018

  • 3830 Citations
  • 23 h-Index
  • 36 Article
  • 1 Chapter
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Article
2018

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

Schauer, S. N., Carreira, P. E., Shukla, R., Gerhardt, D. J., Gerdes, P., Sanchez-Luque, F. J., Nicoli, P., Kindlova, M., Ghisletti, S., Santos, A. D., Rapoud, D., Samuel, D., Faivre, J., Ewing, A. D., Richardson, S. R. & Faulkner, G. J., May 2018, In : Genome Research. 28, 5, p. 639-653 15 p.

Research output: Contribution to journalArticle

Retroelements
Hepatocellular Carcinoma
Neoplasms
Mutagenesis
Mammals

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

Schauer, S. N., Carreira, P. E., Shukla, R., Gerhardt, D. J., Gerdes, P., Sanchez-Luque, F. J., Nicoli, P., Kindlova, M., Ghisletti, S., Dos Santos, A. D., Rapoud, D., Samuel, D., Faivre, J., Ewing, A. D., Richardson, S. R. & Faulkner, G. J., 2018, In : Genome Research. 28, 5, p. 639-653 15 p.

Research output: Contribution to journalArticle

Retroelements
Hepatocellular Carcinoma
Neoplasms
Mutagenesis
Mammals
1 Citation (Scopus)

Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage

Collino, A., Termanini, A., Nicoli, P., Diaferia, G., Polletti, S., Recordati, C., Castiglioni, V., Caruso, D., Mitro, N., Natoli, G. & Ghisletti, S., May 1 2018, In : PLoS Genetics. 14, 5, e1007380.

Research output: Contribution to journalArticle

bile acids
detoxification
Bile Acids and Salts
carcinogenesis
cancer
2 Citations (Scopus)

Zc3h10 is a novel mitochondrial regulator

Audano, M., Pedretti, S., Cermenati, G., Brioschi, E., Diaferia, G. R., Ghisletti, S., Cuomo, A., Bonaldi, T., Salerno, F., Mora, M., Grigore, L., Garlaschelli, K., Baragetti, A., Bonacina, F., Catapano, A. L., Norata, G. D., Crestani, M., Caruso, D., Saez, E., De Fabiani, E. & 1 others, Mitro, N., Apr 1 2018, In : EMBO Reports. 19, 4, e45531.

Research output: Contribution to journalArticle

Myoblasts
Electron Transport
Mitochondria
Zinc Fingers
Skeletal Muscle Fibers

Zc3h10 is a novel mitochondrial regulator

Audano, M., Pedretti, S., Cermenati, G., Brioschi, E., Diaferia, G. R., Ghisletti, S., Cuomo, A., Bonaldi, T., Salerno, F., Mora, M., Grigore, L., Garlaschelli, K., Baragetti, A., Bonacina, F., Catapano, A. L., Norata, G. D., Crestani, M., Caruso, D., Saez, E., De Fabiani, E. & 1 others, Mitro, N., Apr 1 2018, In : EMBO Reports. 19, 4

Research output: Contribution to journalArticle

Myoblasts
Electron Transport
Mitochondria
Zinc Fingers
Skeletal Muscle Fibers

Zc3h10 is a novel mitochondrial regulator

Audano, M., Pedretti, S., Cermenati, G., Brioschi, E., Diaferia, G. R., Ghisletti, S., Cuomo, A., Bonaldi, T., Salerno, F., Mora, M., Grigore, L., Garlaschelli, K., Baragetti, A., Bonacina, F., Catapano, A. L., Norata, G. D., Crestani, M., Caruso, D., Saez, E., De Fabiani, E. & 1 others, Mitro, N., 2018, In : EMBO Reports. 19, 4

Research output: Contribution to journalArticle

Myoblasts
Electron Transport
Mitochondria
Zinc Fingers
Skeletal Muscle Fibers
2017
10 Citations (Scopus)

High constitutive activity of a broad panel of housekeeping and tissue-specific cis-regulatory elements depends on a subset of ETS proteins

Curina, A., Termanini, A., Barozzi, I., Prosperini, E., Simonatto, M., Polletti, S., Silvola, A., Soldi, M., Austenaa, L., Bonaldi, T., Ghisletti, S. & Natoli, G., Feb 15 2017, In : Genes and Development. 31, 4, p. 399-412 14 p.

Research output: Contribution to journalArticle

Housekeeping
Macrophages
Proteins
Transcription Initiation Site
Essential Genes
6 Citations (Scopus)

Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18

Ravà, M., D'Andrea, A., Doni, M., Kress, T. R., Ostuni, R., Bianchi, V., Morelli, M. J., Collino, A., Ghisletti, S., Nicoli, P., Recordati, C., Iascone, M., Sonzogni, A., D'Antiga, L., Shukla, R., Faulkner, G. J., Natoli, G., Campaner, S. & Amati, B., 2017, In : Hepatology. 65, 5, p. 1708-1719 12 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk

Piccolo, V., Curina, A., Genua, M., Ghisletti, S., Simonatto, M., Sabò, A., Amati, B., Ostuni, R. & Natoli, G., 2017, In : Nature Immunology. 18, 5, p. 530-540 11 p.

Research output: Contribution to journalArticle

Epigenomics
Interleukin-4
Macrophages
Interferons
STAT1 Transcription Factor
51 Citations (Scopus)

Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk

Piccolo, V., Curina, A., Genua, M., Ghisletti, S., Simonatto, M., Sabò, A., Amati, B., Ostuni, R. & Natoli, G., Apr 18 2017, In : Nature Immunology. 18, 5, p. 530-540 11 p.

Research output: Contribution to journalArticle

Epigenomics
Interleukin-4
Macrophages
Interferons
STAT1 Transcription Factor
2016
3 Citations (Scopus)

Amine-modified poly(vinyl alcohol) as a novel surfactant to modulate size and surface charge of poly(lactide-co-glycolide) nanoparticles

Cella, C., Martello, F., Ghisletti, S., Lenardi, C., Milani, P. & Argentiere, S., 2016, (Accepted/In press) In : Polymer International.

Research output: Contribution to journalArticle

Polyglactin 910
Surface charge
Surface-Active Agents
Amines
Alcohols
2015
48 Citations (Scopus)

A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages

Mancino, A., Termanini, A., Barozzi, I., Ghisletti, S., Ostuni, R., Prosperini, E., Ozato, K. & Natoli, G., 2015, In : Genes and Development. 29, 4, p. 394-408 15 p.

Research output: Contribution to journalArticle

Macrophages
Gene Expression
Lipopolysaccharides
Genes
Transcription Factors
20 Citations (Scopus)

CAGE profiling of ncRNAs in hepatocellular carcinoma reveals widespread activation of retroviral LTR promoters in virus-induced tumors

Hashimoto, K., Suzuki, A. M., Dos Santos, A., Desterke, C., Collino, A., Ghisletti, S., Braun, E., Bonetti, A., Fort, A., Qin, X. Y., Radælli, E., Kaczkowski, B., Forrest, A. R. R., Kojima, S., Samuel, D., Natoli, G., Buendia, M. A., Faivre, J. & Carninci, P., Dec 1 2015, In : Genome Research. 25, 12, p. 1812-1824 13 p.

Research output: Contribution to journalArticle

Oncogenic Viruses
Untranslated RNA
Hepatocellular Carcinoma
Transcription Initiation Site
Liver
23 Citations (Scopus)

Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination

Austenaa, L. M. I., Barozzi, I., Simonatto, M., Masella, S., Della Chiara, G., Ghisletti, S., Curina, A., de Wit, E., Bouwman, B. A. M., de Pretis, S., Piccolo, V., Termanini, A., Prosperini, E., Pelizzola, M., de Laat, W. & Natoli, G., Nov 5 2015, In : Molecular Cell. 60, 3, p. 460-474 15 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
RNA Polymerase II
Long Noncoding RNA
RNA
Cell Nucleus Active Transport
2014
101 Citations (Scopus)

Coregulation of Transcription Factor Binding and Nucleosome Occupancy through DNA Features of Mammalian Enhancers

Barozzi, I., Simonatto, M., Bonifacio, S., Yang, L., Rohs, R., Ghisletti, S. & Natoli, G., Jun 5 2014, In : Molecular Cell. 54, 5, p. 844-857 14 p.

Research output: Contribution to journalArticle

Nucleosomes
Transcription Factors
DNA
Binding Sites
Genome
34 Citations (Scopus)

Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency

Iannelli, F., Collino, A., Sinha, S., Radaelli, E., Nicoli, P., D'Antiga, L., Sonzogni, A., Faivre, J., Buendia, M. A., Sturm, E., Thompson, R. J., Knisely, A. S., Natoli, G., Ghisletti, S. & Ciccarelli, F. D., May 13 2014, In : Nature Communications. 5, 3850.

Research output: Contribution to journalArticle

Pediatrics
Gene Amplification
Bile Acids and Salts
genes
Hepatocellular Carcinoma
2013
Macrophages
Immune system
immune system
Gene expression
gene expression
9 Citations (Scopus)
Macrophages
Immune system
immune system
Gene expression
gene expression
210 Citations (Scopus)

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma

Shukla, R., Upton, K. R., Muñoz-Lopez, M., Gerhardt, D. J., Fisher, M. E., Nguyen, T., Brennan, P. M., Baillie, J. K., Collino, A., Ghisletti, S., Sinha, S., Iannelli, F., Radaelli, E., Dos Santos, A., Rapoud, D., Guettier, C., Samuel, D., Natoli, G., Carninci, P., Ciccarelli, F. D. & 3 others, Garcia-Perez, J. L., Faivre, J. & Faulkner, G. J., Mar 28 2013, In : Cell. 153, 1, p. 101-111 11 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Retroelements
Genes
Tumors
Colorectal Neoplasms
389 Citations (Scopus)

Latent enhancers activated by stimulation in differentiated cells

Ostuni, R., Piccolo, V., Barozzi, I., Polletti, S., Termanini, A., Bonifacio, S., Curina, A., Prosperini, E., Ghisletti, S. & Natoli, G., Jan 7 2013, In : Cell. 152, 1-2, p. 157-171 15 p.

Research output: Contribution to journalArticle

Transcription Factors
Histone Code
Macrophages
Environmental Exposure
Landing
2011
101 Citations (Scopus)

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

Huang, W., Ghisletti, S., Saijo, K., Gandhi, M., Aouadi, M., Tesz, G. J., Zhang, D. X., Yao, J., Czech, M. P., Goode, B. L., Rosenfeld, M. G. & Glass, C. K., Feb 17 2011, In : Nature. 470, 7334, p. 414-418 5 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Actins
Toll-Like Receptors
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Genes
77 Citations (Scopus)

Mechanisms establishing tlr4-responsive activation states of inflammatory response genes

Escoubet-Lozach, L., Benner, C., Kaikkonen, M. U., Lozach, J., Heinz, S., Spann, N. J., Crotti, A., Stender, J., Ghisletti, S., Reichart, D., Cheng, C. S., Luna, R., Ludka, C., Sasik, R., Garcia-Bassets, I., Hoffmann, A., Subramaniam, S., Hardiman, G., Rosenfeld, M. G. & Glass, C. K., Dec 2011, In : PLoS Genetics. 7, 12, e1002401.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
inflammation
Immediate-Early Genes
gene
Genes
87 Citations (Scopus)

The genomic landscapes of inflammation

Natoli, G., Ghisletti, S. & Barozzi, I., Jan 15 2011, In : Genes and Development. 25, 2, p. 101-106 6 p.

Research output: Contribution to journalArticle

Transcription Factors
Inflammation
Interferon Regulatory Factors
NF-kappa B
Transcription Factor AP-1
2010
438 Citations (Scopus)

A large fraction of extragenic RNA Pol II transcription sites overlap enhancers

de Santa, F., Barozzi, I., Mietton, F., Ghisletti, S., Polletti, S., Tusi, B. K., Muller, H., Ragoussis, J., Wei, C. L. & Natoli, G., May 2010, In : PLoS Biology. 8, 5

Research output: Contribution to journalArticle

Long Noncoding RNA
RNA Polymerase II
Transcription
transcription (genetics)
Genes
386 Citations (Scopus)

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages

Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C. L., Ragoussis, J. & Natoli, G., Mar 2010, In : Immunity. 32, 3, p. 317-328 12 p.

Research output: Contribution to journalArticle

Macrophages
Gene Expression
Transcription Factors
Transcription Factor AP-1
Transferases
2009
163 Citations (Scopus)

Cooperative NCoR/SMRT interactions establish a eorepressor-based strategy for integration of inflammatory ana anti-inflammatory signaling pathways

Ghisletti, S., Huang, W., Jepsen, K., Benner, C., Hardiman, G., Rosenfeld, M. G. & Glass, C. K., Mar 15 2009, In : Genes and Development. 23, 6, p. 681-693 13 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Anti-Inflammatory Agents
Nuclear Receptor Co-Repressor 2
Genes
Virus Diseases
349 Citations (Scopus)

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB

Porta, C., Rimoldi, M., Raes, G., Brys, L., Ghezzi, P., Di Liberto, D., Dieli, F., Ghisletti, S., Natoli, G., De Baetselier, P., Mantovani, A. & Sica, A., Sep 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 35, p. 14978-14983 6 p.

Research output: Contribution to journalArticle

Macrophages
Inflammation
Helminths
Phagocytes
Monocytes
76 Citations (Scopus)

Transcriptional Integration of TLR2 and TLR4 Signaling at the NCoR Derepression Checkpoint

Huang, W., Ghisletti, S., Perissi, V., Rosenfeld, M. G. & Glass, C. K., Jul 10 2009, In : Molecular Cell. 35, 1, p. 48-57 10 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Toll-Like Receptors
Phosphorylation
Calcium-Sensing Receptors
Co-Repressor Proteins
2008
35 Citations (Scopus)

Structure-guided design of N-phenyl tertiary amines as transrepression- selective liver X receptor modulators with anti-inflammatory activity

Chao, E. Y., Caravella, J. A., Watson, M. A., Campobasso, N., Ghisletti, S., Billin, A. N., Galardi, C., Wang, P., Laffitte, B. A., Iannone, M. A., Goodwin, B. J., Nichols, J. A., Parks, D. J., Stewart, E., Wiethe, R. W., Williams, S. P., Smallwood, A., Pearce, K. H., Glass, C. K., Willson, T. M. & 2 others, Zuercher, W. J. & Collins, J. L., Sep 25 2008, In : Journal of Medicinal Chemistry. 51, 18, p. 5758-5765 8 p.

Research output: Contribution to journalArticle

Amines
Anti-Inflammatory Agents
Ligands
Human Activities
Transcriptional Activation
2007
366 Citations (Scopus)

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M. E., Willson, T. M., Rosenfeld, M. G. & Glass, C. K., Jan 12 2007, In : Molecular Cell. 25, 1, p. 57-70 14 p.

Research output: Contribution to journalArticle

Sumoylation
Peroxisome Proliferator-Activated Receptors
Transcriptional Activation
Genes
Ligands
2006
105 Citations (Scopus)

The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation

Vegeto, E., Belcredito, S., Ghisletti, S., Meda, C., Etteri, S. & Maggi, A., May 2006, In : Endocrinology. 147, 5, p. 2263-2272 10 p.

Research output: Contribution to journalArticle

Microglia
Estrogens
Animal Models
Brain
Macrophages
2005
269 Citations (Scopus)

17β-estradiol inhibits inflammatory gene expression by controlling NF-κB intracellular localization

Ghisletti, S., Meda, C., Maggi, A. & Vegeto, E., Apr 2005, In : Molecular and Cellular Biology. 25, 8, p. 2957-2968 12 p.

Research output: Contribution to journalArticle

Transcription Factor RelA
Estrogen Receptor alpha
Estradiol
Anti-Inflammatory Agents
Macrophages
2004
76 Citations (Scopus)

Regulation of the lipopolysaccharide signal transduction pathway by 17β-estradiol in macrophage cells

Vegeto, E., Ghisletti, S., Meda, C., Etteri, S., Belcredito, S. & Maggi, A., Jun 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 91, 1-2, p. 59-66 8 p.

Research output: Contribution to journalArticle

Signal transduction
Macrophages
Lipopolysaccharides
Estradiol
Signal Transduction
2003
31 Citations (Scopus)

Estrogen receptor α, a molecular switch converting transforming growth factor-α-mediated proliferation into differentiation in neuroblastoma cells

Ciana, P., Ghisletti, S., Mussi, P., Eberini, I., Vegeto, E. & Maggi, A., Aug 22 2003, In : Journal of Biological Chemistry. 278, 34, p. 31737-31744 8 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Neuroblastoma
Estrogen Receptors
Switches
STAT3 Transcription Factor
277 Citations (Scopus)

Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol

Vegeto, E., Belcredito, S., Etteri, S., Ghisletti, S., Brusadelli, A., Meda, C., Krust, A., Dupont, S., Ciana, P., Chambon, P. & Maggi, A., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9614-9619 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estradiol
Anti-Inflammatory Agents
Brain
Microglia
2001
36 Citations (Scopus)

Estrogen neuroprotection: The involvement of the Bcl-2 binding protein BNIP2

Belcredito, S., Vegeto, E., Brusadelli, A., Ghisletti, S., Mussi, P., Ciana, P. & Maggi, A., 2001, In : Brain Research Reviews. 37, 1-3, p. 335-342 8 p.

Research output: Contribution to journalArticle

Carrier Proteins
Estrogens
Estradiol
Poisons
Estrogen Receptors