• 1636 Citations
  • 20 h-Index
20022019
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Research Output 2002 2019

  • 1636 Citations
  • 20 h-Index
  • 44 Article
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Article
2019

Altered function of the glutamate–aspartate transporter GLAST, a potential therapeutic target in glioblastoma

Corbetta, C., Di Ianni, N., Bruzzone, M. G., Patanè, M., Pollo, B., Cantini, G., Cominelli, M., Zucca, I., Pisati, F., Poliani, P. L., Finocchiaro, G. & Pellegatta, S., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Glioblastoma
Glutamic Acid
Glioma
Therapeutics
Apoptosis
2018
13 Citations (Scopus)

Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy

Pellegatta, S., Savoldo, B., Di Ianni, N., Corbetta, C., Chen, Y., Patané, M., Sun, C., Pollo, B., Ferrone, S., DiMeco, F., Finocchiaro, G. & Dotti, G., Feb 28 2018, In : Science Translational Medicine. 10, 430, eaao2731.

Research output: Contribution to journalArticle

Antigen Receptors
Glioblastoma
Cell- and Tissue-Based Therapy
Tumor Necrosis Factor-alpha
Neoplasms
9 Citations (Scopus)
temozolomide
Glioblastoma
Immunotherapy
Dendritic Cells
T-Lymphocytes
2017
7 Citations (Scopus)

ER–mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem-like cells

Bassoy, E. Y., Kasahara, A., Chiusolo, V., Jacquemin, G., Boydell, E., Zamorano, S., Riccadonna, C., Pellegatta, S., Hulo, N., Dutoit, V., Derouazi, M., Dietrich, P. Y., Walker, P. R. & Martinvalet, D., Jun 1 2017, In : EMBO Journal. 36, 11, p. 1493-1512 20 p.

Research output: Contribution to journalArticle

Lymphocytes
Control surfaces
Glioma
Polysaccharides
Stem Cells
12 Citations (Scopus)

Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor

Orzan, F., De Bacco, F., Crisafulli, G., Pellegatta, S., Mussolin, B., Siravegna, G., D'Ambrosio, A., Comoglio, P. M., Finocchiaro, G. & Boccaccio, C., Nov 1 2017, In : Stem Cells. 35, 11, p. 2218-2228 11 p.

Research output: Contribution to journalArticle

Molecular Evolution
Glioblastoma
Stem Cells
Neoplasms
temozolomide
7 Citations (Scopus)

Hypermutations in gliomas: A potential immunotherapy target

Finocchiaro, G., Langella, T., Corbetta, C. & Pellegatta, S., Jan 1 2017, In : Discovery medicine. 23, 125, p. 113-120 8 p.

Research output: Contribution to journalArticle

Glioma
Immunotherapy
temozolomide
DNA Mismatch Repair
Neoplasms
2016
3 Citations (Scopus)

Decitabine treatment of glioma-initiating cells enhances immune recognition and killing

Riccadonna, C., Yacoub Maroun, C., Vuillefroy De Silly, R., Boehler, M., Calvo Tardón, M., Jueliger, S., Taverna, P., Barba, L., Marinari, E., Pellegatta, S., Bassoy, E. Y., Martinvalet, D., Dietrich, P. Y. & Walker, P. R., Aug 1 2016, In : PLoS One. 11, 8, e0162105.

Research output: Contribution to journalArticle

decitabine
T-cells
Glioma
Cells
Death Domain Receptors
20 Citations (Scopus)
Glioblastoma
Immunotherapy
Dendritic Cells
Stem Cells
Cancer Vaccines
29 Citations (Scopus)

MET inhibition overcomes radiation resistance of glioblastoma stem-like cells

De Bacco, F., D'Ambrosio, A., Casanova, E., Orzan, F., Neggia, R., Albano, R., Verginelli, F., Cominelli, M., Poliani, P. L., Luraghi, P., Reato, G., Pellegatta, S., Finocchiaro, G., Perera, T., Garibaldi, E., Gabriele, P., Comoglio, P. M. & Boccaccio, C., May 1 2016, In : EMBO Molecular Medicine. 8, 5, p. 550-568 19 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Radiation
DNA Damage
Radiotherapy

MET inhibition overcomes radiation resistance of glioblastoma stem-like cells

De Bacco, F., D'Ambrosio, A., Casanova, E., Orzan, F., Neggia, R., Albano, R., Verginelli, F., Cominelli, M., Poliani, P. L., Luraghi, P., Reato, G., Pellegatta, S., Finocchiaro, G., Perera, T., Garibaldi, E., Gabriele, P., Comoglio, P. M. & Boccaccio, C., May 1 2016, In : EMBO Molecular Medicine. 8, 5, p. 550-568 19 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Radiation
DNA Damage
Radiotherapy
7 Citations (Scopus)

The multidrug-resistance transporter Abcc3 protects NK cells from chemotherapy in a murine model of malignant glioma

Pessina, S., Cantini, G., Kapetis, D., Cazzato, E., Di Ianni, N., Finocchiaro, G. & Pellegatta, S., Apr 18 2016, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

temozolomide
Multiple Drug Resistance
Glioma
Natural Killer Cells
Drug Therapy
2015
18 Citations (Scopus)

EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide

Cominelli, M., Grisanti, S., Mazzoleni, S., Branca, C., Buttolo, L., Furlan, D., Liserre, B., Bonetti, M. F., Medicina, D., Pellegrini, V., Buglione, M., Liserre, R., Pellegatta, S., Finocchiaro, G., Dalerba, P., Facchetti, F., Pizzi, M., Galli, R. & Poliani, P. L., May 1 2015, In : Journal of the National Cancer Institute. 107, 5, djv041.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Survival
Neoplastic Stem Cells
Methylation
8 Citations (Scopus)

Novel mechanisms and approaches in immunotherapy for brain tumors

Finocchiaro, G. & Pellegatta, S., 2015, In : Discovery medicine. 20, 108, p. 7-15 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Immunotherapy
Neoplasms
Glioma
Dendritic Cells
10 Citations (Scopus)
Glioblastoma
Immunotherapy
Dendritic Cells
Clinical Trials, Phase I
Mixed Lymphocyte Culture Test
2014
18 Citations (Scopus)

Perspectives for immunotherapy in glioblastoma treatment

Finocchiaro, G. & Pellegatta, S., 2014, In : Current Opinion in Oncology. 26, 6, p. 608-614 7 p.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
Dendritic Cells
Antigen Receptors
Vaccination
53 Citations (Scopus)

Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma

Favaro, R., Appolloni, I., Pellegatta, S., Sanga, A. B., Pagella, P., Gambini, E., Pisati, F., Ottolenghi, S., Foti, M., Finocchiaro, G., Malatesta, P. & Nicolis, S. K., Mar 15 2014, In : Cancer Research. 74, 6, p. 1833-1844 12 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Neoplastic Stem Cells
Neoplasms
Neural Stem Cells
Stem Cells
2013
35 Citations (Scopus)

DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT

Schneider, L., Pellegatta, S., Favaro, R., Pisati, F., Roncaglia, P., Testa, G., Nicolis, S. K., Finocchiaro, G. & D'Adda Di Fagagna, F., 2013, In : Stem Cell Reports. 1, 2, p. 123-138 16 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
DNA Damage
DNA
Adult Stem Cells
7 Citations (Scopus)

Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres

Patanè, M., Porrati, P., Bottega, E., Morosini, S., Cantini, G., Girgenti, V., Rizzo, A., Eoli, M., Pollo, B., Sciacca, F. L., Pellegatta, S. & Finocchiaro, G., Dec 11 2013, In : Molecular Cancer. 12, 1, 160.

Research output: Contribution to journalArticle

NF-kappa B
Gene Deletion
Glioblastoma
Epidermal Growth Factor Receptor
Epidermal Growth Factor
18 Citations (Scopus)
irinotecan
Endothelial cells
Glioblastoma
endothelial cells
Endothelial Cells
223 Citations (Scopus)

The integrated landscape of driver genomic alterations in glioblastoma

Frattini, V., Trifonov, V., Chan, J. M., Castano, A., Lia, M., Abate, F., Keir, S. T., Ji, A. X., Zoppoli, P., Niola, F., Danussi, C., Dolgalev, I., Porrati, P., Pellegatta, S., Heguy, A., Gupta, G., Pisapia, D. J., Canoll, P., Bruce, J. N., McLendon, R. E. & 9 others, Yan, H., Aldape, K., Finocchiaro, G., Mikkelsen, T., Privé, G. G., Bigner, D. D., Lasorella, A., Rabadan, R. & Iavarone, A., Oct 2013, In : Nature Genetics. 45, 10, p. 1141-1149 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Gene Fusion
Glioma
Mutation
Ubiquitin-Protein Ligases
2012
18 Citations (Scopus)
dendritic cells
Glioblastoma
Dendritic Cells
manufacturing
Vaccines
47 Citations (Scopus)

A Radial Glia Gene Marker, Fatty Acid Binding Protein 7 (FABP7), Is Involved in Proliferation and Invasion of Glioblastoma Cells

de Rosa, A., Pellegatta, S., Rossi, M., Tunici, P., Magnoni, L., Speranza, M. C., Malusa, F., Miragliotta, V., Mori, E., Finocchiaro, G. & Bakker, A., Dec 25 2012, In : PLoS One. 7, 12, e52113.

Research output: Contribution to journalArticle

fatty acid-binding proteins
Fatty Acid-Binding Proteins
cell invasion
Glioblastoma
Neuroglia
18 Citations (Scopus)

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration

Frattini, VJ. É., Pisati, F., Speranza, M. C., Poliani, P. L., Frigé, G., Cantini, G., Kapetis, D., Cominelli, M., Rossi, A., Finocchiaro, G. & Pellegatta, S., 2012, In : Oncotarget. 3, 10, p. 1146-1157 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasms
Regulatory T-Lymphocytes
Heterografts
Glioma
13 Citations (Scopus)

Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity

Cantini, G., Pisati, F., Pessina, S., Finocchiaro, G. & Pellegatta, S., 2012, In : OncoImmunology. 1, 6, p. 884-893 10 p.

Research output: Contribution to journalArticle

Autoimmunity
Glioma
Neuroglia
Immunotherapy
Natural Killer Cells
60 Citations (Scopus)

NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma

Speranza, M. C., Frattini, V., Pisati, F., Kapetis, D., Porrati, P., Eoli, M., Pellegatta, S. & Finocchiaro, G., Jul 2012, In : Oncotarget. 3, 7, p. 723-734 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Neoplasms
Disease-Free Survival
Brain
20 Citations (Scopus)

Rai is a new regulator of neural progenitor migration and glioblastoma invasion

Ortensi, B., Osti, D., Pellegatta, S., Pisati, F., Brescia, P., Fornasari, L., Levi, D., Gaetani, P., Colombo, P., Ferri, A., Nicolis, S., Finocchiaro, G. & Pelicci, G., May 2012, In : Stem Cells. 30, 5, p. 817-832 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Neoplastic Stem Cells
Shc Signaling Adaptor Proteins
Aptitude
84 Citations (Scopus)

The MET oncogene is a functional marker of a glioblastoma stem cell subtype

De Bacco, F., Casanova, E., Medico, E., Pellegatta, S., Orzan, F., Albano, R., Luraghi, P., Reato, G., D'Ambrosio, A., Porrati, P., Patanè, M., Maderna, E., Pollo, B., Comoglio, P. M., Finocchiaro, G. & Boccaccio, C., Sep 1 2012, In : Cancer Research. 72, 17, p. 4537-4550 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Oncogenes
Stem Cells
Neoplastic Stem Cells
Epidermal Growth Factor Receptor
363 Citations (Scopus)

Transforming fusions of FGFR and TACC genes in human glioblastoma

Singh, D., Chan, J. M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E. M., Reichel, J., Porrati, P., Pellegatta, S., Qiu, K., Gao, Z., Ceccarelli, M., Riccardi, R., Brat, D. J., Guha, A., Aldape, K., Golfinos, J. G., Zagzag, D., Mikkelsen, T. & 4 others, Finocchiaro, G., Lasorella, A., Rabadan, R. & Iavarone, A., Sep 7 2012, In : Science. 337, 6099, p. 1231-1235 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Glioblastoma
Genes
Phosphotransferases
Aneuploidy
2011
27 Citations (Scopus)

A critical role for regulatory T cells in driving cytokine profiles of Th17 cells and their modulation of glioma microenvironment

Cantini, G., Pisati, F., Mastropietro, A., Frattini, V., Iwakura, Y., Finocchiaro, G. & Pellegatta, S., Dec 2011, In : Cancer Immunology, Immunotherapy. 60, 12, p. 1739-1750 12 p.

Research output: Contribution to journalArticle

Th17 Cells
Regulatory T-Lymphocytes
Glioma
Interleukin-17
Cytokines
20 Citations (Scopus)

Brain cancer immunoediting: novel examples provided by immunotherapy of malignant gliomas.

Pellegatta, S., Cuppini, L. & Finocchiaro, G., Nov 2011, In : Expert Review of Anticancer Therapy. 11, 11, p. 1759-1774 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Brain Neoplasms
Glioma
Immunotherapy
Neoplasms
15 Citations (Scopus)

DNA microarray analysis identifies CKS2 and LEPR as potential markers of meningioma recurrence

Menghi, F., Orzan, F. N., Eoli, M., Farinotti, M., Maderna, E., Pisati, F., Bianchessi, D., Valletta, L., Lodrini, S., Galli, G., Anghileri, E., Pellegatta, S., Pollo, B. & Gaetano, F., 2011, In : The oncologist. 16, 10, p. 1440-1450 11 p.

Research output: Contribution to journalArticle

Leptin Receptors
Cyclin-Dependent Kinases
Meningioma
Microarray Analysis
Oligonucleotide Array Sequence Analysis
80 Citations (Scopus)

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells

Orzan, F., Pellegatta, S., Poliani, P. L., Pisati, F., Caldera, V., Menghi, F., Kapetis, D., Marras, C., Schiffer, D. & Finocchiaro, G., Jun 2011, In : Neuropathology and Applied Neurobiology. 37, 4, p. 381-394 14 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Glioma
Hydroxamic Acids
Histone Deacetylase Inhibitors
Stem Cells
26 Citations (Scopus)

Immunotherapy for glioma: Getting closer to the clinical arena?

Finocchiaro, G. & Pellegatta, S., Dec 2011, In : Current Opinion in Neurology. 24, 6, p. 641-647 7 p.

Research output: Contribution to journalArticle

Glioma
Immunotherapy
Glioblastoma
Brain Neoplasms
Dendritic Cells
2010
26 Citations (Scopus)

Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment

Pellegatta, S., Poliani, P. L., Stucchi, E., Corno, D., Colombo, C. A., Orzan, F., Ravanini, M. & Finocchiaro, G., Apr 2010, In : Neuro-Oncology. 12, 4, p. 377-388 12 p.

Research output: Contribution to journalArticle

Glioma
Dendritic Cells
Vaccination
Injections
Glioblastoma
2009
14 Citations (Scopus)

Dendritic cell vaccines for cancer stem cells.

Pellegatta, S. & Finocchiaro, G., 2009, In : Methods in molecular biology (Clifton, N.J.). 568, p. 233-247 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Dendritic Cells
Glioblastoma
Vaccines
Glioma
24 Citations (Scopus)

Reelin affects chain-migration and differentiation of neural precursor cells

Massalini, S., Pellegatta, S., Pisati, F., Finocchiaro, G., Farace, M. G. & Ciafrè, S. A., Nov 2009, In : Molecular and Cellular Neuroscience. 42, 4, p. 341-349 9 p.

Research output: Contribution to journalArticle

Emigration and Immigration
Glioma
Brain
Neurologic Mutant Mice
Neural Stem Cells
2007

Future perspectives for immunotherapy of malignant gliomas

Di Stefano, A. L., Pellegatta, S. & Finocchiaro, G., Dec 2007, In : Rivista Medica. 13, 4, p. 75-86 12 p.

Research output: Contribution to journalArticle

Glioma
Immunotherapy
Vaccination
Immunologic Memory
Active Immunotherapy
2006
21 Citations (Scopus)

Dendritic cells pulsed with glioma lysates induce immunity against syngeneic intracranial gliomas and increase survival of tumor-bearing mice

Pellegatta, S., Poliani, P. L., Corno, D., Grisoli, M., Cusimano, M., Ubiali, F., Baggi, F., Bruzzone, M. G. & Finocchiaro, G., Jul 2006, In : Neurological Research. 28, 5, p. 527-531 5 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Dendritic Cells
Immunity
Neoplasms
182 Citations (Scopus)

Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas

Pellegatta, S., Poliani, P. L., Corno, D., Menghi, F., Ghielmetti, F., Suarez-Merino, B., Caldera, V., Nava, S., Ravanini, M., Facchetti, F., Bruzzone, M. G. & Finocchiaro, G., Nov 1 2006, In : Cancer Research. 66, 21, p. 10247-10252 6 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Glioma
Dendritic Cells
Neoplasms
Immunotherapy
36 Citations (Scopus)

The therapeutic potential of neural stem/progenitor cells in murine globoid cell leukodystrophy is conditioned by macrophage/microglia activation

Pellegatta, S., Tunici, P., Poliani, P. L., Dolcetta, D., Cajola, L., Colombelli, C., Ciusani, E., Di Donato, S. & Finocchiaro, G., Feb 2006, In : Neurobiology of Disease. 21, 2, p. 314-323 10 p.

Research output: Contribution to journalArticle

Galactosylceramidase
Globoid Cell Leukodystrophy
Neural Stem Cells
Macrophage Activation
Microglia
2005
7 Citations (Scopus)

Cell therapies in neuro-oncology

Pellegatta, S. & Finocchiaro, G., May 2005, In : Neurological Sciences. 26, SUPPL. 1

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Dendritic Cells
Glioblastoma
Glioma
Immune System
2003
2 Citations (Scopus)

The potential of stem cells for the treatment of brain tumors and globoid cell leukodystrophy

Tunici, P., Pellegatta, S. & Finocchiaro, G., 2003, In : Cytotechnology. 41, 2-3, p. 93-101 9 p.

Research output: Contribution to journalArticle

Globoid Cell Leukodystrophy
Stem cells
Brain Neoplasms
Tumors
Brain
2002
8 Citations (Scopus)

Identification of a novel gp100/pMel17 peptide presented by HLA-A*6801 and recognized on human melanoma by cytolytic T cell clones

Sensi, M., Pellegatta, S., Vegetti, C., Nicolini, G., Parmiani, G. & Anichini, A., 2002, In : Tissue Antigens. 59, 4, p. 273-279 7 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
T-cells
HLA Antigens
Melanoma
Clone Cells