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2019
Open Access

Altered function of the glutamate–aspartate transporter GLAST, a potential therapeutic target in glioblastoma

Corbetta, C., Di Ianni, N., Bruzzone, M. G., Patanè, M., Pollo, B., Cantini, G., Cominelli, M., Zucca, I., Pisati, F., Poliani, P. L., Finocchiaro, G. & Pellegatta, S., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

2018

Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy

Pellegatta, S., Savoldo, B., Di Ianni, N., Corbetta, C., Chen, Y., Patané, M., Sun, C., Pollo, B., Ferrone, S., DiMeco, F., Finocchiaro, G. & Dotti, G., Feb 28 2018, In : Science Translational Medicine. 10, 430, eaao2731.

Research output: Contribution to journalArticle

2017

ER–mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem-like cells

Bassoy, E. Y., Kasahara, A., Chiusolo, V., Jacquemin, G., Boydell, E., Zamorano, S., Riccadonna, C., Pellegatta, S., Hulo, N., Dutoit, V., Derouazi, M., Dietrich, P. Y., Walker, P. R. & Martinvalet, D., Jun 1 2017, In : EMBO Journal. 36, 11, p. 1493-1512 20 p.

Research output: Contribution to journalArticle

Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor

Orzan, F., De Bacco, F., Crisafulli, G., Pellegatta, S., Mussolin, B., Siravegna, G., D'Ambrosio, A., Comoglio, P. M., Finocchiaro, G. & Boccaccio, C., Nov 1 2017, In : Stem Cells. 35, 11, p. 2218-2228 11 p.

Research output: Contribution to journalArticle

Hypermutations in gliomas: A potential immunotherapy target

Finocchiaro, G., Langella, T., Corbetta, C. & Pellegatta, S., Jan 1 2017, In : Discovery medicine. 23, 125, p. 113-120 8 p.

Research output: Contribution to journalArticle

2016

Decitabine treatment of glioma-initiating cells enhances immune recognition and killing

Riccadonna, C., Yacoub Maroun, C., Vuillefroy De Silly, R., Boehler, M., Calvo Tardón, M., Jueliger, S., Taverna, P., Barba, L., Marinari, E., Pellegatta, S., Bassoy, E. Y., Martinvalet, D., Dietrich, P. Y. & Walker, P. R., Aug 1 2016, In : PLoS One. 11, 8, e0162105.

Research output: Contribution to journalArticle

MET inhibition overcomes radiation resistance of glioblastoma stem-like cells

De Bacco, F., D'Ambrosio, A., Casanova, E., Orzan, F., Neggia, R., Albano, R., Verginelli, F., Cominelli, M., Poliani, P. L., Luraghi, P., Reato, G., Pellegatta, S., Finocchiaro, G., Perera, T., Garibaldi, E., Gabriele, P., Comoglio, P. M. & Boccaccio, C., May 1 2016, In : EMBO Molecular Medicine. 8, 5, p. 550-568 19 p.

Research output: Contribution to journalArticle

MET inhibition overcomes radiation resistance of glioblastoma stem-like cells

De Bacco, F., D'Ambrosio, A., Casanova, E., Orzan, F., Neggia, R., Albano, R., Verginelli, F., Cominelli, M., Poliani, P. L., Luraghi, P., Reato, G., Pellegatta, S., Finocchiaro, G., Perera, T., Garibaldi, E., Gabriele, P., Comoglio, P. M. & Boccaccio, C., May 1 2016, In : EMBO Molecular Medicine. 8, 5, p. 550-568 19 p.

Research output: Contribution to journalArticle

The multidrug-resistance transporter Abcc3 protects NK cells from chemotherapy in a murine model of malignant glioma

Pessina, S., Cantini, G., Kapetis, D., Cazzato, E., Di Ianni, N., Finocchiaro, G. & Pellegatta, S., Apr 18 2016, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

2015

EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide

Cominelli, M., Grisanti, S., Mazzoleni, S., Branca, C., Buttolo, L., Furlan, D., Liserre, B., Bonetti, M. F., Medicina, D., Pellegrini, V., Buglione, M., Liserre, R., Pellegatta, S., Finocchiaro, G., Dalerba, P., Facchetti, F., Pizzi, M., Galli, R. & Poliani, P. L., May 1 2015, In : Journal of the National Cancer Institute. 107, 5, djv041.

Research output: Contribution to journalArticle

Novel mechanisms and approaches in immunotherapy for brain tumors

Finocchiaro, G. & Pellegatta, S., 2015, In : Discovery medicine. 20, 108, p. 7-15 9 p.

Research output: Contribution to journalArticle

2014

Perspectives for immunotherapy in glioblastoma treatment

Finocchiaro, G. & Pellegatta, S., 2014, In : Current Opinion in Oncology. 26, 6, p. 608-614 7 p.

Research output: Contribution to journalArticle

Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma

Favaro, R., Appolloni, I., Pellegatta, S., Sanga, A. B., Pagella, P., Gambini, E., Pisati, F., Ottolenghi, S., Foti, M., Finocchiaro, G., Malatesta, P. & Nicolis, S. K., Mar 15 2014, In : Cancer Research. 74, 6, p. 1833-1844 12 p.

Research output: Contribution to journalArticle

2013

DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT

Schneider, L., Pellegatta, S., Favaro, R., Pisati, F., Roncaglia, P., Testa, G., Nicolis, S. K., Finocchiaro, G. & D'Adda Di Fagagna, F., 2013, In : Stem Cell Reports. 1, 2, p. 123-138 16 p.

Research output: Contribution to journalArticle

Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres

Patanè, M., Porrati, P., Bottega, E., Morosini, S., Cantini, G., Girgenti, V., Rizzo, A., Eoli, M., Pollo, B., Sciacca, F. L., Pellegatta, S. & Finocchiaro, G., Dec 11 2013, In : Molecular Cancer. 12, 1, 160.

Research output: Contribution to journalArticle

The integrated landscape of driver genomic alterations in glioblastoma

Frattini, V., Trifonov, V., Chan, J. M., Castano, A., Lia, M., Abate, F., Keir, S. T., Ji, A. X., Zoppoli, P., Niola, F., Danussi, C., Dolgalev, I., Porrati, P., Pellegatta, S., Heguy, A., Gupta, G., Pisapia, D. J., Canoll, P., Bruce, J. N., McLendon, R. E. & 9 others, Yan, H., Aldape, K., Finocchiaro, G., Mikkelsen, T., Privé, G. G., Bigner, D. D., Lasorella, A., Rabadan, R. & Iavarone, A., Oct 2013, In : Nature Genetics. 45, 10, p. 1141-1149 9 p.

Research output: Contribution to journalArticle

2012

A Radial Glia Gene Marker, Fatty Acid Binding Protein 7 (FABP7), Is Involved in Proliferation and Invasion of Glioblastoma Cells

de Rosa, A., Pellegatta, S., Rossi, M., Tunici, P., Magnoni, L., Speranza, M. C., Malusa, F., Miragliotta, V., Mori, E., Finocchiaro, G. & Bakker, A., Dec 25 2012, In : PLoS One. 7, 12, e52113.

Research output: Contribution to journalArticle

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration

Frattini, VJ. É., Pisati, F., Speranza, M. C., Poliani, P. L., Frigé, G., Cantini, G., Kapetis, D., Cominelli, M., Rossi, A., Finocchiaro, G. & Pellegatta, S., 2012, In : Oncotarget. 3, 10, p. 1146-1157 12 p.

Research output: Contribution to journalArticle

Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity

Cantini, G., Pisati, F., Pessina, S., Finocchiaro, G. & Pellegatta, S., 2012, In : OncoImmunology. 1, 6, p. 884-893 10 p.

Research output: Contribution to journalArticle

NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma

Speranza, M. C., Frattini, V., Pisati, F., Kapetis, D., Porrati, P., Eoli, M., Pellegatta, S. & Finocchiaro, G., Jul 2012, In : Oncotarget. 3, 7, p. 723-734 12 p.

Research output: Contribution to journalArticle

Rai is a new regulator of neural progenitor migration and glioblastoma invasion

Ortensi, B., Osti, D., Pellegatta, S., Pisati, F., Brescia, P., Fornasari, L., Levi, D., Gaetani, P., Colombo, P., Ferri, A., Nicolis, S., Finocchiaro, G. & Pelicci, G., May 2012, In : Stem Cells. 30, 5, p. 817-832 16 p.

Research output: Contribution to journalArticle

The MET oncogene is a functional marker of a glioblastoma stem cell subtype

De Bacco, F., Casanova, E., Medico, E., Pellegatta, S., Orzan, F., Albano, R., Luraghi, P., Reato, G., D'Ambrosio, A., Porrati, P., Patanè, M., Maderna, E., Pollo, B., Comoglio, P. M., Finocchiaro, G. & Boccaccio, C., Sep 1 2012, In : Cancer Research. 72, 17, p. 4537-4550 14 p.

Research output: Contribution to journalArticle

Transforming fusions of FGFR and TACC genes in human glioblastoma

Singh, D., Chan, J. M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E. M., Reichel, J., Porrati, P., Pellegatta, S., Qiu, K., Gao, Z., Ceccarelli, M., Riccardi, R., Brat, D. J., Guha, A., Aldape, K., Golfinos, J. G., Zagzag, D., Mikkelsen, T. & 4 others, Finocchiaro, G., Lasorella, A., Rabadan, R. & Iavarone, A., Sep 7 2012, In : Science. 337, 6099, p. 1231-1235 5 p.

Research output: Contribution to journalArticle

2011

A critical role for regulatory T cells in driving cytokine profiles of Th17 cells and their modulation of glioma microenvironment

Cantini, G., Pisati, F., Mastropietro, A., Frattini, V., Iwakura, Y., Finocchiaro, G. & Pellegatta, S., Dec 2011, In : Cancer Immunology, Immunotherapy. 60, 12, p. 1739-1750 12 p.

Research output: Contribution to journalArticle

Brain cancer immunoediting: novel examples provided by immunotherapy of malignant gliomas.

Pellegatta, S., Cuppini, L. & Finocchiaro, G., Nov 2011, In : Expert Review of Anticancer Therapy. 11, 11, p. 1759-1774 16 p.

Research output: Contribution to journalArticle

DNA microarray analysis identifies CKS2 and LEPR as potential markers of meningioma recurrence

Menghi, F., Orzan, F. N., Eoli, M., Farinotti, M., Maderna, E., Pisati, F., Bianchessi, D., Valletta, L., Lodrini, S., Galli, G., Anghileri, E., Pellegatta, S., Pollo, B. & Gaetano, F., 2011, In : The oncologist. 16, 10, p. 1440-1450 11 p.

Research output: Contribution to journalArticle

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells

Orzan, F., Pellegatta, S., Poliani, P. L., Pisati, F., Caldera, V., Menghi, F., Kapetis, D., Marras, C., Schiffer, D. & Finocchiaro, G., Jun 2011, In : Neuropathology and Applied Neurobiology. 37, 4, p. 381-394 14 p.

Research output: Contribution to journalArticle

Immunotherapy for glioma: Getting closer to the clinical arena?

Finocchiaro, G. & Pellegatta, S., Dec 2011, In : Current Opinion in Neurology. 24, 6, p. 641-647 7 p.

Research output: Contribution to journalArticle

2010

Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment

Pellegatta, S., Poliani, P. L., Stucchi, E., Corno, D., Colombo, C. A., Orzan, F., Ravanini, M. & Finocchiaro, G., Apr 2010, In : Neuro-Oncology. 12, 4, p. 377-388 12 p.

Research output: Contribution to journalArticle

2009

Dendritic cell vaccines for cancer stem cells.

Pellegatta, S. & Finocchiaro, G., 2009, In : Methods in molecular biology (Clifton, N.J.). 568, p. 233-247 15 p.

Research output: Contribution to journalArticle

Reelin affects chain-migration and differentiation of neural precursor cells

Massalini, S., Pellegatta, S., Pisati, F., Finocchiaro, G., Farace, M. G. & Ciafrè, S. A., Nov 2009, In : Molecular and Cellular Neuroscience. 42, 4, p. 341-349 9 p.

Research output: Contribution to journalArticle

2007

Future perspectives for immunotherapy of malignant gliomas

Di Stefano, A. L., Pellegatta, S. & Finocchiaro, G., Dec 2007, In : Rivista Medica. 13, 4, p. 75-86 12 p.

Research output: Contribution to journalArticle

2006

Dendritic cells pulsed with glioma lysates induce immunity against syngeneic intracranial gliomas and increase survival of tumor-bearing mice

Pellegatta, S., Poliani, P. L., Corno, D., Grisoli, M., Cusimano, M., Ubiali, F., Baggi, F., Bruzzone, M. G. & Finocchiaro, G., Jul 2006, In : Neurological Research. 28, 5, p. 527-531 5 p.

Research output: Contribution to journalArticle

Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas

Pellegatta, S., Poliani, P. L., Corno, D., Menghi, F., Ghielmetti, F., Suarez-Merino, B., Caldera, V., Nava, S., Ravanini, M., Facchetti, F., Bruzzone, M. G. & Finocchiaro, G., Nov 1 2006, In : Cancer Research. 66, 21, p. 10247-10252 6 p.

Research output: Contribution to journalArticle

The therapeutic potential of neural stem/progenitor cells in murine globoid cell leukodystrophy is conditioned by macrophage/microglia activation

Pellegatta, S., Tunici, P., Poliani, P. L., Dolcetta, D., Cajola, L., Colombelli, C., Ciusani, E., Di Donato, S. & Finocchiaro, G., Feb 2006, In : Neurobiology of Disease. 21, 2, p. 314-323 10 p.

Research output: Contribution to journalArticle

2005

Cell therapies in neuro-oncology

Pellegatta, S. & Finocchiaro, G., May 2005, In : Neurological Sciences. 26, SUPPL. 1

Research output: Contribution to journalArticle

2003

The potential of stem cells for the treatment of brain tumors and globoid cell leukodystrophy

Tunici, P., Pellegatta, S. & Finocchiaro, G., 2003, In : Cytotechnology. 41, 2-3, p. 93-101 9 p.

Research output: Contribution to journalArticle

2002

Identification of a novel gp100/pMel17 peptide presented by HLA-A*6801 and recognized on human melanoma by cytolytic T cell clones

Sensi, M., Pellegatta, S., Vegetti, C., Nicolini, G., Parmiani, G. & Anichini, A., 2002, In : Tissue Antigens. 59, 4, p. 273-279 7 p.

Research output: Contribution to journalArticle