1993 …2019

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2019

1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

D'Alessandro, G., Quaglio, D., Monaco, L., Lauro, C., Ghirga, F., Ingallina, C., De Martino, M., Fucile, S., Porzia, A., Di Castro, M. A., Bellato, F., Mastrotto, F., Mori, M., Infante, P., Turano, P., Salmaso, S., Caliceti, P., Di Marcotullio, L., Botta, B., Ghini, V. & 1 others, Limatola, C., Aug 28 2019, In : Cell Communication and Signaling. 17, 1, p. 108

Research output: Contribution to journalArticle

Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors

Imbriglio, T., Verhaeghe, R., Martinello, K., Pascarelli, M. T., Chece, G., Bucci, D., Notartomaso, S., Quattromani, M., Mascio, G., Scalabrì, F., Simeone, A., Maccari, S., Del Percio, C., Wieloch, T., Fucile, S., Babiloni, C., Battaglia, G., Limatola, C., Nicoletti, F. & Cannella, M., Dec 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 14204-14220 17 p.

Research output: Contribution to journalArticle

Extracellular mild acidosis decreases the Ca2+ permeability of the human NMDA receptors

Plutino, S., Sciaccaluga, M. & Fucile, S., Jun 2019, In : Cell Calcium. 80, p. 63-70 8 p.

Research output: Contribution to journalArticle

Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors

Murineddu, G., Gotti, C., Asproni, B., Corona, P., Martinello, K., Plutino, S., Fucile, S., Temml, V., Moretti, M., Viani, P., Schuster, D., Piras, S., Deligia, F. & Pinna, G. A., Jul 5 2019, In : European Journal of Medicinal Chemistry. 180, p. 51-61 11 p.

Research output: Contribution to journalArticle

2018

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α4β2 nACh receptors

Deligia, F., Murineddu, G., Gotti, C., Ragusa, G., Fasoli, F., Sciaccaluga, M., Plutino, S., Fucile, S., Loriga, G., Asproni, B. & Pinna, G. A., May 25 2018, In : European Journal of Medicinal Chemistry. 152, p. 401-416 16 p.

Research output: Contribution to journalArticle

The fifth subunit in a3b4 nicotinic receptor is more than an accessory subunit

Crespi, A., Plutino, S., Sciaccaluga, M., Righi, M., Borgese, N., Fucile, S., Gotti, C. & Colombo, S. F., Aug 1 2018, In : FASEB Journal. 32, 8, p. 4190-4202 13 p.

Research output: Contribution to journalArticle

2017

From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor

Bolchi, C., Bavo, F., Gotti, C., Fumagalli, L., Fasoli, F., Binda, M., Mucchietto, V., Sciaccaluga, M., Plutino, S., Fucile, S. & Pallavicini, M., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism

Spinelli, C. C., Carrizzo, A., Ferrario, A., Villa, F., Damato, A., Ambrosio, M., Madonna, M., Frati, G., Fucile, S., Sciaccaluga, M., Capunzo, M., Calì, G., Milanesi, L., Maciag, A., Puca, A. A. & Vecchione, C., 2017, In : Cardiovascular Research. 113, 7, p. 795-804 10 p.

Research output: Contribution to journalArticle

LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism

Spinelli, C. C., Carrizzo, A., Ferrario, A., Villa, F., Damato, A., Ambrosio, M., Madonna, M., Frati, G., Fucile, S., Sciaccaluga, M., Capunzo, M., Calì, G., Milanesi, L., Maciag, A., Puca, A. A. & Vecchione, C., Jan 1 2017, In : Cardiovascular Research. 113, 7, p. 795-804 10 p.

Research output: Contribution to journalArticle

2016

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors

Notartomaso, S., Mascio, G., Scarselli, P., Martinello, K., Fucile, S., Gradini, R., Bruno, V., Battaglia, G. & Nicoletti, F., Mar 30 2016, (Accepted/In press) In : Neuropharmacology.

Research output: Contribution to journalArticle

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype

Matera, C., Quadri, M., Sciaccaluga, M., Pomè, D. Y., Fasoli, F., De Amici, M., Fucile, S., Gotti, C., Dallanoce, C. & Grazioso, G., Jan 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 392-405 14 p.

Research output: Contribution to journalArticle

2015

Bifunctional compounds targeting both D2and non-α7 nACh receptors: Design, synthesis and pharmacological characterization

Matera, C., Pucci, L., Fiorentini, C., Fucile, S., Missale, C., Grazioso, G., Clementi, F., Zoli, M., De Amici, M., Gotti, C. & Dallanoce, C., Jul 10 2015, In : European Journal of Medicinal Chemistry. 101, p. 367-383 17 p.

Research output: Contribution to journalArticle

Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists

Bolchi, C., Valoti, E., Gotti, C., Fasoli, F., Ruggeri, P., Fumagalli, L., Binda, M., Mucchietto, V., Sciaccaluga, M., Budriesi, R., Fucile, S. & Pallavicini, M., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6665-6677 13 p.

Research output: Contribution to journalArticle

Crucial role of nicotinic α5 subunit variants for Ca2+ fluxes in ventral midbrain neurons

Sciaccaluga, M., Moriconi, C., Martinello, K., Catalano, M., Bermudez, I., Stitzel, J. A., Maskos, U. & Fucile, S., Aug 1 2015, In : FASEB Journal. 29, 8, p. 3389-3398 10 p.

Research output: Contribution to journalArticle

Genetic analysis reveals a longevity-associated protein modulating endothelial function and angiogenesis

Villa, F., Carrizzo, A., Spinelli, C. C., Ferrario, A., Malovini, A., Maciąg, A., Damato, A., Auricchio, A., Spinetti, G., Sangalli, E., Dang, Z., Madonna, M., Ambrosio, M., Sitia, L., Bigini, P., Calì, G., Schreiber, S., Perls, T., Fucile, S., Mulas, F. & 5 others, Nebel, A., Bellazzi, R., Madeddu, P., Vecchione, C. & Puca, A. A., Jul 1 2015, In : Circulation Research. 117, 4, p. 333-345 13 p.

Research output: Contribution to journalArticle

2014

Fluoxetine prevents acetylcholine-induced excitotoxicity blocking human endplate acetylcholine receptor

Deflorio, C., Catalano, M., Fucile, S., Limatola, C. & Grassi, F., Jan 2014, In : Muscle and Nerve. 49, 1, p. 90-97 8 p.

Research output: Contribution to journalArticle

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of huntington disease

Di Pardo, A., Amico, E., Favellato, M., Castrataro, R., Fucile, S., Squitieri, F. & Maglione, V., 2014, In : Human Molecular Genetics. 23, 9, p. 2251-2265 15 p.

Research output: Contribution to journalArticle

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase

Diógenes, M. J., Neves-Tomé, R., Fucile, S., Martinello, K., Scianni, M., Theofilas, P., Lopatář, J., Ribeiro, J. A., Maggi, L., Frenguelli, B. G., Limatola, C., Boison, D. & Sebastião, A. M., Jan 2014, In : Cerebral Cortex. 24, 1, p. 67-80 14 p.

Research output: Contribution to journalArticle

2013

CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation

Sala, M., Braida, D., Pucci, L., Manfredi, I., Marks, M. J., Wageman, C. R., Grady, S. R., Loi, B., Fucile, S., Fasoli, F., Zoli, M., Tasso, B., Sparatore, F., Clementi, F. & Gotti, C., Feb 2013, In : British Journal of Pharmacology. 168, 4, p. 835-849 15 p.

Research output: Contribution to journalArticle

Fractalkine/CX3CL1 modulates GABAA currents in human temporal lobe epilepsy

Roseti, C., Fucile, S., Lauro, C., Martinello, K., Bertollini, C., Esposito, V., Mascia, A., Catalano, M., Aronica, E., Limatola, C. & Palma, E., Oct 2013, In : Epilepsia. 54, 10, p. 1834-1844 11 p.

Research output: Contribution to journalArticle

Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: A computational and experimental study using epibatidine-related molecular probes

Dallanoce, C., Grazioso, G., Pomè, D. Y., Sciaccaluga, M., Matera, C., Gotti, C., Fucile, S. & De Amici, M., Nov 2013, In : Journal of Computer-Aided Molecular Design. 27, 11, p. 975-987 13 p.

Research output: Contribution to journalArticle

2012

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism

Carnevale, D., Vecchione, C., Mascio, G., Esposito, G., Cifelli, G., Martinello, K., Landolfi, A., Selvetella, G., Grieco, P., Damato, A., Franco, E., Haase, H., Maffei, A., Ciraolo, E., Fucile, S., Frati, G., Mazzoni, O., Hirsch, E. & Lembo, G., Jan 1 2012, In : Cardiovascular Research. 93, 1, p. 200-209 10 p.

Research output: Contribution to journalArticle

2011

Acute and chronic effects of hypercalcaemia on cortical excitability as studied by 5 Hz repetitive transcranial magnetic stimulation

Iacovelli, E., Gilio, F., Mascia, M. L., Scillitani, A., Romagnoli, E., Pichiorri, F., Fucile, S., Minisola, S. & Inghilleri, M., Apr 2011, In : Journal of Physiology. 589, 7, p. 1619-1626 8 p.

Research output: Contribution to journalArticle

Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-Isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors

Dallanoce, C., Magrone, P., Matera, C., Frigerio, F., Grazioso, G., DeAmici, M., Fucile, S., Piccari, V., Frydenvang, K., Pucci, L., Gotti, C., Clementi, F. & DeMicheli, C., May 2 2011, In : ChemMedChem. 6, 5, p. 889-903 15 p.

Research output: Contribution to journalArticle

Modulation of the Ca2+ permeability of human endplate acetylcholine receptor-channel

Piccari, V., Deflorio, C., Bigi, R., Grassi, F. & Fucile, S., Apr 2011, In : Cell Calcium. 49, 4, p. 272-278 7 p.

Research output: Contribution to journalArticle

New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors

Dallanoce, C., Frigerio, F., Grazioso, G., Matera, C., Visconti, G. L., De Amici, M., Pucci, L., Pistillo, F., Fucile, S., Gotti, C., Clementi, F. & De Micheli, C., Dec 2011, In : European Journal of Medicinal Chemistry. 46, 12, p. 5790-5799 10 p.

Research output: Contribution to journalArticle

2010

Enhancement of GABAA-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy

Mazzuferi, M., Palma, E., Martinello, K., Maiolino, F., Roseti, C., Fucile, S., Fabene, P. F., Schio, F., Pellitteri, M., Sperk, G., Miledi, R., Eusebi, F. & Simonato, M., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3180-3185 6 p.

Research output: Contribution to journalArticle

Mechanism of verapamil action on wild-type and slow-channel mutant human muscle acetylcholine receptor

Moriconi, C., Di Castro, M. A., Fucile, S., Eusebi, F. & Grassi, F., 2010, In : Journal of Neurochemistry. 114, 4, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

2009

About a new method to measure fractional Ca2+ currents through ligand-gated ion channels

Fucile, S. & Grassi, F., Sep 2009, In : Journal of General Physiology. 134, 3, p. 259-261 3 p.

Research output: Contribution to journalArticle

Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABAA receptors microtransplanted to Xenopus oocytes

Roseti, C., Palma, E., Martinello, K., Fucile, S., Morace, R., Esposito, V., Cantore, G., Arcella, A., Giangaspero, F., Aronica, E., Mascia, A., Di Gennaro, G., Quarato, P. P., Manfredi, M., Cristalli, G., Lambertucci, C., Marucci, G., Volpini, R., Limatola, C. & Eusebi, F., Sep 15 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 37, p. 15927-15931 5 p.

Research output: Contribution to journalArticle

Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis

Sabatelli, M., Eusebi, F., Al-Chalabi, A., Conte, A., Madia, F., Luigetti, M., Mancuso, I., Limatola, C., Trettel, F., Sobrero, F., Di Angelantonio, S., Grassi, F., Di Castro, A., Moriconi, C., Fucile, S., Lattante, S., Marangi, G., Murdolo, M., Orteschi, D., Del Grande, A. & 3 others, Tonali, P., Neri, G. & Zollino, M., 2009, In : Human Molecular Genetics. 18, 20, p. 3997-4006 10 p.

Research output: Contribution to journalArticle

2008

Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors

Roseti, C., Martinello, K., Fucile, S., Piccari, V., Mascia, A., Di Gennaro, G., Quarato, P. P., Manfredi, M., Esposito, V., Cantore, G., Arcella, A., Simonato, M., Fredholm, B. B., Limatola, C., Miledi, R. & Eusebi, F., Sep 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 39, p. 15118-15123 6 p.

Research output: Contribution to journalArticle

Functional properties of cells obtained from human cord blood CD34 + stem cells and mouse cardiac myocytes in coculture

Orlandi, A., Pagani, F., Avitabile, D., Bonanno, G., Scambia, G., Vigna, E., Grassi, F., Eusebi, F., Fucile, S., Pesce, M. & Capogrossi, M. C., Apr 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 4

Research output: Contribution to journalArticle

GABAergic drugs become neurotoxic in cortical neurons pre-exposed to brain-derived neurotrophic factor

Molinaro, G., Battaglia, G., Riozzi, B., Storto, M., Fucile, S., Eusebi, F., Nicoletti, F. & Bruno, V., Feb 2008, In : Molecular and Cellular Neuroscience. 37, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

2007

GABAA-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABAA "phasic" receptors

Palma, E., Roseti, C., Maiolino, F., Fucile, S., Martinello, K., Mazzuferi, M., Aronica, E., Manfredi, M., Esposito, V., Cantore, G., Miledi, R., Simonato, M. & Eusebi, F., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20944-20948 5 p.

Research output: Contribution to journalArticle

2006

Ca2+ permeability through rat cloned α9-containing nicotinic acetylcholine receptors

Fucile, S., Sucapane, A. & Eusebi, F., Apr 2006, In : Cell Calcium. 39, 4, p. 349-355 7 p.

Research output: Contribution to journalArticle

Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress

Fasanaro, P., Magenta, A., Zaccagnini, G., Cicchillitti, L., Fucile, S., Eusebi, F., Biglioli, P., Capogrossi, M. C. & Martelli, F., Jun 2006, In : FASEB Journal. 20, 8

Research output: Contribution to journalArticle

Effects of cyclothiazide on GluR1/AMPA receptors

Fucile, S., Miledi, R. & Eusebi, F., Feb 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 8, p. 2943-2947 5 p.

Research output: Contribution to journalArticle

Functional properties of neurons derived from fetal mouse neurospheres are compatible with those of neuronal precursors in vivo

Pagani, F., Lauro, C., Fucile, S., Catalano, M., Limatola, C., Eusebi, F. & Grassi, F., Jun 2006, In : Journal of Neuroscience Research. 83, 8, p. 1494-1501 8 p.

Research output: Contribution to journalArticle

The human adult subtype ACh receptor channel has high Ca2+ permeability and predisposes to endplate Ca2+

Fucile, S., Sucapane, A., Grassi, F., Eusebi, F. & Engel, A. G., May 15 2006, In : Journal of Physiology. 573, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

2005

Ca2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neurones

Fucile, S., Sucapane, A. & Eusebi, F., May 15 2005, In : Journal of Physiology. 565, 1, p. 219-228 10 p.

Research output: Contribution to journalArticle

Cysteine residues are critical for chemokine receptor CXCR2 functional properties

Limatola, C., Di Bartolomeo, S., Catalano, M., Trettel, F., Fucile, S., Castellani, L. & Eusebi, F., Jul 1 2005, In : Experimental Cell Research. 307, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

Electrophysiological properties of mouse bone marrow c-kit+ cells co-cultured onto neonatal cardiac myocytes

Lagostena, L., Avitabile, D., De Falco, E., Orlandi, A., Grassi, F., Iachininoto, M. G., Ragone, G., Fucile, S., Pompilio, G., Eusebi, F., Pesce, M. & Capogrossi, M. C., Jun 1 2005, In : Cardiovascular Research. 66, 3, p. 482-492 11 p.

Research output: Contribution to journalArticle

2004

Ca2+ permeability of nicotinic acetylcholine receptors

Fucile, S., Jan 2004, In : Cell Calcium. 35, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Nicotinic cholinergic stimulation promotes survival and reduces motility of cultured rat cerebellar granule cells

Fucile, S., Renzi, M., Lauro, C., Limatola, C., Ciotti, T. & Eusebi, F., 2004, In : Neuroscience. 127, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

2003

Fractional Ca2+ current through human neuronal α7 nicotinic acetylcholine receptors

Fucile, S., Renzi, M., Lax, P. & Eusebi, F., Aug 1 2003, In : Cell Calcium. 34, 2, p. 205-209 5 p.

Research output: Contribution to journalArticle

2002

Ca2+ permeability of human heteromeric nAChRs expressed by transfection in human cells

Lax, P., Fucile, S. & Eusebi, F., Aug 2002, In : Cell Calcium. 32, 2, p. 53-58 6 p.

Research output: Contribution to journalArticle