• 987 Citations
  • 17 h-Index
20012018
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Research Output 2001 2018

  • 987 Citations
  • 17 h-Index
  • 29 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
2018
5 Citations (Scopus)
Interleukin-23
Ulcerative Colitis
Th17 Cells
Interleukin-12 Subunit p40
Drug and Narcotic Control
15 Citations (Scopus)

TREM-1 inhibition restores impaired autophagy activity and reduces colitis in mice

Kökten, T., Gibot, S., Gibot, S., Lepage, P., D'Alessio, S., D'Alessio, S., Hablot, J., Ndiaye, N. C., Busby-Venner, H., Monot, C., Garnier, B., Moulin, D., Jouzeau, J. Y., Hansmannel, F., Danese, S., Danese, S., Guéant, J. L., Muller, S., Peyrin-Birouleta, L. & Peyrin-Birouleta, L., Jan 24 2018, In : Journal of Crohn's and Colitis. 12, 2, p. 230-244 15 p.

Research output: Contribution to journalArticle

Autophagy
Myeloid Cells
Colitis
Unfolded Protein Response
Dysbiosis
2017
12 Citations (Scopus)
Inflammation Mediators
Inflammatory Bowel Diseases
Unsaturated Fatty Acids
Lipids
Inflammation
12 Citations (Scopus)

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Van Welden, S., De Vos, M., Wielockx, B., Tavernier, S. J., Dullaers, M., Neyt, S., Descamps, B., Devisscher, L., Devriese, S., Van den Bossche, L., Holvoet, T., Baeyens, A., Correale, C., D'Alessio, S., Vanhove, C., De Vos, F., Verhasselt, B., Breier, G., Lambrecht, B. N., Janssens, S. & 5 others, Carmeliet, P., Danese, S., Elewaut, D., Laukens, D. & Hindryckx, P., Mar 1 2017, In : Journal of Pathology. 241, 4, p. 547-558 12 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Colitis
Macrophages
Dextran Sulfate
Lipopolysaccharides
15 Citations (Scopus)

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice

Ungaro, F., Tacconi, C., Massimino, L., Corsetto, P. A., Correale, C., Fonteyne, P., Piontini, A., Garzarelli, V., Calcaterra, F., Della Bella, S., Spinelli, A., Carvello, M., Rizzo, A. M., Vetrano, S., Petti, L., Fiorino, G., Furfaro, F., Mavilio, D., Maddipati, K. R., Malesci, A. & 3 others, Peyrin-Biroulet, L., D'Alessio, S. & Danese, S., Nov 1 2017, In : Gastroenterology. 153, 5, p. 1363-1377.e6

Research output: Contribution to journalArticle

Colitis
Docosahexaenoic Acids
Ulcerative Colitis
Inflammation
Lipids
15 Citations (Scopus)

PDE4 inhibition and inflammatory bowel disease: A novel therapeutic avenue

Spadaccini, M., D’Alessio, S., Peyrin-Biroulet, L. & Danese, S., Jun 15 2017, In : International Journal of Molecular Sciences. 18, 6, p. 1276 1 p.

Research output: Contribution to journalReview article

Type 4 Cyclic Nucleotide Phosphodiesterase
Inflammatory Bowel Diseases
Phosphodiesterase 4 Inhibitors
Psoriatic Arthritis
arthritis
2016
1 Citation (Scopus)

Beyond Intestinal Barrier: The Blood Endothelium as a Second Wall of Defense Against Bacterial Invasion

Ungaro, F., Tacconi, C. & D'Alessio, S., Jun 1 2016, In : Gastroenterology. 150, 7, p. 1678-1680 3 p.

Research output: Contribution to journalComment/debate

17 Citations (Scopus)

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes

Alfano, M., Cinque, P., Giusti, G., Proietti, S., Nebuloni, M., Danese, S., D'Alessio, S., Genua, M., Portale, F., Lo Porto, M., Singhal, P. C., Rastaldi, M. P., Saleem, M. A., Mavilio, D. & Mikulak, J., Sep 18 2015, In : Scientific Reports. 5, 13647.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Podocytes
Wilms Tumor
Integrins
Hantavirus Infections
79 Citations (Scopus)

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine

Sala, E., Genua, M., Petti, L., Anselmo, A., Arena, V., Cibella, J., Zanotti, L., D'Alessio, S., Scaldaferri, F., Luca, G., Arato, I., Calafiore, R., Sgambato, A., Rutella, S., Locati, M., Danese, S. & Vetrano, S., Jul 1 2015, In : Gastroenterology. 149, 1, p. 163-176 14 p., 59674.

Research output: Contribution to journalArticle

Colitis
Mesenchymal Stromal Cells
Intestines
Inflammation
Interleukin-10
1 Citation (Scopus)

Targeting lymphatics in inflammatory bowel disease

D'Alessio, S., Tacconi, C. & Danese, S., 2015, In : Oncotarget. 6, 33, p. 34047-34048 2 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

Genua, M., D'Alessio, S., Cibella, J., Gandelli, A., Sala, E., Correale, C., Spinelli, A., Arena, V., Malesci, A., Rutella, S., Ploplis, V. A., Vetrano, S. & Danese, S., Apr 1 2015, In : Gut. 64, 4, p. 589-600 12 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Phagocytosis
Macrophages
Inflammation
Colitis
4 Citations (Scopus)

Urokinase receptor promotes skin tumor formation by preventing epithelial cell activation of Notch1

Mazzieri, R., Pietrogrande, G., Gerasi, L., Gandelli, A., Colombo, P., Moi, D., Brombin, C., Ambrosi, A., Danese, S., Mignatti, P., Blasi, F. & D'Alessio, S., Nov 15 2015, In : Cancer Research. 75, 22, p. 4895-4909 15 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Urokinase-Type Plasminogen Activator
Epithelial Cells
Skin
Neoplasms
40 Citations (Scopus)

Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion

Tacconi, C., Correale, C., Gandelli, A., Spinelli, A., Dejana, E., D'Alessio, S. & Danese, S., Jun 1 2015, In : Gastroenterology. 148, 7, p. 1438-1451.e8

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Colorectal Neoplasms
Lymphatic Vessels
Lymphangiogenesis
Neoplasm Metastasis
2014
19 Citations (Scopus)

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme

Laurenzana, A., Biagioni, A., D'Alessio, S., Bianchini, F., Chillà, A., Margheri, F., Luciani, C., Mazzanti, B., Pimpinelli, N., Torre, E., Danese, S., Calorini, L., Del Rosso, M. & Fibbi, G., 2014, In : Oncotarget. 5, 11, p. 3711-3727 17 p.

Research output: Contribution to journalArticle

Enzyme Activators
Urokinase-Type Plasminogen Activator
Cell- and Tissue-Based Therapy
Melanoma
Peptide Hydrolases
99 Citations (Scopus)

VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

D'Alessio, S., Correale, C., Tacconi, C., Gandelli, A., Pietrogrande, G., Vetrano, S., Genua, M., Arena, V., Spinelli, A., Peyrin-Biroulet, L., Fiocchi, C. & Danese, S., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3863-3878 16 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Inflammatory Bowel Diseases
Lymphangiogenesis
Colitis
Bacterial Antigens
2013
23 Citations (Scopus)

Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease

D'Alessio, S., Tacconi, C., Fiocchi, C. & Danese, S., Nov 2013, In : Current Opinion in Gastroenterology. 29, 6, p. 608-613 6 p.

Research output: Contribution to journalArticle

Lymphatic Endothelium
Vascular Endothelium
Inflammatory Bowel Diseases
Inflammation
Lymphatic System
2012
10 Citations (Scopus)

Chromogranin A binds to αvβ6-integrin and promotes wound healing in mice

Curnis, F., Gasparri, A. M., Longhi, R., Colombo, B., D'Alessio, S., Pastorino, F., Ponzoni, M. & Corti, A., Aug 2012, In : Cellular and Molecular Life Sciences. 69, 16, p. 2791-2803 13 p.

Research output: Contribution to journalArticle

Chromogranin A
Integrins
Wound Healing
Keratinocytes
Neuroendocrine Cells
7 Citations (Scopus)

The protein C pathway in intestinal barrier function: Challenging the hemostasis paradigm

D'Alessio, S., Genua, M. & Vetrano, S., Jul 2012, In : Annals of the New York Academy of Sciences. 1258, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

Protein C
Hemostasis
Thrombin
Factor VIIIa
Factor Va
2009
74 Citations (Scopus)

The urokinase receptor as an entertainer of signal transduction

D'Alessio, S. & Blasi, F., Jan 1 2009, In : Frontiers in Bioscience. 14, 12, p. 4575-4587 13 p.

Research output: Contribution to journalArticle

High Molecular Weight Kininogens
Caveolins
Biological Phenomena
Focal Adhesion Protein-Tyrosine Kinases
Signal transduction
2008
1 Citation (Scopus)

The urokinase plasminogen activator receptor as a target for cancer therapy

D'Alessio, S. & Blasi, F., 2008, The Cancer Degradome: Proteases and Cancer Biology. Springer New York, p. 223-243 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Urokinase Plasminogen Activator Receptors
Tumors
Cells
Neoplasms
Plasminogen Activators
37 Citations (Scopus)

uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro

d'Alessio, S., Gerasi, L. & Blasi, F., Dec 1 2008, In : Journal of Cell Science. 121, 23, p. 3922-3932 11 p.

Research output: Contribution to journalArticle

Keratinocytes
Epidermal Growth Factor Receptor
Wound Healing
Epidermal Growth Factor
Knockout Mice
2007
12 Citations (Scopus)

A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts

Mazzieri, R., Furlan, F., D'Alessio, S., Zonari, E., Talotta, F., Verde, P. & Blasi, F., Feb 1 2007, In : Oncogene. 26, 5, p. 725-732 8 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Fibroblasts
Growth
Oncogenes
Neoplasms
2006
63 Citations (Scopus)

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration

Mazzieri, R., D'Alessio, S., Kenmoe, R. K., Ossowski, L. & Blasi, F., Jan 2006, In : Molecular Biology of the Cell. 17, 1, p. 367-378 12 p.

Research output: Contribution to journalArticle

Urokinase-Type Plasminogen Activator
Cell Movement
Dissection
Epidermal Growth Factor Receptor
Integrins
17 Citations (Scopus)

Cytokine-dependent invasiveness in B16 murine melanoma cells: Role of uPA system and MMP-9

Bianchini, F., D'Alessio, S., Fibbi, G., Del Rosso, M. & Calorini, L., Mar 2006, In : Oncology Reports. 15, 3, p. 709-714 6 p.

Research output: Contribution to journalArticle

Experimental Melanomas
Plasminogen Activators
Urokinase-Type Plasminogen Activator
Matrix Metalloproteinases
Cytokines
8 Citations (Scopus)

Plasminogen activators and inhibitor type-1 in alveolar osteitis

Serratì, S., Margheri, F., Bruschi, S., D'Alessio, S., Pucci, M., Fibbi, G., Tonelli, P. & Rosso, M. D., Dec 2006, In : European Journal of Oral Sciences. 114, 6, p. 500-503 4 p.

Research output: Contribution to journalArticle

Dry Socket
Plasminogen Activator Inhibitor 1
Urokinase-Type Plasminogen Activator
Plasminogen Activators
Fibrinolysis
2005
56 Citations (Scopus)

Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases

Margheri, F., D'Alessio, S., Serratí, S., Pucci, M., Annunziato, F., Cosmi, L., Liotta, F., Angeli, R., Angelucci, A., Gravina, G. L., Rucci, N., Bologna, M., Teti, A., Monia, B., Fibbi, G. & Del Rosso, M., Apr 2005, In : Gene Therapy. 12, 8, p. 702-714 13 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Bone Neoplasms
Antisense Oligonucleotides
Urokinase-Type Plasminogen Activator
Prostatic Neoplasms
20 Citations (Scopus)

Rheumatoid synovial fibroblast constitutively express the fibrinolytic pattern of invasive tumor-like cells

Guiducci, S., Del Rosso, A., Cinelli, M., Margheri, F., D'Alessio, S., Fibbi, G., Cerinic, M. M. & Del Rosso, M., May 2005, In : Clinical and Experimental Rheumatology. 23, 3, p. 364-372 9 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Fibroblasts
Plasminogen Activator Inhibitor 1
Neoplasms
Synovial Membrane
5 Citations (Scopus)
Human Immunodeficiency Virus tat Gene Products
Urokinase Plasminogen Activator Receptors
Kaposi's Sarcoma
Plasminogen Activator Inhibitor 1
Urokinase-Type Plasminogen Activator
2004
41 Citations (Scopus)

Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

D'Alessio, S., Margheri, F., Pucci, M., Del Rosso, A., Monia, B. P., Bologna, M., Leonetti, C., Scarsella, M., Zupi, G., Fibbi, G. & Del Rosso, M., May 20 2004, In : International Journal of Cancer. 110, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Oligodeoxyribonucleotides
Melanoma
Neoplasm Metastasis
Down-Regulation
112 Citations (Scopus)

Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis

D'Alessio, S., Fibbi, G., Cinelli, M., Guiducci, S., Del Rosso, A., Margheri, F., Serratì, S., Pucci, M., Kahaleh, B., Fan, P., Annunziato, F., Cosmi, L., Liotta, F., Matucci-Cerinic, M. & Del Rosso, M., Oct 2004, In : Arthritis and Rheumatism. 50, 10, p. 3275-3285 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 12
Systemic Scleroderma
Urokinase-Type Plasminogen Activator
Endothelial Cells
Morphogenesis
2002
23 Citations (Scopus)

Growth factor-dependent proliferation and invasion of muscle satellite cells require the cell-associated fibrinolytic system

Fibbi, G., D'Alessio, S., Pucci, M., Cerletti, M. & Del Rosso, M., 2002, In : Biological Chemistry. 383, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Muscle Cells
Muscle
Intercellular Signaling Peptides and Proteins
Myoblasts
100 Citations (Scopus)

Multiple pathways of cell invasion are regulated by multiple families of serine proteases

Del Rosso, M., Fibbi, G., Pucci, M., D'Alessio, S., Del Rosso, A., Magnelli, L. & Chiarugi, V., 2002, In : Clinical & Experimental Metastasis. 19, 3, p. 193-207 15 p.

Research output: Contribution to journalArticle

Serine Proteases
Peptide Hydrolases
Hand Strength
Extracellular Matrix
Proteinase-Activated Receptors
2001
20 Citations (Scopus)

Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system

Fibbi, G., Pucci, M., D'Alessio, S., Grappone, C., Pellegrini, G., Salzano, R., Casini, A., Milani, S. & Del Rosso, M., 2001, In : Growth Factors. 19, 2, p. 87-100 14 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Hepatic Stellate Cells
Transforming Growth Factors
Transforming Growth Factor beta
Plasminogen