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Research Output 2001 2019

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2001

Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system

Fibbi, G., Pucci, M., D'Alessio, S., Grappone, C., Pellegrini, G., Salzano, R., Casini, A., Milani, S. & Del Rosso, M., 2001, In : Growth Factors. 19, 2, p. 87-100 14 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Hepatic Stellate Cells
Transforming Growth Factors
Transforming Growth Factor beta
Plasminogen
2002

Growth factor-dependent proliferation and invasion of muscle satellite cells require the cell-associated fibrinolytic system

Fibbi, G., D'Alessio, S., Pucci, M., Cerletti, M. & Del Rosso, M., 2002, In : Biological Chemistry. 383, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Muscle Cells
Muscle
Intercellular Signaling Peptides and Proteins
Myoblasts

Multiple pathways of cell invasion are regulated by multiple families of serine proteases

Del Rosso, M., Fibbi, G., Pucci, M., D'Alessio, S., Del Rosso, A., Magnelli, L. & Chiarugi, V., 2002, In : Clinical & Experimental Metastasis. 19, 3, p. 193-207 15 p.

Research output: Contribution to journalArticle

Serine Proteases
Peptide Hydrolases
Hand Strength
Extracellular Matrix
Proteinase-Activated Receptors
2004

Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

D'Alessio, S., Margheri, F., Pucci, M., Del Rosso, A., Monia, B. P., Bologna, M., Leonetti, C., Scarsella, M., Zupi, G., Fibbi, G. & Del Rosso, M., May 20 2004, In : International Journal of Cancer. 110, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Oligodeoxyribonucleotides
Melanoma
Neoplasm Metastasis
Down-Regulation

Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis

D'Alessio, S., Fibbi, G., Cinelli, M., Guiducci, S., Del Rosso, A., Margheri, F., Serratì, S., Pucci, M., Kahaleh, B., Fan, P., Annunziato, F., Cosmi, L., Liotta, F., Matucci-Cerinic, M. & Del Rosso, M., Oct 2004, In : Arthritis and Rheumatism. 50, 10, p. 3275-3285 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 12
Systemic Scleroderma
Urokinase-Type Plasminogen Activator
Endothelial Cells
Morphogenesis
2005

Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases

Margheri, F., D'Alessio, S., Serratí, S., Pucci, M., Annunziato, F., Cosmi, L., Liotta, F., Angeli, R., Angelucci, A., Gravina, G. L., Rucci, N., Bologna, M., Teti, A., Monia, B., Fibbi, G. & Del Rosso, M., Apr 2005, In : Gene Therapy. 12, 8, p. 702-714 13 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Bone Neoplasms
Antisense Oligonucleotides
Urokinase-Type Plasminogen Activator
Prostatic Neoplasms

Rheumatoid synovial fibroblast constitutively express the fibrinolytic pattern of invasive tumor-like cells

Guiducci, S., Del Rosso, A., Cinelli, M., Margheri, F., D'Alessio, S., Fibbi, G., Cerinic, M. M. & Del Rosso, M., May 2005, In : Clinical and Experimental Rheumatology. 23, 3, p. 364-372 9 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Fibroblasts
Plasminogen Activator Inhibitor 1
Neoplasms
Synovial Membrane
Human Immunodeficiency Virus tat Gene Products
Urokinase Plasminogen Activator Receptors
Kaposi's Sarcoma
Plasminogen Activator Inhibitor 1
Urokinase-Type Plasminogen Activator
2006

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration

Mazzieri, R., D'Alessio, S., Kenmoe, R. K., Ossowski, L. & Blasi, F., Jan 2006, In : Molecular Biology of the Cell. 17, 1, p. 367-378 12 p.

Research output: Contribution to journalArticle

Urokinase-Type Plasminogen Activator
Cell Movement
Dissection
Epidermal Growth Factor Receptor
Integrins

Cytokine-dependent invasiveness in B16 murine melanoma cells: Role of uPA system and MMP-9

Bianchini, F., D'Alessio, S., Fibbi, G., Del Rosso, M. & Calorini, L., Mar 2006, In : Oncology Reports. 15, 3, p. 709-714 6 p.

Research output: Contribution to journalArticle

Experimental Melanomas
Plasminogen Activators
Urokinase-Type Plasminogen Activator
Matrix Metalloproteinases
Cytokines

Plasminogen activators and inhibitor type-1 in alveolar osteitis

Serratì, S., Margheri, F., Bruschi, S., D'Alessio, S., Pucci, M., Fibbi, G., Tonelli, P. & Rosso, M. D., Dec 2006, In : European Journal of Oral Sciences. 114, 6, p. 500-503 4 p.

Research output: Contribution to journalArticle

Dry Socket
Plasminogen Activator Inhibitor 1
Urokinase-Type Plasminogen Activator
Plasminogen Activators
Fibrinolysis
2007

A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts

Mazzieri, R., Furlan, F., D'Alessio, S., Zonari, E., Talotta, F., Verde, P. & Blasi, F., Feb 1 2007, In : Oncogene. 26, 5, p. 725-732 8 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Fibroblasts
Growth
Oncogenes
Neoplasms
2008

uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro

d'Alessio, S., Gerasi, L. & Blasi, F., Dec 1 2008, In : Journal of Cell Science. 121, 23, p. 3922-3932 11 p.

Research output: Contribution to journalArticle

Keratinocytes
Epidermal Growth Factor Receptor
Wound Healing
Epidermal Growth Factor
Knockout Mice
2009

The urokinase receptor as an entertainer of signal transduction

D'Alessio, S. & Blasi, F., Jan 1 2009, In : Frontiers in Bioscience. 14, 12, p. 4575-4587 13 p.

Research output: Contribution to journalArticle

High Molecular Weight Kininogens
Caveolins
Biological Phenomena
Focal Adhesion Protein-Tyrosine Kinases
Signal transduction
2012

Chromogranin A binds to αvβ6-integrin and promotes wound healing in mice

Curnis, F., Gasparri, A. M., Longhi, R., Colombo, B., D'Alessio, S., Pastorino, F., Ponzoni, M. & Corti, A., Aug 2012, In : Cellular and Molecular Life Sciences. 69, 16, p. 2791-2803 13 p.

Research output: Contribution to journalArticle

Chromogranin A
Integrins
Wound Healing
Keratinocytes
Neuroendocrine Cells

The protein C pathway in intestinal barrier function: Challenging the hemostasis paradigm

D'Alessio, S., Genua, M. & Vetrano, S., Jul 2012, In : Annals of the New York Academy of Sciences. 1258, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

Protein C
Hemostasis
Thrombin
Factor VIIIa
Factor Va
2013

Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease

D'Alessio, S., Tacconi, C., Fiocchi, C. & Danese, S., Nov 2013, In : Current Opinion in Gastroenterology. 29, 6, p. 608-613 6 p.

Research output: Contribution to journalArticle

Lymphatic Endothelium
Vascular Endothelium
Inflammatory Bowel Diseases
Inflammation
Lymphatic System
2014

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme

Laurenzana, A., Biagioni, A., D'Alessio, S., Bianchini, F., Chillà, A., Margheri, F., Luciani, C., Mazzanti, B., Pimpinelli, N., Torre, E., Danese, S., Calorini, L., Del Rosso, M. & Fibbi, G., 2014, In : Oncotarget. 5, 11, p. 3711-3727 17 p.

Research output: Contribution to journalArticle

Enzyme Activators
Urokinase-Type Plasminogen Activator
Cell- and Tissue-Based Therapy
Melanoma
Peptide Hydrolases

VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

D'Alessio, S., Correale, C., Tacconi, C., Gandelli, A., Pietrogrande, G., Vetrano, S., Genua, M., Arena, V., Spinelli, A., Peyrin-Biroulet, L., Fiocchi, C. & Danese, S., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3863-3878 16 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Inflammatory Bowel Diseases
Lymphangiogenesis
Colitis
Bacterial Antigens

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes

Alfano, M., Cinque, P., Giusti, G., Proietti, S., Nebuloni, M., Danese, S., D'Alessio, S., Genua, M., Portale, F., Lo Porto, M., Singhal, P. C., Rastaldi, M. P., Saleem, M. A., Mavilio, D. & Mikulak, J., Sep 18 2015, In : Scientific Reports. 5, 13647.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Podocytes
Wilms Tumor
Integrins
Hantavirus Infections

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine

Sala, E., Genua, M., Petti, L., Anselmo, A., Arena, V., Cibella, J., Zanotti, L., D'Alessio, S., Scaldaferri, F., Luca, G., Arato, I., Calafiore, R., Sgambato, A., Rutella, S., Locati, M., Danese, S. & Vetrano, S., Jul 1 2015, In : Gastroenterology. 149, 1, p. 163-176 14 p., 59674.

Research output: Contribution to journalArticle

Colitis
Mesenchymal Stromal Cells
Intestines
Inflammation
Interleukin-10

Targeting lymphatics in inflammatory bowel disease

D'Alessio, S., Tacconi, C. & Danese, S., 2015, In : Oncotarget. 6, 33, p. 34047-34048 2 p.

Research output: Contribution to journalArticle

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

Genua, M., D'Alessio, S., Cibella, J., Gandelli, A., Sala, E., Correale, C., Spinelli, A., Arena, V., Malesci, A., Rutella, S., Ploplis, V. A., Vetrano, S. & Danese, S., Apr 1 2015, In : Gut. 64, 4, p. 589-600 12 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Phagocytosis
Macrophages
Inflammation
Colitis

Urokinase receptor promotes skin tumor formation by preventing epithelial cell activation of Notch1

Mazzieri, R., Pietrogrande, G., Gerasi, L., Gandelli, A., Colombo, P., Moi, D., Brombin, C., Ambrosi, A., Danese, S., Mignatti, P., Blasi, F. & D'Alessio, S., Nov 15 2015, In : Cancer Research. 75, 22, p. 4895-4909 15 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Urokinase-Type Plasminogen Activator
Epithelial Cells
Skin
Neoplasms

Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion

Tacconi, C., Correale, C., Gandelli, A., Spinelli, A., Dejana, E., D'Alessio, S. & Danese, S., Jun 1 2015, In : Gastroenterology. 148, 7, p. 1438-1451.e8

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Colorectal Neoplasms
Lymphatic Vessels
Lymphangiogenesis
Neoplasm Metastasis
2017

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Van Welden, S., De Vos, M., Wielockx, B., Tavernier, S. J., Dullaers, M., Neyt, S., Descamps, B., Devisscher, L., Devriese, S., Van den Bossche, L., Holvoet, T., Baeyens, A., Correale, C., D'Alessio, S., Vanhove, C., De Vos, F., Verhasselt, B., Breier, G., Lambrecht, B. N., Janssens, S. & 5 others, Carmeliet, P., Danese, S., Elewaut, D., Laukens, D. & Hindryckx, P., Mar 1 2017, In : Journal of Pathology. 241, 4, p. 547-558 12 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Colitis
Macrophages
Dextran Sulfate
Lipopolysaccharides

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice

Ungaro, F., Tacconi, C., Massimino, L., Corsetto, P. A., Correale, C., Fonteyne, P., Piontini, A., Garzarelli, V., Calcaterra, F., Della Bella, S., Spinelli, A., Carvello, M., Rizzo, A. M., Vetrano, S., Petti, L., Fiorino, G., Furfaro, F., Mavilio, D., Maddipati, K. R., Malesci, A. & 3 others, Peyrin-Biroulet, L., D'Alessio, S. & Danese, S., Nov 1 2017, In : Gastroenterology. 153, 5, p. 1363-1377.e6

Research output: Contribution to journalArticle

Colitis
Docosahexaenoic Acids
Ulcerative Colitis
Inflammation
Lipids
2018

TREM-1 inhibition restores impaired autophagy activity and reduces colitis in mice

Kökten, T., Gibot, S., Gibot, S., Lepage, P., D'Alessio, S., D'Alessio, S., Hablot, J., Ndiaye, N. C., Busby-Venner, H., Monot, C., Garnier, B., Moulin, D., Jouzeau, J. Y., Hansmannel, F., Danese, S., Danese, S., Guéant, J. L., Muller, S., Peyrin-Birouleta, L. & Peyrin-Birouleta, L., Jan 24 2018, In : Journal of Crohn's and Colitis. 12, 2, p. 230-244 15 p.

Research output: Contribution to journalArticle

Autophagy
Myeloid Cells
Colitis
Unfolded Protein Response
Dysbiosis
2019

Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer

Tacconi, C., Ungaro, F., Correale, C., Arena, V., Massimino, L., Detmar, M., Spinelli, A., Carvello, M., Mazzone, M., Oliveira, A. I., Rubbino, F., Garlatti, V., Spanò, S., Lugli, E., Colombo, F. S., Malesci, A., Peyrin-Biroulet, L., Vetrano, S., Danese, S. & D'Alessio, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4196-4210 15 p.

Research output: Contribution to journalArticle

Tumor Escape
Colorectal Neoplasms
Neoplasms
Lymphatic Vessel Tumors
Macrophages

Hyaluronan Accelerates Intestinal Mucosal Healing through Interaction with TSG-6

Sammarco, G., Shalaby, M., Elangovan, S., Petti, L., Roda, G., Restelli, S., Arena, V., Ungaro, F., Fiorino, G., Day, A. J., D'Alessio, S. & Vetrano, S., Sep 12 2019, In : Cells. 8, 9

Research output: Contribution to journalArticle

Hyaluronic Acid
Ulcerative Colitis
Regeneration
CD44 Antigens
Therapeutic Uses

Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11

Ungaro, F., Colombo, P., Massimino, L., Ugolini, G. S., Correale, C., Rasponi, M., Garlatti, V., Rubbino, F., Tacconi, C., Spaggiari, P., Spinelli, A., Carvello, M., Sacchi, M., Spanò, S., Vetrano, S., Malesci, A., Peyrin-Biroulet, L., Danese, S. & D'Alessio, S., Oct 1 2019, In : International Journal of Cancer. 145, 7, p. 1913-1920 8 p.

Research output: Contribution to journalArticle

Lymphatic Endothelium
Colorectal Neoplasms
Growth
Neoplasms
Growth Differentiation Factors

mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease

Ungaro, F., Garlatti, V., Massimino, L., Spinelli, A., Carvello, M., Sacchi, M., Spanò, S., Colasante, G., Valassina, N., Vetrano, S., Malesci, A., Peyrin-Biroulet, L., Danese, S. & D'Alessio, S., Aug 18 2019, In : Cells. 8, 8

Research output: Contribution to journalArticle

Lymphatic Endothelium
Crohn Disease
Endothelial cells
Endothelial Cells
Mucous Membrane

TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells

Romano, B., Elangovan, S., Erreni, M., Sala, E., Petti, L., Kunderfranco, P., Massimino, L., Restelli, S., Sinha, S., Lucchetti, D., Anselmo, A., Colombo, F. S., Stravalaci, M., Arena, V., D'Alessio, S., Ungaro, F., Inforzato, A., Izzo, A. A., Sgambato, A., Day, A. J. & 1 others, Vetrano, S., Jul 2019, In : Stem Cells. 37, 7, p. 973-987 15 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Genes
Extracellular Matrix
Cytoskeleton
Interleukin-6