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Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer

Tacconi, C., Ungaro, F., Correale, C., Arena, V., Massimino, L., Detmar, M., Spinelli, A., Carvello, M., Mazzone, M., Oliveira, A. I., Rubbino, F., Garlatti, V., Spanò, S., Lugli, E., Colombo, F. S., Malesci, A., Peyrin-Biroulet, L., Vetrano, S., Danese, S. & D'Alessio, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4196-4210 15 p.

Research output: Contribution to journalArticle

A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts

Mazzieri, R., Furlan, F., D'Alessio, S., Zonari, E., Talotta, F., Verde, P. & Blasi, F., Feb 1 2007, In : Oncogene. 26, 5, p. 725-732 8 p.

Research output: Contribution to journalArticle

Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease

D'Alessio, S., Tacconi, C., Fiocchi, C. & Danese, S., Nov 2013, In : Current Opinion in Gastroenterology. 29, 6, p. 608-613 6 p.

Research output: Contribution to journalArticle

Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

D'Alessio, S., Margheri, F., Pucci, M., Del Rosso, A., Monia, B. P., Bologna, M., Leonetti, C., Scarsella, M., Zupi, G., Fibbi, G. & Del Rosso, M., May 20 2004, In : International Journal of Cancer. 110, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration

Mazzieri, R., D'Alessio, S., Kenmoe, R. K., Ossowski, L. & Blasi, F., Jan 2006, In : Molecular Biology of the Cell. 17, 1, p. 367-378 12 p.

Research output: Contribution to journalArticle

Chromogranin A binds to αvβ6-integrin and promotes wound healing in mice

Curnis, F., Gasparri, A. M., Longhi, R., Colombo, B., D'Alessio, S., Pastorino, F., Ponzoni, M. & Corti, A., Aug 2012, In : Cellular and Molecular Life Sciences. 69, 16, p. 2791-2803 13 p.

Research output: Contribution to journalArticle

Cytokine-dependent invasiveness in B16 murine melanoma cells: Role of uPA system and MMP-9

Bianchini, F., D'Alessio, S., Fibbi, G., Del Rosso, M. & Calorini, L., Mar 2006, In : Oncology Reports. 15, 3, p. 709-714 6 p.

Research output: Contribution to journalArticle

Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases

Margheri, F., D'Alessio, S., Serratí, S., Pucci, M., Annunziato, F., Cosmi, L., Liotta, F., Angeli, R., Angelucci, A., Gravina, G. L., Rucci, N., Bologna, M., Teti, A., Monia, B., Fibbi, G. & Del Rosso, M., Apr 2005, In : Gene Therapy. 12, 8, p. 702-714 13 p.

Research output: Contribution to journalArticle

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes

Alfano, M., Cinque, P., Giusti, G., Proietti, S., Nebuloni, M., Danese, S., D'Alessio, S., Genua, M., Portale, F., Lo Porto, M., Singhal, P. C., Rastaldi, M. P., Saleem, M. A., Mavilio, D. & Mikulak, J., Sep 18 2015, In : Scientific Reports. 5, 13647.

Research output: Contribution to journalArticle

Growth factor-dependent proliferation and invasion of muscle satellite cells require the cell-associated fibrinolytic system

Fibbi, G., D'Alessio, S., Pucci, M., Cerletti, M. & Del Rosso, M., 2002, In : Biological Chemistry. 383, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Van Welden, S., De Vos, M., Wielockx, B., Tavernier, S. J., Dullaers, M., Neyt, S., Descamps, B., Devisscher, L., Devriese, S., Van den Bossche, L., Holvoet, T., Baeyens, A., Correale, C., D'Alessio, S., Vanhove, C., De Vos, F., Verhasselt, B., Breier, G., Lambrecht, B. N., Janssens, S. & 5 others, Carmeliet, P., Danese, S., Elewaut, D., Laukens, D. & Hindryckx, P., Mar 1 2017, In : Journal of Pathology. 241, 4, p. 547-558 12 p.

Research output: Contribution to journalArticle

Hyaluronan Accelerates Intestinal Mucosal Healing through Interaction with TSG-6

Sammarco, G., Shalaby, M., Elangovan, S., Petti, L., Roda, G., Restelli, S., Arena, V., Ungaro, F., Fiorino, G., Day, A. J., D'Alessio, S. & Vetrano, S., Sep 12 2019, In : Cells. 8, 9

Research output: Contribution to journalArticle

Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11

Ungaro, F., Colombo, P., Massimino, L., Ugolini, G. S., Correale, C., Rasponi, M., Garlatti, V., Rubbino, F., Tacconi, C., Spaggiari, P., Spinelli, A., Carvello, M., Sacchi, M., Spanò, S., Vetrano, S., Malesci, A., Peyrin-Biroulet, L., Danese, S. & D'Alessio, S., Oct 1 2019, In : International Journal of Cancer. 145, 7, p. 1913-1920 8 p.

Research output: Contribution to journalArticle

Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis

D'Alessio, S., Fibbi, G., Cinelli, M., Guiducci, S., Del Rosso, A., Margheri, F., Serratì, S., Pucci, M., Kahaleh, B., Fan, P., Annunziato, F., Cosmi, L., Liotta, F., Matucci-Cerinic, M. & Del Rosso, M., Oct 2004, In : Arthritis and Rheumatism. 50, 10, p. 3275-3285 11 p.

Research output: Contribution to journalArticle

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme

Laurenzana, A., Biagioni, A., D'Alessio, S., Bianchini, F., Chillà, A., Margheri, F., Luciani, C., Mazzanti, B., Pimpinelli, N., Torre, E., Danese, S., Calorini, L., Del Rosso, M. & Fibbi, G., 2014, In : Oncotarget. 5, 11, p. 3711-3727 17 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine

Sala, E., Genua, M., Petti, L., Anselmo, A., Arena, V., Cibella, J., Zanotti, L., D'Alessio, S., Scaldaferri, F., Luca, G., Arato, I., Calafiore, R., Sgambato, A., Rutella, S., Locati, M., Danese, S. & Vetrano, S., Jul 1 2015, In : Gastroenterology. 149, 1, p. 163-176 14 p., 59674.

Research output: Contribution to journalArticle

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice

Ungaro, F., Tacconi, C., Massimino, L., Corsetto, P. A., Correale, C., Fonteyne, P., Piontini, A., Garzarelli, V., Calcaterra, F., Della Bella, S., Spinelli, A., Carvello, M., Rizzo, A. M., Vetrano, S., Petti, L., Fiorino, G., Furfaro, F., Mavilio, D., Maddipati, K. R., Malesci, A. & 3 others, Peyrin-Biroulet, L., D'Alessio, S. & Danese, S., Nov 1 2017, In : Gastroenterology. 153, 5, p. 1363-1377.e6

Research output: Contribution to journalArticle

mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease

Ungaro, F., Garlatti, V., Massimino, L., Spinelli, A., Carvello, M., Sacchi, M., Spanò, S., Colasante, G., Valassina, N., Vetrano, S., Malesci, A., Peyrin-Biroulet, L., Danese, S. & D'Alessio, S., Aug 18 2019, In : Cells. 8, 8

Research output: Contribution to journalArticle

Multiple pathways of cell invasion are regulated by multiple families of serine proteases

Del Rosso, M., Fibbi, G., Pucci, M., D'Alessio, S., Del Rosso, A., Magnelli, L. & Chiarugi, V., 2002, In : Clinical & Experimental Metastasis. 19, 3, p. 193-207 15 p.

Research output: Contribution to journalArticle

Plasminogen activators and inhibitor type-1 in alveolar osteitis

Serratì, S., Margheri, F., Bruschi, S., D'Alessio, S., Pucci, M., Fibbi, G., Tonelli, P. & Rosso, M. D., Dec 2006, In : European Journal of Oral Sciences. 114, 6, p. 500-503 4 p.

Research output: Contribution to journalArticle

Rheumatoid synovial fibroblast constitutively express the fibrinolytic pattern of invasive tumor-like cells

Guiducci, S., Del Rosso, A., Cinelli, M., Margheri, F., D'Alessio, S., Fibbi, G., Cerinic, M. M. & Del Rosso, M., May 2005, In : Clinical and Experimental Rheumatology. 23, 3, p. 364-372 9 p.

Research output: Contribution to journalArticle

Targeting lymphatics in inflammatory bowel disease

D'Alessio, S., Tacconi, C. & Danese, S., 2015, In : Oncotarget. 6, 33, p. 34047-34048 2 p.

Research output: Contribution to journalArticle

The protein C pathway in intestinal barrier function: Challenging the hemostasis paradigm

D'Alessio, S., Genua, M. & Vetrano, S., Jul 2012, In : Annals of the New York Academy of Sciences. 1258, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

Genua, M., D'Alessio, S., Cibella, J., Gandelli, A., Sala, E., Correale, C., Spinelli, A., Arena, V., Malesci, A., Rutella, S., Ploplis, V. A., Vetrano, S. & Danese, S., Apr 1 2015, In : Gut. 64, 4, p. 589-600 12 p.

Research output: Contribution to journalArticle

The urokinase receptor as an entertainer of signal transduction

D'Alessio, S. & Blasi, F., Jan 1 2009, In : Frontiers in Bioscience. 14, 12, p. 4575-4587 13 p.

Research output: Contribution to journalArticle

TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells

Romano, B., Elangovan, S., Erreni, M., Sala, E., Petti, L., Kunderfranco, P., Massimino, L., Restelli, S., Sinha, S., Lucchetti, D., Anselmo, A., Colombo, F. S., Stravalaci, M., Arena, V., D'Alessio, S., Ungaro, F., Inforzato, A., Izzo, A. A., Sgambato, A., Day, A. J. & 1 others, Vetrano, S., Jul 2019, In : Stem Cells. 37, 7, p. 973-987 15 p.

Research output: Contribution to journalArticle

Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system

Fibbi, G., Pucci, M., D'Alessio, S., Grappone, C., Pellegrini, G., Salzano, R., Casini, A., Milani, S. & Del Rosso, M., 2001, In : Growth Factors. 19, 2, p. 87-100 14 p.

Research output: Contribution to journalArticle

TREM-1 inhibition restores impaired autophagy activity and reduces colitis in mice

Kökten, T., Gibot, S., Gibot, S., Lepage, P., D'Alessio, S., D'Alessio, S., Hablot, J., Ndiaye, N. C., Busby-Venner, H., Monot, C., Garnier, B., Moulin, D., Jouzeau, J. Y., Hansmannel, F., Danese, S., Danese, S., Guéant, J. L., Muller, S., Peyrin-Birouleta, L. & Peyrin-Birouleta, L., Jan 24 2018, In : Journal of Crohn's and Colitis. 12, 2, p. 230-244 15 p.

Research output: Contribution to journalArticle

uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro

d'Alessio, S., Gerasi, L. & Blasi, F., Dec 1 2008, In : Journal of Cell Science. 121, 23, p. 3922-3932 11 p.

Research output: Contribution to journalArticle

Urokinase receptor promotes skin tumor formation by preventing epithelial cell activation of Notch1

Mazzieri, R., Pietrogrande, G., Gerasi, L., Gandelli, A., Colombo, P., Moi, D., Brombin, C., Ambrosi, A., Danese, S., Mignatti, P., Blasi, F. & D'Alessio, S., Nov 15 2015, In : Cancer Research. 75, 22, p. 4895-4909 15 p.

Research output: Contribution to journalArticle

Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion

Tacconi, C., Correale, C., Gandelli, A., Spinelli, A., Dejana, E., D'Alessio, S. & Danese, S., Jun 1 2015, In : Gastroenterology. 148, 7, p. 1438-1451.e8

Research output: Contribution to journalArticle

VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

D'Alessio, S., Correale, C., Tacconi, C., Gandelli, A., Pietrogrande, G., Vetrano, S., Genua, M., Arena, V., Spinelli, A., Peyrin-Biroulet, L., Fiocchi, C. & Danese, S., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3863-3878 16 p.

Research output: Contribution to journalArticle