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Research Output 2002 2019

2019

Shiga toxin triggers endothelial and podocyte injury: the role of complement activation

Zoja, C., Buelli, S. & Morigi, M., Mar 2019, In : Pediatric Nephrology. 34, 3, p. 379-388 10 p.

Research output: Contribution to journalReview article

Shiga Toxin
Podocytes
Hemolytic-Uremic Syndrome
Complement Activation
Endothelium
2016

A previously unrecognized role of C3a in proteinuric progressive nephropathy

Morigi, M., Locatelli, M., Rota, C., Buelli, S., Corna, D., Rizzo, P., Abbate, M., Conti, D., Perico, L., Longaretti, L., Benigni, A., Zoja, C. & Remuzzi, G., Jun 27 2016, In : Scientific Reports. 6, 28445.

Research output: Contribution to journalArticle

Podocytes
Glial Cell Line-Derived Neurotrophic Factor
Epithelial Cells
Bovine Serum Albumin
Alternative Complement Pathway

Untangling the knot in diabetic nephropathy: The unanticipated role of glycocalyx in the antiproteinuric effect of endothelin receptor antagonists

Buelli, S., Perico, L. & Benigni, A., Aug 1 2016, In : Diabetes. 65, 8, p. 2115-2117 3 p.

Research output: Contribution to journalComment/debate

2015

Effects of MCP-1 inhibition by bindarit therapy in a rat model of polycystic kidney disease

Zoja, C., Corna, D., Locatelli, M., Rottoli, D., Pezzotta, A., Morigi, M., Zanchi, C., Buelli, S., Guglielmotti, A., Perico, N., Remuzzi, A. & Remuzzi, G., Jan 1 2015, In : Nephron. 129, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Podocytes
Kidney
Cysts
Therapeutics

Mitochondrial-dependent Autoimmunity in Membranous Nephropathy of IgG4-related Disease

Buelli, S., Perico, L., Galbusera, M., Abbate, M., Morigi, M., Novelli, R., Gagliardini, E., Tentori, C., Rottoli, D., Sabadini, E., Saito, T., Kawano, M., Saeki, T., Zoja, C., Remuzzi, G. & Benigni, A., May 1 2015, In : EBioMedicine. 2, 5, p. 456-466 11 p.

Research output: Contribution to journalArticle

Membranous Glomerulonephritis
Autoimmunity
Immunoglobulin G
Carbonic Anhydrase II
Podocytes

Sirtuin3 dysfunction is the key determinant of skeletal muscle insulin resistance by angiotensin II

Macconi, D., Perico, L., Longaretti, L., Morigi, M., Cassis, P., Buelli, S., Perico, N., Remuzzi, G. & Benigni, A., May 19 2015, In : PLoS One. 10, 5, e0127172.

Research output: Contribution to journalArticle

angiotensin II
insulin resistance
Angiotensin II
Muscle
skeletal muscle
2014

Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement

Locatelli, M., Buelli, S., Pezzotta, A., Corna, D., Perico, L., Tomasoni, S., Rottoli, D., Rizzo, P., Conti, D., Thurman, J. M., Remuzzi, G., Zoja, C. & Morigi, M., Aug 1 2014, In : Journal of the American Society of Nephrology. 25, 8, p. 1786-1798 13 p.

Research output: Contribution to journalArticle

Shiga Toxin
Alternative Complement Pathway
Podocytes
Hemolytic-Uremic Syndrome
Wounds and Injuries

β-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury

Buelli, S., Rosanò, L., Gagliardini, E., Corna, D., Longaretti, L., Pezzotta, A., Perico, L., Conti, S., Rizzo, P., Novelli, R., Morigi, M., Zoja, C., Remuzzi, G., Bagnato, A. & Benigni, A., Mar 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 523-533 11 p.

Research output: Contribution to journalArticle

Arrestin
Podocytes
Endothelin-1
Kidney
Wounds and Injuries
2013

Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via notch1/snail pathway

Gagliardini, E., Perico, N., Rizzo, P., Buelli, S., Longaretti, L., Perico, L., Tomasoni, S., Zoja, C., Macconi, D., Morigi, M., Remuzzi, G. & Benigni, A., Jul 2013, In : American Journal of Pathology. 183, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Podocytes
Snails
Angiotensin II
Rodentia
Diabetic Nephropathies
2011

Alternative pathway activation of complement by shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis

Morigi, M., Galbusera, M., Gastoldi, S., Locatelli, M., Buelli, S., Pezzotta, A., Pagani, C., Noris, M., Gobbi, M., Stravalaci, M., Rottoli, D., Tedesco, F., Remuzzi, G. & Zoja, C., Jul 1 2011, In : Journal of Immunology. 187, 1, p. 172-180 9 p.

Research output: Contribution to journalArticle

Shiga Toxin
Alternative Complement Pathway
Hemolytic-Uremic Syndrome
P-Selectin
Thrombosis

Endothelin in chronic proteinuric kidney disease

Gagliardini, E., Buelli, S. & Benigni, A., Sep 1 2011, Endothelin in Renal Physiology and Disease. S. Karger AG, Vol. 172. p. 171-184 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endothelins
Endothelin-1
Chronic Renal Insufficiency
Kidney
Physiology

Endothelin in chronic proteinuric kidney disease.

Gagliardini, E., Buelli, S. & Benigni, A., 2011, In : Contributions to Nephrology. 172, p. 171-184 14 p.

Research output: Contribution to journalArticle

Endothelins
Chronic Renal Insufficiency
Endothelin-1
Kidney
Kidney Diseases

Membranous nephropathy associated with IgG4-related disease

Cravedi, P., Abbate, M., Gagliardini, E., Galbusera, M., Buelli, S., Sabadini, E., Maras, M., Beck, L. H., Salant, D. J., Benigni, A., D'Agati, V. & Remuzzi, G., Aug 2011, In : American Journal of Kidney Diseases. 58, 2, p. 272-275 4 p.

Research output: Contribution to journalArticle

Membranous Glomerulonephritis
Immunoglobulins
Kidney
Phospholipase A2 Receptors
Mikulicz' Disease

MYO1E mutations and childhood familial focal segmental glomerulosclerosis

Mele, C., Iatropoulos, P., Donadelli, R., Calabria, A., Maranta, R., Cassis, P., Buelli, S., Tomasoni, S., Piras, R., Krendel, M., Bettoni, S., Morigi, M., Delledonne, M., Pecoraro, C., Abbate, I., Capobianchi, M. R., Hildebrandt, F., Otto, E., Schaefer, F., Macciardi, F. & 6 others, Ozaltin, F., Emre, S., Ibsirlioglu, T., Benigni, A., Remuzzi, G. & Noris, M., Jul 28 2011, In : New England Journal of Medicine. 365, 4, p. 295-306 12 p.

Research output: Contribution to journalArticle

Focal Segmental Glomerulosclerosis
Myosins
Podocytes
Mutation
Glomerular Filtration Barrier
2010

Shiga toxin-associated hemolytic uremic syndrome: Pathophysiology of endothelial dysfunction

Zoja, C., Buelli, S. & Morigi, M., Nov 2010, In : Pediatric Nephrology. 25, 11, p. 2231-2240 10 p.

Research output: Contribution to journalArticle

Shiga Toxin
Hemolytic-Uremic Syndrome
Endothelial Cells
Thrombosis
Leukocytes
2009

Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides

Macconi, D., Chiabrando, C., Schiarea, S., Aiello, S., Cassis, L., Gagliardini, E., Noris, M., Buelli, S., Zoja, C., Corna, D., Mele, C., Fanelli, R., Remuzzi, G. & Benigni, A., Jan 2009, In : Journal of the American Society of Nephrology. 20, 1, p. 123-130 8 p.

Research output: Contribution to journalArticle

Dendritic Cells
Albumins
Kidney
Peptides
T-Lymphocytes

Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells

Buelli, S., Abbate, M., Morigi, M., Moioli, D., Zanchi, C., Noris, M., Zoja, C., Pusey, C. D., Zipfel, P. F. & Remuzzi, G., May 2009, In : Kidney International. 75, 10, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

Complement Factor H
Complement Activation
Transferrin
Albumins
Proteins
2008

Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin

Zanchi, C., Zoja, C., Morigi, M., Valsecchi, F., Xue, Y. L., Rottoli, D., Locatelli, M., Buelli, S., Pezzotta, A., Mapelli, P., Geelen, J., Remuzzi, G. & Hawiger, J., Jul 15 2008, In : Journal of Immunology. 181, 2, p. 1460-1469 10 p.

Research output: Contribution to journalArticle

Chemokine CX3CL1
Shiga Toxin
Endothelium
Leukocytes
Endothelial Cells
2006

Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective intervention

Macconi, D., Abbate, M., Morigi, M., Angioletti, S., Mister, M., Buelli, S., Bonomelli, M., Mundel, P., Endlich, K., Remuzzi, A. & Remuzzi, G., Apr 2006, In : American Journal of Pathology. 168, 4, p. 1073-1085 13 p.

Research output: Contribution to journalArticle

Podocytes
Angiotensin II
Actins
Tight Junctions
jasplakinolide

Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling

Morigi, M., Buelli, S., Zanchi, C., Longaretti, L., Macconi, D., Benigni, A., Moioli, D., Remuzzi, G. & Zoja, C., Dec 2006, In : American Journal of Pathology. 169, 6, p. 1965-1975 11 p.

Research output: Contribution to journalArticle

Podocytes
Endothelin-1
Actins
Cytoskeleton
Mitogen-Activated Protein Kinase 1
2005

Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation

Galbusera, M., Buelli, S., Gastoldi, S., Macconi, D., Angioletti, S., Testa, C., Remuzzi, G. & Morigi, M., Mar 2005, In : Xenotransplantation. 12, 2, p. 110-120 11 p.

Research output: Contribution to journalArticle

Platelet Activation
Endothelium
Thrombosis
Swine
Endothelial Cells

In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: Implication for permselective dysfunction of chronic nephropathies

Morigi, M., Buelli, S., Angioletti, S., Zanchi, C., Longaretti, L., Zoja, C., Galbusera, M., Gastoldi, S., Mundel, P., Remuzzi, G. & Benigni, A., May 2005, In : American Journal of Pathology. 166, 5, p. 1309-1320 12 p.

Research output: Contribution to journalArticle

Podocytes
Endothelin-1
Cytoskeleton
Focal Adhesion Protein-Tyrosine Kinases
rho-Associated Kinases
2003
Chemokine CX3CL1
p38 Mitogen-Activated Protein Kinases
Up-Regulation
Proteins
Messenger RNA
2002
Protein Kinase C
Albumins
Reactive Oxygen Species
Proteins
Antioxidants