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2019

Alcohol and the global burden of disease

Di Castelnuovo, A. F., Costanzo, S. & de Gaetano, G., Jun 15 2019, In : Lancet (London, England). 393, 10189, p. 2389

Research output: Contribution to journalArticle

Alcohol consumption and hospitalization burden in an adult Italian population: prospective results from the Moli-sani study

Moli-sani Study Investigators, Apr 2019, In : Addiction. 114, 4, p. 636-650 15 p.

Research output: Contribution to journalArticle

Chili Pepper Consumption and Mortality in Italian Adults

Moli-sani Study Investigators, Dec 24 2019, In : Journal of the American College of Cardiology. 74, 25, p. 3139-3149 11 p.

Research output: Contribution to journalArticle

Consumption of whole grain food and its determinants in a general Italian population: Results from the INHES study

INHES Study Investigators, Jun 2019, In : Nutrition, Metabolism and Cardiovascular Diseases. 29, 6, p. 611-620 10 p.

Research output: Contribution to journalArticle

Interaction between Mediterranean diet and statins on mortality risk in patients with cardiovascular disease: Findings from the Moli-sani Study

Moli-sani Study Investigators, Feb 1 2019, In : International Journal of Cardiology. 276, p. 248-254 7 p.

Research output: Contribution to journalArticle

Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation

Moli-sani Study Investigators, May 2 2019, In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Moderate alcohol consumption and lower total mortality risk: Justified doubts or established facts?

Costanzo, S., de Gaetano, G., Di Castelnuovo, A., Djoussé, L., Poli, A. & van Velden, D. P., Oct 2019, In : Nutrition, Metabolism and Cardiovascular Diseases. 29, 10, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and the Risk of Stroke

BiomarCaRE Investigators, Mar 2019, In : Stroke. 50, 3, p. 610-617 8 p.

Research output: Contribution to journalArticle

Randomized trial of chronic supplementation with a nutraceutical mixture to subjects with Non Alcoholic Fatty Liver Disease (NAFLD)

Cerletti, C., Colucci, M., Storto, M., Semeraro, F., Ammollo, C. T., Incampo, F., Costanzo, S., De Bartolomeo, G., Portincasa, P., Barone, M., Di Castelnuovo, A., Semeraro, N., Iacoviello, L. & de Gaetano, G., Sep 26 2019, In : British Journal of Nutrition. p. 1-19 19 p.

Research output: Contribution to journalArticle

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

NCD Risk Factor Collaboration (NCD-RisC), De Gaetano, G., De Curtis, A., Iacoviello, L., Donati, M. B., Bonaccio, M. & Costanzo, S., May 2019, In : Nature. 569, 7755, p. 260-264 5 p.

Research output: Contribution to journalArticle

Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

BiomarCaRE Consortium, Mar 2019, In : JACC: Heart Failure. 7, 3, p. 204-213 10 p.

Research output: Contribution to journalArticle

Socioeconomic and psychosocial determinants of adherence to the Mediterranean diet in a general adult Italian population

INHES Study Investigators, Apr 1 2019, In : European Journal of Public Health. 29, 2, p. 328-335 8 p.

Research output: Contribution to journalArticle

Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality

Camen, S., Ojeda, F. M., Niiranen, T., Gianfagna, F., Vishram-Nielsen, J. K., Costanzo, S., Söderberg, S., Vartiainen, E., Donati, M. B., Løchen, M-L., Pasterkamp, G., Magnussen, C., Kee, F., Jousilahti, P., Hughes, M., Kontto, J., Mathiesen, E. B., Koenig, W., Palosaari, T., Blankenberg, S. & 8 others, de Gaetano, G., Jørgensen, T., Zeller, T., Kuulasmaa, K., Linneberg, A., Salomaa, V., Iacoviello, L. & Schnabel, R. B., Nov 18 2019, In : Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Research output: Contribution to journalArticle

Vitamin D Status and Indices of Mineral Homeostasis in the Population: Differences Between 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D

Cirillo, M., Bilancio, G., Guarino, E., Cavallo, P., Lombardi, C., Costanzo, S., De Curtis, A., Di Castelnuovo, A. & Iacoviello, L., Aug 1 2019, In : Nutrients. 11, 8

Research output: Contribution to journalArticle

2018

Association of proinflammatory diet with low-grade inflammation: results from the Moli-sani study

UOC Servizio Igiene e Sanità Pubblica—Dipartimento di Prevenzione; Offices of vital statistics of the Molise region and Molise Dati Spa, Moli-sani Study Investigators, Azienda Sanitaria Regionale del Molise, Azienda Sanitaria Regionale del Molise & Presidi Ospedalieri ASReM (Presidio Ospedaliero A. Cardarelli—Campobasso; Ospedale F. Veneziale—Isernia; Ospedale San Timoteo—Termoli (CB); Ospedale Ss. Rosario—Venafro (IS); Ospedale Vietri—Larino (CB); Ospedale San Francesco Caracciolo—Agnone (IS)); Istituto di cura Villa Maria—Campobasso; Fondazione di Ricerca e Cura Giovanni Paolo II—Campobasso; IRCCS Neuromed—Pozzilli (IS), Oct 1 2018, In : Nutrition. 54, p. 182-188 7 p.

Research output: Contribution to journalArticle

Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?

on behalf of the MOLI-SANI Study Investigators, Nov 17 2018, In : Immunological Investigations. 47, 8, p. 774-789 16 p.

Research output: Contribution to journalArticle

Diet and primary prevention of stroke: Systematic review and dietary recommendations by the ad hoc Working Group of the Italian Society of Human Nutrition

Iacoviello, L., Bonaccio, M., Cairella, G., Catani, M. V., Costanzo, S., D'Elia, L., Giacco, R., Rendina, D., Sabino, P., Savini, I., Strazzullo, P., Biffi, B., Bonaccio, M., Cairella, G., Casini, A., Catani, M. V., Costanzo, S., Garbagnati, F., Gensini, G., Giacco, R. & 12 others, Iacoviello, L., Luisi, M. L., Pinto, A., Rendina, D., Sabino, P., Salvia, A., Savini, I., Sandri, G., Scalfi, L., Scognamiglio, U., Strazzullo, P. & Working Group for Nutrition and Stroke, Jan 1 2018, In : Nutrition, Metabolism and Cardiovascular Diseases.

Research output: Contribution to journalArticle

Diet and primary prevention of stroke: Systematic review and dietary recommendations by the ad hoc Working Group of the Italian Society of Human Nutrition

Iacoviello, L., Bonaccio, M., Cairella, G., Catani, M. V., Costanzo, S., D'Elia, L., Giacco, R., Rendina, D., Sabino, P., Savini, I., Strazzullo, P., Biffi, B., Casini, A., Garbagnati, F., Casini, A., Gensini, G., Luisi, M. L., Pinto, A., Rendina, D., Sabino, P. & 7 others, Salvia, A., Sandri, G., Scalfi, L., Scognamiglio, U., Strazzullo, P., Nutrition, W. G. F. & International Stroke Genetics Consortium, S., 2018, In : Nutrition, Metabolism and Cardiovascular Diseases. 28, 4, p. 309-334 26 p.

Research output: Contribution to journalArticle

Favorable association of polyphenol-rich diets with lung function: Cross-sectional findings from the Moli-sani study

Pounis, G., Arcari, A., Costanzo, S., Di Castelnuovo, A., Bonaccio, M., Persichillo, M., Donati, M. B., de Gaetano, G. & Iacoviello, L., Mar 1 2018, In : Respiratory Medicine. 136, p. 48-57 10 p.

Research output: Contribution to journalArticle

Health-related quality of life and risk of composite coronary heart disease and cerebrovascular events in the Moli-sani study cohort

Moli-sani Study Investigators, Feb 2018, In : European Journal of Preventive Cardiology. 25, 3, p. 287-297 11 p.

Research output: Contribution to journalArticle

Mediterranean diet and mortality in the elderly: A prospective cohort study and a meta-analysis

Bonaccio, M., Di Castelnuovo, A., Costanzo, S., Gialluisi, A., Persichillo, M., Cerletti, C., Donati, M. B., De Gaetano, G. & Iacoviello, L., Oct 28 2018, In : British Journal of Nutrition. 120, 8, p. 841-854 14 p.

Research output: Contribution to journalArticle

Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study

MOLI-SANI investigators, Apr 1 2018, In : Nutrition. 48, p. 87-95 9 p.

Research output: Contribution to journalArticle

Serum vitamin D deficiency and risk of hospitalization for heart failure: Prospective results from the Moli-sani study

Moli-sani Study Investigators, Mar 1 2018, In : Nutrition, Metabolism and Cardiovascular Diseases. 28, 3, p. 298-307 10 p.

Research output: Contribution to journalArticle

2017

Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study

Bonaccio, M., Ruggiero, E., Di Castelnuovo, A., Costanzo, S., Persichillo, M., De Curtis, A., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Iacoviello, L., Donati, M. B., de Gaetano, G., Vermylen, J., De Paula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Spagnuolo, P. & 32 others, Staniscia, D., Zito, F., Bonanni, A., Cerletti, C., De Curtis, A., Di Castelnuovo, A., Lorenzet, R., Mascioli, A., Olivieri, M., Rotilio, D., Bonaccio, M., Costanzo, S., Gianfagna, F., Giacci, M., Padulo, A., Petraroia, D., Magnacca, S., Marracino, F., Spinelli, M., Silvestri, C., dell'Elba, G., Grippi, C., De Lucia, F., Vohnout, B., Zito, F., Persichillo, M., Arcari, A., Cugino, D., Ferri, A., Mignogna, M., Moli-sani study Investigators & Moli-sani study Investigators, Oct 1 2017, In : Nutrition, Metabolism and Cardiovascular Diseases. 27, 10, p. 865-873 9 p.

Research output: Contribution to journalArticle

Frontal plane T-wave axis orientation predicts coronary events: Findings from the Moli-sani study

Iacoviello, L., Bonaccio, M., Di Castelnuovo, A., Costanzo, S., De Curtis, A., Persichillo, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Rago, L., Assanelli, D., Badilini, F., Vaglio, M., Macfarlane, P. W., on behalf of the & Moli-sani study Investigators, Sep 1 2017, In : Atherosclerosis. 264, p. 51-57 7 p.

Research output: Contribution to journalArticle

Lipoprotein(a) and the risk of cardiovascular disease in the European population: Results from the BiomarCaRE consortium

Waldeyer, C., Makarova, N., Zeller, T., Schnabel, R. B., Brunner, F. J., Jørgensen, T., Linneberg, A., Niiranen, T., Salomaa, V., Jousilahti, P., Yarnell, J., Ferrario, M. M., Veronesi, G., Brambilla, P., Signorini, S. G., Iacoviello, L., Costanzo, S., Giampaoli, S., Palmieri, L., Meisinger, C. & 8 others, Thorand, B., Kee, F., Koenig, W., Ojeda, F., Kontto, J., Landmesser, U., Kuulasmaa, K. & Blankenberg, S., Aug 21 2017, In : European Heart Journal. 38, 32, p. 2490-2498 9 p.

Research output: Contribution to journalArticle

Mean platelet volume is associated with lower risk of overall and non-vascular mortality in a general population: Results from the Moli-sani study

Bonaccio, M., Di Castelnuovo, A., Costanzo, S., de Curtis, A., Persichillo, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Vermylen, J., de Paula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Spagnuolo, P., Staniscia, D., Bonanni, A., Lorenzet, R., Mascioli, A. & 31 others, Rotilio, D., Olivieri, M., Giacci, M., Padulo, A., Petraroia, D., Grippi, C., Spinelli, M., Silvestri, C., Gianfagna, F., Verna, A., Pampuch, A., Vohnout, B., Pannichella, A., Vizzarri, A. R., Arcari, A., Barbato, D., Bracone, F., Di Giorgio, C., Magnacca, S., Panebianco, S., Chiovitti, A., Marracino, F., Caccamo, S., Caruso, V., Cugino, D., Zito, F., Ferri, A., Mignogna, M., Guszcz, T., Di Giuseppe, R. & Moli-sani Study Investigators, Jun 2 2017, In : Thrombosis and Haemostasis. 117, 6, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

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Moderate Alcohol Consumption Is Associated With Lower Risk for Heart Failure But Not Atrial Fibrillation

Di Castelnuovo, A., Costanzo, S., Bonaccio, M., Rago, L., De Curtis, A., Persichillo, M., Bracone, F., Olivieri, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Iacoviello, L., Donati, M. B., de Gaetano, G., Vermylen, J., De Paula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D. & 32 others, Centritto, V., Spagnuolo, P., Staniscia, D., Zito, F., Bonanni, A., Cerletti, C., De Curtis, A., Di Castelnuovo, A., Iacoviello, L., Lorenzet, R., Di Castelnuovo, A., Bonaccio, M., Costanzo, S., Gianfagna, F., De Curtis, A., Marracino, F., Bonaccio, M., Gianfagna, F., Persichillo, M., Arcari, A., Costanzo, S., Marracino, F., Cugino, D., Gianfagna, F., Costanzo, S., Costanzo, S., Costanzo, S., De Curtis, A., Iacoviello, L., Persichillo, M., Moli-sani Investigators & Moli-sani Investigators, Nov 1 2017, In : JACC: Heart Failure. 5, 11, p. 837-844 8 p.

Research output: Contribution to journalArticle

Obesity and ECG left ventricular hypertrophy

Muiesan, M. L., Salvetti, M., Di Castelnuovo, A., Paini, A., Assanelli, D., Costanzo, S., Badilini, F., Vaglio, M., Donati, M. B., Agabiti Rosei, E., de Gaetano, G., Iacoviello, L. & Moli-sani Study Investigators, Jan 2017, In : Journal of Hypertension. 35, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models

Pounis, G., Tabolacci, C., Costanzo, S., Cordella, M., Bonaccio, M., Rago, L., D'Arcangelo, D., Filippo Di Castelnuovo, A., de Gaetano, G., Donati, M. B., Iacoviello, L., Facchiano, F. & on behalf of the Moli-sani study investigators, Jul 1 2017, In : International Journal of Cancer. 141, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Relative contribution of health-related behaviours and chronic diseases to the socioeconomic patterning of low-grade inflammation

Bonaccio, M., Di Castelnuovo, A., Pounis, G., De Curtis, A., Costanzo, S., Persichillo, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L. & On behalf of the Moli-sani Study Investigators, B. O. T. M. S. I., Jun 1 2017, In : International Journal of Public Health. 62, 5, p. 551-562 12 p.

Research output: Contribution to journalArticle

Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza

Rondy, M., Launay, O., Castilla, J., Costanzo, S., Puig-Barberà, J., Gefenaite, G., Larrauri, A., Rizzo, C., Pitigoi, D., Syrjänen, R. K., Machado, A., Kurečić Filipović, S., Krisztina Horváth, J., Paradowska-Stankiewicz, I., Marbus, S., Moren, A. & InNHOVE/I-MOVE+working group , Aug 3 2017, In : Vaccine. 35, 34, p. 4298-4306 9 p.

Research output: Contribution to journalArticle

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)

Magnussen, C., Niiranen, T. J., Ojeda, F. M., Gianfagna, F., Blankenberg, S., Njølstad, I., Vartiainen, E., Sans, S., Pasterkamp, G., Hughes, M., Costanzo, S., Donati, M. B., Jousilahti, P., Linneberg, A., Palosaari, T., de Gaetano, G., Bobak, M., den Ruijter, H. M., Mathiesen, E., Jørgensen, T. & 7 others, Söderberg, S., Kuulasmaa, K., Zeller, T., Iacoviello, L., Salomaa, V., Schnabel, R. B. & BiomarCaRE Consortium, Oct 24 2017, In : Circulation. 136, 17, p. 1588-1597 10 p.

Research output: Contribution to journalArticle

Socioeconomic status and impact of the economic crisis on dietary habits in Italy: results from the INHES study

Bonaccio, M., Di Castelnuovo, A., Bonanni, A., Costanzo, S., Persichillo, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L. & INHES Study Investigators, Nov 8 2017, In : Journal of Public Health. p. 1-10 10 p.

Research output: Contribution to journalArticle

Timing of surgical correction for the treatment of unilateral congenital ptosis: Effects on cosmetic and functional results

Quaranta-Leoni, F. M., Sposato, S., Leonardi, A., Iacoviello, L. & Costanzo, S., Nov 2 2017, In : Orbit. 36, 6, p. 382-387 6 p.

Research output: Contribution to journalArticle

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure

Zeller, T., Schurmann, C., Schramm, K., Müller, C., Kwon, S., Wild, P. S., Teumer, A., Herrington, D., Schillert, A., Iacoviello, L., Kratzer, A., Jagodzinski, A., Karakas, M., Ding, J., Neumann, J. T., Kuulasmaa, K., Gieger, C., Kacprowski, T., Schnabel, R. B., Roden, M. & 21 others, Wahl, S., Rotter, J. I., Ojeda, F., Carstensen-Kirberg, M., Tregouet, D-A., Dörr, M., Meitinger, T., Lackner, K. J., Wolf, P., Felix, S. B., Landmesser, U., Costanzo, S., Ziegler, A., Liu, Y., Völker, U., Palmas, W., Prokisch, H., Guo, X., Herder, C., Blankenberg, S. & Homuth, G., Oct 2017, In : Hypertension. 70, 4, p. 743-750 8 p.

Research output: Contribution to journalArticle

Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Zhou, B., Bentham, J., Di Cesare, M., Bixby, H., Danaei, G., Cowan, M. J., Paciorek, C. J., Singh, G., Hajifathalian, K., Bennett, J. E., Taddei, C., Bilano, V., Carrillo-Larco, R. M., Djalalinia, S., Khatibzadeh, S., Lugero, C., Peykari, N., Zhang, W. Z., Lu, Y., Stevens, G. A. & 31 others, Riley, L. M., Bovet, P., Elliott, P., Gu, D., Ikeda, N., Jackson, R. T., Joffres, M., Kengne, A. P., Laatikainen, T., Lam, T. H., Laxmaiah, A., Liu, J., Miranda, J. J., Mondo, C. K., Neuhauser, H. K., Sundström, J., Smeeth, L., Sorić, M., Woodward, M., Ezzati, M., Abarca-Gómez, L., Abdeen, Z. A., Rahim, H. A., Abu-Rmeileh, N. M., Costanzo, S., de Gaetano, G., Di Castelnuovo, A. F., Gianfagna, F., Iacoviello, L., Maggi, S. & NCD Risk Factor Collaboration (NCD-RisC), Jan 7 2017, In : The Lancet. 389, 10064, p. 37-55 19 p.

Research output: Contribution to journalArticle

2016

A century of trends in adult human height

Bentham, J., Di Cesare, M., Stevens, G. A., Zhou, B., Bixby, H., Cowan, M., Fortunato, L., Bennett, J. E., Danaei, G., Hajifathalian, K., Lu, Y., Riley, L. M., Laxmaiah, A., Kontis, V., Paciorek, C. J., Ezzati, M., Abdeen, Z. A., Hamid, Z. A., Abu-Rmeileh, N. M., Acosta-Cazares, B. & 31 others, Adams, R., Aekplakorn, W., Aguilar-Salinas, C. A., Agyemang, C., Ahmadvand, A., Ahrens, W., Al-Hazzaa, H. M., Al-Othman, A. R., Raddadi, R. A., Ali, M. M., Alkerwi, A., Alvarez-Pedrerol, M., Aly, E., Amouyel, P., Amuzu, A., Andersen, L. B., Anderssen, S. A., Anjana, R. M., Aounallah-Skhiri, H., Ariansen, I., Aris, T., Arlappa, N., Arveiler, D., Assah, F. K., Avdicová, M., Cottel, D., De Henauw, S., Dias-da-Costa, J. S., Giovannelli, J., Iannone, A. G. & NCD Risk Factor Collaboration (NCD-RisC), Jul 26 2016, In : eLife. 5, 2016JULY, e13410.

Research output: Contribution to journalArticle

A score of low-grade inflammation and risk of mortality: Prospective findings from the moli-sani study

Bonaccio, M., Di Castelnuovo, A., Pounis, G., De Curtis, A., Costanzo, S., Persichillo, M., Cerletti, C., Donati, M. B., De Gaetano, G., Iacoviello, L., Iacoviello, L., Donati, M. B., De Gaetano, G., Vermylen, J., Carrasco, I. D. P., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Spagnuolo, P. & 86 others, Staniscia, D., Zito, F., Bonanni, A., Cerletti, C., De Curtis, A., Di Castelnuovo, A., Iacoviello, L., Lorenzet, R., Mascioli, A., Olivieri, M., Rotilio, D., Di Castelnuovo, A., Bonaccio, M., Costanzo, S., Gianfagna, F., Olivieri, M., Giacci, M., Padulo, A., Petraroia, D., De Curtis, A., Marracino, F., Spinelli, M., Silvestri, C., Bonanni, A., Bonaccio, M., De Lucia, F., Gianfagna, F., Vohnout, B., Zito, F., Coordinator, G., Persichillo, M., Verna, A., Di Lillo, M., Di Stefano, I., Pannichella, A., Vizzarri, A. R., Vohnout, B., Pampuch, A., Arcari, A., Barbato, D., Bracone, F., Costanzo, S., Di Giorgio, C., Magnacca, S., Panebianco, S., Chiovitti, A., Marracino, F., Caccamo, S., Caruso, V., Rago, L., Cugino, D., Zito, F., Gianfagna, F., Ferri, A., Castaldi, C., Mignogna, M., Guszcz, T., Di Giuseppe, R., Barisciano, P., Buonaccorsi, L., Centritto, F., Cutrone, A., De Lucia, F., Fanelli, F., Santimone, I., Sciarretta, A., Di Lillo, M., Sorella, I., Di Stefano, I., Plescia, E., Molinaro, A., Cavone, C., Galuppo, G., Di Lillo, M., Castaldi, C., D’Angelo, D., Ramacciato, R., Costanzo, S., Costanzo, S., Olivieri, M., Rago, L., Costanzo, S., De Curtis, A., Iacoviello, L., Persichillo, M. & Molise, A. S. R. D., Oct 31 2016, In : Haematologica. 101, 11, p. 1434-1441 8 p.

Research output: Contribution to journalArticle