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Research Output 2002 2019

  • 68 Article
  • 7 Review article
  • 1 Conference contribution
2019

Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-κB pathway

Avnet, S., Chano, T., Massa, A., Bonuccelli, G., Lemma, S., Falzetti, L., Grisendi, G., Dominici, M. & Baldini, N., Jun 1 2019, In : American Journal of Cancer Research. 9, 6, p. 1127-1144 18 p.

Research output: Contribution to journalArticle

Sarcoma
Cell Survival
Bone and Bones
Acids
Neoplasms

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer

Avnet, S., Baldini, N., Brisson, L., Pedersen, S. F., Porporato, P. E., Sonveaux, P., Szabadkai, G. & Pastorekova, S., Nov 28 2019, In : Frontiers in Oncology. 9, p. 1-5 5 p.

Research output: Contribution to journalReview article

Neoplasms
Slovakia
Tumor Microenvironment
Metabolic Networks and Pathways
Delivery of Health Care

Cause and effect of microenvironmental acidosis on bone metastases

Avnet, S., Di Pompo, G., Lemma, S. & Baldini, N., Jun 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 133-147 15 p.

Research output: Contribution to journalReview article

Acidosis
Neoplasm Metastasis
Bone and Bones
Neoplasms
Protons

New Advances in the Study of Bone Tumors: A Lesson From the 3D Environment

Cortini, M., Baldini, N. & Avnet, S., Jun 26 2019, In : Frontiers in Physiology. 10, p. 1-8 8 p.

Research output: Contribution to journalArticle

Bone and Bones
Neoplasms
Precision Medicine
Cell Culture Techniques
Neoplasm Metastasis

Photodynamic Surgery for Feline Injection-Site Sarcoma

Martano, M., Morello, E., Avnet, S., Costa, F., Sammartano, F., Kusuzaki, K. & Baldini, N., Jul 8 2019, In : BioMed Research International. 2019, p. 1-10 10 p.

Research output: Contribution to journalArticle

Acridine Orange
Felidae
Sarcoma
Surgery
Tumors
Mesenchymal Stromal Cells
Neoplasms
Epithelial-Mesenchymal Transition
Confounding Factors (Epidemiology)
Tumor Microenvironment
2018

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism

Avnet, S., Baldini, N., Brisson, L., De Milito, A., Otto, A. M., Pastoreková, S., Porporato, P. E., Szabadkai, G. & Sonveaux, P., Oct 3 2018, In : Frontiers in Oncology. 8, p. 1-5 5 p.

Research output: Contribution to journalArticle

Neoplasms
Metabolic Networks and Pathways
Energy Metabolism
Italy
Recurrence

Exosome-like nanovesicles isolated from Citrus limon L. exert antioxidative effect

Baldini, N., Torreggiani, E., Roncuzzi, L., Perut, F., Zini, N. & Avnet, S., 2018, In : Current Pharmaceutical Biotechnology. 19, 11, p. 877 - 885 9 p.

Research output: Contribution to journalArticle

Exosomes
Citrus
Ascorbic Acid
Mesenchymal Stromal Cells
Citric Acid

RAB39A: a Rab small GTPase with a prominent role in cancer stemness

Chano, T. & Avnet, S., Apr 10 2018, In : Journal of Biochemistry. 164, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Cells
Membranes
Molecules

Spheroid-based 3D cell cultures identify salinomycin as a promising drug for the treatment of chondrosarcoma

Perut, F., Sbrana, F. V., Avnet, S., De Milito, A. & Baldini, N., Feb 22 2018, In : Journal of Orthopaedic Research. 36, 8, p. 2305-2312 8 p.

Research output: Contribution to journalArticle

Chondrosarcoma
Cell Culture Techniques
Pharmaceutical Preparations
Doxorubicin
Therapeutics

The Effects of Systemic and Local Acidosis on Insulin Resistance and Signaling

Baldini, N. & Avnet, S., Dec 30 2018, In : International Journal of Molecular Sciences. 20, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

acidosis
insulin
Insulin
Acidosis
Insulin Resistance

Validation of Suitable Housekeeping Genes for the Normalization of mRNA Expression for Studying Tumor Acidosis

Lemma, S., Avnet, S., Meade, M. J., Chano, T. & Baldini, N., Sep 26 2018, In : International Journal of Molecular Sciences. 19, 10, p. 1-15 15 p.

Research output: Contribution to journalArticle

acidosis
Essential Genes
Acidosis
genes
Tumors
2017

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Baldini, N., De Milito, A., Feron, O., Gillies, R. J., Michiels, C., Otto, A. M., Pastorekova, S., Pedersen, S. F., Porporato, P. E., Sonveaux, P., Supuran, C. T. & Avnet, S., 2017, In : Frontiers in Pharmacology. 8, p. 1-5 5 p.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Neoplasms
Precision Medicine
Belgium
Energy Metabolism

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

Avnet, S., Di Pompo, G., Chano, T., Errani, C., Ibrahim-Hashim, A., Gillies, R. J., Donati, D. M. & Baldini, N., Mar 15 2017, In : International Journal of Cancer. 140, 6, p. 1331-1345 15 p.

Research output: Contribution to journalArticle

Osteosarcoma
Acidosis
Mesenchymal Stromal Cells
Neoplasms
Interleukin-6

Immunohistochemical evaluation of bone metastases

Errani, C., Mavrogenis, A. F., Megaloikonomos, P. D., Antoniadou, T., Antonioli, D., Avnet, S., Pellacani, A. & Baldini, N., Aug 25 2017, In : Nowotwory. 67, 1, p. 1-6 6 p.

Research output: Contribution to journalReview article

Neoplasm Metastasis
Bone and Bones
Neoplasms
Unknown Primary Neoplasms
Keratin-20

Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma.

Di Pompo, G., Lemma, S., Canti, L., Rucci, N., Ponzetti, M., Errani, C., Donati, D. M., Russell, S., Gillies, R., Chano, T., Baldini, N. & Avnet, S., Apr 13 2017, In : Oncotarget. 8, 33, p. 54478-54496 19 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Acidosis
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones

MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.

Lemma, S., Di Pompo, G., Porporato, P., Sboarina, M., Russell, S., Gillies, R. J., Baldini, N., Sonveaux, P. & Avnet, S., Sep 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 12, p. 3254-3264 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Lactic Acid

Mesenchymal stroma: Role in osteosarcoma progression.

Cortini, M., Avnet, S. & Baldini, N., Jul 31 2017, In : Cancer Letters. 405, p. 90-99 10 p.

Research output: Contribution to journalArticle

Osteosarcoma
Tumor Microenvironment
Neoplasms
Cellular Microenvironment
Neoplastic Stem Cells

Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates

Ciapetti, G., Di Pompo, G., Avnet, S., Martini, D., Diez-Escudero, A., Montufar, E. B., Ginebra, M. P. & Baldini, N., Mar 1 2017, In : Acta Biomaterialia. 50, p. 102-113 12 p.

Research output: Contribution to journalArticle

Biomimetics
Calcium phosphate
Osteoclasts
Blood
Substrates

Pathobiology and Therapeutic Implications of Tumor Acidosis

Viklund, J., Avnet, S. & De Milito, A., 2017, In : Current Medicinal Chemistry. 24, 26, p. 2827-2845 19 p.

Research output: Contribution to journalReview article

Acidosis
Tumors
Neoplasms
Pharmaceutical Preparations
Therapeutics
1 Downloads (Pure)

The effect of extracellular acidosis on the behaviour of mesenchymal stem cells in vitro.

Massa, A., Perut, F., Chano, T., woloszyk, A., Mitsiadis, T. A., Avnet, S. & Baldini, N., Apr 3 2017, In : European Cells and Materials. 33, p. 252-267 16 p.

Research output: Contribution to journalArticle

Open Access
Acidosis
Stem cells
Mesenchymal Stromal Cells
Stem Cells
Dental Pulp

Therapeutic implications of tumor interstitial acidification

Kolosenko, I., Avnet, S., Baldini, N., Viklund, J. & De Milito, A., 2017, In : Seminars in Cancer Biology. 43, p. 119-133 15 p.

Research output: Contribution to journalArticle

Acidosis
Neoplasms
Therapeutics
Drug Resistance
Pharmaceutical Preparations

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

Chano, T., Avnet, S., Kusuzaki, K., Bonuccelli, G., Sonveaux, P., Rotili, D., Mai, A. & Baldini, N., 2017, In : American Journal of Cancer Research. 6, 4, p. 859-875 17 p.

Research output: Contribution to journalArticle

Osteosarcoma
Acidosis
Epigenomics
Neoplasms
Fibroblasts
2016

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

Avnet, S., Lemma, S., Cortini, M., Pellegrini, P., Perut, F., Zini, N., Kusuzaki, K., Chano, T., Grisendi, G., Dominici, M., De Milito, A. & Baldini, N., 2016, In : Oncotarget. 7, 39, p. 63408-63423 16 p.

Research output: Contribution to journalArticle

Proton-Motive Force
Osteosarcoma
Drug Resistance
Doxorubicin
Cell Membrane

Energy metabolism in osteoclast formation and activity

Lemma, S., Sboarina, M., Porporato, P. E., Zini, N., Sonveaux, P., Di Pompo, G., Baldini, N. & Avnet, S., Oct 1 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 168-180 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Energy Metabolism
Bone
Glycolysis
Mitochondria

Identification and validation of housekeeping genes for gene expression analysis of cancer stem cells

Lemma, S., Avnet, S., Salerno, M., Chano, T. & Baldini, N., Feb 1 2016, In : PLoS One. 11, 2, 149481.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Essential Genes
Stem cells
Gene expression
stem cells

Metabolism and microenvironment in cancer plasticity

Baldini, N., Sonveaux, P., De Milito, A., Supuran, C. T., Otto, A. M., Stock, C., Pedersen, S. F., Favicchio, R. & Avnet, S., 2016, In : Cancer and Metabolism. 7 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Neoplasms
Epigenomics

Role of Pericellular Matrix in the Regulation of Cancer Stemness.

Avnet, S. & Cortini, M., Aug 2016, In : Stem Cell Reviews. p. 464-75 12 p.

Research output: Contribution to journalArticle

Open Access
Neoplastic Stem Cells
Hyaluronic Acid
Neoplasms
CD44 Antigens
Recurrence

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

Sbrana, F. V., Cortini, M., Avnet, S., Perut, F., Columbaro, M., De Milito, A. & Baldini, N., Dec 1 2016, In : Stem Cell Reviews and Reports. 12, 6, p. 621-633 13 p.

Research output: Contribution to journalReview article

Autophagy
Mesenchymal Stromal Cells
Maintenance
Regenerative Medicine
Eukaryotic Cells

Tumor-activated mesenchymal stromal cells promote osteosarcoma stemness and migratory potential via IL-6 secretion

Cortini, M., Massa, A., Avnet, S., Bonuccelli, G. & Baldini, N., Nov 1 2016, In : PLoS One. 11, 11, 22 p., e0166500.

Research output: Contribution to journalArticle

osteosarcoma
stromal cells
Osteosarcoma
Mesenchymal Stromal Cells
interleukin-6
2015

Acridine orange is an effective anti-cancer drug that affects mitochondrial function in osteosarcoma cells

Fotia, C., Avnet, S., Kusuzaki, K., Roncuzzi, L. & Baldini, N., Oct 1 2015, In : Current Pharmaceutical Design. 21, 28, p. 4088-4094 7 p.

Research output: Contribution to journalArticle

Acridine Orange
Osteosarcoma
Pharmaceutical Preparations
Lysosomes
Neoplasms

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

Perut, F., Carta, F., Bonuccelli, G., Grisendi, G., Di Pompo, G., Avnet, S., Sbrana, F. V., Hosogi, S., Dominici, M., Kusuzaki, K., Supuran, C. T. & Baldini, N., Dec 2 2015, In : Expert Opinion on Therapeutic Targets. 19, 12, p. 1593-1605 13 p.

Research output: Contribution to journalArticle

Carbonic Anhydrases
Osteosarcoma
Bone
Cells
Cell proliferation

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: Understanding the osteolytic process triggered by altered lamins

Evangelisti, C., Bernasconi, P., Cavalcante, P., Cappelletti, C., D'Apice, M. R., Sbraccia, P., Novelli, G., Prencipe, S., Lemma, S., Baldini, N., Avnet, S., Squarzoni, S., Martelli, A. M. & Lattanzi, G., 2015, In : Oncotarget. 6, 10, p. 7424-7437 14 p.

Research output: Contribution to journalArticle

Lamins
Lamin Type A
Osteoblasts
Transforming Growth Factor beta
Cathepsin K

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells

Di Pompo, G., Salerno, M., Rotili, D., Valente, S., Zwergel, C., Avnet, S., Lattanzi, G., Baldini, N. & Mai, A., May 14 2015, In : Journal of Medicinal Chemistry. 58, 9, p. 4073-4079 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Neoplastic Stem Cells
Sarcoma
Apoptosis
Ewing's Sarcoma

Proton channels and exchangers in cancer

Spugnini, E. P., Sonveaux, P., Stock, C., Perez-Sayans, M., De Milito, A., Avnet, S., Garcìa, A. G., Harguindey, S. & Fais, S., Oct 1 2015, In : BBA - Biomembranes. 1848, 10, p. 2715-2726 12 p., 81705.

Research output: Contribution to journalArticle

Protons
Tumors
Neoplasms
Cells
Sodium-Hydrogen Antiporter
2014

Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD

Salerno, M., Avnet, S., Bonuccelli, G., Hosogi, S., Granchi, D. & Baldini, N., Oct 20 2014, In : PLoS One. 9, 10, e110340.

Research output: Contribution to journalArticle

Embryonal Rhabdomyosarcoma
Neoplastic Stem Cells
Rhabdomyosarcoma
Stem cells
Vacuolar Proton-Translocating ATPases

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

Bonuccelli, G., Avnet, S., Grisendi, G., Salerno, M., Granchi, D., Dominici, M., Kusuzaki, K. & Baldini, N., 2014, In : Oncotarget. 5, 17, p. 7575-7588 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
Mesenchymal Stromal Cells
Monocarboxylic Acid Transporters
Neoplasms
Lactic Acid

V-ATPase as an effective therapeutic target for sarcomas

Perut, F., Avnet, S., Fotia, C., Baglìo, S. R., Salerno, M., Hosogi, S., Kusuzaki, K. & Baldini, N., Jan 1 2014, In : Experimental Cell Research. 320, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

Sarcoma
Adenosine Triphosphatases
Protons
Esomeprazole
Rhabdomyosarcoma
2013

Corrigendum to "Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant Leukodystrophy" [Biochim. Biophys. Acta, Mol. Basis Dis. 1832 (3) (March 2013) 411-420]

Columbaro, M., Mattioli, E., Maraldi, N. M., Ortolani, M., Gasparini, L., D'Apice, M. R., Postorivo, D., Nardone, A. M., Avnet, S., Cortelli, P., Liguori, R. & Lattanzi, G., Dec 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 12, p. 2244 1 p.

Research output: Contribution to journalArticle

Low toxicity and unprecedented anti-osteoclast activity of a simple sulfur-containing gem-bisphosphonate: A comparative study

Granchi, D., Scarso, A., Bianchini, G., Chiminazzo, A., Minto, A., Sgarbossa, P., Michelin, R. A., Di Pompo, G., Avnet, S. & Strukul, G., 2013, In : European Journal of Medicinal Chemistry. 65, p. 448-455 8 p.

Research output: Contribution to journalArticle

Gems
Diphosphonates
Osteoclasts
Sulfur
Toxicity

Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy

Columbaro, M., Mattioli, E., Maraldi, N. M., Ortolani, M., Gasparini, L., D'Apice, M. R., Postorivo, D., Nardone, A. M., Avnet, S., Cortelli, P., Liguori, R. & Lattanzi, G., Mar 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 3, p. 411-420 10 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Octamer Transcription Factor-1
Oxidative Stress
Phenotype
Sarcomeres

Proton pump inhibitor chemosensitization in human osteosarcoma: From the bench to the patients' bed

Ferrari, S., Perut, F., Fagioli, F., Brach Del Prever, A., Meazza, C., Parafioriti, A., Picci, P., Gambarotti, M., Avnet, S., Baldini, N. & Fais, S., Oct 24 2013, In : Journal of Translational Medicine. 11, 1, 268.

Research output: Contribution to journalArticle

Hospital beds
Proton Pump Inhibitors
Osteosarcoma
Tumors
Cisplatin

Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas

Salerno, M., Avnet, S., Bonuccelli, G., Eramo, A., De Maria, R., Gambarotti, M., Gamberi, G. & Baldini, N., Jul 2013, In : International Journal of Oncology. 43, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Sarcoma
Neoplasms
Molecular Targeted Therapy
Recurrence

Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14+ cells of giant cell tumor of bone

Avnet, S., Salerno, M., Zini, N., Alberghini, M., Gibellini, D. & Baldini, N., Apr 2013, In : American Journal of Pathology. 182, 4, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

Giant Cell Tumor of Bone
Giant Cells
Osteogenesis
Stromal Cells
Osteoclasts

V-ATPase is a candidate therapeutic target for Ewing sarcoma

Avnet, S., Di Pompo, G., Lemma, S., Salerno, M., Perut, F., Bonuccelli, G., Granchi, D., Zini, N. & Baldini, N., 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1105-1116 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Adenosine Triphosphatases
Proton Pumps
Glycolysis
Therapeutics
2012

Insulin receptor isoforms are differently expressed during human osteoblastogenesis

Avnet, S., Perut, F., Salerno, M., Sciacca, L. & Baldini, N., Jun 2012, In : Differentiation. 83, 5, p. 242-248 7 p.

Research output: Contribution to journalArticle

Insulin Receptor
Protein Isoforms
Osteoblasts
Bone and Bones
Insulin

Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids

Bortolini, O., Fantin, G., Fogagnolo, M., Rossetti, S., Maiuolo, L., Di Pompo, G., Avnet, S. & Granchi, D., Jun 2012, In : European Journal of Medicinal Chemistry. 52, p. 221-229 9 p.

Research output: Contribution to journalArticle

Diphosphonates
Bioactivity
Bile Acids and Salts
Hydroxyl Radical
Bone

The effect of poly(D,L-lactide-co-glycolide)-alendronate conjugate nanoparticles on human osteoclast precursors

Cenni, E., Avnet, S., Granchi, D., Fotia, C., Salerno, M., Micieli, D., Sarpietro, M. G., Pignatello, R., Castelli, F. & Baldini, N., 2012, In : Journal of Biomaterials Science, Polymer Edition. 23, 10, p. 1285-1300 16 p.

Research output: Contribution to journalArticle

Alendronate
Osteoclasts
Nanoparticles
Bone
Degradation

The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors

Fotia, C., Avnet, S., Granchi, D. & Baldini, N., Sep 2012, In : Journal of Orthopaedic Research. 30, 9, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Bone and Bones
Bone Neoplasms
Pharmaceutical Preparations
Neoplasms
Osteosarcoma
2011

Efficient synthesis of isoxazolidine-substituted bisphosphonates by 1,3-dipolar cycloaddition reactions

Bortolini, O., Mulani, I., De Nino, A., Maiuolo, L., Nardi, M., Russo, B. & Avnet, S., Aug 5 2011, In : Tetrahedron. 67, 31, p. 5635-5641 7 p.

Research output: Contribution to journalArticle

Cycloaddition
Cycloaddition Reaction
Diphosphonates
Hydrophobic and Hydrophilic Interactions
Bearings (structural)