20022020

Research output per year

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Research Output

  • 69 Article
  • 7 Review article
  • 1 Conference contribution
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Article
2020

Benign albeit glycolytic: MCT4 expression and lactate release in giant cell tumour of bone

Avnet, S., Lemma, S., Errani, C., Falzetti, L., Panza, E., Columbaro, M., Nanni, C. & Baldini, N., Feb 26 2020, In : Bone. 134, p. 115302

Research output: Contribution to journalArticle

2019

Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-κB pathway

Avnet, S., Chano, T., Massa, A., Bonuccelli, G., Lemma, S., Falzetti, L., Grisendi, G., Dominici, M. & Baldini, N., Jun 1 2019, In : American Journal of Cancer Research. 9, 6, p. 1127-1144 18 p.

Research output: Contribution to journalArticle

New Advances in the Study of Bone Tumors: A Lesson From the 3D Environment

Cortini, M., Baldini, N. & Avnet, S., Jun 26 2019, In : Frontiers in Physiology. 10, p. 1-8 8 p.

Research output: Contribution to journalArticle

Photodynamic Surgery for Feline Injection-Site Sarcoma

Martano, M., Morello, E., Avnet, S., Costa, F., Sammartano, F., Kusuzaki, K. & Baldini, N., Jul 8 2019, In : BioMed Research International. 2019, p. 1-10 10 p.

Research output: Contribution to journalArticle

2018

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism

Avnet, S., Baldini, N., Brisson, L., De Milito, A., Otto, A. M., Pastoreková, S., Porporato, P. E., Szabadkai, G. & Sonveaux, P., Oct 3 2018, In : Frontiers in Oncology. 8, p. 1-5 5 p.

Research output: Contribution to journalArticle

Exosome-like nanovesicles isolated from Citrus limon L. exert antioxidative effect

Baldini, N., Torreggiani, E., Roncuzzi, L., Perut, F., Zini, N. & Avnet, S., 2018, In : Current Pharmaceutical Biotechnology. 19, 11, p. 877 - 885 9 p.

Research output: Contribution to journalArticle

RAB39A: a Rab small GTPase with a prominent role in cancer stemness

Chano, T. & Avnet, S., Apr 10 2018, In : Journal of Biochemistry. 164, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Spheroid-based 3D cell cultures identify salinomycin as a promising drug for the treatment of chondrosarcoma

Perut, F., Sbrana, F. V., Avnet, S., De Milito, A. & Baldini, N., Feb 22 2018, In : Journal of Orthopaedic Research. 36, 8, p. 2305-2312 8 p.

Research output: Contribution to journalArticle

Validation of Suitable Housekeeping Genes for the Normalization of mRNA Expression for Studying Tumor Acidosis

Lemma, S., Avnet, S., Meade, M. J., Chano, T. & Baldini, N., Sep 26 2018, In : International Journal of Molecular Sciences. 19, 10, p. 1-15 15 p.

Research output: Contribution to journalArticle

2017

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Baldini, N., De Milito, A., Feron, O., Gillies, R. J., Michiels, C., Otto, A. M., Pastorekova, S., Pedersen, S. F., Porporato, P. E., Sonveaux, P., Supuran, C. T. & Avnet, S., 2017, In : Frontiers in Pharmacology. 8, p. 1-5 5 p.

Research output: Contribution to journalArticle

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

Avnet, S., Di Pompo, G., Chano, T., Errani, C., Ibrahim-Hashim, A., Gillies, R. J., Donati, D. M. & Baldini, N., Mar 15 2017, In : International Journal of Cancer. 140, 6, p. 1331-1345 15 p.

Research output: Contribution to journalArticle

Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma.

Di Pompo, G., Lemma, S., Canti, L., Rucci, N., Ponzetti, M., Errani, C., Donati, D. M., Russell, S., Gillies, R., Chano, T., Baldini, N. & Avnet, S., Apr 13 2017, In : Oncotarget. 8, 33, p. 54478-54496 19 p.

Research output: Contribution to journalArticle

MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.

Lemma, S., Di Pompo, G., Porporato, P., Sboarina, M., Russell, S., Gillies, R. J., Baldini, N., Sonveaux, P. & Avnet, S., Sep 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 12, p. 3254-3264 11 p.

Research output: Contribution to journalArticle

Mesenchymal stroma: Role in osteosarcoma progression.

Cortini, M., Avnet, S. & Baldini, N., Jul 31 2017, In : Cancer Letters. 405, p. 90-99 10 p.

Research output: Contribution to journalArticle

Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates

Ciapetti, G., Di Pompo, G., Avnet, S., Martini, D., Diez-Escudero, A., Montufar, E. B., Ginebra, M. P. & Baldini, N., Mar 1 2017, In : Acta Biomaterialia. 50, p. 102-113 12 p.

Research output: Contribution to journalArticle

The effect of extracellular acidosis on the behaviour of mesenchymal stem cells in vitro.

Massa, A., Perut, F., Chano, T., woloszyk, A., Mitsiadis, T. A., Avnet, S. & Baldini, N., Apr 3 2017, In : European Cells and Materials. 33, p. 252-267 16 p.

Research output: Contribution to journalArticle

Open Access
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Therapeutic implications of tumor interstitial acidification

Kolosenko, I., Avnet, S., Baldini, N., Viklund, J. & De Milito, A., 2017, In : Seminars in Cancer Biology. 43, p. 119-133 15 p.

Research output: Contribution to journalArticle

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

Chano, T., Avnet, S., Kusuzaki, K., Bonuccelli, G., Sonveaux, P., Rotili, D., Mai, A. & Baldini, N., 2017, In : American Journal of Cancer Research. 6, 4, p. 859-875 17 p.

Research output: Contribution to journalArticle

2016

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance

Avnet, S., Lemma, S., Cortini, M., Pellegrini, P., Perut, F., Zini, N., Kusuzaki, K., Chano, T., Grisendi, G., Dominici, M., De Milito, A. & Baldini, N., 2016, In : Oncotarget. 7, 39, p. 63408-63423 16 p.

Research output: Contribution to journalArticle

Energy metabolism in osteoclast formation and activity

Lemma, S., Sboarina, M., Porporato, P. E., Zini, N., Sonveaux, P., Di Pompo, G., Baldini, N. & Avnet, S., Oct 1 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 168-180 13 p.

Research output: Contribution to journalArticle

Identification and validation of housekeeping genes for gene expression analysis of cancer stem cells

Lemma, S., Avnet, S., Salerno, M., Chano, T. & Baldini, N., Feb 1 2016, In : PLoS One. 11, 2, 149481.

Research output: Contribution to journalArticle

Metabolism and microenvironment in cancer plasticity

Baldini, N., Sonveaux, P., De Milito, A., Supuran, C. T., Otto, A. M., Stock, C., Pedersen, S. F., Favicchio, R. & Avnet, S., 2016, In : Cancer and Metabolism. 7 p.

Research output: Contribution to journalArticle

Role of Pericellular Matrix in the Regulation of Cancer Stemness.

Avnet, S. & Cortini, M., Aug 2016, In : Stem Cell Reviews. p. 464-75 12 p.

Research output: Contribution to journalArticle

Open Access

Tumor-activated mesenchymal stromal cells promote osteosarcoma stemness and migratory potential via IL-6 secretion

Cortini, M., Massa, A., Avnet, S., Bonuccelli, G. & Baldini, N., Nov 1 2016, In : PLoS One. 11, 11, 22 p., e0166500.

Research output: Contribution to journalArticle

2015

Acridine orange is an effective anti-cancer drug that affects mitochondrial function in osteosarcoma cells

Fotia, C., Avnet, S., Kusuzaki, K., Roncuzzi, L. & Baldini, N., Oct 1 2015, In : Current Pharmaceutical Design. 21, 28, p. 4088-4094 7 p.

Research output: Contribution to journalArticle

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

Perut, F., Carta, F., Bonuccelli, G., Grisendi, G., Di Pompo, G., Avnet, S., Sbrana, F. V., Hosogi, S., Dominici, M., Kusuzaki, K., Supuran, C. T. & Baldini, N., Dec 2 2015, In : Expert Opinion on Therapeutic Targets. 19, 12, p. 1593-1605 13 p.

Research output: Contribution to journalArticle

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: Understanding the osteolytic process triggered by altered lamins

Evangelisti, C., Bernasconi, P., Cavalcante, P., Cappelletti, C., D'Apice, M. R., Sbraccia, P., Novelli, G., Prencipe, S., Lemma, S., Baldini, N., Avnet, S., Squarzoni, S., Martelli, A. M. & Lattanzi, G., 2015, In : Oncotarget. 6, 10, p. 7424-7437 14 p.

Research output: Contribution to journalArticle

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells

Di Pompo, G., Salerno, M., Rotili, D., Valente, S., Zwergel, C., Avnet, S., Lattanzi, G., Baldini, N. & Mai, A., May 14 2015, In : Journal of Medicinal Chemistry. 58, 9, p. 4073-4079 7 p.

Research output: Contribution to journalArticle

Proton channels and exchangers in cancer

Spugnini, E. P., Sonveaux, P., Stock, C., Perez-Sayans, M., De Milito, A., Avnet, S., Garcìa, A. G., Harguindey, S. & Fais, S., Oct 1 2015, In : BBA - Biomembranes. 1848, 10, p. 2715-2726 12 p., 81705.

Research output: Contribution to journalArticle

2014

Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD

Salerno, M., Avnet, S., Bonuccelli, G., Hosogi, S., Granchi, D. & Baldini, N., Oct 20 2014, In : PLoS One. 9, 10, e110340.

Research output: Contribution to journalArticle

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

Bonuccelli, G., Avnet, S., Grisendi, G., Salerno, M., Granchi, D., Dominici, M., Kusuzaki, K. & Baldini, N., 2014, In : Oncotarget. 5, 17, p. 7575-7588 14 p.

Research output: Contribution to journalArticle

V-ATPase as an effective therapeutic target for sarcomas

Perut, F., Avnet, S., Fotia, C., Baglìo, S. R., Salerno, M., Hosogi, S., Kusuzaki, K. & Baldini, N., Jan 1 2014, In : Experimental Cell Research. 320, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

2013

Corrigendum to "Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant Leukodystrophy" [Biochim. Biophys. Acta, Mol. Basis Dis. 1832 (3) (March 2013) 411-420]

Columbaro, M., Mattioli, E., Maraldi, N. M., Ortolani, M., Gasparini, L., D'Apice, M. R., Postorivo, D., Nardone, A. M., Avnet, S., Cortelli, P., Liguori, R. & Lattanzi, G., Dec 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 12, p. 2244 1 p.

Research output: Contribution to journalArticle

Low toxicity and unprecedented anti-osteoclast activity of a simple sulfur-containing gem-bisphosphonate: A comparative study

Granchi, D., Scarso, A., Bianchini, G., Chiminazzo, A., Minto, A., Sgarbossa, P., Michelin, R. A., Di Pompo, G., Avnet, S. & Strukul, G., 2013, In : European Journal of Medicinal Chemistry. 65, p. 448-455 8 p.

Research output: Contribution to journalArticle

Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy

Columbaro, M., Mattioli, E., Maraldi, N. M., Ortolani, M., Gasparini, L., D'Apice, M. R., Postorivo, D., Nardone, A. M., Avnet, S., Cortelli, P., Liguori, R. & Lattanzi, G., Mar 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 3, p. 411-420 10 p.

Research output: Contribution to journalArticle

Proton pump inhibitor chemosensitization in human osteosarcoma: From the bench to the patients' bed

Ferrari, S., Perut, F., Fagioli, F., Brach Del Prever, A., Meazza, C., Parafioriti, A., Picci, P., Gambarotti, M., Avnet, S., Baldini, N. & Fais, S., Oct 24 2013, In : Journal of Translational Medicine. 11, 1, 268.

Research output: Contribution to journalArticle

Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas

Salerno, M., Avnet, S., Bonuccelli, G., Eramo, A., De Maria, R., Gambarotti, M., Gamberi, G. & Baldini, N., Jul 2013, In : International Journal of Oncology. 43, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14+ cells of giant cell tumor of bone

Avnet, S., Salerno, M., Zini, N., Alberghini, M., Gibellini, D. & Baldini, N., Apr 2013, In : American Journal of Pathology. 182, 4, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

V-ATPase is a candidate therapeutic target for Ewing sarcoma

Avnet, S., Di Pompo, G., Lemma, S., Salerno, M., Perut, F., Bonuccelli, G., Granchi, D., Zini, N. & Baldini, N., 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1105-1116 12 p.

Research output: Contribution to journalArticle

2012

Insulin receptor isoforms are differently expressed during human osteoblastogenesis

Avnet, S., Perut, F., Salerno, M., Sciacca, L. & Baldini, N., Jun 2012, In : Differentiation. 83, 5, p. 242-248 7 p.

Research output: Contribution to journalArticle

Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids

Bortolini, O., Fantin, G., Fogagnolo, M., Rossetti, S., Maiuolo, L., Di Pompo, G., Avnet, S. & Granchi, D., Jun 2012, In : European Journal of Medicinal Chemistry. 52, p. 221-229 9 p.

Research output: Contribution to journalArticle

The effect of poly(D,L-lactide-co-glycolide)-alendronate conjugate nanoparticles on human osteoclast precursors

Cenni, E., Avnet, S., Granchi, D., Fotia, C., Salerno, M., Micieli, D., Sarpietro, M. G., Pignatello, R., Castelli, F. & Baldini, N., 2012, In : Journal of Biomaterials Science, Polymer Edition. 23, 10, p. 1285-1300 16 p.

Research output: Contribution to journalArticle

The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors

Fotia, C., Avnet, S., Granchi, D. & Baldini, N., Sep 2012, In : Journal of Orthopaedic Research. 30, 9, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

2011

Efficient synthesis of isoxazolidine-substituted bisphosphonates by 1,3-dipolar cycloaddition reactions

Bortolini, O., Mulani, I., De Nino, A., Maiuolo, L., Nardi, M., Russo, B. & Avnet, S., Aug 5 2011, In : Tetrahedron. 67, 31, p. 5635-5641 7 p.

Research output: Contribution to journalArticle

IGF2 derived from SH-SY5Y neuroblastoma cells induces the osteoclastogenesis of human monocytic precursors

Avnet, S., Salerno, M., Quacquaruccio, G., Granchi, D., Giunti, A. & Baldini, N., Sep 10 2011, In : Experimental Cell Research. 317, 15, p. 2147-2158 12 p.

Research output: Contribution to journalArticle

Osteoblasts from a mandibuloacral dysplasia patient induce human blood precursors to differentiate into active osteoclasts

Avnet, S., Pallotta, R., Perut, F., Baldini, N., Pittis, M. G., Saponari, A., Lucarelli, E., Dozza, B., Greggi, T., Maraldi, N. M., Capanni, C., Mattioli, E., Columbaro, M. & Lattanzi, G., Jul 2011, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1812, 7, p. 711-718 8 p.

Research output: Contribution to journalArticle

2010

Background and rationale of platelet gel in orthopaedic surgery

Cenni, E., Savarino, L., Perut, F., Fotia, C., Avnet, S. & Sabbioni, G., 2010, In : Musculoskeletal Surgery. 94, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases

Salerno, M., Cenni, E., Fotia, C., Avnet, S., Granchi, D., Castelli, F., Micieli, D., Pignatello, R., Capulli, M., Rucci, N., Angelucci, A., Del Fattore, A., Teti, A., Zini, N., Giunti, A. & Baldini, N., Nov 2010, In : Current Cancer Drug Targets. 10, 7, p. 649-659 11 p.

Research output: Contribution to journalArticle

Platelet-rich plasma impairs osteoclast generation from human precursors of peripheral blood

Cenni, E., Avnet, S., Fotia, C., Salerno, M. & Baldini, N., Jun 2010, In : Journal of Orthopaedic Research. 28, 6, p. 792-797 6 p.

Research output: Contribution to journalArticle