20132019

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2019

Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

Sapienza, M. R., Abate, F., Melle, F., Orecchioni, S., Fuligni, F., Etebari, M., Tabanelli, V., Laginestra, M. A., Pileri, A., Motta, G., Rossi, M., Agostinelli, C., Sabattini, E., Pimpinelli, N., Truni, M., Falini, B., Cerroni, L., Talarico, G., Piccioni, R., Amente, S. & 11 others, Indio, V., Tarantino, G., Brundu, F., Paulli, M., Berti, E., Facchetti, F., Dellino, G. I., Bertolini, F., Tripodo, C., Rabadan, R. & Pileri, S. A., 2019, In : Haematologica. 104, 4, p. 729-737 9 p.

Research output: Contribution to journalArticle

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target

Sapienza, M. R., Abate, F., Melle, F., Orecchioni, S., Fuligni, F., Etebari, M., Tabanelli, V., Laginestra, M. A., Pileri, A., Motta, G., Rossi, M., Agostinelli, C., Sabattini, E., Pimpinelli, N., Truni, M., Falini, B., Cerroni, L., Talarico, G., Piccioni, R., Amente, S. & 11 others, Indio, V., Tarantino, G., Brundu, F., Paulli, M., Berti, E., Facchetti, F., Dellino, G. I., Bertolini, F., Tripodo, C., Rabadan, R. & Pileri, S. A., 2019, In : Haematologica. 104, 4, p. 729-737 9 p.

Research output: Contribution to journalArticle

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target

Sapienza, M. R., Abate, F., Melle, F., Orecchioni, S., Fuligni, F., Etebari, M., Tabanelli, V., Laginestra, M. A., Pileri, A., Motta, G., Rossi, M., Agostinelli, C., Sabattini, E., Pimpinelli, N., Truni, M., Falini, B., Cerroni, L., Talarico, G., Piccioni, R., Amente, S. & 11 others, Indio, V., Tarantino, G., Brundu, F., Paulli, M., Berti, E., Facchetti, F., Dellino, G. I., Bertolini, F., Tripodo, C., Rabadan, R. & Pileri, S. A., 2019, In : Haematologica. 104, 4, p. 729-737 9 p.

Research output: Contribution to journalArticle

The new small tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs

Soncini, D., Orecchioni, S., Ruberti, S., Minetto, P., Martinuzzi, C., Agnelli, L., Todoerti, K., Cagnetta, A., Miglino, M., Clavio, M., Contini, P., Varaldo, R., Bergamaschi, M., Guolo, F., Passalacqua, M., Nencioni, A., Monacelli, F., Gobbi, M., Neri, A., Abbadessa, G. & 5 others, Eathiraj, S., Schwartz, B., Bertolini, F., Lemoli, R. M. & Cea, M., Oct 17 2019, In : Haematologica.

Research output: Contribution to journalArticle

2018

Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

Sapienza, M. R., Abate, F., Melle, F., Orecchioni, S., Fuligni, F., Etebari, M., Tabanelli, V., Laginestra, M. A., Pileri, A., Motta, G., Rossi, M., Agostinelli, C., Sabattini, E., Pimpinelli, N., Truni, M., Falini, B., Cerroni, L., Talarico, G., Piccioni, R., Amente, S. & 11 others, Indio, V., Tarantino, G., Brundu, F., Paulli, M., Berti, E., Facchetti, F., Dellino, G. I., Bertolini, F., Tripodo, C., Rabadan, R. & Pileri, S. A., Oct 31 2018, In : Haematologica.

Research output: Contribution to journalArticle

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status

Belkahla, S., Khan, A. U. H., Gitenay, D., Alexia, C., Gondeau, C., Vo, D. N., Orecchioni, S., Talarico, G., Bertolini, F., Cartron, G., Hernandez, J., Daujat-Chavanieu, M., Allende-Vega, N. & Gonzalez, M. V., Jan 1 2018, In : Oncotarget. 9, 1, p. 1114-1129 16 p.

Research output: Contribution to journalArticle

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

Cagnetta, A., Soncini, D., Orecchioni, S., Talarico, G., Minetto, P., Guolo, F., Retali, V., Colombo, N., Carminati, E., Clavio, M., Miglino, M., Bergamaschi, M., Nahimana, A., Duchosal, M., Todoerti, K., Neri, A., Passalacqua, M., Bruzzone, S., Nencioni, A., Bertolini, F. & 3 others, Gobbi, M., Lemoli, R. M. & Cea, M., Jan 1 2018, In : Haematologica. 103, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

Cagnetta, A., Soncini, D., Orecchioni, S., Talarico, G., Minetto, P., Guolo, F., Retali, V., Colombo, N., Carminati, E., Clavio, M., Miglino, M., Bergamaschi, M., Nahimana, A., Duchosal, M., Todoerti, K., Neri, A., Passalacqua, M., Bruzzone, S., Nencioni, A., Bertolini, F. & 3 others, Gobbi, M., Lemoli, R. M. & Cea, M., 2018, In : Haematologica. 103, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors

Sanchez-Martinez, D., Allende-Vega, N., Orecchioni, S., Talarico, G., Cornillon, A., Vo, D. N., Rene, C., Lu, Z. Y., Krzywinska, E., Anel, A., Galvez, E. M., Pardo, J., Robert, B., Martineau, P., Hicheri, Y., Bertolini, F., Cartron, G. & Villalba, M., Jan 1 2018, In : Theranostics. 8, 14, p. 3856-3869 14 p.

Research output: Contribution to journalArticle

Mitochondrial complex I activity signals antioxidant response through ERK5

Khan, A. U. H., Allende-Vega, N., Gitenay, D., Garaude, J., Vo, D. N., Belkhala, S., Gerbal-Chaloin, S., Gondeau, C., Daujat-Chavanieu, M., Delettre, C., Orecchioni, S., Talarico, G., Bertolini, F., Anel, A., Cuezva, J. M., Enriquez, J. A., Cartron, G., Lecellier, C. H., Hernandez, J. & Villalba, M., Dec 1 2018, In : Scientific Reports. 8, 1, 7420.

Research output: Contribution to journalArticle

2017

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents

Cagnetta, A., Soncini, D., Orecchioni, S., Talarico, G., Minetto, P., Guolo, F., Retali, V., Colombo, N., Carminati, E., Clavio, M., Miglino, M., Bergamaschi, M., Nahimana, A., Duchosal, M., Todoerti, K., Neri, A., Passalacqua, M., Bruzzone, S., Nencioni, A., Bertolini, F. & 3 others, Gobbi, M., Lemoli, R. M. & Cea, M., Oct 12 2017, In : Haematologica.

Research output: Contribution to journalArticle

Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells

Salvestrini, V., Orecchioni, S., Talarico, G., Reggiani, F., Mazzetti, C., Bertolini, F., Orioli, E., Adinolfi, E., Di Virgilio, F., Pezzi, A., Cavo, M., Lemoli, R. M. & Curti, A., Jan 1 2017, In : Oncotarget. 8, 4, p. 5895-5908 14 p.

Research output: Contribution to journalArticle

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Khan, A. U. H., Allende-Vega, N., Gitenay, D., Gerbal-Chaloin, S., Gondeau, C., Vo, D. N., Belkahla, S., Orecchioni, S., Talarico, G., Bertolini, F., Bozic, M., Valdivielso, J. M., Bejjani, F., Jariel, I., Lopez-Mejia, I. C., Fajas, L., Lecellier, C. H., Hernandez, J., Daujat, M. & Villalba, M., Dec 1 2017, In : Scientific Reports. 7, 1, 10654.

Research output: Contribution to journalArticle

2016
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Erratum: The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia (Scientific Reports (2015) 5 (18137) DOI: 10.1038/srep18137)

Allegretti, M., Ricciardi, M. R., Licchetta, R., Mirabilii, S., Orecchioni, S., Reggiani, F., Talarico, G., Foà, R., Bertolini, F., Amadori, S., Torrisi, M. R. & Tafuri, A., Feb 5 2016, In : Scientific Reports. 6, 20743.

Research output: Contribution to journalArticle

Human Leukemic Cells performing Oxidative Phosphorylation (OXPHOS) Generate an Antioxidant Response Independently of Reactive Oxygen species (ROS) Production

Khan, A. U. H., Rathore, M. G., Allende-Vega, N., Vo, D. N., Belkhala, S., Orecchioni, S., Talarico, G., Bertolini, F., Cartron, G., Lecellier, C. H. & Villalba, M., Jan 1 2016, In : EBioMedicine. 3, p. 43-53 11 p.

Research output: Contribution to journalArticle

2015

Mechanisms of obesity in the development of breast cancer

Orecchioni, S., Reggiani, F., Talarico, G. & Bertolini, F., 2015, In : Discovery medicine. 20, 109, p. 121-128 8 p.

Research output: Contribution to journalArticle

The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias

Falzacappa, M. V. I. V., Ronchini, C., Faretta, M., Iacobucci, I., Di Rorà, A. G. H. L., Martinelli, G., Meyer, L. H., Debatin, K. M., Orecchioni, S., Bertolini, F. & Pelicci, P. G. I., Apr 1 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 889-898 10 p.

Research output: Contribution to journalArticle

The pan-class i phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia

Allegretti, M., Ricciardi, M. R., Licchetta, R., Mirabilii, S., Orecchioni, S., Reggiani, F., Talarico, G., Foà, R., Bertolini, F., Amadori, S., Torrisi, M. R. & Tafuri, A., Dec 17 2015, In : Scientific Reports. 5, 18137.

Research output: Contribution to journalArticle

The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism

Allende-Vega, N., Krzywinska, E., Orecchioni, S., Lopez-Royuela, N., Reggiani, F., Talarico, G., Rossi, J. F., Rossignol, R., Hicheri, Y., Cartron, G., Bertolini, F. & Villalba, M., 2015, In : Oncotarget. 6, 22, p. 19228-19245 18 p.

Research output: Contribution to journalArticle

2014

Obesity, proinflammatory mediators, adipose tissue progenitors, and breast cancer

Bertolini, F., Orecchioni, S., Petit, J. Y. & Kolonin, M. G., 2014, In : Current Opinion in Oncology. 26, 6, p. 545-550 6 p.

Research output: Contribution to journalArticle

Paradoxic effects of metformin on endothelial cells and angiogenesis

Dallaglio, K., Bruno, A., Cantelmo, A. R., Esposito, A. I., Ruggiero, L., Orecchioni, S., Calleri, A., Bertolini, F., Pfeffer, U., Noonan, D. M. & Albini, A., 2014, In : Carcinogenesis. 35, 5, p. 1055-1066 12 p.

Research output: Contribution to journalArticle

2013

Complementary populations of human adipose CD34+ progenitor cells promote growth, angiogenesis, and metastasis of breast cancer

Orecchioni, S., Gregato, G., Martin-Padura, I., Reggiani, F., Braidotti, P., Mancuso, P., Calleri, A., Quarna, J., Marighetti, P., Aldeni, C., Pruneri, G., Martella, S., Manconi, A., Petit, J. Y., Rietjens, M. & Bertolini, F., Oct 1 2013, In : Cancer Research. 73, 19, p. 5880-5891 12 p.

Research output: Contribution to journalArticle