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Research Output 2017 2020

2020

Drug repurposing for anticancer therapies. A lesson from proton pump inhibitors

Spugnini, E. P. & Fais, S., Jan 2 2020, In : Expert Opinion on Therapeutic Patents. 30, 1, p. 15-25 11 p.

Research output: Contribution to journalArticle

Drug Repositioning
Proton Pump Inhibitors
Medical Economics
Proton-Translocating ATPases
Tumor Microenvironment
2019

Causes, consequences, and therapy of tumors acidosis

Pillai, S. R., Damaghi, M., Marunaka, Y., Spugnini, E. P., Fais, S. & Gillies, R. J., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 205-222 18 p.

Research output: Contribution to journalReview article

Acidosis
Neoplasms
Therapeutics
Acids
Clonal Evolution

Extracellular acidity and increased exosome release as key phenotypes of malignant tumors

Logozzi, M., Spugnini, E., Mizzoni, D., Di Raimo, R. & Fais, S., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 93-101 9 p.

Research output: Contribution to journalReview article

Exosomes
Phenotype
Neoplasms
Neoplasm Metastasis
Drug Resistance

Human primary macrophages scavenge AuNPs and eliminate it through exosomes. A natural shuttling for nanomaterials

Logozzi, M., Mizzoni, D., Bocca, B., Di Raimo, R., Petrucci, F., Caimi, S., Alimonti, A., Falchi, M., Cappello, F., Campanella, C., Bavisotto, C. C., David, S., Bucchieri, F., Angelini, D. F., Battistini, L. & Fais, S., Apr 1 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 23-36 14 p.

Research output: Contribution to journalArticle

Exosomes
Nanostructures
Macrophages
Nanoparticles
Endocytosis

Increased plasmatic levels of psa-expressing exosomes distinguish prostate cancer patients from benign prostatic hyperplasia: A prospective study

Logozzi, M., Angelini, D. F., Giuliani, A., Mizzoni, D., Raimo, R. D., Maggi, M., Gentilucci, A., Marzio, V., Salciccia, S., Borsellino, G., Battistini, L., Sciarra, A. & Fais, S., Oct 1 2019, In : Cancers. 11, 10, 1449.

Research output: Contribution to journalArticle

Open Access
Exosomes
Prostatic Hyperplasia
Prostatic Neoplasms
Prospective Studies
Prostate-Specific Antigen

Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

Logozzi, M., Mizzoni, D., Capasso, C., Del Prete, S., Di Raimo, R., Falchi, M., Angelini, D. F., Sciarra, A., Maggi, M., Supuran, C. T. & Fais, S., Dec 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 35, 1, p. 280-288 9 p.

Research output: Contribution to journalArticle

Open Access
Exosomes
Prostatic Neoplasms
Prostate
Carcinoma
Neoplasms
2018

A role of tumor-released exosomes in paracrine dissemination and metastasis

Spugnini, E. P., Logozzi, M., Di Raimo, R., Mizzoni, D. & Fais, S., 2018, In : International Journal of Molecular Sciences. 19, 12

Research output: Contribution to journalArticle

Exosomes
metastasis
Tumors
tumors
Neoplasm Metastasis

Cell-in-cell phenomena, cannibalism, and autophagy: is there a relationship?

Fais, S. & Overholtzer, M., Jan 24 2018, In : Cell death & disease. 9, 2, p. 95

Research output: Contribution to journalArticle

Cell-in-cell phenomena in cancer

Fais, S. & Overholtzer, M., Dec 2018, In : Nature Reviews Cancer. 18, 12, p. 758-766 9 p.

Research output: Contribution to journalReview article

Neoplasms
Entosis
Cell-in-Cell Formation
Cytophagocytosis
Physiological Stress

Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives

Caruso Bavisotto, C., Graziano, F., Rappa, F., Marino Gammazza, A., Logozzi, M., Fais, S., Maugeri, R., Bucchieri, F., Conway de Macario, E., Macario, A. J. L., Cappello, F., Iacopino, D. G. & Campanella, C., Sep 5 2018, In : International Journal of Molecular Sciences. 19, 9

Research output: Contribution to journalReview article

cargo
Exosomes
MicroRNAs
Tumors
tumors

Microenvironmental pH and exosome levels interplay in human cancer cell lines of different histotypes

Logozzi, M., Mizzoni, D., Angelini, D. F., Di Raimo, R., Falchi, M., Battistini, L. & Fais, S., Oct 5 2018, In : Cancers. 10, 10

Research output: Contribution to journalArticle

Exosomes
Cell Line
Neoplasms
Osteosarcoma
Tumor Cell Line

Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes

Logozzi, M., Mizzoni, D., Angelini, D. F., Di Raimo, R., Falchi, M., Battistini, L. & Fais, S., Oct 5 2018, In : Cancers. 10, 10

Research output: Contribution to journalArticle

Exosomes
Cell Line
Neoplasms
Osteosarcoma
Tumor Cell Line

Moving the systemic evolutionary approach to cancer forward: Therapeutic implications

Mazzocca, A., Ferraro, G., Misciagna, G. & Fais, S., Dec 2018, In : Medical Hypotheses. 121, p. 80-87 8 p.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
Pharmacology
Electromagnetic Fields
Symbiosis

The key role of extracellular vesicles in the metastatic process

Zhao, H., Achreja, A., Iessi, E., Logozzi, M., Mizzoni, D., Di Raimo, R., Nagrath, D. & Fais, S., Jan 2018, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1869, 1, p. 64-77 14 p.

Research output: Contribution to journalReview article

Neoplasms
Paracrine Communication
Neoplasm Metastasis
Exosomes
Circulating Neoplastic Cells
2017

Acridine orange/exosomes increase the delivery and the effectiveness of acridine orange in human melanoma cells: A new prototype for theranostics of tumors

Iessi, E., Logozzi, M., Lugini, L., Azzarito, T., Federici, C., Spugnini, E. P., Mizzoni, D., Di Raimo, R., Angelini, D. F., Battistini, L., Cecchetti, S. & Fais, S., 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 648-657 10 p.

Research output: Contribution to journalArticle

Exosomes
Acridine Orange
Melanoma
Neoplasms
Theranostic Nanomedicine

Antitumor effect of combination of the inhibitors of two new oncotargets: Proton pumps and reverse transcriptase

Lugini, L., Sciamanna, I., Federici, C., Iessi, E., Spugnini, E. P. & Fais, S., Jan 1 2017, In : Oncotarget. 8, 3, p. 4147-4155 9 p.

Research output: Contribution to journalArticle

efavirenz
Lansoprazole
Proton Pumps
RNA-Directed DNA Polymerase
Reverse Transcriptase Inhibitors

European Network on Microvesicles and Exosomes in Health and Disease (ME-HaD)

O'Driscoll, L., Stoorvogel, W., Théry, C., Buzas, E., Nazarenko, I., Siljander, P., Yáñez-Mó, M., Fais, S., Giebel, B. & Yliperttula, M., 2017, In : European Journal of Pharmaceutical Sciences. 98, p. 1-3 3 p.

Research output: Contribution to journalArticle

Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment

Caruso Bavisotto, C., Cappello, F., Macario, A. J. L., Conway de Macario, E., Logozzi, M., Fais, S. & Campanella, C., Sep 2 2017, In : Expert Review of Molecular Diagnostics. 17, 9, p. 815-822 8 p.

Research output: Contribution to journalReview article

Chaperonin 60
Biomarkers
Exosomes
Neoplasms
Tumor Microenvironment

Exosome levels in human body fluids: A tumor marker by themselves?

Cappello, F., Logozzi, M., Campanella, C., Bavisotto, C. C., Marcilla, A., Properzi, F. & Fais, S., Jan 1 2017, In : European Journal of Pharmaceutical Sciences. 96, p. 93-98 6 p.

Research output: Contribution to journalArticle

Exosomes
Body Fluids
Tumor Biomarkers
Human Body
Neoplasms

Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients

Logozzi, M., Angelini, D. F., Iessi, E., Mizzoni, D., Di Raimo, R., Federici, C., Lugini, L., Borsellino, G., Gentilucci, A., Pierella, F., Marzio, V., Sciarra, A., Battistini, L. & Fais, S., 2017, In : Cancer Letters. 403, p. 318-329 12 p.

Research output: Contribution to journalArticle

Exosomes
Prostate-Specific Antigen
Prostatic Neoplasms
Neoplasms
Prostatic Hyperplasia

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

Kusuzaki, K., Matsubara, T., Murata, H., Logozzi, M., Iessi, E., Di Raimo, R., Carta, F., Supuran, C. T. & Fais, S., Jan 1 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 908-916 9 p.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Neoplasms
Exosomes
Light
Poisons

Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic

Spugnini, E. P., Fais, S., Azzarito, T. & Baldi, A., Mar 2017, In : Journal of Cellular Physiology. 232, 3, p. 490-495 6 p.

Research output: Contribution to journalReview article

Electrochemotherapy
Animal Hospitals
Pets
Drug Therapy
Laboratory Animals

Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH

Schwartz, L., Seyfried, T., Alfarouk, K. O., Da Veiga Moreira, J. & Fais, S., Apr 1 2017, In : Seminars in Cancer Biology. 43, p. 134-138 5 p.

Research output: Contribution to journalReview article

Thioctic Acid
Alkalosis
Neoplasms
Mitochondria
Ketogenic Diet

Proton pump inhibition and cancer therapeutics: A specific tumor targeting or it is a phenomenon secondary to a systemic buffering?

Spugnini, E. & Fais, S., Apr 1 2017, In : Seminars in Cancer Biology. 43, p. 111-118 8 p.

Research output: Contribution to journalReview article

Proton Pumps
Proton Pump Inhibitors
Protons
Neoplasms
Therapeutics

Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy

Iessi, E., Logozzi, M., Mizzoni, D., Di Raimo, R., Supuran, C. T. & Fais, S., Dec 23 2017, In : Metabolites. 8, 1

Research output: Contribution to journalReview article

Protons
Tumors
Cells
Acidity
Neoplasms

Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice

Astigiano, S., Puglisi, A., Mastracci, L., Fais, S. & Barbieri, O., 2017, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 363-368 6 p.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Adenocarcinoma
Tumor Microenvironment
Chemoprevention