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Research Output 2007 2019

2019
Interleukin-9
Interleukin-13
Interleukin-5
Interleukin-4
Brain Injuries

Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model

Violatto, M. B., Casarin, E., Talamini, L., Russo, L., Baldan, S., Tondello, C., Messmer, M., Hintermann, E., Rossi, A., Passoni, A., Bagnati, R., Biffi, S., Toffanin, C., Gimondi, S., Fumagalli, S., De Simoni, M. G., Barisani, D., Salmona, M., Christen, U., Invernizzi, P. & 2 others, Bigini, P. & Morpurgo, M., Apr 23 2019, In : ACS Nano. 13, 4, p. 4410-4423 14 p.

Research output: Contribution to journalArticle

hepatitis
Avidin
Nucleic acids
nucleic acids
conjugation

Exploring Alzheimer's disease mouse brain through X-ray phase contrast tomography: From the cell to the organ

Massimi, L., Bukreeva, I., Santamaria, G., Fratini, M., Corbelli, A., Brun, F., Fumagalli, S., Maugeri, L., Pacureanu, A., Cloetens, P., Pieroni, N., Fiordaliso, F., Forloni, G., Uccelli, A., Kerlero de Rosbo, N., Balducci, C. & Cedola, A., Jan 1 2019, In : NeuroImage. 184, p. 490-495 6 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Tomography
X-Rays
Brain
Neurodegenerative Diseases

Exploring Alzheimer's disease mouse brain through X-ray phase contrast tomography: From the cell to the organ

Massimi, L., Bukreeva, I., Santamaria, G., Fratini, M., Corbelli, A., Brun, F., Fumagalli, S., Maugeri, L., Pacureanu, A., Cloetens, P., Pieroni, N., Fiordaliso, F., Forloni, G., Uccelli, A., Kerlero de Rosbo, N., Balducci, C. & Cedola, A., 2019, In : NeuroImage. 184, p. 490-495 6 p.

Research output: Contribution to journalArticle

Human brain trauma severity is associated with lectin complement pathway activation

De Blasio, D., Fumagalli, S., Orsini, F., Neglia, L., Perego, C., Ortolano, F., Zanier, E. R., Picetti, E., Locatelli, M., Stocchetti, N., Longhi, L., Garred, P. & De Simoni, M. G., 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 5, p. 794-807

Research output: Contribution to journalArticle

Mannose-Binding Lectin Complement Pathway
Complement Activation
Mannose-Binding Protein-Associated Serine Proteases
Brain Injuries
Lectins

Human brain trauma severity is associated with lectin complement pathway activation

De Blasio, D., Fumagalli, S., Orsini, F., Neglia, L., Perego, C., Ortolano, F., Zanier, E. R., Picetti, E., Locatelli, M., Stocchetti, N., Longhi, L., Garred, P. & De Simoni, M-G., May 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 5, p. 794-807 14 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin Complement Pathway
Complement Activation
Mannose-Binding Protein-Associated Serine Proteases
Brain Injuries
Lectins

Mannose-binding lectin has a direct deleterious effect on ischemic brain microvascular endothelial cells

Neglia, L., Fumagalli, S., Orsini, F., Zanetti, A., Perego, C. & De Simoni, M-G., Sep 7 2019, In : Journal of Cerebral Blood Flow and Metabolism. p. 271678X19874509

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Endothelial Cells
Brain
Oxygen
Glucose

Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury

Neglia, L., Oggioni, M., Mercurio, D., De Simoni, M-G. & Fumagalli, S., Apr 9 2019, In : Cellular and Molecular Immunology.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Reperfusion Injury
Brain Ischemia
Protein Isoforms
Middle Cerebral Artery Infarction
Myeloid Cells
Lighting
Microscopy
Ischemia
Brain
2018

Exploring Alzheimer's disease mouse brain through X-ray phase contrast tomography: From the cell to the organ

Massimi, L., Bukreeva, I., Santamaria, G., Fratini, M., Corbelli, A., Brun, F., Fumagalli, S., Maugeri, L., Pacureanu, A., Cloetens, P., Pieroni, N., Fiordaliso, F., Forloni, G., Uccelli, A., Kerlero de Rosbo, N., Balducci, C. & Cedola, A., 2018, In : NeuroImage. 184, p. 490-495 6 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Tomography
X-Rays
Brain
Neurodegenerative Diseases

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α

Orsini, F., Fumagalli, S., Császár, E., Tóth, K., De Blasio, D., Zangari, R., Lénárt, N., Dénes, Á. & De Simoni, M-G., Nov 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 11, p. 2678-2690 13 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Brain Ischemia
Interleukin-1
Blood Vessels
Blood Platelets
2017

C-reactive protein binds to cholesterol crystals and co-localizes with the terminal complement complex in human atherosclerotic plaques

Pilely, K., Fumagalli, S., Rosbjerg, A., Genster, N., Skjoedt, M. O., Perego, C., Ferrante, A. M. R., De Simoni, M. G. & Garred, P., Aug 29 2017, In : Frontiers in Immunology. 8, AUG, p. 1040

Research output: Contribution to journalArticle

Complement Membrane Attack Complex
Atherosclerotic Plaques
C-Reactive Protein
Serum Amyloid P-Component
Cholesterol

Lectin Pathway of Complement Activation Is Associated with Vulnerability of Atherosclerotic Plaques

Fumagalli, S., Perego, C., Zangari, R., De Blasio, D., Oggioni, M., De Nigris, F., Snider, F., Garred, P., Ferrante, A. M. R. & De Simoni, M-G., 2017, In : Frontiers in Immunology. 8, p. 288

Research output: Contribution to journalArticle

Complement Activation
Atherosclerotic Plaques
Lectins
Tunica Media
Mannose-Binding Lectin

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury

De Blasio, D., Fumagalli, S., Longhi, L., Orsini, F., Palmioli, A., Stravalaci, M., Vegliante, G., Zanier, E. R., Bernardi, A., Gobbi, M. & De Simoni, M. G., Mar 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 938-950 13 p.

Research output: Contribution to journalArticle

Targeting extracellular cyclophilin a reduces neuroinflammation and extends survival in a mouse model of amyotrophic lateral sclerosis

Pasetto, L., Pozzi, S., Castelnovo, M., Basso, M., Estevez, A. G., Fumagalli, S., De Simoni, M. G., Castellaneta, V., Bigini, P., Restelli, E., Chiesa, R., Trojsi, F., Monsurrò, M. R., Callea, L., Malešević, M., Fischer, G., Freschi, M., Tortarolo, M., Bendotti, C. & Bonetto, V., Feb 8 2017, In : Journal of Neuroscience. 37, 6, p. 1413-1427 15 p.

Research output: Contribution to journalArticle

Targeting extracellular cyclophilin a reduces neuroinflammation and extends survival in a mouse model of amyotrophic lateral sclerosis

Pasetto, L., Pozzi, S., Castelnovo, M., Basso, M., Estevez, A. G., Fumagalli, S., De Simoni, M. G., Castellaneta, V., Bigini, P., Restelli, E., Chiesa, R., Trojsi, F., Monsurrò, M. R., Callea, L., Malešević, M., Fischer, G., Freschi, M., Tortarolo, M., Bendotti, C. & Bonetto, V., Feb 8 2017, In : Journal of Neuroscience. 37, 6, p. 1413-1427 15 p.

Research output: Contribution to journalArticle

cis-trans-Isomerases
Cyclophilins
Peptidylprolyl Isomerase
Amyotrophic Lateral Sclerosis
Sclerosis

The effects of gender on electrical therapies for the heart

Diemberger, I., Marazzi, R., Casella, M., Vassanelli, F., Galimberti, P., Luzi, M., Borrelli, A., Soldati, E., Golzio, P. G., Fumagalli, S., Francia, P., Padeletti, L., Botto, G. & Boriani, G., Dec 1 2017, In : Europace. 19, 12, p. 1911-1921 11 p.

Research output: Contribution to journalArticle

Catheter Ablation
Cardiac Catheters
Cardiac Resynchronization Therapy
Indwelling Catheters
Implantable Defibrillators
2016

Lectin Complement Pathway and Its Bloody Interactions in Brain Ischemia

Fumagalli, S. & De Simoni, M. G., Dec 1 2016, In : Stroke. 47, 12, p. 3067-3073 7 p.

Research output: Contribution to journalArticle

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury

Perego, C., Fumagalli, S., Zanier, E. R., Carlino, E., Panini, N., Erba, E. & De Simoni, M. G., Dec 1 2016, In : Neurobiology of Disease. 96, p. 284-293 10 p.

Research output: Contribution to journalArticle

Brain Injuries
Macrophages
Monocytes
Microglia
Diphtheria Toxin
2015

The ischemic environment drive s microglia and macrophage function

Fumagalli, S., Perego, C., Pischiutta, F., Zanier, E. R. & De Simoni, M. G., 2015, In : Frontiers in Neurology. 6, MAR, 81.

Research output: Contribution to journalArticle

Microglia
Macrophages
Myeloid Cells
Brain Injuries
Homeostasis
2014

A close look at brain dynamics: Cells and vessels seen by in vivo two-photon microscopy

Fumagalli, S., Ortolano, F. & De Simoni, M. G., Oct 1 2014, In : Progress in Neurobiology. 121, p. 36-54 19 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Brain
Blood Vessels
Post and Core Technique

An integrated approach for the systematic evaluation of polymeric nanoparticles in healthy and diseased organisms

Sitia, L., Paolella, K., Romano, M., Violatto, M. B., Ferrari, R., Fumagalli, S., Colombo, L., Bello, E., De Simoni, M. G., D'Incalci, M., Morbidelli, M., Erba, E., Salmona, M., Moscatelli, D. & Bigini, P., 2014, In : Journal of Nanoparticle Research. 16, 7, 2481.

Research output: Contribution to journalArticle

organisms
Nanoparticles
nanoparticles
evaluation
Evaluation

Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma

Zanier, E. R., Pischiutta, F., Riganti, L., Marchesi, F., Turola, E., Fumagalli, S., Perego, C., Parotto, E., Vinci, P., Veglianese, P., D'Amico, G., Verderio, C. & De Simoni, M. G., 2014, In : Neurotherapeutics. 11, 3, p. 679-695 17 p.

Research output: Contribution to journalArticle

Microglia
Mesenchymal Stromal Cells
Phagocytosis
Tumor Necrosis Factor-alpha
Phenotype

Mannose-binding lectin is expressed after clinical and experimental traumatic brain injury and its deletion is protective

Longhi, L., Orsini, F., De Blasio, D., Fumagalli, S., Ortolano, F., Locatelli, M., Stocchetti, N. & De Simoni, M. G., 2014, In : Critical Care Medicine. 42, 8, p. 1910-1918 9 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Traumatic Brain Injury
Knockout Mice
Mannose-Binding Lectin Complement Pathway
2013

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice

Fumagalli, S., Perego, C., Ortolano, F. & De Simoni, M. G., Jun 2013, In : GLIA. 61, 6, p. 827-842 16 p.

Research output: Contribution to journalArticle

Microglia
Ischemia
Macrophage Activation
Macrophages
Chemokine CX3CL1
Macrophages
Microglia
Brain Injuries
Brain
Polarization

Tumor necrosis factor in traumatic brain injury: Effects of genetic deletion of p55 or p75 receptor

Longhi, L., Perego, C., Ortolano, F., Aresi, S., Fumagalli, S., Zanier, E. R., Stocchetti, N. & De Simoni, M. G., Aug 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1182-1189 8 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptors
Microglia
DNA Damage
Macrophage Activation
2012

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia

Orsini, F., Villa, P., Parrella, S., Zangari, R., Zanier, E. R., Gesuete, R., Stravalaci, M., Fumagalli, S., Ottria, R., Reina, J. J., Paladini, A., Micotti, E., Ribeiro-Viana, R., Rojo, J., Pavlov, V. I., Stahl, G. L., Bernardi, A., Gobbi, M. & De Simoni, M. G., Sep 18 2012, In : Circulation. 126, 12, p. 1484-1494 11 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Brain Ischemia
Brain Injuries
Therapeutics
Mannose-Binding Lectin Complement Pathway
2011

Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma

Zanier, E. R., Montinaro, M., Vigano, M., Villa, P., Fumagalli, S., Pischiutta, F., Longhi, L., Leoni, M. L., Rebulla, P., Stocchetti, N., Lazzari, L. & De Simoni, M. G., Nov 2011, In : Critical Care Medicine. 39, 11, p. 2501-2510 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Fetal Blood
Microglia
Macrophage Activation
Brain

In vivo real-time multiphoton imaging of T lymphocytes in the mouse brain after experimental stroke

Fumagalli, S., Coles, J. A., Ejlerskov, P., Ortolano, F., Bushell, T. J., Brewer, J. M., De Simoni, M. G., Dever, G., Garside, P., Maffia, P. & Carswell, H. V., May 2011, In : Stroke. 42, 5, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

Stroke
T-Lymphocytes
Middle Cerebral Artery Infarction
Brain
Electrocoagulation
Microglia
Brain Injuries
Macrophages
Phenotype
Middle Cerebral Artery Infarction
2007

Neural stem cells exert a neuroprotective action by changing the ischemic microenvironment

Maria-Cristina, P., Capone, C., Frigerio, S., Fumagalli, S., Gelati, M., Storini, C., Montinaro, M., De Curtis, M., Parati, E. & Maria-Grazia, D. S., Nov 13 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1

Research output: Contribution to journalArticle

Neural Stem Cells
Brain
Microglia
Ischemia
Macrophage Activation

Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment

Capone, C., Frigerio, S., Fumagalli, S., Gelati, M., Principato, M. C., Storini, C., Montinaro, M., Kraftsik, R., De Curtis, M., Parati, E. & De Simoni, M. G., Apr 18 2007, In : PLoS One. 2, 4, e373.

Research output: Contribution to journalArticle

neuroprotective effect
Brain
cells
mice
Macrophages