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Research Output 2004 2019

  • 2292 Citations
  • 28 h-Index
  • 125 Article
  • 9 Review article
  • 2 Chapter
2019
2 Citations (Scopus)
Interferon-alpha
Liver
Interferon-gamma
Triglycerides
Fats

Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma

Fattore, L., Ruggiero, C. F., Pisanu, M. E., Liguoro, D., Cerri, A., Costantini, S., Capone, F., Acunzo, M., Romano, G., Nigita, G., Mallardo, D., Ragone, C., Carriero, M. V., Budillon, A., Botti, G., Ascierto, P. A., Mancini, R. & Ciliberto, G., Jul 2019, In : Cell Death and Differentiation. 26, 7, p. 1267-1282 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Melanoma
Recurrence
Mitogen-Activated Protein Kinase Kinases

Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer

Nunziata, C., Polo, A., Sorice, A., Capone, F., Accardo, M., Guerriero, E., Marino, F. Z., Orditura, M., Budillon, A. & Costantini, S., Dec 1 2019, In : Scientific Reports. 9, 1, 16131.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Selenocysteine
Breast Neoplasms
Proteins
Selenoproteins
1 Citation (Scopus)

Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity

Minopoli, M., Polo, A., Ragone, C., Ingangi, V., Ciliberto, G., Pessi, A., Sarno, S., Budillon, A., Costantini, S. & Carriero, M. V., Dec 1 2019, In : Scientific Reports. 9, 1, 12169.

Research output: Contribution to journalArticle

Open Access
Formyl Peptide Receptor
Peptide Receptors
Urokinase-Type Plasminogen Activator
Cell Movement
N-Formylmethionine Leucyl-Phenylalanine
1 Citation (Scopus)

Toxicity of diatom-derived polyunsaturated aldehyde mixtures on sea urchin Paracentrotus lividus development

Ruocco, N., Annunziata, C., Ianora, A., Libralato, G., Manfra, L., Costantini, S. & Costantini, M., Dec 1 2019, In : Scientific Reports. 9, 1, 517.

Research output: Contribution to journalArticle

Paracentrotus
Diatoms
Sea Urchins
Aldehydes
Aquatic Organisms
2018
15 Citations (Scopus)

Aflatoxin B1 and M1: Biological properties and their involvement in cancer development

Marchese, S., Polo, A., Ariano, A., Velotto, S., Costantini, S. & Severino, L., Jun 1 2018, In : Toxins. 10, 6, 214.

Research output: Contribution to journalReview article

Aflatoxin M1
Aflatoxin B1
MicroRNAs
Neoplasms
International Agencies

Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach

Nittoli, A. C., Costantini, S., Sorice, A., Capone, F., Ciarcia, R., Marzocco, S., Budillon, A. & Severino, L., Mar 1 2018, In : Metabolomics. 14, 3, 33.

Research output: Contribution to journalArticle

Metabolome
MCF-7 Cells
Metabolomics
Cells
Nuclear magnetic resonance
1 Citation (Scopus)

Evaluation of Aflatoxin M1 Effects on the Metabolomic and Cytokinomic Profiling of a Hepatoblastoma Cell Line

Marchese, S., Sorice, A., Ariano, A., Florio, S., Budillon, A., Costantini, S. & Severino, L., Oct 28 2018, In : Toxins. 10, 11

Research output: Contribution to journalArticle

Aflatoxin M1
Hepatoblastoma
Metabolomics
Hep G2 Cells
Cells
1 Citation (Scopus)

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Polo, A., Marchese, S., De Petro, G., Montella, M., Ciliberto, G., Budillon, A. & Costantini, S., Dec 1 2018, In : Scientific Reports. 8, 1, 10395.

Research output: Contribution to journalArticle

Arsenicals
Kidney Neoplasms
MicroRNAs
Prostatic Neoplasms
Urinary Bladder
5 Citations (Scopus)

The effect of light exposure at night (LAN) on carcinogenesis via decreased nocturnal melatonin synthesis

Giudice, A., Crispo, A., Grimaldi, M., Polo, A., Bimonte, S., Capunzo, M., Amore, A., Arena, G. D., Cerino, P., Budillon, A., Botti, G., Costantini, S. & Montella, M., Jan 1 2018, In : Molecules. 23, 6, 1308.

Research output: Contribution to journalReview article

melatonin
Melatonin
night
Clocks
Carcinogenesis
Melatonin
Clocks
Mammals
T-cells
Metabolism
5 Citations (Scopus)

Toxigenic effects of two benthic diatoms upon grazing activity of the sea urchin: Morphological, metabolomic and de novo transcriptomic analysis

Ruocco, N., Costantini, S., Zupo, V., Lauritano, C., Caramiello, D., Ianora, A., Budillon, A., Romano, G., Nuzzo, G., D'Ippolito, G., Fontana, A. & Costantini, M., Dec 1 2018, In : Scientific Reports. 8, 1, 5622.

Research output: Contribution to journalArticle

Bacillariophyceae
metabolomics
transcriptomics
Echinoidea
grazing
2017

An interaction network approach to study the correlation between endocrine disrupting chemicals and breast cancer

Polo, A., Nittoli, C., Crispo, A., Langastro, T., Severino, L., Cocco, S., De Laurentiis, M., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2687-2696 10 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Breast Neoplasms
Mycotoxins
Protein Interaction Maps
Proteins
4 Citations (Scopus)

Anti-cancer activity of dose-fractioned mPE +/- bevacizumab regimen is paralleled by immune-modulation in advanced squamous NSLC patients

Pastina, P., Nardone, V., Croci, S., Battaglia, G., Vanni, F., Bellan, C., Barbarino, M., Ricci, V., Costantini, S., Capone, F., Botta, C., Zarone, M. R., Misso, G., Boccellino, M., Caraglia, M., Giordano, A., Paladini, P., Tassone, P., Tagliaferri, P., Cusi, M. G. & 2 others, Pirtoli, L. & Correale, P., Sep 1 2017, In : Journal of Thoracic Disease. 9, 9, p. 3123-3131 9 p.

Research output: Contribution to journalArticle

Neoplasms
Etoposide
Cisplatin
Survival
Histology
9 Citations (Scopus)

Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines

Guerriero, E., Sorice, A., Capone, F., Stor Ti, G., Colonna, G., Ciliberto, G. & Costantini, S., Feb 1 2017, In : International Journal of Oncology. 50, 2, p. 468-476 9 p.

Research output: Contribution to journalArticle

Linseed Oil
Doxorubicin
Breast Neoplasms
Cell Line
Cell Cycle
4 Citations (Scopus)

Comparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell lines

Rusolo, F., Capone, F., Pasquale, R., Angiolillo, A., Colonna, G., Castello, G., Costantini, M. & Costantini, S., Apr 1 2017, In : Oncology Letters. 13, 4, p. 2411-2417 7 p.

Research output: Contribution to journalArticle

Transcriptome
Breast
Epithelial Cells
Selenoproteins
Breast Neoplasms
1 Citation (Scopus)

Conformational analysis of the human chemokine receptor CXCR3

Raucci, R., Polo, A., Budillon, A., Colonna, G. & Costantini, S., Dec 1 2017, In : Molecular Immunology. 92, p. 76-86 11 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Ligands
Lipid Bilayers
Molecular Dynamics Simulation
Neoplasms
12 Citations (Scopus)

Environment and bladder cancer: molecular analysis by interaction networks

Polo, A., Crispo, A., Cerino, P., Falzone, L., Candido, S., Giudice, A., De Petro, G., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., May 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Arsenic
Arsenicals
Environmental Pollutants
Data Mining
4 Citations (Scopus)

Evaluating the associations between human circadian rhythms and dysregulated genes in liver cancer cells

Polo, A., Singh, S., Crispo, A., Russo, M., Giudice, A., Montella, M., Colonna, G. & Costantini, S., Dec 2017, In : Oncology Letters. 14, 6, p. 7353-7359 7 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Circadian Rhythm
Genes
Casein Kinase I
Kinetochores
4 Citations (Scopus)

Evaluating the effects of an organic extract from the mediterranean sponge Geodia cydonium on human breast cancer cell lines

Costantini, S., Guerriero, E., Teta, R., Capone, F., Caso, A., Sorice, A., Romano, G., Ianora, A., Ruocco, N., Budillon, A., Costantino, V. & Costantini, M., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2112.

Research output: Contribution to journalArticle

Geodia
Rosaceae
Metabolomics
Porifera
cultured cells
8 Citations (Scopus)

High-quality RNA extraction from the sea urchin Paracentrotus lividus embryos

Ruocco, N., Costantini, S., Zupo, V., Romano, G., Ianora, A., Fontana, A. & Costantini, M., Feb 1 2017, In : PLoS One. 12, 2, e0172171.

Research output: Contribution to journalArticle

Paracentrotus
Paracentrotus lividus
Sea Urchins
Echinoidea
embryo (animal)
7 Citations (Scopus)

Marine sponges and bacteria as challenging sources of enzyme inhibitors for pharmacological applications

Ruocco, N., Costantini, S., Palumbo, F. & Costantini, M., Jun 1 2017, In : Marine Drugs. 15, 6, 173.

Research output: Contribution to journalReview article

Porifera
Enzyme Inhibitors
Pharmacology
Bacteria
Enzymes
7 Citations (Scopus)

Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients

Marianna, S., Alessia, P., Susan, C., Francesca, C., Angela, S., Francesca, C., Antonella, N., Patrizia, I., Nicola, C. & Emilio, C., 2017, In : Molecular BioSystems. 13, 6, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

Follicular Fluid
Metabolomics
Endometriosis
Oocytes
Cumulus Cells
36 Citations (Scopus)

MicroRNAs in melanoma development and resistance to target therapy

Fattore, L., Costantini, S., Malpicci, D., Ruggiero, C. F., Ascierto, P. A., Croce, C. M., Mancini, R. & Ciliberto, G., 2017, In : Oncotarget. 8, 13, p. 22262-22278 17 p.

Research output: Contribution to journalReview article

MicroRNAs
Melanoma
Therapeutics
Messenger RNA
Mitogen-Activated Protein Kinase Kinases
7 Citations (Scopus)

New inter-correlated genes targeted by diatom-derived polyunsaturated aldehydes in the sea urchin Paracentrotus lividus

Ruocco, N., Maria Fedele, A., Costantini, S., Romano, G., Ianora, A. & Costantini, M., Aug 1 2017, In : Ecotoxicology and Environmental Safety. 142, p. 355-362 8 p.

Research output: Contribution to journalArticle

Paracentrotus
Diatoms
Sea Urchins
Aldehydes
Genes
20 Citations (Scopus)
Oxidative stress
Transcriptome
Gene expression
Oxidative Stress
Genes
8 Citations (Scopus)

Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas

Carriero, M. V., Bifulco, K., Ingangi, V., Costantini, S., Botti, G., Ragone, C., Minopoli, M., Motti, M. L., Rea, D., Scognamiglio, G., Botti, G., Arra, C., Ciliberto, G. & Pessi, A., May 2 2017, In : Scientific Reports. 7, 1, p. 1312

Research output: Contribution to journalArticle

Urokinase-Type Plasminogen Activator
Sarcoma
Cell Movement
Peptides
Biochemical Phenomena
37 Citations (Scopus)

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Noto, A., De Vitis, C., Pisanu, M. E., Roscilli, G., Ricci, G., Catizone, A., Sorrentino, G., Chianese, G., Taglialatela-Scafati, O., Trisciuoglio, D., Del Bufalo, D., Di Martile, M., Napoli, A., Ruco, L., Costantini, S., Jakopin, Z., Budillon, A., Melino, G., Del Sal, G., Ciliberto, G. & 1 others, Mancini, R., Aug 2017, In : Oncogene.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Lung Neoplasms
Catenins
Proteins
Neoplastic Stem Cells
1 Citation (Scopus)

Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain?

Mercurio, F. A., Costantini, S., Di Natale, C., Pirone, L., Guariniello, S., Scognamiglio, P. L., Marasco, D., Pedone, E. M. & Leone, M., Sep 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 9, p. 1095-1104 10 p.

Research output: Contribution to journalArticle

Ephrin-A2
Eph Family Receptors
Mutation
Peptides
Tumors
2016
5 Citations (Scopus)
Molecular Dynamics Simulation
Hepatocellular Carcinoma
Lipids
Membranes
Water
14 Citations (Scopus)

Blue-print autophagy: Potential for cancer treatment

Ruocco, N., Costantini, S. & Costantini, M., Jul 1 2016, In : Marine Drugs. 14, 7, 138.

Research output: Contribution to journalReview article

Autophagy
Pharmacology
Neoplasms
Biological Products
Monosaccharides
9 Citations (Scopus)

Deducing the functional characteristics of the human selenoprotein SELK from the structural properties of its intrinsically disordered C-terminal domain

Polo, A., Colonna, G., Guariniello, S., Ciliberto, G. & Costantini, S., Mar 1 2016, In : Molecular BioSystems. 12, 3, p. 758-772 15 p.

Research output: Contribution to journalArticle

Selenoproteins
Molecular Dynamics Simulation
Proteins
Endoplasmic Reticulum
Intrinsically Disordered Proteins
7 Citations (Scopus)

Differential response of two human breast cancer cell lines to the phenolic extract from flaxseed oil

Sorice, A., Guerriero, E., Volpe, M. G., Capone, F., La Cara, F., Ciliberto, G., Colonna, G., Costantini, S. & McPhee, D. J., Mar 1 2016, In : Molecules. 21, 3, 319.

Research output: Contribution to journalArticle

Linseed Oil
Genes
Cells
Lipids
Chemical activation
17 Citations (Scopus)

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

Roscilli, G., De Vitis, C., Ferrara, F. F., Noto, A., Cherubini, E., Ricci, A., Mariotta, S., Giarnieri, E., Giovagnoli, M. R., Torrisi, M. R., Bergantino, F., Costantini, S., Fenizia, F., Lambiase, M., Aurisicchio, L., Normanno, N., Ciliberto, G. & Mancini, R., Feb 29 2016, In : Journal of Translational Medicine. 14, 1, 61.

Research output: Contribution to journalArticle

Malignant Pleural Effusion
Cell culture
Cell Culture Techniques
Cells
Chemotherapy
8 Citations (Scopus)

Human MiR-544a modulates SELK expression in hepatocarcinoma cell lines

Potenza, N., Castiello, F., Panella, M., Colonna, G., Ciliberto, G., Russo, A. & Costantini, S. C., Jun 1 2016, In : PLoS One. 11, 6, e0156908.

Research output: Contribution to journalArticle

Selenoproteins
selenoproteins
hepatoma
Cells
cell lines
55 Citations (Scopus)

Polysaccharides from the marine environment with pharmacological, cosmeceutical and nutraceutical potential

Ruocco, N., Costantini, S., Guariniello, S. & Costantini, M., May 1 2016, In : Molecules. 21, 5, 551.

Research output: Contribution to journalArticle

Polysaccharides
Carbohydrates
Biological Products
Health
Chitin

Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential

Ruocco, N., Costantini, S., Guariniello, S. & Costantini, M., Apr 27 2016, In : Molecules. 21, 5

Research output: Contribution to journalReview article

Dietary Supplements
Polysaccharides
Pharmacology
Carbohydrates
Biological Products
10 Citations (Scopus)

Potential anticancer effects of polyphenols from chestnut shell extracts: Modulation of cell growth, and cytokinomic and metabolomic profiles

Sorice, A., Siano, F., Capone, F., Guerriero, E., Picariello, G., Budillon, A., Ciliberto, G., Paolucci, M., Costantini, S. & Volpe, M. G., Oct 1 2016, In : Molecules. 21, 10, 1411.

Research output: Contribution to journalArticle

Metabolomics
Catechin
Depolarization
Cell growth
Polyphenols

Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles

Sorice, A., Siano, F., Capone, F., Guerriero, E., Picariello, G., Budillon, A., Ciliberto, G., Paolucci, M., Costantini, S. & Volpe, M. G., Oct 21 2016, In : Molecules. 21, 10

Research output: Contribution to journalArticle

Metabolomics
Catechin
Depolarization
Cell growth
Polyphenols
6 Citations (Scopus)
Immunoassay
Cytokines
Serum
Neoplasms
Inflammation
3 Citations (Scopus)

Small heterodimer partner 1 directly interacts with NS5A viral protein and has a key role in HCV related liver cell transformation

Conti, B., Porcu, C., Viscomi, C., Minutolo, A., Costantini, S., Iannucci, G., Barbaro, B. & Balsano, C., 2016, In : Oncotarget. 7, 51, p. 84575-84586 12 p.

Research output: Contribution to journalArticle

Viral Proteins
Fatty Liver
Life Cycle Stages
Hepatocytes
Liver
6 Citations (Scopus)

Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues

Mercurio, F. A., Marasco, D., Di Natale, C., Pirone, L., Costantini, S., Pedone, E. M. & Leone, M., Nov 17 2016, In : ChemBioChem. 17, 22, p. 2179-2188 10 p.

Research output: Contribution to journalArticle

Peptides
EphA2 Receptor
Endocytosis
Nuclear magnetic resonance
Thermophoresis
12 Citations (Scopus)

Toxic diatom aldehydes affect defence gene networks in sea urchins

Varrella, S., Romano, G., Costantini, S., Ruocco, N., Ianora, A., Bentley, M. G. & Costantini, M., Feb 1 2016, In : PLoS One. 11, 2, e0149734.

Research output: Contribution to journalArticle

Diatoms
Sea Urchins
Bacillariophyceae
Gene Regulatory Networks
Poisons
2015
11 Citations (Scopus)

Anti-Inflammatory Effects of a Methanol Extract from the Marine Sponge Geodia cydonium on the Human Breast Cancer MCF-7 Cell Line

Costantini, S., Romano, G., Rusolo, F., Capone, F., Guerriero, E., Colonna, G., Ianora, A., Ciliberto, G. & Costantini, M., 2015, In : Mediators of Inflammation. 2015, 204975.

Research output: Contribution to journalArticle

Geodia
Rosaceae
MCF-7 Cells
Porifera
Methanol
4 Citations (Scopus)

Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4

Vincenzi, M., Costantini, S., Scala, S., Tesauro, D., Accardo, A., Leone, M., Colonna, G., Guillon, J., Portella, L., Trotta, A. M., Ronga, L. & Rossi, F., May 28 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12159-12173 15 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Peptides
peptides
Assays
CXCR4 Receptors
18 Citations (Scopus)
Hepatocellular Carcinoma
Survival
Ligands
Chemokine Receptors
Chemokines
17 Citations (Scopus)

Evaluation of the selenotranscriptome expression in two hepatocellular carcinoma cell lines

Guariniello, S., Di Bernardo, G., Colonna, G., Cammarota, M., Castello, G. & Costantini, S., 2015, In : Analytical Cellular Pathology. 2015, 419561.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Cell Line
Selenoproteins
Genes
Hep G2 Cells
17 Citations (Scopus)

GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues

Guerriero, E., Capone, F., Accardo, M., Sorice, A., Costantini, M., Colonna, G., Castello, G. & Costantini, S., Dec 1 2015, In : European journal of histochemistry : EJH. 59, 4, p. 5-10 6 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Selenium
Selenoproteins
Glutathione Peroxidase
Neoplasms
2 Citations (Scopus)

Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles

Vincenzi, M., Accardo, A., Costantini, S., Scala, S., Portella, L., Trotta, A., Ronga, L., Guillon, J., Leone, M., Colonna, G., Rossi, F. & Tesauro, D., 2015, In : Molecular BioSystems. 11, 11, p. 2925-2932 8 p.

Research output: Contribution to journalArticle

Peptides
Pharmaceutical Preparations
CXCR4 Receptors
Intrinsically Disordered Proteins
Spectrum Analysis
8 Citations (Scopus)
Vascular Endothelial Growth Factor A
Protein Isoforms
Carcinogenesis
Exons
Site selection