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2018

Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease

Russo, R., Cattaneo, F., Lippiello, P., Cristiano, C., Zurlo, F., Castaldo, M., Irace, C., Borsello, T., Santamaria, R., Ammendola, R., Calignano, A. & Miniaci, M. C., Aug 2018, In : Neurobiology of Aging. 68, p. 123-133 11 p.

Research output: Contribution to journalArticle

Pharmacological c-Jun NH2-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice

Schellino, R., Boido, M., Borsello, T. & Vercelli, A., 2018, In : Frontiers in Molecular Neuroscience. 11, p. 308

Research output: Contribution to journalArticle

The Stress c-Jun N-terminal Kinase Signaling Pathway Activation Correlates with Synaptic Pathology and Presents A Sex Bias in P301L Mouse Model of Tauopathy

Buccarello, L., Musi, C. A., Turati, A. & Borsello, T., Nov 21 2018, In : Neuroscience. 393, p. 196-205 10 p.

Research output: Contribution to journalArticle

2017

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase

Biggi, S., Buccarello, L., Sclip, A., Lippiello, P., Tonna, N., Rumio, C., Di Marino, D., Miniaci, M. C. & Borsello, T., Jan 1 2017, In : Neural Plasticity. 2017, 6468356.

Research output: Contribution to journalArticle

Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy

Buccarello, L., Grignaschi, G., Di Giancamillo, A., Domeneghini, C., Melcangi, R. C. & Borsello, T., Jun 23 2017, In : Neuroscience. 354, p. 208-220 13 p.

Research output: Contribution to journalArticle

Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy

Buccarello, L., Grignaschi, G., Castaldo, A. M., DI Giancamillo, A., Domeneghini, C., Melcangi, R. C. & Borsello, T., Jan 1 2017, In : Journal of Alzheimer's Disease. 56, 4, p. 1279-1292 14 p.

Research output: Contribution to journalArticle

The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of alzheimer disease suggesting a correlation between ocular and brain pathologies

Buccarello, L., Sclip, A., Sacchi, M., Castaldo, AM., Bertani, I., ReCecconi, A., Maestroni, S., Zerbini, G., Nucci, P. & Borsello, T., 2017, In : Oncotarget. 8, 47, p. 83038-83051 14 p.

Research output: Contribution to journalArticle

The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of alzheimer disease suggesting a correlation between ocular and brain pathologies

Buccarello, L., Sclip, A., Sacchi, M., Castaldo, A. M., Bertani, I., ReCecconi, A., Maestroni, S., Zerbini, G., Nucci, P. & Borsello, T., Jan 1 2017, In : Oncotarget. 8, 47, p. 83038-83051 14 p.

Research output: Contribution to journalArticle

The Tat-Aβ1-6A2V(D) peptide against AD synaptopathy

Buccarello, L. & Borsello, T., Feb 14 2017, In : Oncotarget. 8, 7, p. 10773-10774 2 p.

Research output: Contribution to journalArticle

2016

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein

Massignan, T., Cimini, S., Stincardini, C., Cerovic, M., Vanni, I., Elezgarai, S. R., Moreno, J., Stravalaci, M., Negro, A., Sangiovanni, V., Restelli, E., Riccardi, G., Gobbi, M., Castilla, J., Borsello, T., Nonno, R. & Biasini, E., Mar 15 2016, In : Scientific Reports. 6, 23180.

Research output: Contribution to journalArticle

Epidermal RAF prevents allergic skin disease

Raguz, J., Jeric, I., Niault, T., Nowacka, J. D., Kuzet, S. E., Rupp, C., Fischer, I., Biggi, S., Borsello, T. & Baccarini, M., Jul 19 2016, In : eLife. 5, 2016JULY, p. e14012

Research output: Contribution to journalArticle

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt

Cimini, S., Sclip, A., Mancini, S., Colombo, L., Messa, M., Cagnotto, A., Di Fede, G., Tagliavini, F., Salmona, M. & Borsello, T., May 1 2016, In : Neurobiology of Disease. 89, p. 101-111 11 p.

Research output: Contribution to journalArticle

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt

Cimini, S., Sclip, A., Mancini, S., Colombo, L., Messa, M., Cagnotto, A., Di Fede, G., Tagliavini, F., Salmona, M. & Borsello, T., May 1 2016, In : Neurobiology of Disease. 89, p. 101-111 11 p.

Research output: Contribution to journalArticle

2015

Abnormal cortical lysosomal β-hexosaminidase and β-galactosidase activity at post-synaptic sites during Alzheimer's disease progression

Magini, A., Polchi, A., Tozzi, A., Tancini, B., Tantucci, M., Urbanelli, L., Borsello, T., Calabresi, P. & Emiliani, C., 2015, In : International Journal of Biochemistry and Cell Biology. 58, p. 62-70 9 p.

Research output: Contribution to journalArticle

Differential relevance of NF-κB and JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding

Relja, B., Weber, R., Maraslioglu, M., Wagner, N., Borsello, T., Jobin, C., Marzi, I. & Lehnert, M., Sep 14 2015, In : PLoS One. 10, 9, e0137875.

Research output: Contribution to journalArticle

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: A novel pharmacological strategy against brain injury

Vercelli, A., Biggi, S., Sclip, A., Repetto, I. E., Cimini, S., Falleroni, F., Tomasi, S., Monti, R., Tonna, N., Morelli, F., Grande, V., Stravalaci, M., Biasini, E., Marin, O., Bianco, F., Di Marino, D. & Borsello, T., Feb 5 2015, In : Cell Death and Disease. 6

Research output: Contribution to journalArticle

Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease

Tozzi, A., Sclip, A., Tantucci, M., de Iure, A., Ghiglieri, V., Costa, C., Di Filippo, M., Borsello, T. & Calabresi, P., Jan 1 2015, In : Neurobiology of Aging. 36, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

2014

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.

Sclip, A., Tozzi, A., Abaza, A., Cardinetti, D., Colombo, I., Calabresi, P., Salmona, M., Welker, E. & Borsello, T., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

Determination of tissue levels of a neuroprotectant drug: The cell permeable JNK inhibitor peptide

Davoli, E., Sclip, A., Cecchi, M., Cimini, S., Carrà, A., Salmona, M. & Borsello, T., 2014, In : Journal of Pharmacological and Toxicological Methods. 70, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

2013

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

Fluharty, B. R., Biasini, E., Stravalaci, M., Sclip, A., Diomede, L., Balducci, C., La Vitola, P., Messa, M., Colombo, L., Forloni, G., Borsello, T., Gobbi, M. & Harris, D. A., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7857-7866 10 p.

Research output: Contribution to journalArticle

Soluble Aβ oligomer-induced synaptopathy: C-Jun N-terminal kinase's role

Sclip, A., Arnaboldi, A., Colombo, I., Veglianese, P., Colombo, L., Messa, M., Mancini, S., Cimini, S., Morelli, F., Antoniou, X., Welker, E., Salmona, M. & Borsello, T., Aug 2013, In : Journal of Molecular Cell Biology. 5, 4, p. 277-279 3 p.

Research output: Contribution to journalArticle

The neurodegeneration in Alzheimer disease and the prion protein

Forloni, G., Sclip, A., Borsello, T. & Balducci, C., Jan 2013, In : Prion. 7, 1, p. 60-65 6 p.

Research output: Contribution to journalArticle

2012

Contribution of serine racemase/d-serine pathway to neuronal apoptosis

Esposito, S., Pristerà, A., Maresca, G., Cavallaro, S., Felsani, A., Florenzano, F., Manni, L., Ciotti, M. T., Pollegioni, L., Borsello, T. & Canu, N., Aug 2012, In : Aging Cell. 11, 4, p. 588-598 11 p.

Research output: Contribution to journalArticle

Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury

Repici, M., Chen, X., Morel, M. P., Doulazmi, M., Sclip, A., Cannaya, V., Veglianese, P., Kraftsik, R., Mariani, J., Borsello, T. & Dusart, I., Jun 2012, In : Neurobiology of Disease. 46, 3, p. 710-721 12 p.

Research output: Contribution to journalArticle

The JNK signalling transduction pathway in the brain

Antoniou, X. & Borsello, T., Jan 1 2012, In : Frontiers in Bioscience - Elite. 4 E, 6, p. 2110-2120 11 p.

Research output: Contribution to journalArticle

2011

C-Jun N-terminal kinase (JNK) and p38 play different roles in age-related purkinje cell death in murine organotypic culture

Repici, M., Wehrlé, R., Antoniou, X., Borsello, T. & Dusart, I., Jun 2011, In : Cerebellum. 10, 2, p. 281-290 10 p.

Research output: Contribution to journalArticle

c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model

Sclip, A., Antoniou, X., Colombo, A., Camici, G. G., Pozzi, L., Cardinetti, D., Feligioni, M., Veglianese, P., Bahlmann, F. H., Cervo, L., Balducci, C., Costa, C., Tozzi, A., Calabresi, P., Forloni, G. & Borsello, T., Dec 23 2011, In : Journal of Biological Chemistry. 286, 51, p. 43871-43880 10 p.

Research output: Contribution to journalArticle

Crosstalk between JNK and SUMO signaling pathways: DeSUMOylation is protective against H 2O 2-induced cell injury

Feligioni, M., Brambilla, E., Camassa, A., Sclip, A., Arnaboldi, A., Morelli, F., Antoniou, X. & Borsello, T., Dec 2 2011, In : PLoS One. 6, 12, e28185.

Research output: Contribution to journalArticle

JNK3 as a therapeutic target for neurodegenerative diseases

Antoniou, X., Falconi, M., Di Marino, D. & Borsello, T., 2011, In : Journal of Alzheimer's Disease. 24, 4, p. 633-642 10 p.

Research output: Contribution to journalArticle

JNK plays a key role in tau hyperphosphorylation in alzheimer's disease models

Ploia, C., Antoniou, X., Sclip, A., Grande, V., Cardinetti, D., Colombo, A., Canu, N., Benussi, L., Ghidoni, R., Forloni, G. & Borsello, T., 2011, In : Journal of Alzheimer's Disease. 26, 2, p. 315-329 15 p.

Research output: Contribution to journalArticle

2010

A new fluorogenic peptide determines proteasome activity in single cells

Urru, S. A. M., Veglianese, P., De Luigi, A., Fumagalli, E., Erba, E., Gonella Diaza, R., Carrà, A., Davoli, E., Borsello, T., Forloni, G., Pengo, N., Monzani, E., Cascio, P., Cenci, S., Sitia, R. & Salmona, M., Oct 28 2010, In : Journal of Medicinal Chemistry. 53, 20, p. 7452-7460 9 p.

Research output: Contribution to journalArticle

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease

Epis, R., Marcello, E., Gardoni, F., Vastagh, C., Malinverno, M., Balducci, C., Colombo, A., Borroni, B., Vara, H., Dell'Agli, M., Cattabeni, F., Giustetto, M., Borsello, T., Forloni, G., Padovani, A. & Di Luca, M., Nov 2010, In : Brain. 133, 11, p. 3323-3335 13 p.

Research output: Contribution to journalArticle

Cell permeable peptides: A promising tool to deliver neuroprotective agents in the brain

Antoniou, X. & Borsello, T., 2010, In : Pharmaceuticals. 3, 2, p. 379-392 14 p.

Research output: Contribution to journalArticle

JNK contributes to Hif-1α regulation in hypoxic neurons

Antoniou, X., Sclip, A., Ploia, C., Colombo, A., Moroy, G. & Borsello, T., Jan 2010, In : Molecules. 15, 1, p. 114-127 14 p.

Research output: Contribution to journalArticle

Role of glycogen synthase kinase-3β in APP hyperphosphorylation induced by NMDA stimulation in cortical neurons

Ploia, C., Sclip, A., Colombo, A., Repici, M., Gardoni, F., di Luca, M., Forloni, G., Antoniou, X. & Borsello, T., 2010, In : Pharmaceuticals. 3, 1, p. 42-58 17 p.

Research output: Contribution to journalArticle

Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein

Balducci, C., Beeg, M., Stravalaci, M., Bastone, A., Sclip, A., Biasini, E., Tapella, L., Colombo, L., Manzoni, C., Borsello, T., Chiesa, R., Gobbi, M., Salmona, M. & Forloni, G., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2295-2300 6 p.

Research output: Contribution to journalArticle

2009

C-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion

Ortolano, F., Colombo, A., Zanier, E. R., Sclip, A., Longhi, L., Perego, C., Stocchetti, N., Borsello, T. & De Simoni, M. G., Sep 1 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 9, p. 964-971 8 p.

Research output: Contribution to journalArticle

Inhibition of c-jun n-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats

Relja, B., Schwestka, B., Lee, V. S. Y., Henrich, D., Czerny, C., Borsello, T., Marzi, I. & Lehnert, M., Nov 2009, In : Shock. 32, 5, p. 509-516 8 p.

Research output: Contribution to journalArticle

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

Colombo, A., Bastone, A., Ploia, C., Sclip, A., Salmona, M., Forloni, G. & Borsello, T., Mar 2009, In : Neurobiology of Disease. 33, 3, p. 518-525 8 p.

Research output: Contribution to journalArticle

2008

A peptide inhibitor of C-JUN N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation

Lehnert, M., Relja, B., Sun-Young Lee, V., Schwestka, B., Henrich, D., Czerny, C., Froh, M., Borsello, T. & Marzi, I., Aug 2008, In : Shock. 30, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse

Bigini, P., Repici, M., Cantarella, G., Fumagalli, E., Barbera, S., Cagnotto, A., De Luigi, A., Tonelli, R., Bernardini, R., Borsello, T. & Mennini, T., Mar 2008, In : Neurobiology of Disease. 29, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse

Repici, M., Zanjani, H. S., Gautheron, V., Borsello, T., Dusart, I. & Mariani, J., Dec 2008, In : Cerebellum. 7, 4, p. 534-538 5 p.

Research output: Contribution to journalArticle

2007

Excitotoxicity-related endocytosis in cortical neurons

Vaslin, A., Puyal, J., Borsello, T. & Clarke, P. G. H., Aug 2007, In : Journal of Neurochemistry. 102, 3, p. 789-800 12 p.

Research output: Contribution to journalArticle

JNK signalling: A possible target to prevent neurodegeneration

Borsello, T. & Forloni, G., Jun 2007, In : Current Pharmaceutical Design. 13, 18, p. 1875-1886 12 p.

Research output: Contribution to journalArticle

Neuronal death and neuroprotection: a review.

Repici, M., Mariani, J. & Borsello, T., 2007, In : Methods in molecular biology (Clifton, N.J.). 399, p. 1-14 14 p.

Research output: Contribution to journalArticle

Phosphorylation-dependent dimerization and subcellular localization of islet-brain 1/c-Jun N-terminal kinase-interacting protein 1

Borsello, T., Centeno, C., Riederer, I. M., Haefliger, J. A. & Riederer, B. M., Dec 2007, In : Journal of Neuroscience Research. 85, 16, p. 3632-3641 10 p.

Research output: Contribution to journalArticle

Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons

Centeno, C., Repici, M., Chatton, J. Y., Riederer, B. M., Bonny, C., Nicod, P., Price, M., Clarke, P. G. H., Papa, S., Franzoso, G. & Borsello, T., Feb 2007, In : Cell Death and Differentiation. 14, 2, p. 240-253 14 p.

Research output: Contribution to journalArticle

The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability [4]

Colombo, A., Repici, M., Pesaresi, M., Santambrogio, S., Forloni, G. & Borsello, T., Oct 2007, In : Cell Death and Differentiation. 14, 10, p. 1845-1848 4 p.

Research output: Contribution to journalArticle

Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation

Repici, M., Centeno, C., Tomasi, S., Forloni, G., Bonny, C., Vercelli, A. & Borsello, T., Nov 30 2007, In : Neuroscience. 150, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle