Uliana De Simone

2020

Neuron-like cells generated from human umbilical cord lining-derived Mesenchymal stem cells as a new in vitro model for neuronal toxicity screening: Using magnetite nanoparticles as an example

De Simone, U., Spinillo, A., Caloni, F., Gribaldo, L. & Coccini, T., Jan 1 2020, In : International Journal of Molecular Sciences. 21, 1, 271.

Research output: Contribution to journal › Article

Open Access

Magnetite Nanoparticles

Magnetite nanoparticles

stem cells

Umbilical Cord

linings

Neuron-like cells generated from human umbilical cord lining-derived Mesenchymal stem cells as a new in vitro model for neuronal toxicity screening: Using magnetite nanoparticles as an example

De Simone, U., Spinillo, A., Caloni, F., Gribaldo, L. & Coccini, T., 2020, In : International Journal of Molecular Sciences. 21, 1

Research output: Contribution to journal › Article

2019

Cytotoxic Effects of 3,4-Catechol-PV (One Major MDPV Metabolite) on Human Dopaminergic SH-SY5Y Cells

Coccini, T., Vecchio, S., Crevani, M. & De Simone, U., Jan 2019, In : Neurotoxicity Research. 35, 1, p. 49-62 14 p.

Research output: Contribution to journal › Article

Metabolites

Cells

Cell Survival

Poisons

Cytoplasmic Vesicles

In vitro evaluation of magnetite nanoparticles in human mesenchymal stem cells: comparison of different cytotoxicity assays

De Simone, U., Spinillo, A., Caloni, F., Avanzini, M. A. & Coccini, T., Jan 1 2019, In : Toxicology Mechanisms and Methods.

Research output: Contribution to journal › Article

Magnetite Nanoparticles

Cytotoxicity

Stem cells

Mesenchymal Stromal Cells

Assays

In vitro toxicity screening of magnetite nanoparticles by applying mesenchymal stem cells derived from human umbilical cord lining

Coccini, T., De Simone, U., Roccio, M., Croce, S., Lenta, E., Zecca, M., Spinillo, A. & Avanzini, M. A., Jan 1 2019, In : Journal of Applied Toxicology.

Research output: Contribution to journal › Article

Magnetite Nanoparticles

Umbilical Cord

Stem cells

Mesenchymal Stromal Cells

Linings

In vitro toxicity screening of magnetite nanoparticles by applying mesenchymal stem cells derived from human umbilical cord lining

Coccini, T., De Simone, U., Roccio, M., Croce, S., Lenta, E., Zecca, M., Spinillo, A. & Avanzini, M. A., Sep 2019, In : Journal of Applied Toxicology. 39, 9, p. 1320-1336 17 p.

Research output: Contribution to journal › Article

Magnetite Nanoparticles

Umbilical Cord

Stem cells

Mesenchymal Stromal Cells

Linings

Neuron-Like Cells Generated from Human Umbilical Cord Lining-Derived Mesenchymal Stem Cells as a New In Vitro Model for Neuronal Toxicity Screening: Using Magnetite Nanoparticles as an Example

De Simone, U., Spinillo, A., Caloni, F., Gribaldo, L. & Coccini, T., Dec 31 2019, In : International Journal of Molecular Sciences. 21, 1

Research output: Contribution to journal › Article

Magnetite Nanoparticles

Magnetite nanoparticles

stem cells

Umbilical Cord

linings

2018

From 3Rs to 3D: In vitro alternative models for replacement

Nagy, A-L., Catoi, C., Socaciu, C., Pintea, A., Oros, N. A., Coman, C., Rugina, D., Matea, C. T., Mocan, T., Coccini, T., De Simone, U., De Angelis, I., Bertero, A., Sambuy, Y. & Caloni, F., Jul 17 2018, In : Altex. 35, 3, p. 420-421 2 p.

Research output: Contribution to journal › Article

Human 3D cultures as models for evaluating magnetic nanoparticle CNS cytotoxicity after short- and repeated long-term exposure

De Simone, U., Roccio, M., Gribaldo, L., Spinillo, A., Caloni, F. & Coccini, T., Jul 8 2018, In : International Journal of Molecular Sciences. 19, 7, 1993.

Research output: Contribution to journal › Article

central nervous system

Neurology

Cytotoxicity

Cell culture

Nanoparticles

Human 3D Cultures as Models for Evaluating Magnetic Nanoparticle CNS Cytotoxicity after Short- and Repeated Long-Term Exposure

De Simone, U., Roccio, M., Gribaldo, L., Spinillo, A., Caloni, F. & Coccini, T., Jul 8 2018, In : International Journal of Molecular Sciences. 19, 7

Research output: Contribution to journal › Article

central nervous system

Neurology

Cytotoxicity

Cell culture

Nanoparticles

2017

Cytotoxicity and proliferative capacity impairment induced on human brain cell cultures after short- and long-term exposure to magnetite nanoparticles

Coccini, T., Caloni, F., Ramírez Cando, L. J. & De Simone, U., Mar 2017, In : Journal of Applied Toxicology.

Research output: Contribution to journal › Article

Magnetite Nanoparticles

Neurology

Cytotoxicity

Cell culture

Astrocytes

Human Co-culture Model of Neurons and Astrocytes to Test Acute Cytotoxicity of Neurotoxic Compounds

De Simone, U., Caloni, F., Gribaldo, L. & Coccini, T., Nov 21 2017, In : International Journal of Toxicology. 36, 6, p. 463-477 15 p.

Research output: Contribution to journal › Article

Cytotoxicity

Coculture Techniques

Astrocytes

Neurons

Neurology

Human neuronal cell based assay: A new in vitro model for toxicity evaluation of ciguatoxin

Coccini, T., Caloni, F. & De Simone, U., Jun 2017, In : Environmental Toxicology and Pharmacology. 52, p. 200-213 14 p.

Research output: Contribution to journal › Article

Ciguatoxins

Ouabain

Veratridine

Toxicity

Assays

Toxicity evaluation of iron oxide (Fe₃O₄) nanoparticles on human neuroblastoma-derived SH-SY5Y cell line

Ramírez Cando, L. J., De Simone, U. & Coccini, T., 2017, In : Journal of Nanoscience and Nanotechnology. 17, 1, p. 203-211 9 p.

Research output: Contribution to journal › Article

Neuroblastoma

Iron oxides

cultured cells

iron oxides

toxicity

2016

Brief exposure to nanosized and bulk titanium dioxide forms induces subtle changes in human D384 astrocytes

De Simone, U., Lonati, D., Ronchi, A. & Coccini, T., Jul 8 2016, In : Toxicology Letters. 254, p. 8-21 14 p.

Research output: Contribution to journal › Article

Oxidative stress

Caspase 3

Astrocytes

Optical microscopy

Health

2015

Comparative cellular toxicity of titanium dioxide nanoparticles on human astrocyte and neuronal cells after acute and prolonged exposure

Coccini, T., Grandi, S., Lonati, D., Locatelli, C. & De Simone, U., May 1 2015, In : NeuroToxicology. 48, p. 77-89 13 p.

Research output: Contribution to journal › Article

Astrocytes

Nanoparticles

Toxicity

Cells

Brain

Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins

Soria, C., Coccini, T., De Simone, U., Marchese, L., Zorzoli, I., Giorgetti, S., Raimondi, S., Mangione, P. P., Ramat, S., Bellotti, V., Manzo, L. & Stoppini, M., Oct 2 2015, In : Amyloid. 22, 4, p. 221-228 8 p.

Research output: Contribution to journal › Article

Amyloidogenic Proteins

Caenorhabditis elegans

Silver

Nanoparticles

Nanostructures

2014

Assessment of cellular responses after short- and long-term exposure to silver nanoparticles in human neuroblastoma (SH-SY5Y) and astrocytoma (D384) cells

Coccini, T., Manzo, L., Bellotti, V. & De Simone, U., 2014, In : TheScientificWorldJournal. 2014, 259765.

Research output: Contribution to journal › Article

Silver Nitrate

Astrocytoma

Cell proliferation

Cell membranes

Neuroblastoma

2013

In vitro toxicity evaluation of engineered cadmium-coated silica nanoparticles on human pulmonary cells

De Simone, U., Manzo, L., Profumo, A. & Coccini, T., 2013, In : Journal of Toxicology. 2013, 931785.

Research output: Contribution to journal › Article

Cadmium Chloride

Cadmium

Silicon Dioxide

Nanoparticles

Toxicity

Short and long-term exposure of CNS cell lines to BPA-f a radiosensitizer for Boron Neutron Capture Therapy: Safety dose evaluation by a battery of cytotoxicity tests

De Simone, U., Manzo, L., Ferrari, C., Bakeine, J., Locatelli, C. & Coccini, T., Mar 2013, In : NeuroToxicology. 35, 1, p. 84-90 7 p.

Research output: Contribution to journal › Article

Boron Neutron Capture Therapy

Boron

Cytotoxicity

Fructose

Neutrons

2012

Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms

Coccini, T., Manzo, L., De Simone, U., Acerbi, D. & Roda, E., Apr 2012, In : Giornale Italiano di Medicina del Lavoro ed Ergonomia. 34, 2, p. 175-186 12 p.

Research output: Contribution to journal › Article

Air Pollution

Cardiovascular Diseases

Inflammation

Toxicology

Chronic Obstructive Pulmonary Disease

2011

Hypocrellin-B acetate as a fluorogenic substrate for enzyme-assisted cell photosensitization

Croce, A. C., Fasani, E., Bottone, M. G., De Simone, U., Santin, G., Pellicciari, C. & Bottiroli, G., Nov 2011, In : Photochemical and Photobiological Sciences. 10, 11, p. 1783-1790 8 p.

Research output: Contribution to journal › Article

Fluorescent Dyes

enzymes

acetates

Enzymes

cells

Naturally-occurring porphyrins in a spontaneous-tumour bearing mouse model

Croce, A. C., Santamaria, G., De Simone, U., Lucchini, F., Freitas, I. & Bottiroli, G., Jul 2011, In : Photochemical and Photobiological Sciences. 10, 7, p. 1189-1195 7 p.

Research output: Contribution to journal › Article

Bearings (structural)

Porphyrins

porphyrins

mice

Tumors

2010

Human liver autofluorescence: An intrinsic tissue parameter discriminating normal and diseased conditions

Croce, A. C., De Simone, U., Freitas, I., Boncompagni, E., Neri, D., Cillo, U. & Bottiroli, G., Jul 2010, In : Lasers in Surgery and Medicine. 42, 5, p. 371-378 8 p.

Research output: Contribution to journal › Article

Liver

Biopsy

Optical Imaging

Vitamin A

NAD

2008

Liver autofluorescence properties in animal model under altered nutritional conditions

Croce, A. C., De Simone, U., Vairetti, M., Ferrigno, A., Boncompagni, E., Freitas, I. & Bottiroli, G., 2008, In : Photochemical and Photobiological Sciences. 7, 9, p. 1046-1053 8 p.

Research output: Contribution to journal › Article

animal models

liver

Liver

retinene

Vitamin A

2007

Autofluorescence properties of rat liver under hypermetabolic conditions

Croce, A. C., De Simone, U., Vairetti, M., Ferrigno, A. & Bottiroli, G., 2007, In : Photochemical and Photobiological Sciences. 6, 11, p. 1202-1209 8 p.

Research output: Contribution to journal › Article

liver

Liver

rats

Rats

NADP