• 7380 Citations
  • 51 h-Index
1988 …2019
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Research Output 1988 2019

2019

Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status

Celli, R., Santolini, I., Van Luijtelaar, G., Ngomba, R. T., Bruno, V. & Nicoletti, F., Apr 2019, In : Expert Opinion on Therapeutic Targets. 23, 4, p. 341-351 11 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Synaptic Transmission
Absence Epilepsy
Epilepsy
Seizures

Targeting mGlu receptors for optimization of antipsychotic activity and disease-modifying effect in schizophrenia

Nicoletti, F., Orlando, R., Menna, L. D., Cannella, M., Notartomaso, S., Mascio, G., Iacovelli, L., Matrisciano, F., Fazio, F., Caraci, F., Copani, A., Battaglia, G. & Bruno, V., Jan 1 2019, In : Frontiers in Psychiatry. 10, FEB, 49.

Research output: Contribution to journalArticle

Open Access
Metabotropic Glutamate Receptors
Antipsychotic Agents
Schizophrenia
Animal Models
Pharmaceutical Preparations

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

Nicoletti, F., Orlando, R., Di Menna, L., Cannella, M., Notartomaso, S., Mascio, G., Iacovelli, L., Matrisciano, F., Fazio, F., Caraci, F., Copani, A., Battaglia, G. & Bruno, V., 2019, In : Frontiers in Psychiatry. 10, p. 49

Research output: Contribution to journalReview article

Metabotropic Glutamate Receptors
Antipsychotic Agents
Schizophrenia
Animal Models
Pharmaceutical Preparations
2018
1 Citation (Scopus)

Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor

Busceti, C. L., Di Menna, L., Bianchi, F., Mastroiacovo, F., Di Pietro, P., Traficante, A., Bozza, G., Niehrs, C., Battaglia, G., Bruno, V., Fornai, F., Volpe, M., Rubattu, S. & Nicoletti, F., Sep 11 2018, In : Frontiers in Cellular Neuroscience. 12, 292.

Research output: Contribution to journalArticle

Astrocytes
Vascular Endothelial Growth Factor A
N-Methylaspartate
Neurons
Neuroprotection
11 Citations (Scopus)
Metabotropic Glutamate Receptors
Amyotrophic Lateral Sclerosis
Motor Neurons
Nerve Growth Factors
Life Expectancy
1 Citation (Scopus)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors

Notartomaso, S., Nakao, H., Mascio, G., Scarselli, P., Cannella, M., Zappulla, C., Madonna, M., Motolese, M., Gradini, R., Liberatore, F., Zonta, M., Carmignoto, G., Battaglia, G., Bruno, V., Watanabe, M., Aiba, A. & Nicoletti, F., Dec 1 2018, In : Scientific Reports. 8, 1, 13361.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
Purkinje Cells
Cerebellar Cortex
Knockout Mice
Methylation
2017
8 Citations (Scopus)

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Notartomaso, S., Mascio, G., Bernabucci, M., Zappulla, C., Scarselli, P., Cannella, M., Imbriglio, T., Gradini, R., Battaglia, G., Bruno, V. & Nicoletti, F., Jan 1 2017, In : Molecular Pain. 13

Research output: Contribution to journalArticle

Acetylcarnitine
Neuralgia
Epigenomics
Chronic Pain
Analgesia
18 Citations (Scopus)

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors

Fazio, F., Lionetto, L., Curto, M., Iacovelli, L., Copeland, C. S., Neale, S. A., Bruno, V., Battaglia, G., Salt, T. E. & Nicoletti, F., Jan 1 2017, In : Neuropharmacology.

Research output: Contribution to journalArticle

Kynurenine
Metabotropic Glutamate Receptors
3-Hydroxyanthranilic Acid
Vesicular Glutamate Transport Proteins
Aryl Hydrocarbon Receptors
5 Citations (Scopus)
Activin Receptors
Vascular Endothelial Growth Factor A
Up-Regulation
Endothelial Cells
Type I Bone Morphogenetic Protein Receptors
4 Citations (Scopus)

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

Mastroiacovo, F., Moyanova, S., Cannella, M., Gaglione, A., Verhaeghe, R., Bozza, G., Madonna, M., Motolese, M., Traficante, A., Riozzi, B., Bruno, V., Battaglia, G., Lodge, D. & Nicoletti, F., Aug 18 2017, In : Molecular Brain. 10, 1, 39.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Transient Ischemic Attack
Ischemia
Middle Cerebral Artery Infarction
Endothelin-1
2 Citations (Scopus)

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Liberatore, F., Bucci, D., Mascio, G., Madonna, M., Di Pietro, P., Beneventano, M., Puliti, A. M., Battaglia, G., Bruno, V., Nicoletti, F. & Romano, M. R., Nov 5 2017, In : Neuroscience. 363, p. 142-149 8 p.

Research output: Contribution to journalArticle

Sodium Glutamate
Retinal Degeneration
Metabotropic Glutamate Receptors
Retinal Ganglion Cells
Poisons
29 Citations (Scopus)
Metabotropic Glutamate Receptors
Nervous System Diseases
Psychiatry
Major Depressive Disorder
Parkinson Disease
2 Citations (Scopus)

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling

Iacovelli, L., Di Menna, L., Peterlik, D., Stangl, C., Orlando, R., Molinaro, G., De Blasi, A., Bruno, V., Battaglia, G., Flor, P. J., Uschold-Schmidt, N. & Nicoletti, F., Feb 1 2017, In : Neuropharmacology. 113, p. 343-353 11 p.

Research output: Contribution to journalArticle

Phenylephrine
Phosphoserine
Phosphatidylinositol Phosphates
Adrenergic Receptors
Serine
3 Citations (Scopus)

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

Fazio, F., Carrizzo, A., Lionetto, L., Damato, A., Capocci, L., Ambrosio, M., Battaglia, G., Bruno, V., Madonna, M., Simmaco, M., Nicoletti, F. & Vecchione, C., 2017, In : Frontiers in Pharmacology. 8, p. 214

Research output: Contribution to journalArticle

Controlled Hypotension
Kynurenine
Endotoxins
Lipopolysaccharides
Nitric Oxide Synthase Type III
2016
4 Citations (Scopus)

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors

Notartomaso, S., Mascio, G., Scarselli, P., Martinello, K., Fucile, S., Gradini, R., Bruno, V., Battaglia, G. & Nicoletti, F., Mar 30 2016, (Accepted/In press) In : Neuropharmacology.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Purkinje Cells
Cerebellum
GABA-A Receptors
GABA-A Receptor Agonists
2015
8 Citations (Scopus)
Receptor, Serotonin, 5-HT2C
tau Proteins
Neuronal Plasticity
Long-Term Memory
Long-Term Potentiation
20 Citations (Scopus)
LY 379268
Metabotropic Glutamate Receptors
Nerve Growth Factors
Amyotrophic Lateral Sclerosis
Motor Neurons
4 Citations (Scopus)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinsonian Disorders
Haloperidol
Cannabinoid Receptor CB1
Gene Expression
58 Citations (Scopus)

Metabotropic glutamate receptors as drug targets: What's new?

Nicoletti, F., Bruno, V., Ngomba, R. T., Gradini, R. & Battaglia, G., 2015, In : Current Opinion in Pharmacology. 20, p. 89-94 6 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Hope
Pharmaceutical Preparations
Spinocerebellar Ataxias
Absence Epilepsy
13 Citations (Scopus)

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

Motolese, M., Mastroiacovo, F., Cannella, M., Bucci, D., Gaglione, A., Riozzi, B., Lütjens, R., Poli, S. M., Celanire, S., Bruno, V., Battaglia, G. & Nicoletti, F., Oct 24 2015, In : Molecular Brain. 8, 1, 66.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine
Neurons
Ischemia
Hippocampal CA1 Region
2 Citations (Scopus)

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

Romano, M. R., Di Menna, L., Scarselli, P., Mascio, G., Madonna, M., Notartomaso, S., Puliti, A., Bruno, V., Battaglia, G. & Nicoletti, F., Dec 23 2015, (Accepted/In press) In : Neurochemical Research. p. 1-9 9 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Phosphatidylinositol Phosphates
Retina
Hydrolysis
Metabotropic Glutamate Receptors
31 Citations (Scopus)

Xanthurenic Acid Activates mGlu2/3 metabotropic glutamate receptors and is a potential trait marker for schizophrenia

Fazio, F., Lionetto, L., Curto, M., Iacovelli, L., Cavallari, M., Zappulla, C., Ulivieri, M., Napoletano, F., Capi, M., Corigliano, V., Scaccianoce, S., Caruso, A., Miele, J., De Fusco, A., Di Menna, L., Comparelli, A., De Carolis, A., Gradini, R., Nisticò, R., De Blasi, A. & 5 others, Girardi, P., Bruno, V., Battaglia, G., Nicoletti, F. & Simmaco, M., Dec 8 2015, In : Scientific Reports. 5, 17799.

Research output: Contribution to journalArticle

Schizophrenia
Kynurenine
Acids
Antipsychotic Agents
LY 341495
2014
50 Citations (Scopus)

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

Pignatelli, M., Piccinin, S., Molinaro, G., Di Menna, L., Riozzi, B., Cannella, M., Motolese, M., Vetere, G., Catania, M. V., Battaglia, G., Nicoletti, F., Nisticò, R. & Bruno, V., 2014, In : Journal of Neuroscience. 34, 13, p. 4558-4566 9 p.

Research output: Contribution to journalArticle

Angelman Syndrome
Neuronal Plasticity
Hippocampus
Phosphatidylinositol 3-Kinase
Autistic Disorder
2013
54 Citations (Scopus)

Fingolimod protects cultured cortical neurons against excitotoxic death

Di Menna, L., Molinaro, G., Di Nuzzo, L., Riozzi, B., Zappulla, C., Pozzilli, C., Turrini, R., Caraci, F., Copani, A., Battaglia, G., Nicoletti, F. & Bruno, V., Jan 2013, In : Pharmacological Research. 67, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Neurons
Aspartic Acid
Phosphatidylinositol 3-Kinase
Lysosphingolipid Receptors
Relapsing-Remitting Multiple Sclerosis
2012
39 Citations (Scopus)

Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H. O., Acher, F., Ngomba, R. T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R., Battaglia, G., Bruno, V., Simmaco, M., Pin, J. P., Nicoletti, F. & Goudet, C., May 2012, In : Molecular Pharmacology. 81, 5, p. 643-656 14 p.

Research output: Contribution to journalArticle

Kynurenine
Droseraceae
metabotropic glutamate receptor 4
cinnabarinic acid
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9 Citations (Scopus)

Dual effect of 17β-estradiol on NMDA-induced neuronal death: Involvement of metabotropic glutamate receptor 1

Spampinato, S. F., Merlo, S., Molinaro, G., Battaglia, G., Bruno, V., Nicoletti, F. & Sortino, M. A., Dec 1 2012, In : Endocrinology. 153, 12, p. 5940-5948 9 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Estradiol
Calpain
Estrogen Receptors
Estrogens
61 Citations (Scopus)

Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection

Caraci, F., Spampinato, S., Sortino, M. A., Bosco, P., Battaglia, G., Bruno, V., Drago, F., Nicoletti, F. & Copani, A., Jan 2012, In : Cell & Tissue Research. 347, 1, p. 291-301 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Alzheimer Disease
Neurofibrillary Tangles
Neuronal Plasticity
Amyloid Plaques
23 Citations (Scopus)

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

Spampinato, S. F., Molinaro, G., Merlo, S., Iacovelli, L., Caraci, F., Battaglia, G., Nicoletti, F., Bruno, V. & Sortino, M. A., Jan 2012, In : Molecular Pharmacology. 81, 1, p. 12-20 9 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Amyloid
Estrogen Receptors
Neurons
Estrogens
12 Citations (Scopus)

Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons

Busceti, C. L., Bucci, D., Molinaro, G., Di Pietro, P., Zangrandi, L., Gradini, R., Moratalla, R., Battaglia, G., Bruno, V., Nicoletti, F. & Fornai, F., Sep 18 2012, In : PLoS One. 7, 9, e44025.

Research output: Contribution to journalArticle

tyrosine 3-monooxygenase
Corpus Striatum
interneurons
Tyrosine 3-Monooxygenase
Interneurons
47 Citations (Scopus)

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?

Caraci, F., Battaglia, G., Sortino, M. A., Spampinato, S., Molinaro, G., Copani, A., Nicoletti, F. & Bruno, V., Sep 2012, In : Neurochemistry International. 61, 4, p. 559-565 7 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Parkinson Disease
Corpus Striatum
Nerve Growth Factors
Neuroglia
27 Citations (Scopus)

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors

Bernabucci, M., Notartomaso, S., Zappulla, C., Fazio, F., Cannella, M., Motolese, M., Battaglia, G., Bruno, V., Gradini, R. & Nicoletti, F., Oct 23 2012, In : Molecular Pain. 8, 77.

Research output: Contribution to journalArticle

Analgesia
Cysteine
LY 341495
Constriction
Freund's Adjuvant
2011
38 Citations (Scopus)

Early defect of transforming growth factor β1 formation in Huntington's disease

Battaglia, G., Cannella, M., Riozzi, B., Orobello, S., Maat-Schieman, M. L., Aronica, E., Busceti, C. L., Ciarmiello, A., Alberti, S., Amico, E., Sassone, J., Sipione, S., Bruno, V., Frati, L., Nicoletti, F. & Squitieri, F., Mar 2011, In : Journal of Cellular and Molecular Medicine. 15, 3, p. 555-571 17 p.

Research output: Contribution to journalArticle

Huntington Disease
Transforming Growth Factors
Corpus Striatum
Asymptomatic Diseases
Astrocytes
37 Citations (Scopus)

Induction of the Wnt antagonist dickkopf-1 is involved in stress-induced hippocampal damage

Matrisciano, F., Busceti, C. L., Bucci, D., Orlando, R., Caruso, A., Molinaro, G., Cappuccio, I., Riozzi, B., Gradini, R., Motolese, M., Caraci, F., Copani, A., Scaccianoce, S., Melchiorri, D., Bruno, V., Battaglia, G. & Nicoletti, F., 2011, In : PLoS One. 6, 1, e16447.

Research output: Contribution to journalArticle

antagonists
mice
Wnt Signaling Pathway
corticosterone
Corticosterone
27 Citations (Scopus)

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. & Nicoletti, F., Jun 2011, In : Neuropharmacology. 60, 7-8, p. 1281-1291 11 p.

Research output: Contribution to journalArticle

Absence Epilepsy
Thalamus
Neuropharmacology
Phosphatidylinositol Phosphates
Thalamic Nuclei
26 Citations (Scopus)

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. & Ngomba, R. T., Apr 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 4, p. 1107-1118 12 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Ischemia
Endothelin-1
Brain
Putamen
57 Citations (Scopus)

Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective

Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M. L., Riozzi, B., Traficante, A., Bruno, V., Cannella, M., Merlo, S., Wang, X., Heinz, B. A., Nisenbaum, E. S., Britton, T. C., Drago, F., Sortino, M. A., Copani, A. & Nicoletti, F., Mar 2011, In : Molecular Pharmacology. 79, 3, p. 618-626 9 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Amyloid
Psychotic Disorders
Alzheimer Disease
Neurons
68 Citations (Scopus)

TGF-β1 pathway as a new target for neuroprotection in alzheimer's disease

Caraci, F., Battaglia, G., Bruno, V., Bosco, P., Carbonaro, V., Giuffrida, M. L., Drago, F., Sortino, M. A., Nicoletti, F. & Copani, A., Aug 2011, In : CNS Neuroscience and Therapeutics. 17, 4, p. 237-249 13 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Alzheimer Disease
Neurofibrillary Tangles
Pharmaceutical Preparations
Neuroprotection
11 Citations (Scopus)
Autoimmune Diseases
Chronic Disease
Immunological Synapses
Monoclonal Antibodies
T-Lymphocytes
2010
14 Citations (Scopus)

D-Aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices

Molinaro, G., Pietracupa, S., Di Menna, L., Pescatori, L., Usiello, A., Battaglia, G., Nicoletti, F. & Bruno, V., Jul 2010, In : Neuroscience Letters. 478, 3, p. 128-130 3 p.

Research output: Contribution to journalArticle

D-Aspartic Acid
Phosphatidylinositol Phosphates
Aspartic Acid
Hydrolysis
Brain
92 Citations (Scopus)

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

Fallarino, F., Volpi, C., Fazio, F., Notartomaso, S., Vacca, C., Busceti, C., Bicciato, S., Battaglia, G., Bruno, V., Puccetti, P., Fioretti, M. C., Nicoletti, F., Grohmann, U. & Di Marco, R., Aug 2010, In : Nature Medicine. 16, 8, p. 897-902 6 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Multiple Sclerosis
Glutamic Acid
Regulatory T-Lymphocytes
Dendritic Cells

Metabotropic Glutamate Receptors (mGluRs): Molecular Biology, Pharmacology and Cell Biology

Nicoletti, F., Bruno, V. & Battaglia, G., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 801-810 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabotropic Glutamate Receptors
Cell Biology
Molecular Biology
Pharmacology
Neurosciences
2009
35 Citations (Scopus)
LY 379268
Phosphatidylinositol Phosphates
Frontal Lobe
Phosphatidylinositols
Hydrolysis
32 Citations (Scopus)

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

Battaglia, G., Molinaro, G., Riozzi, B., Storto, M., Busceti, C. L., Spinsanti, P., Bucci, D., Di Liberto, V., Mudò, G., Corti, C., Corsi, M., Nicoletti, F., Belluardo, N. & Bruno, V., Aug 12 2009, In : PLoS One. 4, 8, e6591.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Corpus Striatum
LY 379268
neurotrophins
neuroglia
28 Citations (Scopus)
Dopamine Agonists
Glutamate Receptors
Corpus Striatum
Dopamine
4-aminho-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid
72 Citations (Scopus)
Wnt Signaling Pathway
Brain Ischemia
Neurons
Catenins
Middle Cerebral Artery Infarction
15 Citations (Scopus)
Memantine
GABA-A Receptors
Cerebral Cortex
Hippocampus
Diazepam
31 Citations (Scopus)

Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: MGlu2 receptors are resistant to homologous desensitization

Iacovelli, L., Molinaro, G., Battaglia, G., Motolese, M., Di Menna, L., Alfiero, M., Blahos, J., Matrisciano, F., Corsi, M., Corti, C., Bruno, V., De Blasi, A. & Nicoletti, F., Apr 2009, In : Molecular Pharmacology. 75, 4, p. 991-1003 13 p.

Research output: Contribution to journalArticle

LY 379268
G-Protein-Coupled Receptor Kinases
Metabotropic Glutamate Receptors
Phosphotransferases
G-Protein-Coupled Receptor Kinase 2
239 Citations (Scopus)

β-amyloid monomers are neuroprotective

Giuffrida, M. L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Pappalardo, G., Messina, A., Palmigiano, A., Garozzo, D., Nicoletti, F., Rizzarelli, E. & Copani, A., Aug 26 2009, In : Journal of Neuroscience. 29, 34, p. 10582-10587 6 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Neurons
Phosphatidylinositol 3-Kinase
Somatomedin Receptors