1988 …2020

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2020

Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease

Cavalli, E., Battaglia, G., Basile, M. S., Bruno, V., Petralia, M. C., Lombardo, S. D., Pennisi, M., Kalfin, R., Tancheva, L., Fagone, P., Nicoletti, F. & Mangano, K., Mar 13 2020, In : Brain Sciences. 10, 3

Research output: Contribution to journalArticle

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N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy

Notartomaso, S., Scarselli, P., Mascio, G., Liberatore, F., Mazzon, E., Mammana, S., Gugliandolo, A., Cruccu, G., Bruno, V., Nicoletti, F. & Battaglia, G., Feb 6 2020, In : Molecular Pain. 16, p. 1744806920904292

Research output: Contribution to journalArticle

Open Access
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The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia

Ulivieri, M., Wierońska, J. M., Lionetto, L., Martinello, K., Cieslik, P., Chocyk, A., Curto, M., Di Menna, L., Iacovelli, L., Traficante, A., Liberatore, F., Mascio, G., Antenucci, N., Giannino, G., Vergassola, M., Pittaluga, A., Bruno, V., Battaglia, G., Fucile, S., Simmaco, M. & 3 others, Nicoletti, F., Pilc, A. & Fazio, F., Jun 7 2020, In : Schizophrenia Bulletin.

Research output: Contribution to journalArticle

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Transcriptomic Analysis Reveals Abnormal Expression of Prion Disease Gene Pathway in Brains from Patients with Autism Spectrum Disorders

Lombardo, S. D., Battaglia, G., Petralia, M. C., Mangano, K., Basile, M. S., Bruno, V., Fagone, P., Bella, R., Nicoletti, F. & Cavalli, E., Mar 29 2020, In : Brain Sciences. 10, 4

Research output: Contribution to journalArticle

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2019

Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status

Celli, R., Santolini, I., Van Luijtelaar, G., Ngomba, R. T., Bruno, V. & Nicoletti, F., Apr 2019, In : Expert Opinion on Therapeutic Targets. 23, 4, p. 341-351 11 p.

Research output: Contribution to journalArticle

2018

Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor

Busceti, C. L., Di Menna, L., Bianchi, F., Mastroiacovo, F., Di Pietro, P., Traficante, A., Bozza, G., Niehrs, C., Battaglia, G., Bruno, V., Fornai, F., Volpe, M., Rubattu, S. & Nicoletti, F., Sep 11 2018, In : Frontiers in Cellular Neuroscience. 12, 292.

Research output: Contribution to journalArticle

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors

Notartomaso, S., Nakao, H., Mascio, G., Scarselli, P., Cannella, M., Zappulla, C., Madonna, M., Motolese, M., Gradini, R., Liberatore, F., Zonta, M., Carmignoto, G., Battaglia, G., Bruno, V., Watanabe, M., Aiba, A. & Nicoletti, F., Dec 1 2018, In : Scientific Reports. 8, 1, 13361.

Research output: Contribution to journalArticle

2017

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Notartomaso, S., Mascio, G., Bernabucci, M., Zappulla, C., Scarselli, P., Cannella, M., Imbriglio, T., Gradini, R., Battaglia, G., Bruno, V. & Nicoletti, F., Jan 1 2017, In : Molecular Pain. 13

Research output: Contribution to journalArticle

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors

Fazio, F., Lionetto, L., Curto, M., Iacovelli, L., Copeland, C. S., Neale, S. A., Bruno, V., Battaglia, G., Salt, T. E. & Nicoletti, F., Jan 1 2017, In : Neuropharmacology.

Research output: Contribution to journalArticle

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

Mastroiacovo, F., Moyanova, S., Cannella, M., Gaglione, A., Verhaeghe, R., Bozza, G., Madonna, M., Motolese, M., Traficante, A., Riozzi, B., Bruno, V., Battaglia, G., Lodge, D. & Nicoletti, F., Aug 18 2017, In : Molecular Brain. 10, 1, 39.

Research output: Contribution to journalArticle

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Liberatore, F., Bucci, D., Mascio, G., Madonna, M., Di Pietro, P., Beneventano, M., Puliti, A. M., Battaglia, G., Bruno, V., Nicoletti, F. & Romano, M. R., Nov 5 2017, In : Neuroscience. 363, p. 142-149 8 p.

Research output: Contribution to journalArticle

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling

Iacovelli, L., Di Menna, L., Peterlik, D., Stangl, C., Orlando, R., Molinaro, G., De Blasi, A., Bruno, V., Battaglia, G., Flor, P. J., Uschold-Schmidt, N. & Nicoletti, F., Feb 1 2017, In : Neuropharmacology. 113, p. 343-353 11 p.

Research output: Contribution to journalArticle

2016

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors

Notartomaso, S., Mascio, G., Scarselli, P., Martinello, K., Fucile, S., Gradini, R., Bruno, V., Battaglia, G. & Nicoletti, F., Mar 30 2016, (Accepted/In press) In : Neuropharmacology.

Research output: Contribution to journalArticle

2015

Metabotropic glutamate receptors as drug targets: What's new?

Nicoletti, F., Bruno, V., Ngomba, R. T., Gradini, R. & Battaglia, G., 2015, In : Current Opinion in Pharmacology. 20, p. 89-94 6 p.

Research output: Contribution to journalArticle

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

Motolese, M., Mastroiacovo, F., Cannella, M., Bucci, D., Gaglione, A., Riozzi, B., Lütjens, R., Poli, S. M., Celanire, S., Bruno, V., Battaglia, G. & Nicoletti, F., Oct 24 2015, In : Molecular Brain. 8, 1, 66.

Research output: Contribution to journalArticle

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

Romano, M. R., Di Menna, L., Scarselli, P., Mascio, G., Madonna, M., Notartomaso, S., Puliti, A., Bruno, V., Battaglia, G. & Nicoletti, F., Dec 23 2015, (Accepted/In press) In : Neurochemical Research. p. 1-9 9 p.

Research output: Contribution to journalArticle

Xanthurenic Acid Activates mGlu2/3 metabotropic glutamate receptors and is a potential trait marker for schizophrenia

Fazio, F., Lionetto, L., Curto, M., Iacovelli, L., Cavallari, M., Zappulla, C., Ulivieri, M., Napoletano, F., Capi, M., Corigliano, V., Scaccianoce, S., Caruso, A., Miele, J., De Fusco, A., Di Menna, L., Comparelli, A., De Carolis, A., Gradini, R., Nisticò, R., De Blasi, A. & 5 others, Girardi, P., Bruno, V., Battaglia, G., Nicoletti, F. & Simmaco, M., Dec 8 2015, In : Scientific Reports. 5, 17799.

Research output: Contribution to journalArticle

2014

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

Pignatelli, M., Piccinin, S., Molinaro, G., Di Menna, L., Riozzi, B., Cannella, M., Motolese, M., Vetere, G., Catania, M. V., Battaglia, G., Nicoletti, F., Nisticò, R. & Bruno, V., 2014, In : Journal of Neuroscience. 34, 13, p. 4558-4566 9 p.

Research output: Contribution to journalArticle

2013

Fingolimod protects cultured cortical neurons against excitotoxic death

Di Menna, L., Molinaro, G., Di Nuzzo, L., Riozzi, B., Zappulla, C., Pozzilli, C., Turrini, R., Caraci, F., Copani, A., Battaglia, G., Nicoletti, F. & Bruno, V., Jan 2013, In : Pharmacological Research. 67, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

2012

Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H. O., Acher, F., Ngomba, R. T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R., Battaglia, G., Bruno, V., Simmaco, M., Pin, J. P., Nicoletti, F. & Goudet, C., May 2012, In : Molecular Pharmacology. 81, 5, p. 643-656 14 p.

Research output: Contribution to journalArticle

Dual effect of 17β-estradiol on NMDA-induced neuronal death: Involvement of metabotropic glutamate receptor 1

Spampinato, S. F., Merlo, S., Molinaro, G., Battaglia, G., Bruno, V., Nicoletti, F. & Sortino, M. A., Dec 1 2012, In : Endocrinology. 153, 12, p. 5940-5948 9 p.

Research output: Contribution to journalArticle

Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection

Caraci, F., Spampinato, S., Sortino, M. A., Bosco, P., Battaglia, G., Bruno, V., Drago, F., Nicoletti, F. & Copani, A., Jan 2012, In : Cell & Tissue Research. 347, 1, p. 291-301 11 p.

Research output: Contribution to journalArticle

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

Spampinato, S. F., Molinaro, G., Merlo, S., Iacovelli, L., Caraci, F., Battaglia, G., Nicoletti, F., Bruno, V. & Sortino, M. A., Jan 2012, In : Molecular Pharmacology. 81, 1, p. 12-20 9 p.

Research output: Contribution to journalArticle

Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons

Busceti, C. L., Bucci, D., Molinaro, G., Di Pietro, P., Zangrandi, L., Gradini, R., Moratalla, R., Battaglia, G., Bruno, V., Nicoletti, F. & Fornai, F., Sep 18 2012, In : PLoS One. 7, 9, e44025.

Research output: Contribution to journalArticle

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?

Caraci, F., Battaglia, G., Sortino, M. A., Spampinato, S., Molinaro, G., Copani, A., Nicoletti, F. & Bruno, V., Sep 2012, In : Neurochemistry International. 61, 4, p. 559-565 7 p.

Research output: Contribution to journalArticle

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors

Bernabucci, M., Notartomaso, S., Zappulla, C., Fazio, F., Cannella, M., Motolese, M., Battaglia, G., Bruno, V., Gradini, R. & Nicoletti, F., Oct 23 2012, In : Molecular Pain. 8, 77.

Research output: Contribution to journalArticle

2011

Early defect of transforming growth factor β1 formation in Huntington's disease

Battaglia, G., Cannella, M., Riozzi, B., Orobello, S., Maat-Schieman, M. L., Aronica, E., Busceti, C. L., Ciarmiello, A., Alberti, S., Amico, E., Sassone, J., Sipione, S., Bruno, V., Frati, L., Nicoletti, F. & Squitieri, F., Mar 2011, In : Journal of Cellular and Molecular Medicine. 15, 3, p. 555-571 17 p.

Research output: Contribution to journalArticle

Induction of the Wnt antagonist dickkopf-1 is involved in stress-induced hippocampal damage

Matrisciano, F., Busceti, C. L., Bucci, D., Orlando, R., Caruso, A., Molinaro, G., Cappuccio, I., Riozzi, B., Gradini, R., Motolese, M., Caraci, F., Copani, A., Scaccianoce, S., Melchiorri, D., Bruno, V., Battaglia, G. & Nicoletti, F., 2011, In : PLoS One. 6, 1, e16447.

Research output: Contribution to journalArticle

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. & Nicoletti, F., Jun 2011, In : Neuropharmacology. 60, 7-8, p. 1281-1291 11 p.

Research output: Contribution to journalArticle

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. & Ngomba, R. T., Apr 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 4, p. 1107-1118 12 p.

Research output: Contribution to journalArticle

Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective

Caraci, F., Molinaro, G., Battaglia, G., Giuffrida, M. L., Riozzi, B., Traficante, A., Bruno, V., Cannella, M., Merlo, S., Wang, X., Heinz, B. A., Nisenbaum, E. S., Britton, T. C., Drago, F., Sortino, M. A., Copani, A. & Nicoletti, F., Mar 2011, In : Molecular Pharmacology. 79, 3, p. 618-626 9 p.

Research output: Contribution to journalArticle

TGF-β1 pathway as a new target for neuroprotection in alzheimer's disease

Caraci, F., Battaglia, G., Bruno, V., Bosco, P., Carbonaro, V., Giuffrida, M. L., Drago, F., Sortino, M. A., Nicoletti, F. & Copani, A., Aug 2011, In : CNS Neuroscience and Therapeutics. 17, 4, p. 237-249 13 p.

Research output: Contribution to journalArticle

2010

D-Aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices

Molinaro, G., Pietracupa, S., Di Menna, L., Pescatori, L., Usiello, A., Battaglia, G., Nicoletti, F. & Bruno, V., Jul 2010, In : Neuroscience Letters. 478, 3, p. 128-130 3 p.

Research output: Contribution to journalArticle

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

Fallarino, F., Volpi, C., Fazio, F., Notartomaso, S., Vacca, C., Busceti, C., Bicciato, S., Battaglia, G., Bruno, V., Puccetti, P., Fioretti, M. C., Nicoletti, F., Grohmann, U. & Di Marco, R., Aug 2010, In : Nature Medicine. 16, 8, p. 897-902 6 p.

Research output: Contribution to journalArticle

2009

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

Battaglia, G., Molinaro, G., Riozzi, B., Storto, M., Busceti, C. L., Spinsanti, P., Bucci, D., Di Liberto, V., Mudò, G., Corti, C., Corsi, M., Nicoletti, F., Belluardo, N. & Bruno, V., Aug 12 2009, In : PLoS One. 4, 8, e6591.

Research output: Contribution to journalArticle

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia

Mastroiacovo, F., Busceti, C. L., Biagioni, F., Moyanova, S. G., Meisler, M. H., Battaglia, G., Caricasole, A., Bruno, V. & Nicoletti, F., Feb 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 2, p. 264-276 13 p.

Research output: Contribution to journalArticle

Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: MGlu2 receptors are resistant to homologous desensitization

Iacovelli, L., Molinaro, G., Battaglia, G., Motolese, M., Di Menna, L., Alfiero, M., Blahos, J., Matrisciano, F., Corsi, M., Corti, C., Bruno, V., De Blasi, A. & Nicoletti, F., Apr 2009, In : Molecular Pharmacology. 75, 4, p. 991-1003 13 p.

Research output: Contribution to journalArticle

β-amyloid monomers are neuroprotective

Giuffrida, M. L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Pappalardo, G., Messina, A., Palmigiano, A., Garozzo, D., Nicoletti, F., Rizzarelli, E. & Copani, A., Aug 26 2009, In : Journal of Neuroscience. 29, 34, p. 10582-10587 6 p.

Research output: Contribution to journalArticle

2008

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

Matrisciano, F., Caruso, A., Orlando, R., Marchiafava, M., Bruno, V., Battaglia, G., Gruber, S. H. M., Melchiorri, D., Tatarelli, R., Girardi, P., Mathè, A. A. & Nicoletti, F., Sep 2008, In : Neuropharmacology. 55, 4, p. 525-531 7 p.

Research output: Contribution to journalArticle