• 561 Citations
  • 13 h-Index
20032019
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Research Output 2003 2019

  • 561 Citations
  • 13 h-Index
  • 19 Article
  • 2 Review article
  • 1 Short survey
2019
2 Citations (Scopus)

Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation

Mongiardi, M. P., Radice, G., Piras, M., Stagni, V., Pacioni, S., Re, A., Putti, S., Ferrè, F., Farsetti, A., Pallini, R., Barilà, D., Levi, A. & Falchetti, M. L., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Cell Aging
Endothelial Cells
Vascular Endothelial Growth Factor Receptor
Antioxidants
2018
6 Citations (Scopus)
Ataxia Telangiectasia
Autophagy
Mitochondria
Oxidative Stress
Phosphotransferases
Ataxia Telangiectasia
Autophagy
Mitochondria
Oxidative Stress
Phosphotransferases
1 Citation (Scopus)

Caspase-8: A novel target to overcome resistance to chemotherapy in glioblastoma

Fianco, G., Contadini, C., Ferri, A., Cirotti, C., Stagni, V. & Barilà, D., Dec 1 2018, In : International Journal of Molecular Sciences. 19, 12, 3798.

Research output: Contribution to journalReview article

Chemotherapy
Caspase 8
chemotherapy
Glioblastoma
cancer
2017
8 Citations (Scopus)

ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy

Antonelli, M., Strappazzon, F., Arisi, I., Brandi, R., D'Onofrio, M., Sambucci, M., Manic, G., Vitale, I., Barilà, D. & Stagni, V., Jan 1 2017, In : Oncotarget. 8, 13, p. 21692-21709 18 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Neoplastic Stem Cells
Autophagy
Cysteine
Peptide Hydrolases
2016

ATM: An unexpected tumor-promoting factor in HER2-expressing tumors

Stagni, V., Oropallo, V. & Barilà, D., Mar 2016, In : Molecular & cellular oncology. 3, 2, p. e1054551

Research output: Contribution to journalArticle

Genomic Instability
Carcinogens
Phosphotransferases
Breast Neoplasms
Neoplasms
2015
21 Citations (Scopus)

ATM kinase sustains HER2 tumorigenicity in breast cancer

Stagni, V., Manni, I., Oropallo, V., Mottolese, M., Di Benedetto, A., Piaggio, G., Falcioni, R., Giaccari, D., Di Carlo, S., Sperati, F., Cencioni, M. T. & Barilà, D., Apr 16 2015, In : Nature Communications. 6, 6886.

Research output: Contribution to journalArticle

asynchronous transfer mode
Automatic teller machines
breast
Phosphotransferases
cancer
2014
17 Citations (Scopus)

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

Santini, S., Stagni, V., Giambruno, R., Fianco, G., Di Benedetto, A., Mottolese, M., Pellegrini, M. & Barilà, D., Feb 27 2014, In : Oncogene. 33, 9, p. 1113-1123 11 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Ubiquitin-Protein Ligases
Phosphotransferases
Ubiquitination
DNA Damage
4 Citations (Scopus)

ITCH E3 ligase in ATM network

Stagni, V., Santini, S. & Barilà, D., 2014, In : Oncoscience. 1, 6, p. 394-395 2 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Tug of war between survival and death: Exploring ATM function in cancer

Stagni, V., Oropallo, V., Fianco, G., Antonelli, M., Cinà, I. & Barilà, D., Mar 27 2014, In : International Journal of Molecular Sciences. 15, 4, p. 5388-5409 22 p.

Research output: Contribution to journalArticle

ataxia
Ataxia Telangiectasia
death
Tumors
cancer
2013
58 Citations (Scopus)

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

Gilardini Montani, M. S., Prodosmo, A., Stagni, V., Merli, D., Monteonofrio, L., Gatti, V., Gentileschi, M. P., Barilà, D. & Soddu, S., Nov 19 2013, In : Journal of Experimental and Clinical Cancer Research. 32, 1, 95.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Poly(ADP-ribose) Polymerases
Breast Neoplasms
MCF-7 Cells
DNA Damage
2012
4 Citations (Scopus)

A new player in the development of TRAIL based therapies for hepatocarcinoma treatment: ATM kinase

Stagni, V., Santini, S. & Barilà, D., Jun 2012, In : Cancers. 4, 2, p. 354-378 25 p.

Research output: Contribution to journalArticle

Phosphotransferases
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
Neoplasms
15 Citations (Scopus)

Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver

Furlan, A., Lamballe, F., Stagni, V., Hussain, A., Richelme, S., Prodosmo, A., Moumen, A., Brun, C., Del Barco Barrantes, I., Arthur, J. S. C., Koleske, A. J., Nebreda, A. R., Barilà, D. & Maina, F., Dec 2012, In : Journal of Hepatology. 57, 6, p. 1292-1298 7 p.

Research output: Contribution to journalArticle

Cell Survival
Hepatocytes
Liver
Cell Death
cdc Genes
15 Citations (Scopus)

Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity

Marzano, V., Santini, S., Rossi, C., Zucchelli, M., D'Alessandro, A., Marchetti, C., Mingardi, M., Stagni, V., Barilà, D. & Urbani, A., Aug 3 2012, In : Journal of Proteomics. 75, 15, p. 4632-4646 15 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Proteasome Endopeptidase Complex
Proteomics
Phosphotransferases
Cells
2011
52 Citations (Scopus)

Abl interconnects oncogenic Met and p53 core pathways in cancer cells

Furlan, A., Stagni, V., Hussain, A., Richelme, S., Conti, F., Prodosmo, A., Destro, A., Roncalli, M., Barilà, D. & Mainá, F., Oct 2011, In : Cell Death and Differentiation. 18, 10, p. 1608-1616 9 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Neoplasms
Carcinogenesis
Leukemia
p38 Mitogen-Activated Protein Kinases
13 Citations (Scopus)

Oxygen sensing is impaired in ATM defective cells

Mongiardi, M. P., Stagni, V., Natoli, M., Giaccari, D., D'Agnano, I., Falchetti, M. L., Barilà, D. & Levi, A., Dec 15 2011, In : Cell Cycle. 10, 24, p. 4311-4320 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Oxygen
Oxidative Stress
Cell Hypoxia
Ataxia Telangiectasia
2010
29 Citations (Scopus)

ATM kinase activity modulates cFLIP protein levels: Potential interplay between DNA damage signalling and TRAIL-induced apoptosis

Stagni, V., Mingardi, M., Santini, S., Giaccari, D. & Barilà, D., Nov 2010, In : Carcinogenesis. 31, 11, p. 1956-1963 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
DNA Damage
Phosphotransferases
Apoptosis
Down-Regulation
2008
22 Citations (Scopus)

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

Stagni, V., Di Bari, M. G., Cursi, S., Condò, I., Cencioni, M. T., Testi, R., Lerenthal, Y., Cundari, E. & Barilà, D., Jan 15 2008, In : Blood. 111, 2, p. 829-837 9 p.

Research output: Contribution to journalArticle

Automatic teller machines
Ataxia Telangiectasia
Phosphotransferases
Lymphocytes
Apoptosis
61 Citations (Scopus)

Identification of a critical tyrosine residue in caspase 8 that promotes cell migration

Barbero, S., Barilà, D., Mielgo, A., Stagni, V., Clair, K. & Stupack, D., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 13031-13034 4 p.

Research output: Contribution to journalArticle

Caspase 8
Cell Movement
Tyrosine
Phosphorylation
src Homology Domains
2006
147 Citations (Scopus)

Src kinase phosphorylates Caspase-8 on Tyr380: A novel mechanism of apoptosis suppression

Cursi, S., Rufini, A., Stagni, V., Condò, I., Matafora, V., Bachi, A., Bonifazi, A. P., Coppola, L., Superti-Furga, G., Testi, R. & Barilà, D., May 3 2006, In : EMBO Journal. 25, 9, p. 1895-1905 11 p.

Research output: Contribution to journalArticle

src-Family Kinases
Caspase 8
Phosphorylation
Apoptosis
Chemical activation
2003

Erratum: p120 catenin is required for growth factor-dependent cell motility and scattering in epithelial cells (Molecular Biology of the Cell (2003) 14 (1964-1977))

Cozzolino, M., Stagni, V., Spinardi, L., Campioni, N., Fiorentini, C., Salvati, E., Alema, S. & Salvatore, A. M., Jun 1 2003, In : Molecular Biology of the Cell. 14, 6

Research output: Contribution to journalArticle

70 Citations (Scopus)

P120 catenin is required for growth factor-dependent cell motility and scattering in epithelial cells

Cozzolino, M., Stagni, V., Spinardi, L., Campioni, N., Fiorentini, C., Salvati, E., Alemà, S. & Salvatore, A. M., May 1 2003, In : Molecular Biology of the Cell. 14, 5, p. 1964-1977 14 p.

Research output: Contribution to journalArticle

Cell Movement
Intercellular Signaling Peptides and Proteins
Cadherins
Epithelial Cells
Phosphatidylinositol 3-Kinases