α 1-Antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis

S. Fargion, E. C. Klasen, F. Lalatta, G. Sangalli, M. Tommasini, G. Fiorelli

Research output: Contribution to journalArticle

Abstract

Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for α 1-antitrypsin (α 1AT) levels and types and compared with a previously screened healthy Italian population. Serum α 1AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalClinical Genetics
Volume19
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Fargion, S., Klasen, E. C., Lalatta, F., Sangalli, G., Tommasini, M., & Fiorelli, G. (1981). α 1-Antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis. Clinical Genetics, 19(2), 134-139.