α-Adducin may control blood pressure both in rats and humans

G. Bianchi, M. G. Tripodi, G. Casari, L. Torielli, D. Cusi, C. Barlassina, P. Stella, L. Zagato, B. R. Barber

Research output: Contribution to journalArticle

Abstract

1. Previous studies on the pathogenetic mechanisms of hypertension in the Milan hypertensive strain of rat (MHS) showed that a polymorphism within the α-adducin gene is responsible for up to 50% of the blood pressure difference between MHS and their MNS normotensive control strain. A case-control study has shown also in humans an association between α-adducin locus and hypertension using 4 multiallelic markers surrounding the α-adducin locus. 2. With a multiple regression approach we provide an estimate of the contribution of the genotype for each marker to the blood pressure variability in comparison to that provided by sex, body mass index and age. 3. While sex, body mass index and age contributed by about 40-45% to the overall blood pressure variability, the inclusion of the genotype for the marker closer to the α-adducin locus provided a further increase of the variability explained of about 5%. 4. The contribution independently provided by the other markers decreased exponentially with the increase of distance from α-adducin locus.

Original languageEnglish
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue numberSUPPL. 1
Publication statusPublished - 1995

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Keywords

  • Adducin locus
  • Association study
  • Cytoskeleton
  • DNA polymorphism
  • Essential hypertension

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bianchi, G., Tripodi, M. G., Casari, G., Torielli, L., Cusi, D., Barlassina, C., Stella, P., Zagato, L., & Barber, B. R. (1995). α-Adducin may control blood pressure both in rats and humans. Clinical and Experimental Pharmacology and Physiology, 22(SUPPL. 1).