α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans

Gerd Heusch; Dietrich Baumgart; Paolo Camici; William Chilian; Luisa Gregorini; Otto Hess; Ciro Indolfi; Ornella Rimoldi

α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans

Gerd Heusch, Dietrich Baumgart, Paolo Camici, William Chilian, Luisa Gregorini, Otto Hess, Ciro Indolfi, Ornella Rimoldi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of α-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of α-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to α-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both α₁- and α₂-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented α-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of α₂-adrenergic coronary constriction.

Original language	English
Pages (from-to)	689-694
Number of pages	6
Journal	Circulation
Volume	101
Issue number	6
Publication status	Published - Feb 15 2000

Keywords

Coronary disease
Ischemia
Microcirculation
Nervous system
Receptors, adrenergic, alpha

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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abstract = "The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of α-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of α-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to α-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both α1- and α2-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented α-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of α2-adrenergic coronary constriction.",

keywords = "Coronary disease, Ischemia, Microcirculation, Nervous system, Receptors, adrenergic, alpha",

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T1 - α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans

AU - Heusch, Gerd

AU - Baumgart, Dietrich

AU - Camici, Paolo

AU - Chilian, William

AU - Gregorini, Luisa

AU - Hess, Otto

AU - Indolfi, Ciro

AU - Rimoldi, Ornella

PY - 2000/2/15

Y1 - 2000/2/15

N2 - The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of α-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of α-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to α-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both α1- and α2-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented α-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of α2-adrenergic coronary constriction.

AB - The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of α-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of α-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to α-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both α1- and α2-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented α-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of α2-adrenergic coronary constriction.

KW - Coronary disease

KW - Ischemia

KW - Microcirculation

KW - Nervous system

KW - Receptors, adrenergic, alpha

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