α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans

Gerd Heusch, Dietrich Baumgart, Paolo Camici, William Chilian, Luisa Gregorini, Otto Hess, Ciro Indolfi, Ornella Rimoldi

Research output: Contribution to journalArticlepeer-review

Abstract

The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of α-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of α-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to α-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both α1- and α2-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented α-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of α2-adrenergic coronary constriction.

Original languageEnglish
Pages (from-to)689-694
Number of pages6
JournalCirculation
Volume101
Issue number6
Publication statusPublished - Feb 15 2000

Keywords

  • Coronary disease
  • Ischemia
  • Microcirculation
  • Nervous system
  • Receptors, adrenergic, alpha

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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