α-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat

Hiroya Mizusawa, Petter Hedlund, Karl Erik Andersson

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: α-Melanocyte stimulating hormone (α-MSH; Fluka Chemie AG, Geneva, Switzerland) and oxytocin induce erection in rats after intracerebroventricular administration. We studied possible interactions of α-melanocyte stimulating hormone with mechanisms pertaining to oxytocin or nitric oxide. Materials and Methods: We used 78 anesthetized male Sprague-Dawley rats. Catheters were implanted in the lateral cerebral ventricle or into the subarachnoid space at L6 to S1. Intracavernous pressure was documented and arterial blood pressure was directly measured. Results: Intracerebroventricular α-MSH (3μg.) produced a mean of 2.6 ± 0.6 erectile responses (p

Original languageEnglish
Pages (from-to)757-760
Number of pages4
JournalJournal of Urology
Volume167
Issue number2 I
Publication statusPublished - 2002

Keywords

  • MSH
  • Nitric oxide
  • Penile erection
  • Penis
  • Rats
  • Sprague-Dawley

ASJC Scopus subject areas

  • Urology

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