Objective: To investigate whether and to what extent α1-antitrypsin faecal clearance predicts the severity of intestinal mucosal abnormalities in adult coeliac disease. Design: Prospective bioptic assessment and laboratory analysis of adult untreated and treated coeliac patients. Setting: Gastroenterology department of a teaching hospital, Buenos Aires, Argentina and tertiary referral-based university hospital, Bologna, Italy. Main outcome measures: Assessment of intestinal protein loss by α1-antitrypsin clearance and morphometric analysis of intestinal biopsy specimens expressed as surface to volume ratio in 31 untreated and 17 treated adult coeliac patients. Results: Significantly higher α1-antitrypsin clearance values were found in untreated compared with treated patients. The mean surface to volume ratio of untreated coeliac patients was significantly lower than that of treated patients. Although an overall significant inverse correlation was found between α1-antitrypsin clearance and surface to volume ratio, a discrepancy between these two parameters was observed in about one-quarter of our patients. Conclusions: α1-Antitrypsin clearance cannot be accepted as a non-invasive reliable method to predict intestinal mucosal status in adult coeliac disease.
|Number of pages||4|
|Journal||European Journal of Gastroenterology and Hepatology|
|Publication status||Published - 1992|
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