α2-Adrenergic receptor sensitivity in panic disorder: II. Cortisol response to clonidine stimulation in panic disorder

F. Brambilla, L. Bellodi, C. Arancio, P. Nobile, G. Perna

Research output: Contribution to journalArticlepeer-review

Abstract

The cortisol responses to acute administration of saline and of clonidine (Clon), 150 μg IV, were examined in 12 patients with panic disorder and agoraphobia, before and after 32 days of alprazolam therapy (2.5 mg/day), and in 12 normal controls. The responses in the Clon test corrected for the responses to saline differed in the two groups, and in patients were not changed by the therapy even though significant symptomatological improvement was achieved. The results suggest that presynaptic α2- or postsynaptic α1-β-adrenoceptor sensitivity is impaired in panic disorder.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalPsychoneuroendocrinology
Volume20
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • Alprazolam therapy
  • Clonidine test
  • Cortisol
  • Panic disorder

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

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