α2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease

Benedetta Nacmias, Andrea Tedde, Elena Cellini, Paolo Forleo, Antonio Orlacchio, Bianca Maria Guarnieri, Concetta Petruzzi, Francesco D'Andrea, Antonio Serio, Sandro Sorbi

Research output: Contribution to journalArticle

Abstract

A 5-bp deletion and a Val1000 polymorphism at the α2-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or families, we analyzed the segregation of A2M and apolipoprotein E polymorphisms in Italian sporadic and familial AD. We analyzed the two polymorphisms in a total of 346 subjects including 98 controls by polymerase chain reaction-restriction fragment length polymorphism method. Our data do not confirm these associations, in particular we found a significant decrease of the deletion allele in AD with respect to controls. Our data do not support a role for the A2M gene as genetic risk factor for AD.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalNeuroscience Letters
Volume299
Issue number1-2
DOIs
Publication statusPublished - Feb 16 2001

Keywords

  • Alzheimer's disease
  • Genetics
  • Polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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    Nacmias, B., Tedde, A., Cellini, E., Forleo, P., Orlacchio, A., Guarnieri, B. M., Petruzzi, C., D'Andrea, F., Serio, A., & Sorbi, S. (2001). α2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease. Neuroscience Letters, 299(1-2), 9-12. https://doi.org/10.1016/S0304-3940(00)01758-4