α6β4 and α6β1 integrins in astrocytomas and other CNS tumors

Stefano Previtali, Angelo Quattrini, Raffaello Nemni, Giulio Truci, Alessandro Ducati, Lawrence Wrabetz, Nicola Canal

Research output: Contribution to journalArticle

Abstract

Laminin may alter the biological behavior of gliomas. Therefore, we investigated the expression of two laminin receptors, α6β1 and α6β4 integrins in normal brain, astrogliotic brain, and astrocytomas as compared to other central nervous system (CNS) tumors. In most CNS tumors, the expression of these integrins was unchanged in neoplastic as compared to normal counterpart cells. In contrast, increased numbers of reactive and neoplastic astrocytes expressed β4 integrin as compared to normal astrocytes, whereas α6 and β1 integrin expression did not change. Conversely, lower numbers of astrocytoma blood vessels expressed β4, whereas all blood vessels in normal brain expressed β4. These data suggest that the profile of laminin receptors changes in neoplastic astrocytes and in astrocytoma blood vessels; this change may play an important role in astrocytoma pathogenesis.

Original languageEnglish
Pages (from-to)456-465
Number of pages10
JournalJournal of Neuropathology and Experimental Neurology
Volume55
Issue number4
Publication statusPublished - Apr 1996

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Keywords

  • Blood vessels
  • Brain tumors
  • Central nervous system
  • Extracellular matrix
  • Glioma
  • Invasion
  • Laminin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

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