α7 nAChR in airway respiratory epithelial cells

Candida Nastrucci, Patrizia Russo

Research output: Contribution to journalArticle

Abstract

This review examines the role of α7 nAChR in different types of airway epithelial cells of the normal human bronchial tree. In each of these cells α7 nAChR activation elicits a specific effect. The effect is essentially mitogenic, whereas in the airway basal cells are antiproliferative. It is postulated that α7 nAChR may have mitogenic or antiproliferative signals differentially activated in different types of airway cells and under exposure to exogenous stimuli such as nicotine.

Original languageEnglish
Pages (from-to)666-670
Number of pages5
JournalCurrent Drug Targets
Volume13
Issue number5
Publication statusPublished - May 2012

Keywords

  • α7 nAChr
  • Basal cells
  • HBEC
  • HSAEC
  • Lung disease
  • Lung function
  • Neuroendocrine cell
  • Nicotine

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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