αvβ3 and αvβ5 Integrin expression in meningiomas

Lorenzo Bello, Jianping Zhang, Demetrios C. Nikas, Jon F. Strasser, Roberto M. Villani, David A. Cheresh, Rona S. Carroll, Peter McL Black

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: Integrins are emerging as alternative receptors capable of mediating several biological functions, such as cell-matrix and cell-cell adhesion, cell migration, signal transduction, and angiogenesis. Two αv integrins, i.e., αvβ3 and αvβ5, play critical roles in mediating these activities, particularly in tumors. No data are available on the expression of these integrins in meningiomas. METHODS: Using Western blot and immunohistochemical analyses with LM609 and PG32, two monoclonal antibodies capable of recognizing the functional integrin heterodimer, we evaluated the expression of αvβ3 and αvβ5 integrins in a series of 34 meningiomas of different histological subtypes and grades. We studied their expression in tumor cells and vasculature, as well as the expression of their related angiogenic factors (fibroblast growth factor 2 and vascular endothelial growth factor) and the αvβ3 ligand vitronectin. RESULTS: αvβ3 and αvβ5 integrins were expressed by neoplastic vasculature and cells. αvβ3 and αvβ5 expression was associated and correlated with that of their respective growth factors (fibroblast growth factor 2 and vascular endothelial growth factor) and microvessel counts and densities. αvβ3 was more strongly expressed than αvβ5 in two cases of histologically benign meningiomas with aggressive clinical behavior. αvβ3 expression was associated with that of its related ligand vitronectin and was also evident in small vessels of brain tissue closely surrounding meningiomas. CONCLUSION: Our data demonstrate the expression of αvβ3 and αvβ5 integrins in meningioma cells and vasculature. Our findings suggest a role for both of these integrins, and particularly αvβ3, in meningioma angiogenesis.

Original languageEnglish
Pages (from-to)1185-1195
Number of pages11
JournalNeurosurgery
Volume47
Issue number5
Publication statusPublished - 2000

Keywords

  • Angiogenesis
  • Growth factors
  • Integrins
  • Meningiomas

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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