β-adrenergic-blocking drugs and melanoma: Current state of the art

Vincenzo De Giorgi, Marta Grazzini, Sara Gandini, Silvia Benemei, Curtis D. Asbury, Niccolò Marchionni, Pierangelo Geppetti

Research output: Contribution to journalArticle

Abstract

The purpose of this review is to present the preclinical, epidemiological and clinical data relevant to the association between β-blockers and melanoma progression. Preclinical studies have shown that β-adrenergic receptor (β-AR) signaling can inhibit multiple cellular processes involved in melanoma progression and metastasis. These observations have suggested the possibility that drugs originally intended for the treatment of cardiovascular disease, the β-AR blockers, may provide new therapeutic opportunities for the control of tumor progression. A large number of observational studies demonstrated the protective effect of β-blockers in breast cancer but, more recently, similar findings were also reported in other cancers such as prostate cancer and melanoma. With regard to melanoma, two recently published studies demonstrated a great reduction in the risk of disease progression for each year of treatment with β-blockers. The results from these studies have suggested a potential role for targeting the β-AR pathway in melanoma patients. Questions regarding the type of β-blocker or tumor characteristics, appropriate treatment paradigms and, most importantly, efficacy must be answered in randomized clinical studies before β-blockers can be considered a therapeutic option for patients with melanoma.

Original languageEnglish
Pages (from-to)1461-1467
Number of pages7
JournalExpert Review of Anticancer Therapy
Volume12
Issue number11
DOIs
Publication statusPublished - Nov 2012

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Keywords

  • β-blocker
  • adrenergic system
  • hypertension
  • melanoma
  • VEGF

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

Cite this

De Giorgi, V., Grazzini, M., Gandini, S., Benemei, S., Asbury, C. D., Marchionni, N., & Geppetti, P. (2012). β-adrenergic-blocking drugs and melanoma: Current state of the art. Expert Review of Anticancer Therapy, 12(11), 1461-1467. https://doi.org/10.1586/era.12.118