β-adrenergic receptor responsiveness in aging heart and clinical implications

Nicola Ferrara, Klara Komici, Graziamaria Corbi, Gennaro Pagano, Giuseppe Furgi, Carlo Rengo, Grazia D. Femminella, Dario Leosco, Domenico Bonaduce

Research output: Contribution to journalArticle

Abstract

Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiveness is altered with aging and the age-related changes are limited to the β-adrenergic receptor density reduction and to the β-adrenoceptor-G-protein(s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. Epidemiological studies have shown an high incidence and prevalence of heart failure in the elderly and a great body of evidence correlate the changes of β-adrenergic system with heart failure pathogenesis. In particular it is well known that: (a) levels of cathecolamines are directly correlated with mortality and functional status in heart failure, (b) β1-adrenergic receptor subtype is down-regulated in heart failure, (c) heart failure-dependent cardiac adrenergic responsiveness reduction is related to changes in G proteins activity. In this review we focus on the cardiovascular β-adrenergic changes involvement in the aging process and on similarities and differences between aging heart and heart failure.

Original languageEnglish
Article numberArticle 396
JournalFrontiers in Physiology
Volume4 JAN
DOIs
Publication statusPublished - 2014

Keywords

  • β-adrenergic receptors
  • β-adrenoceptor desensitization
  • β-adrenoceptor down-regulation
  • Aging heart
  • Exercise
  • Failing heart
  • G-protein coupled receptor kinase

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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  • Cite this

    Ferrara, N., Komici, K., Corbi, G., Pagano, G., Furgi, G., Rengo, C., Femminella, G. D., Leosco, D., & Bonaduce, D. (2014). β-adrenergic receptor responsiveness in aging heart and clinical implications. Frontiers in Physiology, 4 JAN, [Article 396]. https://doi.org/10.3389/fphys.2013.00396