β-Adrenergic Receptor Signaling and Heart Failure: From Bench to Bedside

Leonardo Bencivenga, Daniela Liccardo, Carmen Napolitano, Lucia Visaggi, Giuseppe Rengo, Dario Leosco

Research output: Contribution to journalReview article

Abstract

Despite improvements in management and therapeutic approach in the last decades, heart failure is still associated with high mortality rates. The sustained enhancement in the sympathetic nervous system tone, observed in patients with heart failure, causes alteration in β-adrenergic receptor signaling and function. This latter phenomenon is the result of several heart failure-related molecular abnormalities involving adrenergic receptors, G-protein-coupled receptor kinases, and β-arrestins. This article summarizes novel encouraging preclinical strategies to reactivate β-adrenergic receptor signaling in heart failure, including pharmacologic and gene therapy approaches, and attempts to translate acquired notions into the clinical setting.

Original languageEnglish
Pages (from-to)409-419
Number of pages11
JournalHeart Failure Clinics
Volume15
Issue number3
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Heart Failure/genetics
  • Humans
  • Polymorphism, Genetic
  • Receptors, Adrenergic, beta/genetics
  • Signal Transduction

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    Bencivenga, L., Liccardo, D., Napolitano, C., Visaggi, L., Rengo, G., & Leosco, D. (2019). β-Adrenergic Receptor Signaling and Heart Failure: From Bench to Bedside. Heart Failure Clinics, 15(3), 409-419. https://doi.org/10.1016/j.hfc.2019.02.009