β-Adrenergic receptors and intracellular signalling pathway in stunned and non-ischemic regions of pig myocardium

Antonella Boraso, Claudio Ceconi, Anna Cargnoni, Palmira Bernocchi, Roberto Ferrari, Michel Ovize

Research output: Contribution to journalArticle

Abstract

The β-adrenergic pathway may have a role in the pathophysiology of ischemic syndromes characterised by reversible left ventricular dysfunction, such as myocardial stunning and other clinical conditions of unstable angina or coronary spasms, or chronic reversible left ventricular dysfunction, which might be a consequence of repeated events of short-term ischemia ("repetitive stunning"). A partial-to-total occlusion of the left anterior descending coronary artery in pigs was used to induce short periods of ischemia (total ischemic time 12 ± 2 min). Hypokinesis and dyskinesis of the myocardium were considered signs of myocardial dysfunction. We found a maintained function of the β-adrenergic signalling system. Density and affinity of β-adrenergic receptors were not different in stunned and non-ischemic regions, nor were cyclic AMP and cyclic GMP intracellular contents and ratio, nor well as the ratio of stimulatory/inhibitory G protein a subunits. Our findings are in agreement with a maintained β-adrenergic signalling system in the pathophysiology of chronic reversible left ventricular dysfunction.

Original languageEnglish
Pages (from-to)388-394
Number of pages7
JournalBasic Research in Cardiology
Volume96
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • β-Adrenergic receptors
  • β-Adrenergic signalling system
  • G proteins
  • Left ventricular dysfunction
  • Myocardial stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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