β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease

Tiziana Casoli; Giuseppina Di Stefano; Alessia Delfino; Moreno Solazzi; Patrizia Fattoretti; Carlo Bertoni-Freddari; Marco Guidi; Osvaldo Scarpino; Sergio Giunta; Luciano Galeazzi

β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease

Tiziana Casoli, Giuseppina Di Stefano, Alessia Delfino, Moreno Solazzi, Patrizia Fattoretti, Carlo Bertoni-Freddari, Marco Guidi, Osvaldo Scarpino, Sergio Giunta, Luciano Galeazzi

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA_25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.

Original language	English
Pages (from-to)	296-302
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	977
Publication status	Published - 2002

Keywords

Aging
Alzheimer's disease (AD)
Calcium
Platelets
Ultrastructure
β-amyloid

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease. / Casoli, Tiziana ; Di Stefano, Giuseppina; Delfino, Alessia; Solazzi, Moreno; Fattoretti, Patrizia; Bertoni-Freddari, Carlo; Guidi, Marco; Scarpino, Osvaldo; Giunta, Sergio; Galeazzi, Luciano.

In: Annals of the New York Academy of Sciences, Vol. 977, 2002, p. 296-302.

Research output: Contribution to journal › Article › peer-review

Casoli, Tiziana ; Di Stefano, Giuseppina ; Delfino, Alessia ; Solazzi, Moreno ; Fattoretti, Patrizia ; Bertoni-Freddari, Carlo ; Guidi, Marco ; Scarpino, Osvaldo ; Giunta, Sergio ; Galeazzi, Luciano. / β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease. In: Annals of the New York Academy of Sciences. 2002 ; Vol. 977. pp. 296-302.

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abstract = "In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.",

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AU - Casoli, Tiziana

AU - Di Stefano, Giuseppina

AU - Delfino, Alessia

AU - Solazzi, Moreno

AU - Fattoretti, Patrizia

AU - Bertoni-Freddari, Carlo

AU - Guidi, Marco

AU - Scarpino, Osvaldo

AU - Giunta, Sergio

AU - Galeazzi, Luciano

PY - 2002

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N2 - In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.

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KW - Aging

KW - Alzheimer's disease (AD)

KW - Calcium

KW - Platelets

KW - Ultrastructure

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