In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.
|Number of pages||7|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 2002|
- Alzheimer's disease (AD)
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)