β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease

Tiziana Casoli, Giuseppina Di Stefano, Alessia Delfino, Moreno Solazzi, Patrizia Fattoretti, Carlo Bertoni-Freddari, Marco Guidi, Osvaldo Scarpino, Sergio Giunta, Luciano Galeazzi

Research output: Contribution to journalArticlepeer-review

Abstract

In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume977
Publication statusPublished - 2002

Keywords

  • Aging
  • Alzheimer's disease (AD)
  • Calcium
  • Platelets
  • Ultrastructure
  • β-amyloid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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