Abstract
In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.
| Original language | English |
|---|---|
| Pages (from-to) | 296-302 |
| Number of pages | 7 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 977 |
| Publication status | Published - 2002 |
Fingerprint
Keywords
- Aging
- Alzheimer's disease (AD)
- Calcium
- Platelets
- Ultrastructure
- β-amyloid
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease. / Casoli, Tiziana; Di Stefano, Giuseppina; Delfino, Alessia; Solazzi, Moreno; Fattoretti, Patrizia; Bertoni-Freddari, Carlo; Guidi, Marco; Scarpino, Osvaldo; Giunta, Sergio; Galeazzi, Luciano.
In: Annals of the New York Academy of Sciences, Vol. 977, 2002, p. 296-302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease
AU - Casoli, Tiziana
AU - Di Stefano, Giuseppina
AU - Delfino, Alessia
AU - Solazzi, Moreno
AU - Fattoretti, Patrizia
AU - Bertoni-Freddari, Carlo
AU - Guidi, Marco
AU - Scarpino, Osvaldo
AU - Giunta, Sergio
AU - Galeazzi, Luciano
PY - 2002
Y1 - 2002
N2 - In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.
AB - In order to analyze the metabolic response of AD patient platelets to β-amyloid, we have carried out fluorimetric measurements of intracellular calcium and an ultrastructural survey of platelets exposed to the β-amyloid active fragment 25-35 (βA25-35). Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of β-amyloid on AD neuronal cells.
KW - Aging
KW - Alzheimer's disease (AD)
KW - Calcium
KW - Platelets
KW - Ultrastructure
KW - β-amyloid
UR - http://www.scopus.com/inward/record.url?scp=18744415134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18744415134&partnerID=8YFLogxK
M3 - Article
C2 - 12480764
AN - SCOPUS:18744415134
VL - 977
SP - 296
EP - 302
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -