β amyloid-induced disruption of ionic balance: Studies on the isolated frog labyrinth

Laura Botta, Paolo Valli, Annalia Asti, Paola Perin, Gianpiero Zucca, Marco Racchi, Stefano Govoni, Alessia Pascale

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The β-amyloid peptide (Aβ) is a key player in the pathogenesis of Alzheimer's disease. Although its mechanisms of action are not fully elucidated, a disruption of ionic homeostasis has been suggested, and Aβ aggregation in fibrils seems correlated to its toxic potential. In the present work, we studied the effects of different Aβ fragments on the activity of frog ampullar nerve fibers. Our results show that Aβ fragments are able to reduce ampullar nerve responses, with a potency correlated to their fibrillogenic capability. This study may have clinical implications, since vestibular problems are often reported in Alzheimer patients, and provide a model for the dissection of Aβ effects in a simple multicomponent system.

Original languageEnglish
Pages (from-to)2493-2497
Number of pages5
JournalNeuroReport
Volume12
Issue number11
Publication statusPublished - Aug 8 2001

Fingerprint

Poisons
Inner Ear
Nerve Fibers
Amyloid
Anura
Dissection
Alzheimer Disease
Homeostasis
peptide A

Keywords

  • β-Amyloid
  • Fibril
  • Frog
  • Semicircular canal
  • Vestibular

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Botta, L., Valli, P., Asti, A., Perin, P., Zucca, G., Racchi, M., ... Pascale, A. (2001). β amyloid-induced disruption of ionic balance: Studies on the isolated frog labyrinth. NeuroReport, 12(11), 2493-2497.

β amyloid-induced disruption of ionic balance : Studies on the isolated frog labyrinth. / Botta, Laura; Valli, Paolo; Asti, Annalia; Perin, Paola; Zucca, Gianpiero; Racchi, Marco; Govoni, Stefano; Pascale, Alessia.

In: NeuroReport, Vol. 12, No. 11, 08.08.2001, p. 2493-2497.

Research output: Contribution to journalArticle

Botta, L, Valli, P, Asti, A, Perin, P, Zucca, G, Racchi, M, Govoni, S & Pascale, A 2001, 'β amyloid-induced disruption of ionic balance: Studies on the isolated frog labyrinth', NeuroReport, vol. 12, no. 11, pp. 2493-2497.
Botta L, Valli P, Asti A, Perin P, Zucca G, Racchi M et al. β amyloid-induced disruption of ionic balance: Studies on the isolated frog labyrinth. NeuroReport. 2001 Aug 8;12(11):2493-2497.
Botta, Laura ; Valli, Paolo ; Asti, Annalia ; Perin, Paola ; Zucca, Gianpiero ; Racchi, Marco ; Govoni, Stefano ; Pascale, Alessia. / β amyloid-induced disruption of ionic balance : Studies on the isolated frog labyrinth. In: NeuroReport. 2001 ; Vol. 12, No. 11. pp. 2493-2497.
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